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- Antibody Data
- Antigen structure
- References [140]
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- Western blot [1]
- Immunocytochemistry [2]
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- Product number
- 66200-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66200-1-Ig, RRID:AB_2722562
- Product name
- acetylated Tubulin(Lys40) antibody
- Antibody type
- Monoclonal
- Description
- acetylated Tubulin(Lys40) antibody (Cat. #66200-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, Canine, pig and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 7E5H8
- Vial size
- 20ul, 150ul
Submitted references Primary cilia regulate GLP-1 signaling in pancreatic β cells.
JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution.
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.
Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity.
SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells.
In silico discovery and biological evaluation of a novel selective HDAC8 inhibitor featuring 1H-pyrazolo[3,4-b]pyridine scaffold.
Genome-wide CRISPR/Cas9 screen identified MCL1 as a senolytic target for clearing palbociclib-induced senescent and PD-L1-positive cells in colorectal cancer.
Spatiotemporally engineered microneedle for microenvironment remodeling propels mucosal regeneration after tracheal mucosal injury.
3D perfusable minichannels stented with matrix bound vesicles derived from gingival mesenchymal stem cells ameliorated granuloma-related stenosis and improved survival in a rabbit tracheal replacement model.
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
Serum valeric acid stimulates lung epithelial cilia assembly and improves prognosis in patients with severe respiratory infections.
Breaking epigenetic shackles: targeting ARID1A methylation and the PI3K/AKT/mTOR-PD-L1 axis to overcome immune escape in gastric cancer.
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance.
Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
Characterisation of a primary ciliary dyskinesia model generated from BMI1-transduced basal epithelial cells.
Sulfonium lipid nanoparticles for intranasal mRNA delivery to lung epithelial and immune cells.
Porcine Nasal Organoids (PNOs) as a Model to Study the Pig Nasal Microbiota.
Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit.
Targeting the p38/MAPK pathway to induce apoptosis: a multidimensional mechanistic exploration of Mentha and its active compound diosmetin against liver cancer.
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.
Porcine nasal organoids to model interactions between the swine nasal microbiota and the host.
Beyond the Axoneme: Whole-Cell Proteomics Identifies Novel Regulators of Ciliogenesis in Xenopus Epidermal Multiciliated Cells.
Xin-shu-bao tablets ameliorates ventricular remodeling against HFrEF via PPARγ/MFGE8 pathway based on MALDI-MSI and lipidomics.
Role of intraflagellar transport protein IFT140 in the formation and function of motile cilia in mammals.
ACLY inhibitor reduced Porphyromonas gingivalis-induced pyroptosis by suppressing microtubules acetylation in macrophages.
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms.
A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.
A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice.
Discovery of TNI-97 as a Highly Selective, Orally Bioavailable HDAC6 Inhibitor for the Treatment of Triple-Negative Breast Cancer.
Two Spag6 genes control sperm formation and male fertility in mice.
Human HDAC6 senses valine abundancy to regulate DNA damage.
A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus.
Effects of patient pleural effusion fluids on the BBSome components expression of human benign mesothelial cells.
ARIH1 Inhibition Promotes Microtubule Stability and Sensitizes Breast Cancer Cells to Microtubule-Stabilizing Agents.
A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.
Zmynd10 drives centriole biogenesis and multiciliogenesis through the transcriptional regulation of E2f4.
RalGAP complexes control secretion and primary cilia in pancreatic disease.
ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non-Small Cell Lung Cancer.
Aspirin reverses the inhibitory effect of soluble fms-like tyrosine kinase-1 on trophoblast invasiveness and ciliogenesis through Sonic hedgehog signaling in preeclampsia.
SMOC2 (high) myofibroblastic cancer-associated fibroblast drives primary cilia-associated tumor microenvironment remodeling and poor prognosis in gastric cancer.
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling.
Polymer-based nanodrugs enhance sonodynamic therapy through epigenetic reprogramming of the immunosuppressive tumor microenvironment.
CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway.
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
The lysosome-related characteristics affects the prognosis and tumor microenvironment of lung adenocarcinoma.
Aspirin alleviates fibronectin-induced preeclampsia phenotypes in a mouse model and reverses fibronectin-mediated trophoblast invasiveness under hypoxia by regulating ciliogenesis and Akt and MAPK signaling.
Immuno-scanning electron microscopy of islet primary cilia.
Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC.
A New Method for Lateral Visualization of the Primary Cilia on the Surfaces of Cells Cultured on White Glass Rods.
A unique compound ameliorating endoplasmic reticulum stress and insulin resistance by binding to β tubulin.
Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis.
SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia.
HDA6 modulates Arabidopsis pavement cell morphogenesis through epigenetic suppression of ROP6 GTPase expression and signaling.
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
Identification and Analysis of Primary Cilia in the Corneal Endothelial Cells of Patients with Bullous Keratopathy.
Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Immuno-Scanning Electron Microscopy of Islet Primary Cilia.
The BRAF(V600E) mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia.
Isolation and Comprehensive Analysis of Cochlear Tissue-Derived Small Extracellular Vesicles.
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer.
Discovery of Novel Imidazo[1,2-a]pyridine-Based HDAC6 Inhibitors as an Anticarcinogen with a Cardioprotective Effect.
Histone deacetylase 6 suppression of renal tubular epithelial cell promotes interstitial mineral deposition via alpha-tubulin acetylation.
DNALI1 Promotes Neurodegeneration after Traumatic Brain Injury via Inhibition of Autophagosome-Lysosome Fusion.
CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice.
NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models.
Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti.
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis.
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study.
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
Scanning electron microscopy of human islet cilia.
Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress.
Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.
Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.
Optimization of Primary Human Bronchial Epithelial 3D Cell Culture with Donor-Matched Fibroblasts and Comparison of Two Different Culture Media.
Scanning electron microscopy of human islet cilia.
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models.
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells.
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.
Fluorescence imaging of beta cell primary cilia.
Temperature effects on the disappearance and reappearance of corneal-endothelium primary cilia.
Novel Compound Heterozygous Mutation in FSIP2 Causes Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) and Male Infertility.
Islet primary cilia motility controls insulin secretion.
A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins.
Endothelial RGS12 governs angiogenesis in inflammatory arthritis by controlling cilia formation and elongation via MYCBP2 signaling.
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Biallelic mutations in spermatogenesis and centriole-associated 1 like (SPATC1L) cause acephalic spermatozoa syndrome and male infertility.
