Antibody data
- Antibody Data
- Antigen structure
- References [74]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 14999-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14999-1-AP, RRID:AB_2272597
- Product name
- Thioredoxin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Thioredoxin antibody (Cat. #14999-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease.
Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells.
Curdione inhibits ferroptosis in isoprenaline-induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway.
Thioredoxin 1 overexpression attenuated diabetes-induced endoplasmic reticulum stress in Müller cells via apoptosis signal-regulating kinase 1.
Thioredoxin-1 regulates the autophagy induced by oxidative stress through LC3-II in human lens epithelial cells.
Thioredoxin-1 regulates IRE1α to ameliorate sepsis-induced NLRP3 inflammasome activation and oxidative stress in Raw 264.7 cell.
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Antibiotics administration alleviates the high fat diet-induced obesity through altering the lipid metabolism in young mice.
Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity.
Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles.
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling.
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential.
Label-Free Quantification Mass Spectrometry Identifies Protein Markers of Chemotherapy Response in High-Grade Serous Ovarian Cancer.
Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD.
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Thioredoxin-1 inhibits amyloid-β(25-35)-induced activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury.
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1.
LPS induces pulmonary microvascular endothelial cell barrier dysfunction by upregulating ceramide production.
Pumpless three-dimensional photo paper-based microfluidic analytical device for automatic detection of thioredoxin-1 using enzyme-linked immunosorbent assay.
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney.
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Thioredoxin-1 Rescues MPP(+)/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4.
Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Methods to separate nuclear soluble fractions reflecting localizations in living cells.
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity via Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum.
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection.
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.
Detection of thioredoxin-1 using ultra-sensitive ELISA with enzyme-encapsulated human serum albumin nanoparticle.
Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation.
Overexpression of Thioredoxin-1 Blocks Morphine-Induced Conditioned Place Preference Through Regulating the Interaction of γ-Aminobutyric Acid and Dopamine Systems.
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Thioredoxin silencing-induced cardiac supercontraction occurs through endoplasmic reticulum stress and calcium overload in chicken.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
Mild Hypothermia Protects Renal Function in Ischemia-reperfusion Kidney: An Experimental Study in Mice.
Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference.
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Gene expression of selenoproteins can be regulated by thioredoxin(Txn) silence in chicken cardiomyocytes.
Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.
Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro.
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Ischemic postconditioning relieves cerebral ischemia and reperfusion injury through activating T-LAK cell-originated protein kinase/protein kinase B pathway in rats.
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Interaction between M-like protein and macrophage thioredoxin facilitates antiphagocytosis for Streptococcus equi ssp. zooepidemicus.
Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue.
Gu R, Bai L, Yan F, Zhang S, Zhang X, Deng R, Zeng X, Sun B, Hu X, Li Y, Bai J
Cell death discovery 2024 Feb 22;10(1):93
Cell death discovery 2024 Feb 22;10(1):93
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Gao S, Cheng Q, Hu Y, Fan X, Liang C, Niu C, Kang Q, Wei T
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Zhang S, Zhao N, Song S, Wang Y, Wang Y, Sun C, Dong M, Huo M, Xu N, Liu W, Li G
Toxicology and applied pharmacology 2024 Apr;485:116890
Toxicology and applied pharmacology 2024 Apr;485:116890
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease.
Zeng X, Geng W, Zhang Y, Yin J, Xu G, Yu M, Li L, Jia J
Ageing research reviews 2023 Sep;90:102000
Ageing research reviews 2023 Sep;90:102000
Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
Savage H, Pareek S, Lee J, Ballarò R, Conterno Minussi D, Hayek K, Sadullozoda M, Lochmann BS, McQuade JL, LaVoy EC, Marmonti E, Patel H, Wang G, Imanishi M, Kotla S, Abe JI, Schadler K
Cancer immunology research 2023 Sep 1;11(9):1168-1183
Cancer immunology research 2023 Sep 1;11(9):1168-1183
Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells.
