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- Product number
- 25614-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- P27; KIP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P27; KIP1 antibody (Cat. #25614-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model.
Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2.
D-arabinose induces cell cycle arrest by promoting autophagy via p38 MAPK signaling pathway in breast cancer.
PELI1: key players in the oncogenic characteristics of pancreatic Cancer.
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade.
Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling.
The miR-34b/MEK/ERK pathway is regulated by NR5A1 and promotes differentiation in primary bovine Sertoli cells.
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
Identification and Validation of Basement Membrane Related LncRNA Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma.
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component.
SHCBP1 Promotes the Proliferation of Breast Cancer Cells by Inhibiting CXCL2.
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.
Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma.
Ethanol Extract of Citrus grandis 'Tomentosa' Exerts Anticancer Effects by Targeting Skp2/p27 Pathway in Non-Small Cell Lung Cancer.
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B.
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation.
The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma.
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
miR-196a Promotes Proliferation of Mammary Epithelial Cells by Targeting CDKN1B.
Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells.
FBXO28 promotes proliferation, invasion, and metastasis of pancreatic cancer cells through regulation of SMARCC2 ubiquitination.
Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Dioscin reduced chemoresistance for colon cancer and analysis of sensitizing targets.
Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
AKAP12 inhibits esophageal squamous carcinoma cell proliferation, migration, and cell cycle via the PI3K/AKT signaling pathway.
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase suppresses human esophageal cancer cell growth by inducing mitotic catastrophe through the P27/cyclin A/CDK2 signaling pathway.
The innate immune sensor STING accelerates neointima formation via NF-κB signaling pathway.
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle.
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway.
microRNA-106b-5p Promotes Cell Growth and Sensitizes Chemosensitivity to Sorafenib by Targeting the BTG3/Bcl-xL/p27 Signaling Pathway in Hepatocellular Carcinoma.
EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways.
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma.
Identification and validation of a potential key gene SGOL1 for poor prognosis in hepatocellular carcinoma based on a bioinformatics approach.
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.
Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.
p27(kip1) Modulates the Morphology and Phagocytic Activity of Microglia.
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway.
Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.
tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis.
Skin chronological aging drives age-related bone loss via secretion of cystatin-A.
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension.
MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.
Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster.
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Cucurbitacin E Triggers Cellular Senescence in Colon Cancer Cells via Regulating the miR-371b-5p/TFAP4 Signaling Pathway.
Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy.
Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
High expression of 14-3-3ơ indicates poor prognosis and progression of lung adenocarcinoma.
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma.
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality.
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling.
Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis.
Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells.
The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50.
MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1.
Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.
l-Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein-Barr virus-positive Burkitt lymphoma.
Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells.
α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression.
LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells.
Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.
Synergistic Silencing of Skp2 by siRNA Self-Assembled Nanoparticles as a Therapeutic Strategy for Advanced Prostate Cancer.
DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation.
Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma.
Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway.
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
PRRSV Promotes MARC-145 Cells Entry Into S Phase of the Cell Cycle to Facilitate Viral Replication via Degradation of p21 by nsp11.
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
ACTL6A Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells and Correlates with Poor Clinical Outcomes.
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.
Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G(0)/G(1) Cell Cycle Arrest and Antiproliferation in A549 Cells.
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells.
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation.
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Chemopreventive effects of pterostilbene through p53 and cell cycle in mouse lung of squamous cell carcinoma model.
Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota.
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.
ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis.
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer.
Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway.
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways.
NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.
Hsa-MiR-590-3p Promotes the Malignancy Progression of Pancreatic Ductal Carcinoma by Inhibiting the Expression of p27 and PPP2R2A via G1/S Cell Cycle Pathway.
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.
MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI.
α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway.
UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.
Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.
KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity.
Involvement of MicroRNA-1-FAM83A Axis Dysfunction in the Growth and Motility of Lung Cancer Cells.
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.
MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.
Endogenous thrombopoietin promotes non-small-cell lung carcinoma cell proliferation and migration by regulating EGFR signalling.
Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
miR-203a suppresses cell proliferation by targeting RING-finger protein 6 in colorectal cancer.
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Prognostic significance of LAPTM4B and p27kip1 expression in triple-negative breast cancer.
Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma.
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.
The Capsid Protein VP1 of Coxsackievirus B Induces Cell Cycle Arrest by Up-Regulating Heat Shock Protein 70.
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner.
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.
Knockdown of TRIM27 expression suppresses the dysfunction of mesangial cells in lupus nephritis by FoxO1 pathway.