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy.
Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.
The acetylome of adult mouse sciatic nerve.
Successful outcomes of intracytoplasmic sperm injection-embryo transfer using ejaculated spermatozoa from two Chinese asthenoteratozoospermic brothers with a compound heterozygous FSIP2 mutation.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome.
Analysis of Key Distinct Biological Characteristics of Human Placenta-Derived Mesenchymal Stromal Cells and Individual Heterogeneity Attributing to Donors.
The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer.
Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia.
Biallelic mutations of CFAP58 are associated with multiple morphological abnormalities of the sperm flagella.
Mutations in DNAH8 contribute to multiple morphological abnormalities of sperm flagella and male infertility.
Sub-toxic levels of cobalt ions impair chondrocyte mechanostranduction via HDAC6-dependent primary cilia shortening.
UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration.
SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19.
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.
UNG2 deacetylation confers cancer cell resistance to hydrogen peroxide-induced cytotoxicity.
MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
Photo-triggered self-destructive ROS-responsive nanoparticles of high paclitaxel/chlorin e6 co-loading capacity for synergetic chemo-photodynamic therapy.
Loss-of-function mutations in centrosomal protein 112 is associated with human acephalic spermatozoa phenotype.
HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation.
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Improved early development potence of in vitro fertilization embryos by treatment with tubacin increasing acetylated tubulin of matured porcine oocytes.
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Alternatively Polarized Macrophages Regulate the Growth and Differentiation of Ependymal Stem Cells through the SIRT2 Pathway.
Novel IFT140 variants cause spermatogenic dysfunction in humans.
Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells.
A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions.
Biallelic mutations in Sperm flagellum 2 cause human multiple morphological abnormalities of the sperm flagella (MMAF) phenotype.
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Novel Mutations in CFAP44 and CFAP43 Cause Multiple Morphological Abnormalities of the Sperm Flagella (MMAF).
Biallelic mutations in PMFBP1 cause acephalic spermatozoa.
KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.
CCDC9 is identified as a novel candidate gene of severe asthenozoospermia.
Ttc39c is upregulated during skeletal muscle atrophy and modulates ERK1/2 MAP kinase and hedgehog signaling.
EIF4G1 is a novel candidate gene associated with severe asthenozoospermia.
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.
C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia.
Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates.
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
ProBDNF inhibits collective migration and chemotaxis of rat Schwann cells.
NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition.
The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation.
Melena I, Jo JH, Townsend SE, DiGruccio SA, Dong X, Zhu L, Campbell J, Hughes JW
Molecular metabolism 2026 May;107:102357
Molecular metabolism 2026 May;107:102357
JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution.
Chen Q, Ma S, Liu H, Liu J, Li Q, Lyu Q, Yin H, Zhao J, Nai S, Song T, Liu H, Zhou J, Yan X, Zhu X, Zhao H
EMBO reports 2026 Mar;27(5):1161-1179
EMBO reports 2026 Mar;27(5):1161-1179
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.
Wu J, Cui G, Lin Z, Lin W, Zhang Y, Zhou T, He P, Zhang Y, Yao G
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695
Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity.
Yang W, Meng X, Zhu Y, Ma X, Cao Z, Wang M, Dai W, Tao Y, Jian X, Tian R, Yang Z, Wang R
Cell death discovery 2026 Mar 16;12(1)
Cell death discovery 2026 Mar 16;12(1)
SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells.
Patra M, Sadhukhan R, Allen E, Kalantari F, Allam H, Xia F
Cancer letters 2026 Mar 1;640:218239
Cancer letters 2026 Mar 1;640:218239
In silico discovery and biological evaluation of a novel selective HDAC8 inhibitor featuring 1H-pyrazolo[3,4-b]pyridine scaffold.
Yan W, Shi H, Li T, Fu Y, Zhang Y, Zhang Y, Liu J, Li X
Bioorganic chemistry 2026 Jun 5;173:109660
Bioorganic chemistry 2026 Jun 5;173:109660
Genome-wide CRISPR/Cas9 screen identified MCL1 as a senolytic target for clearing palbociclib-induced senescent and PD-L1-positive cells in colorectal cancer.
Wang H, Shen T, Yang S, Zhou X, Cao P, Yu H, He K, Fu M, Yu H, Liu X, Zhou T, Wang J, Huang M, Qian X, Wang X, Wang Q, Liu L, Fan Z, Zhang Y, Lin F
Cancer letters 2026 Jun 1;647:218446
Cancer letters 2026 Jun 1;647:218446
Spatiotemporally engineered microneedle for microenvironment remodeling propels mucosal regeneration after tracheal mucosal injury.
Wang P, Ci Z, Zhao E, Hu C, Chen B, Gao E, Bo Q, Bian C, Li Y, Song X, Zhou G, Xu T, Duan L
Bioactive materials 2026 Jul;61:272-289
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3D perfusable minichannels stented with matrix bound vesicles derived from gingival mesenchymal stem cells ameliorated granuloma-related stenosis and improved survival in a rabbit tracheal replacement model.
Liu B, Zhang X, Wei N, Wu X, Yuan P, Zeng T, Liang L, Zhang H, Wu W
Biomaterials 2026 Apr;327:123769
Biomaterials 2026 Apr;327:123769
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
Konishi S, Enkhbayar K, Liu S, Miyashita N, Kobayashi Y, Hutchison V, Sai A, Agarwal P, Witonsky J, Jackson ND, Seibold MA, Chen J, Tata A, Tata PR
The Journal of clinical investigation 2026 Apr 1;136(7)
The Journal of clinical investigation 2026 Apr 1;136(7)
Serum valeric acid stimulates lung epithelial cilia assembly and improves prognosis in patients with severe respiratory infections.
Zhang Y, Zhang Y, Wang L, Liu B, Zheng J, Cao J, Xie L, Shen N, Wang J
Frontiers in pharmacology 2025;16:1761517
Frontiers in pharmacology 2025;16:1761517
Breaking epigenetic shackles: targeting ARID1A methylation and the PI3K/AKT/mTOR-PD-L1 axis to overcome immune escape in gastric cancer.
Duan X, Huo X, Zhang Y, Lan H, Yang F, Zhang X, Zhou N
PeerJ 2025;13:e20251
PeerJ 2025;13:e20251
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance.