Rydz L, Wróbel M, Janik K, Jurkowska H
Biomolecules 2023 Oct 7;13(10)
Biomolecules 2023 Oct 7;13(10)
Curdione inhibits ferroptosis in isoprenaline-induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway.
Wang H, Xie B, Shi S, Zhang R, Liang Q, Liu Z, Cheng Y
Phytotherapy research : PTR 2023 Nov;37(11):5328-5340
Phytotherapy research : PTR 2023 Nov;37(11):5328-5340
Thioredoxin 1 overexpression attenuated diabetes-induced endoplasmic reticulum stress in Müller cells via apoptosis signal-regulating kinase 1.
Yu X, Teng Q, Bao K, Chudhary M, Qi H, Zhou W, Che H, Liu J, Ren X, Kong L
Journal of cellular biochemistry 2023 Mar;124(3):421-433
Journal of cellular biochemistry 2023 Mar;124(3):421-433
Thioredoxin-1 regulates the autophagy induced by oxidative stress through LC3-II in human lens epithelial cells.
Hu J, Liu J, Chen S, Zhang C, Shen L, Yao K, Yu Y
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):476-485
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):476-485
Thioredoxin-1 regulates IRE1α to ameliorate sepsis-induced NLRP3 inflammasome activation and oxidative stress in Raw 264.7 cell.
Shao R, Lou X, Xue J, Yang Y, Ning D, Chen G, Jiang L
Immunopharmacology and immunotoxicology 2023 Jun;45(3):277-286
Immunopharmacology and immunotoxicology 2023 Jun;45(3):277-286
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Ge XF, Li SS, Liu YH, Lu MQ, Su HN, Yang X, Sun XW
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Antibiotics administration alleviates the high fat diet-induced obesity through altering the lipid metabolism in young mice.
Luo S, Zhang H, Jiang X, Xia Y, Tang S, Duan X, Sun W, Gao M, Chen C, Zou Z, Zhou L, Qiu J
Lipids 2023 Jan;58(1):19-32
Lipids 2023 Jan;58(1):19-32
Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity.
Prather BL, Ji S, Zhao Y, Shajan FJ, Zhao M, Buuh ZY, Maloney R, Zhang R, Cohen C, Wang RE
Acta pharmaceutica Sinica. B 2023 Jan;13(1):204-212
Acta pharmaceutica Sinica. B 2023 Jan;13(1):204-212
Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles.
Zhang L, Zhang Y, Jiang X, Mao L, Xia Y, Fan Y, Li N, Jiang Z, Qin X, Jiang Y, Liu G, Qiu F, Zhang J, Zou Z, Chen C
Toxicology 2023 Feb;485:153390
Toxicology 2023 Feb;485:153390
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
Tang S, Zhang H, Xia Y, Luo S, Liu Y, Duan X, Zou Z, Chen C, Zhou L, Qiu J
Toxicology mechanisms and methods 2023 Feb;33(2):113-122
Toxicology mechanisms and methods 2023 Feb;33(2):113-122
TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling.
Chen Y, Yin H, Sun J, Zhang G, Zhang Y, Zeng H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115822
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115822
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential.
Sans M, Makino Y, Min J, Rajapakshe KI, Yip-Schneider M, Schmidt CM, Hurd MW, Burks JK, Gomez JA, Thege FI, Fahrmann JF, Wolff RA, Kim MP, Guerrero PA, Maitra A
Cancer discovery 2023 Aug 4;13(8):1844-1861
Cancer discovery 2023 Aug 4;13(8):1844-1861
Label-Free Quantification Mass Spectrometry Identifies Protein Markers of Chemotherapy Response in High-Grade Serous Ovarian Cancer.
Arentz G, Mittal P, Klingler-Hoffmann M, Condina MR, Ricciardelli C, Lokman NA, Kaur G, Oehler MK, Hoffmann P
Cancers 2023 Apr 6;15(7)
Cancers 2023 Apr 6;15(7)
Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD.