Thyroid hormone (T(3)) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.
Effect of ingredients from Chinese herbs on enterovirus D68 production.
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2.
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.
Autophagy mediates serum starvation-induced quiescence in nucleus pulposus stem cells by the regulation of P27.
EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma.
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ.
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade.
Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro.
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
[Corrigendum] Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells.
Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells.
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells.
Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis.
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D-arabinose induces cell cycle arrest by promoting autophagy via p38 MAPK signaling pathway in breast cancer.
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OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
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VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
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Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade.
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Journal of molecular histology 2024 Jun;55(3):241-251
Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling.
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The miR-34b/MEK/ERK pathway is regulated by NR5A1 and promotes differentiation in primary bovine Sertoli cells.
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Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
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MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
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TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
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ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
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Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.
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Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma.
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Ethanol Extract of Citrus grandis 'Tomentosa' Exerts Anticancer Effects by Targeting Skp2/p27 Pathway in Non-Small Cell Lung Cancer.
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Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Guo Y, Shao J, Zhang R, Han M, Kong L, Liu Z, Li H, Wei D, Lu M, Zhang S, Zhang C, Wei H, Chen Z, Bian H
International journal of molecular sciences 2023 Sep 7;24(18)
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The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
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Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B.
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Aging 2023 Sep 26;15(18):9377-9390
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RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation.
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Medical oncology (Northwood, London, England) 2023 Sep 1;40(10):288
Medical oncology (Northwood, London, England) 2023 Sep 1;40(10):288
The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma.
Luo H, Huang K, Cheng M, Long X, Zhu X, Wu M
Aging 2023 Oct 17;15(20):11052-11066
Aging 2023 Oct 17;15(20):11052-11066
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Zhao S, Li Y, Li G, Ye J, Wang R, Zhang X, Li F, Gao C, Li J, Jiang J, Mi Y
European journal of pharmacology 2023 Oct 15;957:176004
European journal of pharmacology 2023 Oct 15;957:176004
miR-196a Promotes Proliferation of Mammary Epithelial Cells by Targeting CDKN1B.
Chen G, Sun W, Li Y, Li M, Jia X, Wang J, Lai S
Animals : an open access journal from MDPI 2023 Nov 28;13(23)
Animals : an open access journal from MDPI 2023 Nov 28;13(23)
Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.
Wan W, Miao Y, Niu Y, Zhu K, Ma Y, Pan M, Ma B, Wei Q
Stem cell research & therapy 2023 Mar 20;14(1):46
Stem cell research & therapy 2023 Mar 20;14(1):46
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells.
Zhou Y, Fu R, Yang M, Liu W, Tong Z
The Journal of nutritional biochemistry 2023 Jun;116:109313
The Journal of nutritional biochemistry 2023 Jun;116:109313
FBXO28 promotes proliferation, invasion, and metastasis of pancreatic cancer cells through regulation of SMARCC2 ubiquitination.
Liu S, Liu P, Zhu C, Yang R, He Z, Li Y, Li Y, Fei X, Hou J, Wang X, Pan Y
Aging 2023 Jun 21;15(12):5381-5398
Aging 2023 Jun 21;15(12):5381-5398
Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.
Song Y, Guo D, Liu JF, Ge LN, Liu P, Qu YM, Cong HY, Li T, Chang X, Wang YR, Shao LY, Du ZJ, Wang MY
International journal of oncology 2023 Jul;63(1)
International journal of oncology 2023 Jul;63(1)
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Ma C, Wang D, Tian Z, Gao W, Zang Y, Qian L, Xu X, Jia J, Liu Z
Oncogene 2023 Jul;42(29):2249-2262
Oncogene 2023 Jul;42(29):2249-2262
Dioscin reduced chemoresistance for colon cancer and analysis of sensitizing targets.
Li R, Qin J, Wang Z, Lv F, Guo J, Zhu H, Huang Y
Biochemical and biophysical research communications 2023 Jan 1;638:94-102
Biochemical and biophysical research communications 2023 Jan 1;638:94-102
Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.
Gao X, Jiang P, Wei X, Zhang W, Zheng J, Sun S, Yao H, Liu X, Zhang Q
BMC cancer 2023 Feb 15;23(1):154
BMC cancer 2023 Feb 15;23(1):154
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
Hong X, Ma N, Li D, Zhang M, Dong W, Huang J, Ci X, Zhang S
Cell death & disease 2023 Feb 10;14(2):100
Cell death & disease 2023 Feb 10;14(2):100
AKAP12 inhibits esophageal squamous carcinoma cell proliferation, migration, and cell cycle via the PI3K/AKT signaling pathway.