Li Z, Liu J, Ju J, Peng X, Zhao W, Ren J, Jia X, Wang J, Tu Y, Gao F
British journal of pharmacology 2025 Sep;182(17):4058-4079
British journal of pharmacology 2025 Sep;182(17):4058-4079
Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
Lee MD, Hilgendorf KI
Journal of cell science 2025 Oct 15;138(20)
Journal of cell science 2025 Oct 15;138(20)
Characterisation of a primary ciliary dyskinesia model generated from BMI1-transduced basal epithelial cells.
Dalbay MT, Shahaj E, Guerrini I, Lee DDH, Straatman-Iwanowska A, Mitchison HM, Baines DL, Hirst RA, Hogg C, O'Callaghan C, Hart SL
Journal of cell science 2025 Oct 15;138(20)
Journal of cell science 2025 Oct 15;138(20)
Sulfonium lipid nanoparticles for intranasal mRNA delivery to lung epithelial and immune cells.
Men Y, Popoola DO, Cao Z, Li Y, Wilkens S, Teng Y, Meng Q, Hershenson M, Li Y
Acta biomaterialia 2025 Oct 1;205:616-633
Acta biomaterialia 2025 Oct 1;205:616-633
Porcine Nasal Organoids (PNOs) as a Model to Study the Pig Nasal Microbiota.
Bonillo-Lopez L, Tarrés-Freixas F, Aragón V, Carmona-Vicente N
Methods in molecular biology (Clifton, N.J.) 2025 Nov 7;
Methods in molecular biology (Clifton, N.J.) 2025 Nov 7;
Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit.
Yu C, Li M, Shen F, Gao S, Wang J, He C, Wang L, Wu Y, Du Y
Chinese medicine 2025 Nov 13;20(1):188
Chinese medicine 2025 Nov 13;20(1):188
Targeting the p38/MAPK pathway to induce apoptosis: a multidimensional mechanistic exploration of Mentha and its active compound diosmetin against liver cancer.
Song Y, Du Y, Li W, Fan Y, Zhang Y, Shen H, Cheng L, Wang J, Deng F, Tang B
Scientific reports 2025 Nov 11;15(1):39432
Scientific reports 2025 Nov 11;15(1):39432
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.
Cheng Y, Liu B, Xin J, Wu X, Li W, Shang J, Wu J, Zhang Z, Xu B, Du M, Cheng G, Wang M
Nature aging 2025 May;5(5):909-928
Nature aging 2025 May;5(5):909-928
Porcine nasal organoids to model interactions between the swine nasal microbiota and the host.
Bonillo-Lopez L, Carmona-Vicente N, Tarrés-Freixas F, Kochanowski K, Martínez J, Perez M, Sibila M, Correa-Fiz F, Aragon V
Microbiome 2025 May 22;13(1):131
Microbiome 2025 May 22;13(1):131
Beyond the Axoneme: Whole-Cell Proteomics Identifies Novel Regulators of Ciliogenesis in Xenopus Epidermal Multiciliated Cells.
Xu X, Yu Y, Zheng T, Clark F, Ross J, Tavares ALP, Wei S, Sun J
bioRxiv : the preprint server for biology 2025 May 21;
bioRxiv : the preprint server for biology 2025 May 21;
Xin-shu-bao tablets ameliorates ventricular remodeling against HFrEF via PPARγ/MFGE8 pathway based on MALDI-MSI and lipidomics.
Zhang F, Li Z, Zhang Y, Yang J, Xiao H, Li X, Yang H
Journal of ethnopharmacology 2025 May 12;347:119741
Journal of ethnopharmacology 2025 May 12;347:119741
Role of intraflagellar transport protein IFT140 in the formation and function of motile cilia in mammals.
Yap YT, Pan J, Xu J, Yuan S, Niu C, Zheng C, Li W, Zhou T, Li T, Zhang Y, Holtzman MJ, Pazour GJ, Hess RA, Kelly CV, Touré A, Brody SL, Zhang Z
Cellular and molecular life sciences : CMLS 2025 May 10;82(1):198
Cellular and molecular life sciences : CMLS 2025 May 10;82(1):198
ACLY inhibitor reduced Porphyromonas gingivalis-induced pyroptosis by suppressing microtubules acetylation in macrophages.
Mao H, Guo F, Wang C, Jiang K, Li H, Lei L
International immunopharmacology 2025 Mar 26;150:114249
International immunopharmacology 2025 Mar 26;150:114249
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms.
Yang F, He Z, Pan X, Xie S, Liang X, Geng L, Xu W, Gong S
Cell communication and signaling : CCS 2025 Jun 4;23(1):263
Cell communication and signaling : CCS 2025 Jun 4;23(1):263
A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.
Hong J, Lee C, Madhu G, Papoulas O, Atayeter E, Hoogerbrugge G, Pan J, Takagishi M, Manzi N, Dickinson DJ, Horani A, Brody SL, Marcotte E, Prakash VN, Park TJ, Wallingford JB
bioRxiv : the preprint server for biology 2025 Jun 25;
bioRxiv : the preprint server for biology 2025 Jun 25;
A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice.
Cao A, Li Y, Feng Y, Wang X, Wei W, Sun H, Quan J
Molecules (Basel, Switzerland) 2025 Jul 31;30(15)
Molecules (Basel, Switzerland) 2025 Jul 31;30(15)
Discovery of TNI-97 as a Highly Selective, Orally Bioavailable HDAC6 Inhibitor for the Treatment of Triple-Negative Breast Cancer.
Wang S, Luo M, Xu Q, Guo R, Zhang W, Li B, Qin H, Wei L, Cui Y, Sha J, Shao S, Yu X, Zhao L, Sun P, Bai C, Wen J, Liu D
Journal of medicinal chemistry 2025 Jul 24;68(14):14333-14356
Journal of medicinal chemistry 2025 Jul 24;68(14):14333-14356
Two Spag6 genes control sperm formation and male fertility in mice.
Liu Y, Li W, Li T, Zheng C, Niu C, Schmitt A, Yap YT, Abdulghani M, Yuan S, Melander C, Strauss JF 3rd, Toure A, Zhang L, Zhang Z
bioRxiv : the preprint server for biology 2025 Jul 22;
bioRxiv : the preprint server for biology 2025 Jul 22;
Human HDAC6 senses valine abundancy to regulate DNA damage.