Yang Q, Cai W, Jin H, Shen T, Yu J
Oxidative medicine and cellular longevity 2022;2022:1497813
Oxidative medicine and cellular longevity 2022;2022:1497813
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Wang R, Guo Y, Li L, Luo M, Peng L, Lv D, Cheng Z, Xue Q, Wang L, Huang J
Genes & diseases 2022 May;9(3):753-765
Genes & diseases 2022 May;9(3):753-765
Thioredoxin-1 inhibits amyloid-β(25-35)-induced activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells.
Jia J, Zhang X, Xu G, Zeng X, Li L
Molecular biology reports 2022 May;49(5):3445-3452
Molecular biology reports 2022 May;49(5):3445-3452
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Prutton KM, Marentette JO, Leifheit BA, Esquer H, LaBarbera DV, Anderson CC, Maclean KN, Roede JR
Free radical biology & medicine 2022 Jun;186:32-42
Free radical biology & medicine 2022 Jun;186:32-42
Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
Zhang L, Zhang Y, Qin X, Jiang X, Zhang J, Mao L, Jiang Z, Jiang Y, Liu G, Qiu J, Chen C, Qiu F, Zou Z
Critical care (London, England) 2022 Jun 9;26(1):171
Critical care (London, England) 2022 Jun 9;26(1):171
Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury.
Li H, Yang DH, Zhang Y, Zheng F, Gao F, Sun J, Shi G
Chinese medicine 2022 Jun 17;17(1):73
Chinese medicine 2022 Jun 17;17(1):73
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y
Metabolic brain disease 2022 Dec;37(8):2965-2978
Metabolic brain disease 2022 Dec;37(8):2965-2978
Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1.
Tian Y, Ge Z, Xu M, Ge X, Zhao M, Ding F, Yin J, Wang X, You Y, Shi Z, Qian X
Free radical biology & medicine 2022 Aug 20;189:157-168
Free radical biology & medicine 2022 Aug 20;189:157-168
LPS induces pulmonary microvascular endothelial cell barrier dysfunction by upregulating ceramide production.
Jiang J, Ouyang H, Zhou Q, Tang S, Fang P, Xie G, Yang J, Sun G
Cellular signalling 2022 Apr;92:110250
Cellular signalling 2022 Apr;92:110250
Pumpless three-dimensional photo paper-based microfluidic analytical device for automatic detection of thioredoxin-1 using enzyme-linked immunosorbent assay.
Lee MJ, Soum V, Lee SN, Choi JH, Shin JH, Shin K, Oh BK
Analytical and bioanalytical chemistry 2022 Apr;414(10):3219-3230
Analytical and bioanalytical chemistry 2022 Apr;414(10):3219-3230
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Zhang H, Zhao J, Lu Q, Sun B, Liu X, Yang C, Li S, Li L, Yi S, Yang Z, Xu J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Ren X, Lv J, Fu Y, Zhang N, Zhang C, Dong Z, Chudhary M, Zhong S, Kong L, Kong H
Diabetes research and clinical practice 2021 Sep;179:109025
Diabetes research and clinical practice 2021 Sep;179:109025
Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney.
Song Y, Guo F, Zhao Y, Zhao L, Fan X, Zhang Y, Liu Y, Qin G
European journal of pharmacology 2021 Nov 15;911:174552
European journal of pharmacology 2021 Nov 15;911:174552
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Qin W, Tong X, Liang R, Tang K, Wu X, Jia Y, Tan N
Journal of ethnopharmacology 2021 May 10;271:113827
Journal of ethnopharmacology 2021 May 10;271:113827
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.
Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z, Chen C, Ju Z
Cell reports 2021 Mar 30;34(13):108922
Cell reports 2021 Mar 30;34(13):108922
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Nunoue T, Yamaguchi S, Teshigawara S, Katayama A, Nakatsuka A, Eguchi J, Niki T, Wada J
Scientific reports 2021 Mar 16;11(1):5991
Scientific reports 2021 Mar 16;11(1):5991
Thioredoxin-1 Rescues MPP(+)/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4.
Bai L, Yan F, Deng R, Gu R, Zhang X, Bai J
Molecular neurobiology 2021 Jul;58(7):3187-3197
Molecular neurobiology 2021 Jul;58(7):3187-3197
Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.
