BS7821
antibody from Bioworld Technology, Inc
Targeting: PRPF31
hPrp31, NY-BR-99, PRP31, RP11, SNRNP61
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS7821 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PRPF31 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human PRPF31.
- Description
- PRPF31 (PRP31 pre-mRNA processing factor 31 homolog), also known as RP11, PRP31 or NY-BR-99, is a ubiquitously expressed protein that localizes to the nucleus and is found in Cajal bodies and speckles. PRPF31 is involved in pre-mRNA splicing and functions as a component of the U4/U6.U5 tri-snRNP (small nuclear ribonucleoprotein) complex. More specifically, PRPF31 is believed to mediate the tethering of the tri-snRNP to the spliceosome (a large ribonucleoprotien responsible for catalyzing the splicing of pre-mRNA), thereby assisting in the assembly of the mature spliceosome. Mutations in the gene encoding PRPF31 result in autosomal dominant retinitis pigmentosa type 11 (RP11), which leads to photoreceptor cell degeneration. RP11 patients initially exhibit a loss of their midperipheral visual field as well as night vision blindness. The disease eventually progresses to the loss of far peripheral visual field and finally the loss of central vision. This suggests that PRPF31 is a key player in the pre-mRNA splicing of photoreceptor-specific genes.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- WesternBlot (WB) analysis of PRPF31 polyclonal antibody