Jin J, Meng T, Yu Y, Wu S, Jiao CC, Song S, Li YX, Zhang Y, Zhao YY, Li X, Wang Z, Liu YF, Huang R, Qin J, Chen Y, Cao H, Tan X, Ge X, Jiang C, Xue J, Yuan J, Wu D, Wu W, Jiang CZ, Wang P
Nature 2025 Jan;637(8044):215-223
Nature 2025 Jan;637(8044):215-223
A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus.
Wu L, Sun Y, Wu Z, Liu R, Yin Y, Wong NL, Ju W, Zhang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jan;182:117746
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jan;182:117746
Effects of patient pleural effusion fluids on the BBSome components expression of human benign mesothelial cells.
Jagirdar RM, Rouka E, Pitaraki E, Sarrigeorgiou I, Kotsiou OS, Sinis SI, Papazoglou ED, Marnas P, Malami Z, Lymberi P, Giannou AD, Hatzoglou C, Gourgoulianis KI, Zarogiannis SG
American journal of physiology. Lung cellular and molecular physiology 2025 Jan 1;328(1):L105-L112
American journal of physiology. Lung cellular and molecular physiology 2025 Jan 1;328(1):L105-L112
ARIH1 Inhibition Promotes Microtubule Stability and Sensitizes Breast Cancer Cells to Microtubule-Stabilizing Agents.
Elshaer M, Howley BV, Howe PH
Cancers 2025 Feb 25;17(5)
Cancers 2025 Feb 25;17(5)
A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.
Hong J, Lee C, Madhu G, Papoulas O, Atayeter E, Hoogerbrugge G, Pan J, Takagishi M, Manzi NI, Dickinson DJ, Horani A, Brody SL, Marcotte EM, Prakash VN, Park TJ, Wallingford JB
Nature communications 2025 Dec 21;17(1):394
Nature communications 2025 Dec 21;17(1):394
Zmynd10 drives centriole biogenesis and multiciliogenesis through the transcriptional regulation of E2f4.
Liu Z, Wu Q, Zhou Z, Tan W, Zhong J, Fan S, Cao K, Huang L
Scientific reports 2025 Dec 18;15(1):44097
Scientific reports 2025 Dec 18;15(1):44097
RalGAP complexes control secretion and primary cilia in pancreatic disease.
Apken LH, Barz H, Beel S, Michalke E, Rasche R, Verma A, Ricker A, Nüsse H, Klingauf J, Kerl K, Wardelmann E, Kümmel D, Steinestel K, Pethő Z, Meisterernst M, Oeckinghaus A
Life science alliance 2025 Aug;8(8)
Life science alliance 2025 Aug;8(8)
ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non-Small Cell Lung Cancer.
Zhong T, Liu N, Wang J, Xie S, Liu L, Wang M, Wu F, Chen X, Xiao C, Gongye X, Wu M, Wen L, Yu J, Chen D
Exploration (Beijing, China) 2025 Aug;5(4):e20230024
Exploration (Beijing, China) 2025 Aug;5(4):e20230024
Aspirin reverses the inhibitory effect of soluble fms-like tyrosine kinase-1 on trophoblast invasiveness and ciliogenesis through Sonic hedgehog signaling in preeclampsia.
Chen YJ, Lee CI, Tsai PY, Tam HL, Su MT
Biochemical pharmacology 2025 Aug;238:116975
Biochemical pharmacology 2025 Aug;238:116975
SMOC2 (high) myofibroblastic cancer-associated fibroblast drives primary cilia-associated tumor microenvironment remodeling and poor prognosis in gastric cancer.
Xu Q, Yang C, Ning J, Niu Y, Zhao X, Zhao L, Wang C, Wang S, Ye Y, Shen Z
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2025 Aug 30;37(4):603-623
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2025 Aug 30;37(4):603-623
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling.
Ji M, Cui W, Feng Q, Qi J, Wang X, Zhu H, Zhang W, Fu W
Life science alliance 2025 Apr;8(4)
Life science alliance 2025 Apr;8(4)
Polymer-based nanodrugs enhance sonodynamic therapy through epigenetic reprogramming of the immunosuppressive tumor microenvironment.
Yu L, Gao L, Liang B, Zhang L, Wu M, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:125-137
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:125-137
CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway.
Hu K, Xie L, Wu W, Zhang J, Li Y, He J, Zhang Y, Lu D, Koeffler HP, Lin L, Yin D
International journal of biological sciences 2024;20(8):3140-3155
International journal of biological sciences 2024;20(8):3140-3155
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Liu S, He Y, Gu Z
Frontiers in oncology 2024;14:1442911
Frontiers in oncology 2024;14:1442911
The lysosome-related characteristics affects the prognosis and tumor microenvironment of lung adenocarcinoma.
Chang W, Gao W, Wu Y, Luo B, Zhong L, Zhong L, Lin W, Wen Z, Chen Y
Frontiers in medicine 2024;11:1497312
Frontiers in medicine 2024;11:1497312
Aspirin alleviates fibronectin-induced preeclampsia phenotypes in a mouse model and reverses fibronectin-mediated trophoblast invasiveness under hypoxia by regulating ciliogenesis and Akt and MAPK signaling.
Tsai PY, Lee CI, Tam HL, Su MT
Biochemical pharmacology 2024 Sep;227:116423
Biochemical pharmacology 2024 Sep;227:116423
Immuno-scanning electron microscopy of islet primary cilia.
Sviben S, Polino AJ, Melena IL, Hughes JW
Journal of cell science 2024 Oct 15;137(20)
Journal of cell science 2024 Oct 15;137(20)
Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC.
Tian S, Du S, Wang C, Zhang Y, Wang H, Fan Y, Gao Y, Gu L, Huang Q, Wang B, Ma X, Zhang X, Huang Y
Cell death & disease 2024 Oct 10;15(10):739
Cell death & disease 2024 Oct 10;15(10):739
A New Method for Lateral Visualization of the Primary Cilia on the Surfaces of Cells Cultured on White Glass Rods.
Tanioka H, Deguchi H, Kinoshita S, Sotozono C
Translational vision science & technology 2024 Nov 4;13(11):19
Translational vision science & technology 2024 Nov 4;13(11):19
A unique compound ameliorating endoplasmic reticulum stress and insulin resistance by binding to β tubulin.
Horiuchi K, Matsushima G, Wada M, Thon M, Sobhy MH, Ayoub AT, Hara M, Yoshii M, Arakawa K, Ozawa K, Hosoi T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70150
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70150
Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis.
Parolek J, Burd CG
Molecular biology of the cell 2024 May 1;35(5):br11
Molecular biology of the cell 2024 May 1;35(5):br11
SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia.
