11060-1-AP

antibody from Proteintech Group

Targeting: ANXA5 ANX5, ENX2

Provider product page for 11060-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [46]
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Validations
Western blot [1]
Immunoprecipitation [1]
Flow cytometry [1]

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Product number: 11060-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11060-1-AP, RRID:AB_2057585
Product name: Annexin V antibody
Antibody type: Polyclonal
Description: KD/KO validated Annexin V antibody (Cat. #11060-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ANXA5 protein structure - 11060-1-AP shown in red.

Submitted references Relationship between localization of annexins and dentinogenesis during rat tooth development.

Shibui T, Hosoya A, Takahashi M, Takebe H, Shibata S, Irie K
Anatomical record (Hoboken, N.J. : 2007) 2026 Jun;309(6):1667-1679

Identification of ADAR1i-124: The first effective A-to-I RNA editing inhibitor with promising cancer therapeutic potential.

Minakuchi M, Zhang H, Cassel J, Shiromoto Y, Villanueva J, Skordalakes E, Salvino JM, Li Q, Nishikura K
iScience 2026 Feb 20;29(2):114615

Intranasal methylene blue administration confers neuroprotection in rats subjected to exhaustive exercise training.

Peng G, Pan W, Cai Z, Lin L, Ma X
Frontiers in behavioral neuroscience 2025;19:1648837

Integrative analysis of single-cell and bulk RNA sequencing reveals the oncogenic role of ANXA5 in gastric cancer and its association with drug resistance.

Chen D, Zhang P, Gong L, Wei H, Yu G, Zhang T, Bai C
Frontiers in immunology 2025;16:1562395

Febrile temperature enhances Plasmodium falciparum cytoadhesion by disrupting the endothelial glycocalyx.

Introini V, Long R, Oyerinde OR, Sender SS, Stein F, Hwang GM, Gutierrez BL, Seydel KB, Birbeck G, Bernabeu M
bioRxiv : the preprint server for biology 2025 Sep 8;

Inhibition of antiapoptotic BCL-2 proteins with Lipo-NPs induces fibroblast apoptosis, alleviating pulmonary fibrosis in VILI mice.

Yu Q, Tang R, Tang W, Fan S, Wang D, Peng J
Respiratory research 2025 Nov 10;26(1):312

Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells.

Yin H, Shan Y, Zhu Q, Yuan L, Ju F, Shi Y, Han Y, Wu R, Xia T, Zhang K, You Y, You B
Cancer & metabolism 2025 May 23;13(1):24

2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.

Luo M, Mo J, Huang C, Mao Y, Wang H, Wang X
Chemical biology & drug design 2025 Jul;106(1):e70161

Bioprinting of a Liposomal Oxygen-Releasing Scaffold for Ovary Tissue Engineering.

Dadashzadeh A, Moghassemi S, Amorim CA
Tissue engineering. Part A 2025 Jan;31(1-2):69-78

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice.

Zhu Y, Zhang Y, Zhang Q, Song P, Zhang J, Ma A, Wang C, Gao P, Yang T, Zhou L, Shi Q, Wong YK, Luo Y, Tang H, Wang J
Exploration (Beijing, China) 2025 Dec;5(6):20240069

An Inflammation-Targeting Engineered Probiotic Escherichia coli Nissle 1917 with High Anti-TNF-α Nanobody Secretion Efficacy Alleviates Ulcerative Colitis.

Hua S, Li K, Shang P, Liu L, Pan J, Zhu B, Hua Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e12360

Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.

Hu J, Jin Z, Gao Y, Liu Q, Yu Y, Kong R, Zhao D, Gao J
Journal of proteome research 2025 Apr 4;24(4):1732-1744

Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation.

Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W
International journal of biological sciences 2024;20(8):2994-3007

Annexin A5 is a novel prognostic biomarker in oral squamous cell carcinoma.

Zhou T, Zhang X, Song Y, Ding L, Huang X, Zhang L, Ye C, Yang Y, Celentano A, Hu Q, Ni Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2024 Sep;53(8):538-543

Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor.