Zhang W, Zhu Y, Yu H, Liu X, Jiao B, Lu X
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Li A, Wu X, Yang J, Li J, Guo H, Zhang Y, Jiang H, Huo T
Journal of ethnopharmacology 2021 Dec 5;281:114584
Journal of ethnopharmacology 2021 Dec 5;281:114584
Methods to separate nuclear soluble fractions reflecting localizations in living cells.
Ogawa Y, Imamoto N
iScience 2021 Dec 17;24(12):103503
iScience 2021 Dec 17;24(12):103503
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Zhou H, Yao L, Jiang X, Sumayyah G, Tu B, Cheng S, Qin X, Zhang J, Zou Z, Chen C
Neurotoxicity research 2021 Aug;39(4):1160-1170
Neurotoxicity research 2021 Aug;39(4):1160-1170
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
Zhang L, Zou L, Jiang X, Cheng S, Zhang J, Qin X, Qin Z, Chen C, Zou Z
Nanotoxicology 2021 Aug;15(6):779-797
Nanotoxicology 2021 Aug;15(6):779-797
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.
Wang K, Zheng X, Pan Z, Yao W, Gao X, Wang X, Ding X
Frontiers in cell and developmental biology 2020;8:559
Frontiers in cell and developmental biology 2020;8:559
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity via Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.
Wang W, Huang L, Thomas ER, Hu Y, Zeng F, Li X
Frontiers in pharmacology 2020;11:559046
Frontiers in pharmacology 2020;11:559046
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.
Wang W, Huang L, Hu Y, Thomas ER, Li X
Human & experimental toxicology 2020 Jun;39(6):797-807
Human & experimental toxicology 2020 Jun;39(6):797-807
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum.
Tang L, Ren X, Han Y, Chen L, Meng X, Zhang C, Chu H, Kong L, Ma H
Neurochemistry international 2020 Jun;136:104728
Neurochemistry international 2020 Jun;136:104728
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Jasek-Gajda E, Jurkowska H, Jasińska M, Lis GJ
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection.
Hirata Y, Ito Y, Takashima M, Yagyu K, Oh-Hashi K, Suzuki H, Ono K, Furuta K, Sawada M
ACS chemical neuroscience 2020 Jan 2;11(1):76-85
ACS chemical neuroscience 2020 Jan 2;11(1):76-85
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Ji L, Wang Q, Huang F, An T, Guo F, Zhao Y, Liu Y, He Y, Song Y, Qin G
Oxidative medicine and cellular longevity 2019;2019:3286928
Oxidative medicine and cellular longevity 2019;2019:3286928
Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells.
Takashima M, Ichihara K, Hirata Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Oct;132:110669
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Oct;132:110669
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.
Shen F, Xiong Z, Kong J, Wang L, Cheng Y, Jin J, Huang Z
Toxicology letters 2019 Jan;300:105-115
Toxicology letters 2019 Jan;300:105-115
Detection of thioredoxin-1 using ultra-sensitive ELISA with enzyme-encapsulated human serum albumin nanoparticle.
Lee MJ, Lee ES, Kim TH, Jeon JW, Kim Y, Oh BK
Nano convergence 2019 Dec 9;6(1):37
Nano convergence 2019 Dec 9;6(1):37
Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation.
Yang L, Guo Y, Huang M, Wu X, Li X, Chen G, Li Y, Bai J
Frontiers in neurology 2018;9:49
Frontiers in neurology 2018;9:49
Overexpression of Thioredoxin-1 Blocks Morphine-Induced Conditioned Place Preference Through Regulating the Interaction of γ-Aminobutyric Acid and Dopamine Systems.
Li X, Huang M, Yang L, Guo N, Yang X, Zhang Z, Bai M, Ge L, Zhou X, Li Y, Bai J
Frontiers in neurology 2018;9:309
Frontiers in neurology 2018;9:309
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Wang K, Lv Q, Miao YM, Qiao SM, Dai Y, Wei ZF
Biochemical pharmacology 2018 Sep;155:494-509
Biochemical pharmacology 2018 Sep;155:494-509
Thioredoxin silencing-induced cardiac supercontraction occurs through endoplasmic reticulum stress and calcium overload in chicken.