Li L, Zhao H, Li Z, Shi W, Jiao Z
DNA and cell biology 2024 Mar;43(3):141-151
DNA and cell biology 2024 Mar;43(3):141-151
HDA6 modulates Arabidopsis pavement cell morphogenesis through epigenetic suppression of ROP6 GTPase expression and signaling.
Du X, Gao Y, Zhang H, Xu X, Li Y, Zhao L, Luo M, Wang H
The New phytologist 2024 Mar;241(6):2523-2539
The New phytologist 2024 Mar;241(6):2523-2539
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
Feng T, Du H, Yang C, Wang Y, Hu F
Acta neuropathologica 2024 Mar 25;147(1):62
Acta neuropathologica 2024 Mar 25;147(1):62
Identification and Analysis of Primary Cilia in the Corneal Endothelial Cells of Patients with Bullous Keratopathy.
Deguchi H, Tanioka H, Watanabe M, Horiuchi N, Fukuoka H, Hieda O, Inatomi T, Kinoshita S, Sotozono C
Current eye research 2024 Jan;49(1):10-15
Current eye research 2024 Jan;49(1):10-15
Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Liu L, Liu X, Chen Y, Kong M, Zhang J, Jiang M, Zhou H, Yang J, Chen X, Zhang Z, Wu C, Jiang X, Zhang J
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119628
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119628
Immuno-Scanning Electron Microscopy of Islet Primary Cilia.
Sviben S, Polino AJ, Melena I, Hughes JW
bioRxiv : the preprint server for biology 2024 Feb 16;
bioRxiv : the preprint server for biology 2024 Feb 16;
The BRAF(V600E) mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia.
Ma CX, Ma XN, Liu JJ, Guan CH, Li YD, Zhao N, Mauricio D, Fu SB
Molecular and cellular endocrinology 2024 Feb 1;581:112113
Molecular and cellular endocrinology 2024 Feb 1;581:112113
Isolation and Comprehensive Analysis of Cochlear Tissue-Derived Small Extracellular Vesicles.
Jiang P, Ma X, Wang X, Huang J, Wang Y, Ai J, Xiao H, Dai M, Lin Y, Shao B, Tang X, Tong W, Ye Z, Chai R, Zhang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408964
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408964
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
Ma L, Zhang K, Huang Z, Guo Y, Liu N, Chen J, Wang X, Liu Y, Li M, Li J, Yang C, Liu S, Yang G
Journal of medicinal chemistry 2024 Dec 12;67(23):21344-21363
Journal of medicinal chemistry 2024 Dec 12;67(23):21344-21363
Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer.
Chen X, Ding X, Fang J, Mao C, Gong X, Zhang Y, Zhang N, Yan F, Lou Y, Chen Z, Ding W, Ma Z
Journal of medicinal chemistry 2024 Aug 22;67(16):14609-14632
Journal of medicinal chemistry 2024 Aug 22;67(16):14609-14632
Discovery of Novel Imidazo[1,2-a]pyridine-Based HDAC6 Inhibitors as an Anticarcinogen with a Cardioprotective Effect.
Yang FF, Liu JJ, Xu XL, Hu T, Liu JQ, He ZX, Zhao GY, Wei B, Ma LY
Journal of medicinal chemistry 2024 Aug 22;67(16):14345-14369
Journal of medicinal chemistry 2024 Aug 22;67(16):14345-14369
Histone deacetylase 6 suppression of renal tubular epithelial cell promotes interstitial mineral deposition via alpha-tubulin acetylation.
Li S, Wu W, Yang B, Liu Z, Duan X, Sun X, Liu H, Zhang S, Zhou Y, Wu W
Cellular signalling 2024 Apr;116:111057
Cellular signalling 2024 Apr;116:111057
DNALI1 Promotes Neurodegeneration after Traumatic Brain Injury via Inhibition of Autophagosome-Lysosome Fusion.
Ding X, Cao S, Wang Q, Du B, Lu K, Qi S, Cheng Y, Tuo QZ, Liang W, Lei P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2306399
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2306399
CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice.
Wei X, Wang X, Yang C, Gao Y, Zhang Y, Xiao Y, Ju Z, Jiang Q, Wang J, Liu W, Li Y, Gao Y, Huang J
Development (Cambridge, England) 2024 Apr 1;151(7)
Development (Cambridge, England) 2024 Apr 1;151(7)
NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models.
Zhou H, Zhang Q, Huang W, Zhou S, Wang Y, Zeng X, Wang H, Xie W, Kong H
International journal of biological sciences 2023;19(6):1875-1893
International journal of biological sciences 2023;19(6):1875-1893
Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti.
Lindner LA, Derstroff D, Oliver D, Reimann K
Frontiers in neuroscience 2023;17:1162937
Frontiers in neuroscience 2023;17:1162937
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis.
Wang B, Liang Z, Tan T, Zhang M, Jiang Y, Shang Y, Gao X, Song S, Wang R, Chen H, Liu J, Li J, Ren Y, Liu P
eLife 2023 Sep 22;12
eLife 2023 Sep 22;12
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study.
Rouka E, Jagirdar RM, Sarrigeorgiou I, Pitaraki E, Sinis SI, Varsamas C, Papazoglou ED, Kotsiou OS, Lymberi P, Giannou A, Hatzoglou C, Gourgoulianis KI, Zarogiannis SG
Pharmacological reports : PR 2023 Oct;75(5):1230-1239
Pharmacological reports : PR 2023 Oct;75(5):1230-1239
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
Feng T, Du H, Hu F
bioRxiv : the preprint server for biology 2023 Nov 15;
bioRxiv : the preprint server for biology 2023 Nov 15;
Scanning electron microscopy of human islet cilia.
Polino AJ, Sviben S, Melena I, Piston DW, Hughes JW
Proceedings of the National Academy of Sciences of the United States of America 2023 May 30;120(22):e2302624120
Proceedings of the National Academy of Sciences of the United States of America 2023 May 30;120(22):e2302624120
Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress.
Grande V, Schuld J, van der Ven PFM, Gruss OJ, Fürst DO
Cell and tissue research 2023 Jul;393(1):133-147
Cell and tissue research 2023 Jul;393(1):133-147
Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
Hua J, Xu B, Liu W, Shi J, Jiang H, Zha X, Zhang X, Wan Y
Human molecular genetics 2023 Jul 4;32(14):2307-2317
Human molecular genetics 2023 Jul 4;32(14):2307-2317
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Xu W, Yuan Y, Tian Y, Cheng C, Chen Y, Zeng L, Yuan Y, Li D, Zheng L, Luo T
Journal of hazardous materials 2023 Jul 15;454:131470
Journal of hazardous materials 2023 Jul 15;454:131470
SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.
