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Learn10545-2-AP
antibody from Proteintech Group
Targeting: PRDX2
MGC4104, NKEFB, PRP, PRX2, PRXII, TDPX1, TSA
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [46]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10545-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10545-2-AP, RRID:AB_2168202
- Product name
- peroxiredoxin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated peroxiredoxin 2 antibody (Cat. #10545-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
Peroxiredoxin 2 Is a Potential Objective Indicator for Severity and the Clinical Status of Subarachnoid Hemorrhage Patients.
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.
Geraniol prevents Helicobacterium pylori-induced human gastric cancer signalling by enhancing peroxiredoxin-1 expression in GES-1 cells.
Profiling of proteome changes in plasma of HIV-infected patients receiving antiretroviral therapy.
Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.
Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Compartmentally scavenging hepatic oxidants through AMPK/SIRT3-PGC1α axis improves mitochondrial biogenesis and glucose catabolism.
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.
Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis.
Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease.
Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS.
Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Direct Proteomic Mapping of Cysteine Persulfidation.
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells.
Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis.
Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.
Sall2 knockdown exacerbates palmitic acid induced dysfunction and apoptosis of pancreatic NIT-1 beta cells.
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer.
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats.
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells.
Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma.
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.
Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa.
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Peroxiredoxin 2 inhibits granulosa cell apoptosis during follicle atresia through the NFKB pathway in mice.
Peroxiredoxins in colorectal neoplasms.
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics.
Formalin fixation and immunoreactivity in prostate cancer and benign prostatic tissues.
Du Y, Wang J, Zhang J, Li N, Li G, Liu X, Lin Y, Wang D, Kang K, Bian L, Zhao X
CNS neuroscience & therapeutics 2024 Mar;30(3):e14681
CNS neuroscience & therapeutics 2024 Mar;30(3):e14681
Peroxiredoxin 2 Is a Potential Objective Indicator for Severity and the Clinical Status of Subarachnoid Hemorrhage Patients.
Peng Z, Pang C, Li XJ, Zhang HS, Zhang JT, Zhu Q, Xu HJ, Gao YY, Zhuang Z, Li W, Zhang QR, Lu Y, Hang CH
Disease markers 2023;2023:5781180
Disease markers 2023;2023:5781180
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
Dong Y, Han F, Su Y, Sun B, Zhao W, Pan C
International immunopharmacology 2023 May;118:110056
International immunopharmacology 2023 May;118:110056
Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.
Szeliga M, Rola R
Cells 2023 Jul 26;12(15)
Cells 2023 Jul 26;12(15)
Geraniol prevents Helicobacterium pylori-induced human gastric cancer signalling by enhancing peroxiredoxin-1 expression in GES-1 cells.
Zhuang K, Tang H, Guo H, Yuan S
Microbial pathogenesis 2023 Jan;174:105937
Microbial pathogenesis 2023 Jan;174:105937
Profiling of proteome changes in plasma of HIV-infected patients receiving antiretroviral therapy.
Li T, Qu H, Ding H, Deng H, Chen Y
Proteomics. Clinical applications 2022 Nov;16(6):e2100099
Proteomics. Clinical applications 2022 Nov;16(6):e2100099
Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.
Sayles NM, Southwell N, McAvoy K, Kim K, Pesini A, Anderson CJ, Quinzii C, Cloonan S, Kawamata H, Manfredi G
Cell reports 2022 Mar 8;38(10):110475
Cell reports 2022 Mar 8;38(10):110475
Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.
Liu S, Wen X, Huang Q, Zhu M, Lu J
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
Li J, Wang C, Wang W, Liu L, Zhang Q, Zhang J, Wang B, Wang S, Hou L, Gao C, Yu X, Sun L
Frontiers in cardiovascular medicine 2021;8:624796
Frontiers in cardiovascular medicine 2021;8:624796
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Compartmentally scavenging hepatic oxidants through AMPK/SIRT3-PGC1α axis improves mitochondrial biogenesis and glucose catabolism.