Li X, Dong H, Zheng Y, Ding S, Li Y, Li H, Huang H, Zhong C, Xie T, Xu Y
Molecular and cellular probes 2023 Dec;72:101939
Molecular and cellular probes 2023 Dec;72:101939
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Bai Y, Zhou L, Zhang C, Guo M, Xia L, Tang Z, Liu Y, Deng S
Oncogene 2023 Dec;42(49):3605-3618
Oncogene 2023 Dec;42(49):3605-3618
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Ren J, Liu J, Zhang J, Hu X, Cui Y, Wei X, Ma Y, Li X, Zhao Y
International journal of molecular sciences 2023 Dec 23;25(1)
International journal of molecular sciences 2023 Dec 23;25(1)
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Wang Z, Cai H, Li Z, Sun W, Zhao E, Cui H
Clinical epigenetics 2023 Dec 13;15(1):192
Clinical epigenetics 2023 Dec 13;15(1):192
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase suppresses human esophageal cancer cell growth by inducing mitotic catastrophe through the P27/cyclin A/CDK2 signaling pathway.
Ruifang D, Changqing Y, Chenxia R, Ji L, Zibai W
Acta histochemica 2023 Aug;125(6):152066
Acta histochemica 2023 Aug;125(6):152066
The innate immune sensor STING accelerates neointima formation via NF-κB signaling pathway.
He L, Liu D, Zhou W, Han Y, Ju Y, Liu H, Chen Y, Yu J, Wang L, Wang J, He C
International immunopharmacology 2023 Aug;121:110412
International immunopharmacology 2023 Aug;121:110412
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Cell death & disease 2023 Aug 4;14(8):497
Cell death & disease 2023 Aug 4;14(8):497
TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle.
Jiang Y, Zhu C, Huang H, Huang G, Fu B, Xi X
BMC cancer 2023 Aug 1;23(1):716
BMC cancer 2023 Aug 1;23(1):716
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Zou P, Zhang X, Zhang R, Chai X, Zhao Y, Li E, Zhang Q, Yan R, Yang J, Liao B
Frontiers in molecular biosciences 2022;9:853654
Frontiers in molecular biosciences 2022;9:853654
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway.
Wen Y, Li Y, Yang B, Guo X, Lin L, Liang J, Zhang K, Li X, Jiang Z, Wang Y, Li Y, Wu X, Fan X, Li F, Yuan W
Disease markers 2022;2022:6993994
Disease markers 2022;2022:6993994
microRNA-106b-5p Promotes Cell Growth and Sensitizes Chemosensitivity to Sorafenib by Targeting the BTG3/Bcl-xL/p27 Signaling Pathway in Hepatocellular Carcinoma.
Enkhnaran B, Zhang GC, Zhang NP, Liu HN, Wu H, Xuan S, Yu XN, Song GQ, Shen XZ, Zhu JM, Liu XP, Liu TT
Journal of oncology 2022;2022:1971559
Journal of oncology 2022;2022:1971559
EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways.
Chen X, Huang Y, Liu J, Lin W, Chen C, Chen Y, Ding Y, Yang Y, Chen Y, Wang H, Teng L
Journal of Cancer 2022;13(5):1456-1467
Journal of Cancer 2022;13(5):1456-1467
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Zhou Z, Wei B, Liu Y, Liu T, Zeng S, Gan J, Qi G
Frontiers in genetics 2022;13:1035638
Frontiers in genetics 2022;13:1035638
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma.
Li SR, Man QW, Liu B
Frontiers in oncology 2022;12:943945
Frontiers in oncology 2022;12:943945
Identification and validation of a potential key gene SGOL1 for poor prognosis in hepatocellular carcinoma based on a bioinformatics approach.
Fei X, Liu S, Liu P, Wang X, Zhu C, Hou J, Cai J, Pan Y
Frontiers in oncology 2022;12:1043161
Frontiers in oncology 2022;12:1043161
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.
Li G, Fan M, Zheng Z, Zhang Y, Zhang Z, Huang Z, Luo W, Zhao W, Lai X, Chen H, Zeng F, Deng F
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119296
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119296
Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.