Lin R, Yang Y, Wu E, Zhou M, Wang S, Zhang Q
The Prostate 2023 Jan;83(1):71-81
The Prostate 2023 Jan;83(1):71-81
Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.
Lee D, Gimple RC, Wu X, Prager BC, Qiu Z, Wu Q, Daggubati V, Mariappan A, Gopalakrishnan J, Sarkisian MR, Raleigh DR, Rich JN
The Journal of clinical investigation 2023 Jan 17;133(2)
The Journal of clinical investigation 2023 Jan 17;133(2)
Optimization of Primary Human Bronchial Epithelial 3D Cell Culture with Donor-Matched Fibroblasts and Comparison of Two Different Culture Media.
Maurer J, Walles T, Wiese-Rischke C
International journal of molecular sciences 2023 Feb 18;24(4)
International journal of molecular sciences 2023 Feb 18;24(4)
Scanning electron microscopy of human islet cilia.
Polino AJ, Sviben S, Melena I, Piston DW, Hughes J
bioRxiv : the preprint server for biology 2023 Feb 15;
bioRxiv : the preprint server for biology 2023 Feb 15;
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models.
Sanz-Alcázar A, Britti E, Delaspre F, Medina-Carbonero M, Pazos-Gil M, Tamarit J, Ros J, Cabiscol E
Cellular and molecular life sciences : CMLS 2023 Dec 21;81(1):12
Cellular and molecular life sciences : CMLS 2023 Dec 21;81(1):12
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells.
Cai H, Wang Y, Zhang J, Wei Z, Yan T, Feng C, Xu Z, Zhou A, Wu Y
Journal of chemical information and modeling 2023 Aug 14;63(15):4780-4790
Journal of chemical information and modeling 2023 Aug 14;63(15):4780-4790
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
Wang L, Pu W, Wang C, Lei L, Li H
Journal of oral microbiology 2022;14(1):2015130
Journal of oral microbiology 2022;14(1):2015130
Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.
Hou Q, Kan S, Wang Z, Shi J, Zeng C, Yang D, Jiang S, Liu Z
Frontiers in pharmacology 2022;13:938391
Frontiers in pharmacology 2022;13:938391
Fluorescence imaging of beta cell primary cilia.
Li ZA, Cho JH, Woodhams LG, Hughes JW
Frontiers in endocrinology 2022;13:1004136
Frontiers in endocrinology 2022;13:1004136
Temperature effects on the disappearance and reappearance of corneal-endothelium primary cilia.
Tanioka H, Shinomiya K, Kinoshita S, Sotozono C
Japanese journal of ophthalmology 2022 Sep;66(5):481-486
Japanese journal of ophthalmology 2022 Sep;66(5):481-486
Novel Compound Heterozygous Mutation in FSIP2 Causes Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) and Male Infertility.
Hou M, Xi Q, Zhu L, Jia W, Liu Z, Wang C, Zhou X, Zhang D, Xing C, Peng X, Luo Y, Jin L, Li Z, Zhang X
Reproductive sciences (Thousand Oaks, Calif.) 2022 Sep;29(9):2697-2702
Reproductive sciences (Thousand Oaks, Calif.) 2022 Sep;29(9):2697-2702
Islet primary cilia motility controls insulin secretion.
Cho JH, Li ZA, Zhu L, Muegge BD, Roseman HF, Lee EY, Utterback T, Woodhams LG, Bayly PV, Hughes JW
Science advances 2022 Sep 23;8(38):eabq8486
Science advances 2022 Sep 23;8(38):eabq8486
A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins.
Zhang X, Qiao Y, Han R, Gao Y, Yang X, Zhang Y, Wan Y, Yu W, Pan X, Xing J
Cells 2022 Sep 15;11(18)
Cells 2022 Sep 15;11(18)
Endothelial RGS12 governs angiogenesis in inflammatory arthritis by controlling cilia formation and elongation via MYCBP2 signaling.
Yuan G, Yang ST, Yang S
Cell insight 2022 Oct;1(5):100055
Cell insight 2022 Oct;1(5):100055
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Li T, Zhai D, Zhang M, Ye R, Kuang X, Shao N, Bi J, Lin Y
Cancer letters 2022 Nov 1;548:215904
Cancer letters 2022 Nov 1;548:215904
Biallelic mutations in spermatogenesis and centriole-associated 1 like (SPATC1L) cause acephalic spermatozoa syndrome and male infertility.
Li YZ, Li N, Liu WS, Sha YW, Wu RF, Tang YL, Zhu XS, Wei XL, Zhang XY, Wang YF, Lu ZX, Zhang FX
Asian journal of andrology 2022 Jan-Feb;24(1):67-72
Asian journal of andrology 2022 Jan-Feb;24(1):67-72
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Chen Y, Bao M, Liu JT, Bao H, Zhang SM, Lou Y, Qi YX
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy.
Shi L, Song Z, Li C, Deng F, Xia Y, Huang J, Wu X, Zhu J
Cells 2022 Dec 7;11(24)
Cells 2022 Dec 7;11(24)
Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.
Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP, Ramchandran R
Biochemical pharmacology 2022 Aug;202:115143
Biochemical pharmacology 2022 Aug;202:115143
The acetylome of adult mouse sciatic nerve.
Shen M, Chen Z, Ming M, Cheng Z, Sun J, Liang Q, Shang T, Zhang Q, Zhou S, Ji Y, Ding F
Journal of neurochemistry 2022 Aug;162(3):262-275
Journal of neurochemistry 2022 Aug;162(3):262-275
Successful outcomes of intracytoplasmic sperm injection-embryo transfer using ejaculated spermatozoa from two Chinese asthenoteratozoospermic brothers with a compound heterozygous FSIP2 mutation.
Yuan Y, Xu WQ, Chen ZY, Chen Y, Zhang L, Zheng L, Luo T, Chen HY
Andrologia 2022 Apr;54(3):e14351
Andrologia 2022 Apr;54(3):e14351
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome.