Wu M, Zhang C, Xie M, Zhen Y, Lai B, Liu J, Qiao L, Liu S, Shi D
Free radical biology & medicine 2021 May 20;168:117-128
Free radical biology & medicine 2021 May 20;168:117-128
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Ma Y, Liang Y, Liang N, Zhang Y, Xiao F
Ecotoxicology and environmental safety 2021 Mar 15;211:111908
Ecotoxicology and environmental safety 2021 Mar 15;211:111908
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Wang W, Wei J, Zhang H, Zheng X, Zhou H, Luo Y, Yang J, Deng Q, Huang S, Fu Z
Cell death & disease 2021 Jun 11;12(6):605
Cell death & disease 2021 Jun 11;12(6):605
Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.
Li J, Cheng P, Li S, Zhao P, Han B, Ren X, Zhong JL, Lloyd MD, Pourzand C, Holmgren A, Lu J
Antioxidants & redox signaling 2021 Jun 10;34(17):1355-1367
Antioxidants & redox signaling 2021 Jun 10;34(17):1355-1367
Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis.
Zhang Y, Zhang L, Lu S, Xiang Y, Zeng C, He T, Ding Y, Wang W
Cancer research and treatment 2021 Jan;53(1):184-198
Cancer research and treatment 2021 Jan;53(1):184-198
Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway.
Zhang D, Luo Z, Jin Y, Chen Y, Yang T, Yang Q, Wu B, Shang Y, Liu X, Wei Y, Zhou F
Oxidative medicine and cellular longevity 2020;2020:1295984
Oxidative medicine and cellular longevity 2020;2020:1295984
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C
BioMed research international 2020;2020:1276328
BioMed research international 2020;2020:1276328
Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease.
Yan S, Wei X, Jian W, Qin Y, Liu J, Zhu S, Jiang F, Lou H, Zhang B
Frontiers in aging neuroscience 2020;12:78
Frontiers in aging neuroscience 2020;12:78
Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS.
Zhao T, Zhang-Akiyama QM
Free radical research 2020 Sep;54(8-9):585-605
Free radical research 2020 Sep;54(8-9):585-605
Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Aoki R, Kuwabara S
Clinical and experimental immunology 2020 Nov;202(2):239-248
Clinical and experimental immunology 2020 Nov;202(2):239-248
Direct Proteomic Mapping of Cysteine Persulfidation.
Fu L, Liu K, He J, Tian C, Yu X, Yang J
Antioxidants & redox signaling 2020 Nov 20;33(15):1061-1076
Antioxidants & redox signaling 2020 Nov 20;33(15):1061-1076
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells.
Zheng X, Wei J, Li W, Li X, Wang W, Guo J, Fu Z
Aging 2020 Jul 20;12(16):16390-16409
Aging 2020 Jul 20;12(16):16390-16409
Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis.
Ci C, Tang B, Lyu D, Liu W, Qiang D, Ji X, Qiu X, Chen L, Ding W
International journal of molecular medicine 2019 Jan;43(1):404-412
International journal of molecular medicine 2019 Jan;43(1):404-412
Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
Svistunova DM, Simon JN, Rembeza E, Crabtree M, Yue WW, Oliver PL, Finelli MJ
Free radical biology & medicine 2019 Jan;130:151-162
Free radical biology & medicine 2019 Jan;130:151-162
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Zhao B, Hu T
Oncology letters 2019 Feb;17(2):1939-1945
Oncology letters 2019 Feb;17(2):1939-1945
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)
Proteomes 2018 May 22;6(2)
Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.
Wei B, Lin Q, Ji YG, Zhao YC, Ding LN, Zhou WJ, Zhang LH, Gao CY, Zhao W
British journal of pharmacology 2018 Aug;175(16):3315-3332
British journal of pharmacology 2018 Aug;175(16):3315-3332
Sall2 knockdown exacerbates palmitic acid induced dysfunction and apoptosis of pancreatic NIT-1 beta cells.
Wang Y, Liu J, Liu Z, Chen J, Hu X, Hu Y, Yuan Y, Wu G, Dai Z, Xu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:375-382
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:375-382
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, Lou H, Yan S, Li X, Zhou J, Zhang B
Neuroscience letters 2017 Sep 29;658:114-120
Neuroscience letters 2017 Sep 29;658:114-120
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q
Neurobiology of aging 2017 Jan;49:165-182
Neurobiology of aging 2017 Jan;49:165-182
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer.
Lv Z, Wei J, You W, Wang R, Shang J, Xiong Y, Yang H, Yang X, Fu Z
Journal of translational medicine 2017 Dec 19;15(1):257
Journal of translational medicine 2017 Dec 19;15(1):257
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
Redox biology 2017 Aug;12:987-1003
Redox biology 2017 Aug;12:987-1003
Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats.
Yang X, Wu Q, Zhang L, Feng L
Frontiers in molecular neuroscience 2016;9:131
Frontiers in molecular neuroscience 2016;9:131
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Park YH, Kim SU, Kwon TH, Kim JM, Song IS, Shin HJ, Lee BK, Bang DH, Lee SJ, Lee DS, Chang KT, Kim BY, Yu DY
Oncogene 2016 Jul 7;35(27):3503-13
Oncogene 2016 Jul 7;35(27):3503-13
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Hirahashi M, Koga Y, Kumagai R, Aishima S, Taguchi K, Oda Y
Pathology international 2014 Apr;64(4):155-63
Pathology international 2014 Apr;64(4):155-63
Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells.
Kim SU, Park YH, Kim JM, Sun HN, Song IS, Huang SM, Lee SH, Chae JI, Hong S, Sik Choi S, Choi SC, Lee TH, Kang SW, Rhee SG, Chang KT, Lee SH, Yu DY, Lee DS
Stem cells (Dayton, Ohio) 2014 Apr;32(4):998-1011
Stem cells (Dayton, Ohio) 2014 Apr;32(4):998-1011
Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma.
Fushimi F, Taguchi K, Izumi H, Kohno K, Kuwano M, Ono M, Nakashima Y, Takesue T, Naito S, Oda Y
Virchows Archiv : an international journal of pathology 2013 Oct;463(4):553-62
Virchows Archiv : an international journal of pathology 2013 Oct;463(4):553-62
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Ho KY, Yeh TS, Huang HH, Hung KF, Chai CY, Chen WT, Tsai SM, Chang NC, Chien CY, Wang HM, Wu YJ
International journal of molecular sciences 2013 Jul 11;14(7):14439-59
International journal of molecular sciences 2013 Jul 11;14(7):14439-59
A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.
Suleman F, Gualeni B, Gregson HJ, Leighton MP, Piróg KA, Edwards S, Holden P, Boot-Handford RP, Briggs MD
Human mutation 2012 Jan;33(1):218-31
Human mutation 2012 Jan;33(1):218-31
Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa.
Otani A, Kojima H, Guo C, Oishi A, Yoshimura N
The American journal of pathology 2012 Jan;180(1):328-36
The American journal of pathology 2012 Jan;180(1):328-36
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Su TR, Lin JJ, Chiu CC, Chen JY, Su JH, Cheng ZJ, Hwang WI, Huang HH, Wu YJ
Electrophoresis 2012 Apr;33(7):1139-52
Electrophoresis 2012 Apr;33(7):1139-52
Peroxiredoxin 2 inhibits granulosa cell apoptosis during follicle atresia through the NFKB pathway in mice.
Yang S, Luo A, Hao X, Lai Z, Ding T, Ma X, Mayinuer M, Shen W, Wang X, Lu Y, Ma D, Wang S
Biology of reproduction 2011 Jun;84(6):1182-9
Biology of reproduction 2011 Jun;84(6):1182-9
Peroxiredoxins in colorectal neoplasms.
Wu XY, Fu ZX, Wang XH
Histology and histopathology 2010 Oct;25(10):1297-303
Histology and histopathology 2010 Oct;25(10):1297-303
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics.
Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, Hosono A, Suehara Y, Beppu Y, Kawai A, Hirohashi S, Kondo T
Proteomics. Clinical applications 2010 May;4(5):560-7
Proteomics. Clinical applications 2010 May;4(5):560-7
Formalin fixation and immunoreactivity in prostate cancer and benign prostatic tissues.
Jaraj SJ, Egevad L
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010 May;118(5):383-8
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010 May;118(5):383-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10545-2-AP(PRDX2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The peroxiredoxin 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human peroxiredoxin 2. This antibody recognizes human,mouse,rat antigen. The peroxiredoxin 2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