Zhan P, Zhang Y, Shi W, Liu X, Qiao Z, Wang Z, Wang X, Wu J, Tang W, Sun Y, Zhang Y, Zhen J, Shang J, Liu M, Yi F
Kidney international 2022 Sep;102(3):546-559
Kidney international 2022 Sep;102(3):546-559
p27(kip1) Modulates the Morphology and Phagocytic Activity of Microglia.
Beeken J, Kessels S, Rigo JM, Alpizar YA, Nguyen L, Brône B
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway.
Liu M, Xu X, Peng K, Hou P, Yuan Y, Li S, Sun X, Shi Z, Zhang J, Dong Y, Liu Q, Ai L, Liang L, Gan L, Huang Q, Yu Y, Liu T
Oncogenesis 2022 Sep 21;11(1):58
Oncogenesis 2022 Sep 21;11(1):58
Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.
Zhang C, Wang X, Zhang C
iScience 2022 Sep 16;25(9):104991
iScience 2022 Sep 16;25(9):104991
tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis.
Liu Y, Zhou J, Li X, Zhang X, Shi J, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zheng J, Liu RJ, Su B, Ye Y, Flavell RA, Yi C, Wu Y, Li HB
Nature immunology 2022 Oct;23(10):1433-1444
Nature immunology 2022 Oct;23(10):1433-1444
Skin chronological aging drives age-related bone loss via secretion of cystatin-A.
Liang W, Chen Q, Cheng S, Wei R, Li Y, Yao C, Ouyang Z, Kang D, Chen A, Liu Z, Li K, Bai X, Li Q, Huang B
Nature aging 2022 Oct;2(10):906-922
Nature aging 2022 Oct;2(10):906-922
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Cui X, Pei X, Wang H, Feng P, Qin H, Liu S, Yan Q, Liu J
Cells 2022 Oct 6;11(19)
Cells 2022 Oct 6;11(19)
Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension.
Fang X, Ma L, Wang Y, Ren F, Yu Y, Yuan Z, Wei H, Zhang H, Sun Y
Journal of hypertension 2022 Oct 1;40(10):2045-2057
Journal of hypertension 2022 Oct 1;40(10):2045-2057
MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.
Gu XJ, Li YJ, Wang F, Ye T
World journal of gastrointestinal oncology 2022 Nov 15;14(11):2170-2182
World journal of gastrointestinal oncology 2022 Nov 15;14(11):2170-2182
Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster.
Fu R, Dou Z, Li N, Zhang J, Li Z, Yang P
Biochemical pharmacology 2022 May;199:115021
Biochemical pharmacology 2022 May;199:115021
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Miao Y, Wan W, Zhu K, Pan M, Zhao X, Ma B, Wei Q
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
Cucurbitacin E Triggers Cellular Senescence in Colon Cancer Cells via Regulating the miR-371b-5p/TFAP4 Signaling Pathway.
Yang P, Lian Q, Fu R, Ding GB, Amin S, Li Z, Li Z
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2936-2947
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2936-2947
Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy.
Li R, Li H, Lan J, Yang D, Lin X, Xu H, Han B, Yang M, Su B, Liu F, Jiang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154084
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154084
Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
Bao X, Liu Y, Huang J, Yin S, Sheng H, Han X, Chen Q, Wang T, Chen S, Qiu Y, Zhang C, Yu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154066
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154066
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, Wang F, Zhao G, Lü M, Cui H
Cell death & disease 2022 Jun 22;13(6):564
Cell death & disease 2022 Jun 22;13(6):564
High expression of 14-3-3ơ indicates poor prognosis and progression of lung adenocarcinoma.
Feng J, Leng J, Zhao C, Guo J, Chen Y, Li H
Oncology letters 2022 Jul;24(1):203
Oncology letters 2022 Jul;24(1):203
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma.
Liu L, Gu M, Ma J, Wang Y, Li M, Wang H, Yin X, Li X
Molecular cancer 2022 Jul 20;21(1):149
Molecular cancer 2022 Jul 20;21(1):149
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality.
Li P, Chen T, Kuang P, Liu F, Li Z, Liu F, Wang Y, Zhang W, Cai X
Cell death & disease 2022 Jul 13;13(7):606
Cell death & disease 2022 Jul 13;13(7):606
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling.
Zhou X, Wang W, Li Z, Chen L, Wen C, Ruan Q, Xu Z, Liu R, Xu J, Bai Y, Deng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153861
Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis.
Xing S, Nong F, Wang Y, Huang D, Qin J, Chen YF, He DH, Wu PE, Huang H, Zhan R, Xu H, Liu YQ
Pharmacological research 2022 Feb;176:106059
Pharmacological research 2022 Feb;176:106059
Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells.