Wang H, Lin Y, Chen R, Zhu Y, Wang H, Li S, Yu L, Zhang K, Liu Y, Jing T, Sun F
Endocrinology 2024 Mar 29;165(5)

Baohuoside I chemosensitises breast cancer to paclitaxel by suppressing extracellular vesicle/CXCL1 signal released from apoptotic cells.

Wang S, Li J, Xu S, Wang N, Pan B, Yang B, Zheng Y, Zhang J, Peng F, Peng C, Wang Z
Journal of extracellular vesicles 2024 Jul;13(7):e12493

The macrophage-associated prognostic gene ANXA5 promotes immunotherapy resistance in gastric cancer through angiogenesis.

Hong Z, Wen P, Wang K, Wei X, Xie W, Rao S, Chen X, Hou J, Zhuo H
BMC cancer 2024 Jan 29;24(1):141

Discovery of Balasubramide Derivative with Tissue-Specific Anti-Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1.

Song JQ, Shen LJ, Wang HJ, Liu QB, Ye LB, Liu K, Shi L, Cai B, Lin HS, Pang T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2410550

Isolation and Comprehensive Analysis of Cochlear Tissue-Derived Small Extracellular Vesicles.

Jiang P, Ma X, Wang X, Huang J, Wang Y, Ai J, Xiao H, Dai M, Lin Y, Shao B, Tang X, Tong W, Ye Z, Chai R, Zhang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408964

Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway.

Zhao L, Cao H, Yuan Y, Liao C, Huang D, Li X, Zhao Y, Huang Q, Li S, Zhang B
Scientific reports 2024 Dec 30;14(1):31915

Augmentation of hepatocellular carcinoma malignancy by annexin A5 through modulation of invasion and angiogenesis.

Zheng J, Wang Y, Zhou Y, Li Z, Yang L, Gao J, Zhu J
Scandinavian journal of gastroenterology 2024 Aug;59(8):939-953

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice.

Lee YS, Gavzy SJ, Jang J, Kamberi S, Zhang T, Sands L, Scalea JR
IEEE journal of translational engineering in health and medicine 2023;11:145-150

Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin.

Escarcega RD, Patil AA, Moruno-Manchon JF, Urayama A, Marrelli SP, Kim N, Monchaud D, McCullough LD, Tsvetkov AS
The Journal of biological chemistry 2023 Oct;299(10):105157

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.

Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A
bioRxiv : the preprint server for biology 2023 Nov 28;

The Tardigrade damage suppressor protein Dsup promotes DNA damage in neurons.

Escarcega RD, Patil AA, Meyer MD, Moruno-Manchon JF, Silvagnoli AD, McCullough LD, Tsvetkov AS
Molecular and cellular neurosciences 2023 Jun;125:103826

Prostate cancer extracellular vesicle digital scoring assay - a rapid noninvasive approach for quantification of disease-relevant mRNAs.

Wang JJ, Sun N, Lee YT, Kim M, Vagner T, Rohena-Rivera K, Wang Z, Chen Z, Zhang RY, Lee J, Zhang C, Tang H, Widjaja J, Zhang TX, Qi D, Teng PC, Jan YJ, Hou KC, Hamann C, Sandler HM, Daskivich TJ, Luthringer DJ, Bhowmick NA, Pei R, You S, Di Vizio D, Tseng HR, Chen JF, Zhu Y, Posadas EM
Nano today 2023 Feb;48

Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.

Zhang Z, Zhu Z, Fu J, Liu X, Mi Z, Tao H, Fan H
International immunopharmacology 2023 Feb;115:109684

DNA-Encoded and Spatial Proximity Replaced Glycoprotein Analysis Reveals Glycosylation Heterogeneity of Extracellular Vesicles.

Li P, Chang Q, Liu M, Lei K, Ping S, Wang J, Gu Y, Ren H, Ma Y
Analytical chemistry 2023 Dec 5;95(48):17467-17476

Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis.

Bakhshian Nik A, Ng HH, Ashbrook SK, Sun P, Iacoviello F, Shearing PR, Bertazzo S, Mero D, Khomtchouk BB, Hutcheson JD
American journal of physiology. Heart and circulatory physiology 2023 Apr 1;324(4):H553-H570

Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.