Sha Y, Liu W, Li L, Serafimovski M, Isachenko V, Li Y, Chen J, Zhao B, Wang Y, Wei X
Frontiers in cell and developmental biology 2021;9:676246
Frontiers in cell and developmental biology 2021;9:676246
Analysis of Key Distinct Biological Characteristics of Human Placenta-Derived Mesenchymal Stromal Cells and Individual Heterogeneity Attributing to Donors.
Tai C, Wang L, Xie Y, Gao T, Huang F, Wang B
Cells, tissues, organs 2021;210(1):45-57
Cells, tissues, organs 2021;210(1):45-57
The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer.
Yang T, Wang P, Yin X, Zhang J, Huo M, Gao J, Li G, Teng X, Yu H, Huang W, Wang Y
Theranostics 2021;11(5):2058-2076
Theranostics 2021;11(5):2058-2076
Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia.
Wei X, Liu W, Zhu X, Li Y, Zhang X, Chen J, Isachenko V, Sha Y, Lu Z
Clinical genetics 2021 Oct;100(4):376-385
Clinical genetics 2021 Oct;100(4):376-385
Biallelic mutations of CFAP58 are associated with multiple morphological abnormalities of the sperm flagella.
Sha Y, Sha Y, Liu W, Zhu X, Weng M, Zhang X, Wang Y, Zhou H
Clinical genetics 2021 Mar;99(3):443-448
Clinical genetics 2021 Mar;99(3):443-448
Mutations in DNAH8 contribute to multiple morphological abnormalities of sperm flagella and male infertility.
Weng M, Sha Y, Zeng YU, Huang N, Liu W, Zhang X, Zhou H
Acta biochimica et biophysica Sinica 2021 Mar 26;53(4):472-480
Acta biochimica et biophysica Sinica 2021 Mar 26;53(4):472-480
Sub-toxic levels of cobalt ions impair chondrocyte mechanostranduction via HDAC6-dependent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Liu S, Fu S
Biochemical and biophysical research communications 2021 Mar 12;544:38-43
Biochemical and biophysical research communications 2021 Mar 12;544:38-43
UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration.
Guo Z, Li C, Cao Y, Qin T, Jiang L, Xu Y, Li M, Luo Z, Hu J, Lu H
Molecular therapy. Methods & clinical development 2021 Mar 12;20:337-349
Molecular therapy. Methods & clinical development 2021 Mar 12;20:337-349
SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
Zhao Y, Xie L, Shen C, Qi Q, Qin Y, Xing J, Zhou D, Qi Y, Yan Z, Lin X, Dai R, Lin J, Yu W
Aging cell 2021 Jun;20(6):e13391
Aging cell 2021 Jun;20(6):e13391
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19.
Ahn JH, Kim J, Hong SP, Choi SY, Yang MJ, Ju YS, Kim YT, Kim HM, Rahman MDT, Chung MK, Hong SD, Bae H, Lee CS, Koh GY
The Journal of clinical investigation 2021 Jul 1;131(13)
The Journal of clinical investigation 2021 Jul 1;131(13)
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Gailey CD, Wang EJ, Jin L, Ahmadi S, Brautigan DL, Li X, Xu W, Scott MM, Fu Z
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.
Zhan Y, Wang H, Zhang L, Pei F, Chen Z
Frontiers in cell and developmental biology 2020;8:605609
Frontiers in cell and developmental biology 2020;8:605609
UNG2 deacetylation confers cancer cell resistance to hydrogen peroxide-induced cytotoxicity.
Bao Y, Tong L, Song B, Liu G, Zhu Q, Lu X, Zhang J, Lu YF, Wen H, Tian Y, Sun Y, Zhu WG
Free radical biology & medicine 2020 Nov 20;160:403-417
Free radical biology & medicine 2020 Nov 20;160:403-417
MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
Liang Y, Zhu D, Hou L, Wang Y, Huang X, Zhou C, Zhu L, Wang Y, Li L, Gu Y, Luo M, Wang J, Meng X
British journal of cancer 2020 Mar;122(5):705-714
British journal of cancer 2020 Mar;122(5):705-714
Photo-triggered self-destructive ROS-responsive nanoparticles of high paclitaxel/chlorin e6 co-loading capacity for synergetic chemo-photodynamic therapy.
Yang X, Shi X, Zhang Y, Xu J, Ji J, Ye L, Yi F, Zhai G
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:333-349
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:333-349
Loss-of-function mutations in centrosomal protein 112 is associated with human acephalic spermatozoa phenotype.
Sha Y, Wang X, Yuan J, Zhu X, Su Z, Zhang X, Xu X, Wei X
Clinical genetics 2020 Feb;97(2):321-328
Clinical genetics 2020 Feb;97(2):321-328
HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation.
Sui L, Zhang S, Huang R, Li Z
Cell cycle (Georgetown, Tex.) 2020 Feb;19(3):354-362
Cell cycle (Georgetown, Tex.) 2020 Feb;19(3):354-362
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Wu Y, Wang D, Wei F, Xiong F, Zhang S, Gong Z, Shi L, Li X, Xiang B, Ma J, Deng H, He Y, Liao Q, Zhang W, Li X, Li Y, Guo C, Zeng Z, Li G, Xiong W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16205-16223
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16205-16223
Improved early development potence of in vitro fertilization embryos by treatment with tubacin increasing acetylated tubulin of matured porcine oocytes.
Sun J, Cui K, Li ZP, Gao B, Huang B, Liu Q, Shi D
Mechanisms of development 2020 Dec;164:103631
Mechanisms of development 2020 Dec;164:103631
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
Cui L, Zheng J, Zhao Q, Chen JR, Liu H, Peng G, Wu Y, Chen C, He Q, Shi H, Yin S, Friedman RA, Chen Y, Guan MX
JCI insight 2020 Dec 3;5(23)
JCI insight 2020 Dec 3;5(23)
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Wu Z, Zhang Y, Zhang Y, Zhao P
Cellular and molecular neurobiology 2020 Apr;40(3):437-446
Cellular and molecular neurobiology 2020 Apr;40(3):437-446
Alternatively Polarized Macrophages Regulate the Growth and Differentiation of Ependymal Stem Cells through the SIRT2 Pathway.
Ma Y, Deng M, Zhao XQ, Liu M
Experimental neurobiology 2020 Apr 30;29(2):150-163
Experimental neurobiology 2020 Apr 30;29(2):150-163
Novel IFT140 variants cause spermatogenic dysfunction in humans.