Zhang M, Peng R, Wang H, Yang Z, Zhang H, Zhang Y, Wang M, Wang H, Lin J, Zhao Q, Liu J
Cell death & disease 2022 Feb 17;13(2):159
Cell death & disease 2022 Feb 17;13(2):159
The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50.
Gao C, Zhou G, Shi J, Shi P, Jin L, Li Y, Wang X, Liao S, Yan H, Wu J, Lu Y, Zhai Y, Zhang J, Zhang H, Zhang H, Yang C, Cao P, Cheng S, Zhou G
Journal of experimental & clinical cancer research : CR 2022 Dec 8;41(1):338
Journal of experimental & clinical cancer research : CR 2022 Dec 8;41(1):338
MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1.
Zhou H, Zhou J, Teng H, Yang H, Qiu J, Li X
Biochemical and biophysical research communications 2022 Dec 3;632:92-99
Biochemical and biophysical research communications 2022 Dec 3;632:92-99
Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.
Zhang B, Liu ZY, Wu R, Zhang CM, Cao K, Shan WG, Liu Z, Ji M, Tian ZL, Sethi G, Shi HL, Wang RH
Acta pharmacologica Sinica 2022 Aug;43(8):2109-2118
Acta pharmacologica Sinica 2022 Aug;43(8):2109-2118
l-Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein-Barr virus-positive Burkitt lymphoma.
Sang W, Tu D, Zhang M, Qin Y, Yin W, Song X, Sun C, Yan D, Wang X, Zeng L, Li Z, Xu K, Xu L
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23117
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23117
Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells.
Qin X, Dang W, Yang X, Wang K, Kebreab E, Lyu L
Journal of cellular physiology 2022 Aug;237(8):3278-3291
Journal of cellular physiology 2022 Aug;237(8):3278-3291
α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression.
Gan X, Huang H, Wen J, Liu K, Yang Y, Li X, Fang G, Liu Y, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113266
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113266
LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells.
Li L, Li F, Hu X, Wu Z, Ren W, Wang T, Ji Z, Li N, Gu J, Sun C, Feng X, Han W, Huang J, Lei L
BMC cancer 2022 Aug 8;22(1):864
BMC cancer 2022 Aug 8;22(1):864
Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.
Xu Y, Zhang L, Wang Q, Zheng M
Cellular signalling 2022 Apr;92:110273
Cellular signalling 2022 Apr;92:110273
Synergistic Silencing of Skp2 by siRNA Self-Assembled Nanoparticles as a Therapeutic Strategy for Advanced Prostate Cancer.
Liang H, Zhang F, Hong Y, Wu Y, Xie H, Zhang C, Wang Z, Lu Z, Yang H
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(14):e2106046
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(14):e2106046
DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation.
Zhou Y, Yang Z, Zhang H, Li H, Zhang M, Wang H, Zhang M, Qiu P, Zhang R, Liu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Apr 1;1868(4):166353
Biochimica et biophysica acta. Molecular basis of disease 2022 Apr 1;1868(4):166353
Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma.
Guo M, Ding P, Zhu Z, Fan L, Zhou Y, Yang S, Yang Y, Gu C
Frontiers in cell and developmental biology 2021;9:675939
Frontiers in cell and developmental biology 2021;9:675939
Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway.
Ou G, Jiang X, Gao A, Li X, Lin Z, Pei S
Frontiers in veterinary science 2021;8:801407
Frontiers in veterinary science 2021;8:801407
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Song H, Zhuang L, Xu X, Shi J, Hu W, Liu Z, Shi S
Frontiers in medicine 2021;8:777563
Frontiers in medicine 2021;8:777563
PRRSV Promotes MARC-145 Cells Entry Into S Phase of the Cell Cycle to Facilitate Viral Replication via Degradation of p21 by nsp11.
Wen X, Ge X, Zhou L, Zhang Y, Guo X, Yang H
Frontiers in veterinary science 2021;8:642095
Frontiers in veterinary science 2021;8:642095
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.
Bai R, Yuan C, Sun W, Zhang J, Luo Y, Gao Y, Li Y, Gong Y, Xie C
International journal of biological sciences 2021;17(8):1995-2008
International journal of biological sciences 2021;17(8):1995-2008
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Bao D, Su H, Lei CT, Tang H, Ye C, Xiong W, He FF, Lin JH, Hammes HP, Zhang C
International journal of biological sciences 2021;17(15):4396-4408
International journal of biological sciences 2021;17(15):4396-4408
ACTL6A Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells and Correlates with Poor Clinical Outcomes.