Alvarez FA, Kaddour H, Lyu Y, Preece C, Cohen J, Baer L, Stopeck AT, Thompson P, Okeoma CM
Breast cancer research and treatment 2022 Nov;196(2):423-437

DNA Methyltransferase 3B-Mediated Intratumoral Heterogeneity and Therapeutic Targeting in Breast Cancer Recurrence and Metastasis.

So JY, Yang HH, Park WY, Skrypek N, Ishii H, Chen JM, Lee MP, Yang L
Molecular cancer research : MCR 2022 Nov 3;20(11):1674-1685

Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility.

Ouni E, Nedbal V, Da Pian M, Cao H, Haas KT, Peaucelle A, Van Kerk O, Herinckx G, Marbaix E, Dolmans MM, Tuuri T, Otala M, Amorim CA, Vertommen D
Matrix biology : journal of the International Society for Matrix Biology 2022 May;109:91-120

Protective effects of adipose-derived biogenic nanoparticles on the pulmonary microvascular endothelial barrier in mice with ventilator-induced lung injury via the TRPV4/ROCK1 signalling pathway.

Yu Q, Wang D, Fan S, Tang X, He J, Peng J, Qi D
Pulmonary pharmacology & therapeutics 2022 Jun;73-74:102123

Reassessment of the Proteomic Composition and Function of Extracellular Vesicles in the Seminal Plasma.

Wang H, Zhu Y, Tang C, Zhou Z, Wang Z, Li Z, Zheng X, Chen S, Zhou Y, Liang A, Li Y, Lin Y, Sun F
Endocrinology 2022 Jan 1;163(1)

6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.

Sokouti H, Mohajeri D, Nourazar MA
Physiological research 2022 Aug 31;71(4):551-560

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis.

Li M, Li X, Liu B, Lv L, Wang W, Gao D, Zhang Q, Jiang J, Chai M, Yun Z, Tan Y, Gong F, Wu Z, Zhu Y, Ma J, Leng L
Frontiers in cell and developmental biology 2021;9:783456

Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing.

Asada K, Sakaue F, Nagata T, Zhang JC, Yoshida-Tanaka K, Abe A, Nawa M, Nishina K, Yokota T
Nucleic acids research 2021 May 21;49(9):4864-4876

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models.

Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T
Journal of proteome research 2021 Mar 5;20(3):1733-1743

Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.

Peng G, Zheng H, Wu C, Wu C, Ma X, Xiong J, Hou J, Zhang L, Yang L, Pan H
Brain research 2021 Dec 1;1772:147665

Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.

Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

Sheng W, Shi X, Lin Y, Tang J, Jia C, Cao R, Sun J, Wang G, Zhou L, Dong M
Journal of experimental & clinical cancer research : CR 2020 Jan 17;39(1):16

The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.

Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y
Communications biology 2020 Jan 16;3(1):30

CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.

Ji NN, Wu L, Shao BM, Meng QX, Xu JN, Zhu HW, Zhang YM
Frontiers in neurology 2019;10:1306

Annexin A5 regulates hepatocarcinoma malignancy via CRKI/II-DOCK180-RAC1 integrin and MEK-ERK pathways.

Sun X, Liu S, Wang J, Wei B, Guo C, Chen C, Sun MZ
Cell death & disease 2018 May 25;9(6):637

Usefulness of material recovered from distal embolic protection devices after carotid angioplasty for proteomic studies.

Cristobo I, Brea D, Blanco M, Vázquez F, Rodríguez-Yáñez M, Vivancos J, Silva Y, de la Ossa NP, Pumar JM, Forteza J, Castillo J
Journal of vascular and interventional radiology : JVIR 2012 Jun;23(6):818-24

Proteomic and tissue array profiling identifies elevated hypoxia-regulated proteins in pancreatic ductal adenocarcinoma.

Cui Y, Zhang D, Jia Q, Li T, Zhang W, Han J
Cancer investigation 2009 Aug;27(7):747-55

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11060-1-AP(ANXA5 antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-ANXA5 (IP:11060-1-AP, 3ug; Detection:11060-1-AP 1:500) with HeLa cells lysate 3000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Annexin V antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Annexin V. This antibody recognizes human,mouse,rat antigen. The Annexin V antibody has been validated for the following applications: ELISA, WB, IP, IHC, FC analysis.
Appendix: 11060-1-AP.pdf

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