Wang X, Sha YW, Wang WT, Cui YQ, Chen J, Yan W, Hou XT, Mei LB, Yu CC, Wang J
Molecular genetics & genomic medicine 2019 Sep;7(9):e920
Molecular genetics & genomic medicine 2019 Sep;7(9):e920
Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells.
Li L, Yan S, Zhang H, Zhang M, Huang G, Chen M
BMC cancer 2019 Sep 6;19(1):894
BMC cancer 2019 Sep 6;19(1):894
A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions.
Wang J, Wang C, Xu N, Liu ZF, Pang DW, Zhang ZL
Biomaterials 2019 Oct;219:119367
Biomaterials 2019 Oct;219:119367
Biallelic mutations in Sperm flagellum 2 cause human multiple morphological abnormalities of the sperm flagella (MMAF) phenotype.
Sha Y, Liu W, Wei X, Zhu X, Luo X, Liang L, Guo T
Clinical genetics 2019 Nov;96(5):385-393
Clinical genetics 2019 Nov;96(5):385-393
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Sun X, Xie Y, Sun X, Yao Y, Li H, Li Z, Yao R, Xu K
Bioscience reports 2019 Mar 29;39(3)
Bioscience reports 2019 Mar 29;39(3)
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Xu D, Wu L, Jiang X, Yang L, Cheng J, Chen H, Hua R, Geng G, Yang L, Li Q
International journal of molecular sciences 2019 Mar 18;20(6)
International journal of molecular sciences 2019 Mar 18;20(6)
Novel Mutations in CFAP44 and CFAP43 Cause Multiple Morphological Abnormalities of the Sperm Flagella (MMAF).
Sha YW, Wang X, Xu X, Su ZY, Cui Y, Mei LB, Huang XJ, Chen J, He XM, Ji ZY, Bao H, Yang X, Li P, Li L
Reproductive sciences (Thousand Oaks, Calif.) 2019 Jan;26(1):26-34
Reproductive sciences (Thousand Oaks, Calif.) 2019 Jan;26(1):26-34
Biallelic mutations in PMFBP1 cause acephalic spermatozoa.
Sha YW, Wang X, Xu X, Ding L, Liu WS, Li P, Su ZY, Chen J, Mei LB, Zheng LK, Wang HL, Kong SB, You M, Wu JF
Clinical genetics 2019 Feb;95(2):277-286
Clinical genetics 2019 Feb;95(2):277-286
KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.
Zhao L, Zhang D, Shen Q, Jin M, Lin Z, Ma H, Huang S, Zhou P, Wu G, Zhang T
Oncogene 2019 Feb;38(7):935-949
Oncogene 2019 Feb;38(7):935-949
CCDC9 is identified as a novel candidate gene of severe asthenozoospermia.
Sha Y, Xu Y, Wei X, Liu W, Mei L, Lin S, Ji Z, Wang X, Su Z, Qiu P, Chen J, Wang X
Systems biology in reproductive medicine 2019 Dec;65(6):465-473
Systems biology in reproductive medicine 2019 Dec;65(6):465-473
Ttc39c is upregulated during skeletal muscle atrophy and modulates ERK1/2 MAP kinase and hedgehog signaling.
Hayes CS, Labuzan SA, Menke JA, Haddock AN, Waddell DS
Journal of cellular physiology 2019 Dec;234(12):23807-23824
Journal of cellular physiology 2019 Dec;234(12):23807-23824
EIF4G1 is a novel candidate gene associated with severe asthenozoospermia.
Sha Y, Liu W, Huang X, Li Y, Ji Z, Mei L, Lin S, Kong S, Lu J, Kong L, Zhu X, Lu Z, Ding L
Molecular genetics & genomic medicine 2019 Aug;7(8):e807
Molecular genetics & genomic medicine 2019 Aug;7(8):e807
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.
Tata A, Kobayashi Y, Chow RD, Tran J, Desai A, Massri AJ, McCord TJ, Gunn MD, Tata PR
Cell stem cell 2018 May 3;22(5):668-683.e6
Cell stem cell 2018 May 3;22(5):668-683.e6
C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia.
Fassad MR, Shoemark A, le Borgne P, Koll F, Patel M, Dixon M, Hayward J, Richardson C, Frost E, Jenkins L, Cullup T, Chung EMK, Lemullois M, Aubusson-Fleury A, Hogg C, Mitchell DR, Tassin AM, Mitchison HM
American journal of human genetics 2018 May 3;102(5):956-972
American journal of human genetics 2018 May 3;102(5):956-972
Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates.
Phadwal K, Kurian D, Salamat MKF, MacRae VE, Diack AB, Manson JC
Scientific reports 2018 Jul 3;8(1):10004
Scientific reports 2018 Jul 3;8(1):10004
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP
eLife 2018 Feb 2;7
eLife 2018 Feb 2;7
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindström-Battle A, Lam SM, Shui G, Deng WM, Jiao R
Developmental cell 2017 Oct 9;43(1):99-111.e5
Developmental cell 2017 Oct 9;43(1):99-111.e5
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
Dutta N, Seo S
Biology open 2016 Sep 15;5(9):1283-9
Biology open 2016 Sep 15;5(9):1283-9
ProBDNF inhibits collective migration and chemotaxis of rat Schwann cells.
Ding YQ, Li XY, Xia GN, Ren HY, Zhou XF, Su BY, Qi JG
Tissue & cell 2016 Oct;48(5):503-10
Tissue & cell 2016 Oct;48(5):503-10
NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition.
Chen T, Wu Q, Zhang Y, Zhang D
Brain research 2015 Nov 2;1625:102-10
Brain research 2015 Nov 2;1625:102-10
The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation.
Li L, Liu B, Zhang X, Ye L
Biochemical and biophysical research communications 2015 Mar 13;458(3):720-725
Biochemical and biophysical research communications 2015 Mar 13;458(3):720-725
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 66200-1-Ig( TUBA1A(ace-40Lys) Antibody) at dilution of 1:1000
- Other comments
- WB
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Acetylated tubulin (Lys40) antibody from Proteintech is a mouse monoclonal antibody to a peptide of human Acetylated tubulin (Lys40). This antibody recognizes human, mouse, rat antigen. The Acetylated tubulin (Lys40) antibody has been validated for the following applications: ELISA, IF, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MDCK cells using 66200-1-Ig( TUBA1A(ace-40Lys) Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)
- Other comments
- IF
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 66200-1-Ig( TUBA1A(ace-40Lys) Antibody) at dilution of 1:50 (under 40x lens)
- Other comments
- IHC