Li RZ, Li YY, Qin H, Li SS
OncoTargets and therapy 2021;14:199-211
OncoTargets and therapy 2021;14:199-211
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Fan S, Wang C, Huang K, Liang M
Frontiers in physiology 2021;12:790345
Frontiers in physiology 2021;12:790345
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
Yang M, Li WY, Xie J, Wang ZL, Wen YL, Zhao CC, Tao L, Li LF, Tian Y, Sheng J
Frontiers in pharmacology 2021;12:639256
Frontiers in pharmacology 2021;12:639256
KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Liu W, Zhan Z, Zhang M, Sun B, Shi Q, Luo F, Zhang M, Zhang W, Hou Y, Xiao X, Li Y, Feng H
Theranostics 2021;11(13):6278-6292
Theranostics 2021;11(13):6278-6292
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
Zhang D, Lu P, Zhu K, Wu H, Dai Y
Frontiers in oncology 2021;11:724437
Frontiers in oncology 2021;11:724437
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.
Sanches JGP, Song B, Zhang Q, Cui X, Yabasin IB, Ntim M, Li X, He J, Zhang Y, Mao J, Lu Y, Li L
Frontiers in oncology 2021;11:637298
Frontiers in oncology 2021;11:637298
Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G(0)/G(1) Cell Cycle Arrest and Antiproliferation in A549 Cells.
Zhang YL, Chen GL, Liu Y, Zhuang XC, Guo MQ
Antioxidants (Basel, Switzerland) 2021 Sep 30;10(10)
Antioxidants (Basel, Switzerland) 2021 Sep 30;10(10)
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Yuan Y, Xu J, Jiang L, Yu K, Ge Y, Li M, He H, Niu Q, Shi X, Fan L, Chen Z, Zhao Z, Li S, Xu Y, Wang Z, Li H
Journal of medicinal chemistry 2021 Sep 23;64(18):13572-13587
Journal of medicinal chemistry 2021 Sep 23;64(18):13572-13587
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
Zhang J, Zou L, Shi D, Liu J, Zhang J, Zhao R, Wang G, Zhang L, Ouyang L, Liu B
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, González-García P, Zenezini Chiozzi R, Acuña-Castroviejo D, López LC
Biomedicines 2021 Oct 13;9(10)
Biomedicines 2021 Oct 13;9(10)
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)
International journal of molecular sciences 2021 Oct 12;22(20)
miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells.
Liu Q, Tian R, Yu P, Shu M
FEBS letters 2021 Nov;595(22):2829-2843
FEBS letters 2021 Nov;595(22):2829-2843
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
Song AN, Yin XJ, Gao P, Tang H, Meng XF, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation.
Wang H, Luo J, Tian X, Xu L, Zhai Z, Cheng M, Chen L, Luo S
Biochimica et biophysica acta. Molecular cell research 2021 May;1868(6):118994
Biochimica et biophysica acta. Molecular cell research 2021 May;1868(6):118994
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Wu H, Cui M, Li C, Li H, Dai Y, Cui K, Li Z
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Zhao X, Jiang L, Hu D, Tang Y, Zhao G, Du X, Luo S, Tang W
Experimental cell research 2021 Jun 15;403(2):112614
Experimental cell research 2021 Jun 15;403(2):112614
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198
Cell death discovery 2021 Jul 29;7(1):198
Chemopreventive effects of pterostilbene through p53 and cell cycle in mouse lung of squamous cell carcinoma model.
Surien O, Ghazali AR, Masre SF
Scientific reports 2021 Jul 21;11(1):14862
Scientific reports 2021 Jul 21;11(1):14862
Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota.
Chen Q, Ren D, Wu J, Yu H, Chen X, Wang J, Zhang Y, Liu M, Wang T
Journal of natural medicines 2021 Jan;75(1):84-98
Journal of natural medicines 2021 Jan;75(1):84-98
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Tian D, Teng X, Jin S, Chen Y, Xue H, Xiao L, Wu Y
Journal of advanced research 2021 Jan;27:115-125
Journal of advanced research 2021 Jan;27:115-125
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.
Chen CH, Chou YT, Yang YW, Lo KY
Apoptosis : an international journal on programmed cell death 2021 Dec;26(11-12):612-627
Apoptosis : an international journal on programmed cell death 2021 Dec;26(11-12):612-627
ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis.