Yang J, Gong Y, Liu Q, Cai J, Zhang B, Zhang Z
Metallomics : integrated biometal science 2018 Nov 14;10(11):1667-1677
Metallomics : integrated biometal science 2018 Nov 14;10(11):1667-1677
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
Mild Hypothermia Protects Renal Function in Ischemia-reperfusion Kidney: An Experimental Study in Mice.
Xia Z, Wang W, Xiao Q, Ye Q, Zhang X, Wang Y
Transplantation proceedings 2018 Dec;50(10):3816-3821
Transplantation proceedings 2018 Dec;50(10):3816-3821
Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference.
Guo N, Zhang X, Huang M, Li X, Li Y, Zhou X, Bai J
Neuropharmacology 2018 Dec;143:63-70
Neuropharmacology 2018 Dec;143:63-70
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Petersen DR, Orlicky DJ, Roede JR, Shearn CT
Experimental and molecular pathology 2018 Aug;105(1):32-36
Experimental and molecular pathology 2018 Aug;105(1):32-36
Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.
Xin X, Dang H, Zhao X, Wang H
International journal of medical sciences 2017;14(10):943-950
International journal of medical sciences 2017;14(10):943-950
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Yang J, Hamid S, Cai J, Liu Q, Xu S, Zhang Z
Cellular signalling 2017 Oct;38:192-200
Cellular signalling 2017 Oct;38:192-200
Gene expression of selenoproteins can be regulated by thioredoxin(Txn) silence in chicken cardiomyocytes.
Yang J, Hamid S, Liu Q, Cai J, Xu S, Zhang Z
Journal of inorganic biochemistry 2017 Dec;177:118-126
Journal of inorganic biochemistry 2017 Dec;177:118-126
Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.
Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR
Free radical biology & medicine 2017 Dec;113:280-290
Free radical biology & medicine 2017 Dec;113:280-290
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.
Mvunta DH, Miyamoto T, Asaka R, Yamada Y, Ando H, Higuchi S, Ida K, Kashima H, Shiozawa T
Translational oncology 2017 Aug;10(4):621-631
Translational oncology 2017 Aug;10(4):621-631
Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro.
Yang JB, Khan M, He YY, Yao M, Li YM, Gao HW, Ma TH
Acta pharmacologica Sinica 2016 Jul;37(7):950-62
Acta pharmacologica Sinica 2016 Jul;37(7):950-62
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Dong K, Wu M, Liu X, Huang Y, Zhang D, Wang Y, Yan LJ, Shi D
Free radical biology & medicine 2016 Dec;101:334-347
Free radical biology & medicine 2016 Dec;101:334-347
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Armstrong V, Rojanathammanee L
Longevity & healthspan 2014;3(1):10
Longevity & healthspan 2014;3(1):10
Ischemic postconditioning relieves cerebral ischemia and reperfusion injury through activating T-LAK cell-originated protein kinase/protein kinase B pathway in rats.
Zhao H, Wang R, Tao Z, Gao L, Yan F, Gao Z, Liu X, Ji X, Luo Y
Stroke 2014 Aug;45(8):2417-24
Stroke 2014 Aug;45(8):2417-24
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D
Cell reports 2013 May 30;3(5):1663-77
Cell reports 2013 May 30;3(5):1663-77
Interaction between M-like protein and macrophage thioredoxin facilitates antiphagocytosis for Streptococcus equi ssp. zooepidemicus.
Ma Z, Zhang H, Zheng J, Li Y, Yi L, Fan H, Lu C
PloS one 2012;7(2):e32099
PloS one 2012;7(2):e32099
Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue.
Zhu X, Huang C, Peng B
Oral oncology 2011 Jul;47(7):609-14
Oral oncology 2011 Jul;47(7):609-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 14999-1-AP(TXN antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TXN antibody 14999-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 14999-1-AP(TXN antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 14999-1-AP(TXN antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue