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- Antibody Data
- Antigen structure
- References [25]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 18137-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18137-1-AP, RRID:AB_2133553
- Product name
- Importin Alpha 5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Importin Alpha 5 antibody (Cat. #18137-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Respiratory syncytial virus NS1 inhibits anti-viral Interferon-α-induced JAK/STAT signaling, by limiting the nuclear translocation of STAT1.
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.
ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells.
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
Baicalin confers hepatoprotective effect against alcohol-associated liver disease by upregulating microRNA-205.
PACS-1 contains distinct motifs for nuclear-cytoplasmic transport and interacts with the RNA-binding protein PTBP1 in the nucleus and cytosol.
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Tumor-derived exosomes antagonize innate antiviral immunity.
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.
Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.
The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.
Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD.
Targeted disruption of one of the importin α family members leads to female functional incompetence in delivery.
Efstathiou C, Zhang Y, Kandwal S, Fayne D, Molloy EJ, Stevenson NJ
Frontiers in immunology 2024;15:1395809
Frontiers in immunology 2024;15:1395809
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gao X, Xuan Y, Zhou Z, Chen C, Wen Wang D, Wen Z
International immunopharmacology 2024 May 30;133:112073
International immunopharmacology 2024 May 30;133:112073
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
Zhang Y, He B, Zhang D, Zhang Y, Chen C, Zhang W, Yang S, Yao M, Cui G, Gu J, Wang T, Lin Z, Fan Y, Xiong Z, Hao Y
Cell reports 2023 Mar 28;42(3):112188
Cell reports 2023 Mar 28;42(3):112188
Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.
Alkhoury C, Henneman NF, Petrenko V, Shibayama Y, Segaloni A, Gadault A, Nemazanyy I, Le Guillou E, Wolide AD, Antoniadou K, Tong X, Tamaru T, Ozawa T, Girard M, Hnia K, Lutter D, Dibner C, Panasyuk G
Nature cell biology 2023 Jul;25(7):975-988
Nature cell biology 2023 Jul;25(7):975-988
ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells.
Sato K, Yoshino H, Sato Y, Nakano M, Tsuruga E
Current issues in molecular biology 2023 Jul 27;45(8):6262-6271
Current issues in molecular biology 2023 Jul 27;45(8):6262-6271
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Wu X, Liu L, Zheng Q, Ye H, Yang H, Hao H, Li P
Acta pharmaceutica Sinica. B 2023 Jan;13(1):113-127
Acta pharmaceutica Sinica. B 2023 Jan;13(1):113-127
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
Nakanishi A, Okumura H, Hashita T, Yamashita A, Nishimura Y, Watanabe C, Kamimura S, Hayashi S, Murakami S, Ito K, Iwao T, Ikeda A, Hirose T, Sunazuka T, Tanaka Y, Matsunaga T
Viruses 2022 Nov 8;14(11)
Viruses 2022 Nov 8;14(11)
Baicalin confers hepatoprotective effect against alcohol-associated liver disease by upregulating microRNA-205.
Fang L, Wang HF, Chen YM, Bai RX, Du SY
International immunopharmacology 2022 Jun;107:108553
International immunopharmacology 2022 Jun;107:108553
PACS-1 contains distinct motifs for nuclear-cytoplasmic transport and interacts with the RNA-binding protein PTBP1 in the nucleus and cytosol.
Trothen SM, Zang RX, Lurie A, Dikeakos JD
FEBS letters 2022 Jan;596(2):232-248
FEBS letters 2022 Jan;596(2):232-248
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.
Marco S, Neilson M, Moore M, Perez-Garcia A, Hall H, Mitchell L, Lilla S, Blanco GR, Hedley A, Zanivan S, Norman JC
Nature communications 2021 Nov 24;12(1):6829
Nature communications 2021 Nov 24;12(1):6829
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
Kawasaki T, Sugihara F, Fukushima K, Matsuki T, Nabeshima H, Machida T, Mitsui Y, Fujimura S, Sagawa R, Gaheun L, Kuniyoshi K, Tanaka H, Narazaki M, Kumanogoh A, Akira S, Satoh T
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 29;118(26)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 29;118(26)
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.
Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y
The Journal of biological chemistry 2021 Jul;297(1):100803
The Journal of biological chemistry 2021 Jul;297(1):100803
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.
Zeng H, Wang L, Zhang J, Pan T, Yu Y, Lu J, Zhou P, Yang H, Li P
Acta pharmaceutica Sinica. B 2021 Jan;11(1):71-88
Acta pharmaceutica Sinica. B 2021 Jan;11(1):71-88
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Zhuo Y, Guo Z, Ba T, Zhang C, He L, Zeng C, Dai H
Virologica Sinica 2021 Apr;36(2):176-186
Virologica Sinica 2021 Apr;36(2):176-186
Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.
Ayanlaja AA, Ji G, Wang J, Gao Y, Cheng B, Kanwore K, Zhang L, Xiong Y, Kambey PA, Gao D
Cell communication and signaling : CCS 2020 Feb 12;18(1):24
Cell communication and signaling : CCS 2020 Feb 12;18(1):24
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H
Nature communications 2019 Sep 5;10(1):4013
Nature communications 2019 Sep 5;10(1):4013
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Wang H, Yuan M, Wang S, Zhang L, Zhang R, Zou X, Wang X, Chen D, Wu Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Tumor-derived exosomes antagonize innate antiviral immunity.
Gao L, Wang L, Dai T, Jin K, Zhang Z, Wang S, Xie F, Fang P, Yang B, Huang H, van Dam H, Zhou F, Zhang L
Nature immunology 2018 Mar;19(3):233-245
Nature immunology 2018 Mar;19(3):233-245
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD
eLife 2018 Aug 7;7
eLife 2018 Aug 7;7
Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.
Laitman BM, Mariani JN, Zhang C, Sawai S, John GR
PloS one 2017;12(1):e0170477
PloS one 2017;12(1):e0170477
Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.
Zhu Y, Vidaurre OG, Adula KP, Kezunovic N, Wentling M, Huntley GW, Casaccia P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Aug 2;37(31):7547-7559
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Aug 2;37(31):7547-7559
The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.
Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, Zaslavsky E, Lee YM, Braun DA, Lu QR, Narla G, Raine CS, Friedman SL, Casaccia P, John GR
PLoS biology 2016 May;14(5):e1002467
PLoS biology 2016 May;14(5):e1002467
Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD.
Rolhion N, Furniss RC, Grabe G, Ryan A, Liu M, Matthews SA, Holden DW
PLoS pathogens 2016 May;12(5):e1005653
PLoS pathogens 2016 May;12(5):e1005653
Targeted disruption of one of the importin α family members leads to female functional incompetence in delivery.
Moriyama T, Nagai M, Oka M, Ikawa M, Okabe M, Yoneda Y
The FEBS journal 2011 May;278(9):1561-72
The FEBS journal 2011 May;278(9):1561-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 18137-1-AP(KPNA1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using KPNA1 antibody 18137-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 18137-1-AP(KPNA1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 18137-1-AP(KPNA1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