Gong W, Xu J, Wang G, Li D, Zhan Q
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2021 Dec 31;33(6):637-648
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2021 Dec 31;33(6):637-648
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y, Zhao L
Oncogenesis 2021 Dec 3;10(12):84
Oncogenesis 2021 Dec 3;10(12):84
PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer.
Xu Y, Liu J, Jiang T, Shi L, Shang L, Song J, Li L
Experimental cell research 2021 Dec 15;409(2):112924
Experimental cell research 2021 Dec 15;409(2):112924
Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
Guo H, Luo X, Sun L, Li J, Cui S
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):742-752
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):742-752
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
Sun W, Li S, Tang G, Sun S, Luo Y, Bai R, Han L, Jiang X, Gao Y, Huang Z, Zhang J, Gong Y, Xie C
Cancer medicine 2021 Aug;10(15):5256-5269
Cancer medicine 2021 Aug;10(15):5256-5269
Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway.
Zhou Y, Li X, Ye M
International journal of molecular medicine 2021 Apr;47(4):1
International journal of molecular medicine 2021 Apr;47(4):1
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
Liu X, Gu Y, Bian Y, Cai D, Li Y, Zhao Y, Zhang Z, Xue M, Zhang L
Apoptosis : an international journal on programmed cell death 2021 Apr;26(3-4):195-208
Apoptosis : an international journal on programmed cell death 2021 Apr;26(3-4):195-208
THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways.
Zhang J, Zhang H, Shi H, Wang F, Du J, Wang Y, Wei Y, Xue W, Li D, Feng Y, Yan J, Gao Y, Li J, Han J
BioMed research international 2020;2020:7838924
BioMed research international 2020;2020:7838924
NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.
Zhang X, Wang H, Han Y, Zhu M, Song Z, Zhan D, Jia J
OncoTargets and therapy 2020;13:11315-11326
OncoTargets and therapy 2020;13:11315-11326
Hsa-MiR-590-3p Promotes the Malignancy Progression of Pancreatic Ductal Carcinoma by Inhibiting the Expression of p27 and PPP2R2A via G1/S Cell Cycle Pathway.
Shi X, Sheng W, Jia C, Tang J, Dong M
OncoTargets and therapy 2020;13:11045-11058
OncoTargets and therapy 2020;13:11045-11058
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Yang B, Bai H, Sa Y, Zhu P, Liu P
Journal of Cancer 2020;11(8):2303-2317
Journal of Cancer 2020;11(8):2303-2317
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.
Jin Y, Liu J, Liu Y, Liu Y, Guo G, Yu S, An R
Frontiers in pharmacology 2020;11:808
Frontiers in pharmacology 2020;11:808
MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI.
Wei X, Wang B, Wang Q, Yang X, Yang Y, Fang Z, Yi C, Shi L, Fan X, Tao J, Guo Y, Song D
Frontiers in pharmacology 2020;11:164
Frontiers in pharmacology 2020;11:164
α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway.
Pei XD, Yao HL, Shen LQ, Yang Y, Lu L, Xiao JS, Wang XY, He ZL, Jiang LH
European journal of pharmacology 2020 Sep 15;883:173355
European journal of pharmacology 2020 Sep 15;883:173355
UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.
Gu C, Zhao K, Zhou N, Liu F, Xie F, Yu S, Feng Y, Chen L, Yang J, Tian F, Jiang G
Cell death & disease 2020 Sep 10;11(9):733
Cell death & disease 2020 Sep 10;11(9):733
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.
Liu A, Zuo Z, Liu L, Liu L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Oct;98(5):548-555
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Oct;98(5):548-555
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
Sun Q, Ye Z, Qin Y, Fan G, Ji S, Zhuo Q, Xu W, Liu W, Hu Q, Liu M, Zhang Z, Xu X, Yu X
Oncogene 2020 Oct;39(42):6572-6588
Oncogene 2020 Oct;39(42):6572-6588
Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.
Rai KR, Chen B, Zhao Z, Chen Y, Hu J, Liu S, Maarouf M, Li Y, Xiao M, Liao Y, Chen JL
Cellular microbiology 2020 Nov;22(11):e13242
Cellular microbiology 2020 Nov;22(11):e13242
Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.
Shi B, Xu FF, Xiang CP, Jia R, Yan CH, Ma SQ, Wang N, Wang AJ, Fan P
Oncology letters 2020 Nov;20(5):148
Oncology letters 2020 Nov;20(5):148
KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity.
Jiang X, Xu Y, Ren H, Jiang J, Wudu M, Wang Q, Guan J, Su H, Zhang Y, Zhang B, Guo Y, Hu Y, Jiang L, Liu Z, Wang H, Cheng Y, Sun L, Qiu X
Cell & bioscience 2020 Nov 27;10(1):139
Cell & bioscience 2020 Nov 27;10(1):139
Involvement of MicroRNA-1-FAM83A Axis Dysfunction in the Growth and Motility of Lung Cancer Cells.
Liu PJ, Chen YH, Tsai KW, Yeah HY, Yeh CY, Tu YT, Yang CY
International journal of molecular sciences 2020 Nov 22;21(22)
International journal of molecular sciences 2020 Nov 22;21(22)
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
Wang N, Liu H, Liu G, Li M, He X, Yin C, Tu Q, Shen X, Bai W, Wang Q, Tao Y, Yin H
Redox biology 2020 May;32:101495
Redox biology 2020 May;32:101495
The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function.
Jiang B, Adams Z, Moonah S, Shi H, Maupin-Furlow J, Moskovitz J
Antioxidants (Basel, Switzerland) 2020 May 24;9(5)
Antioxidants (Basel, Switzerland) 2020 May 24;9(5)
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.
Jin X, Ge LP, Li DQ, Shao ZM, Di GH, Xu XE, Jiang YZ
Molecular cancer 2020 May 11;19(1):87
Molecular cancer 2020 May 11;19(1):87
MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.
Pan S, Wu W, Ren F, Li L, Li Y, Li W, Wang A, Liu D, Dong Y
Life sciences 2020 Mar 1;244:117300
Life sciences 2020 Mar 1;244:117300
Endogenous thrombopoietin promotes non-small-cell lung carcinoma cell proliferation and migration by regulating EGFR signalling.
Zou Z, Fan X, Liu Y, Sun Y, Zhang X, Sun G, Li X, Xu S
Journal of cellular and molecular medicine 2020 Jun;24(12):6644-6657
Journal of cellular and molecular medicine 2020 Jun;24(12):6644-6657
Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
Luo F, Zhao Y, Liu J
The international journal of biochemistry & cell biology 2020 Jun;123:105750
The international journal of biochemistry & cell biology 2020 Jun;123:105750
miR-203a suppresses cell proliferation by targeting RING-finger protein 6 in colorectal cancer.
Miao J, Hou N, Yang W, Jiang Q, Xue W, Wang X, Zhang H, Xiong X, Wang L, Zhao L, Huang C
Anti-cancer drugs 2020 Jul;31(6):583-591
Anti-cancer drugs 2020 Jul;31(6):583-591
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, Shi L, Song D
Cancer medicine 2020 Jan;9(2):724-736
Cancer medicine 2020 Jan;9(2):724-736
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
Xu M, Zhang X, Zhang S, Piao J, Yang Y, Wang X, Lin Z
Aging 2020 Dec 3;13(1):1032-1050
Aging 2020 Dec 3;13(1):1032-1050
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, Chen P, Williamson RA, Wang B, Hu J
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Shi L, Duan Y, Yao X, Song R, Ren Y
Animal reproduction science 2020 Apr;215:106330
Animal reproduction science 2020 Apr;215:106330
Prognostic significance of LAPTM4B and p27kip1 expression in triple-negative breast cancer.
Li X, Song C, Wang K, Li N, Sun S, Li N, Zhao Z, Li M
Cancer biomarkers : section A of Disease markers 2019;25(1):19-27
Cancer biomarkers : section A of Disease markers 2019;25(1):19-27
Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
Cui D, Zhao Y, Xu J
Cancer biology & therapy 2019;20(5):608-616
Cancer biology & therapy 2019;20(5):608-616
Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma.
Sun Q, Xu W, Ji S, Qin Y, Liu W, Hu Q, Zhang Z, Liu M, Yu X, Xu X
Cancer cell international 2019;19:49
Cancer cell international 2019;19:49
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582
International journal of medical sciences 2019;16(12):1573-1582
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
Li T, Wang F, Dang Y, Dong J, Zhang Y, Zhang C, Liu P, Gao Y, Wang X, Yang S, Lu S
International journal of biological sciences 2019;15(10):2198-2210
International journal of biological sciences 2019;15(10):2198-2210
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL, Wang YX
OncoTargets and therapy 2019;12:8105-8115
OncoTargets and therapy 2019;12:8105-8115
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
Liu LL, Zhu JM, Yu XN, Zhu HR, Shi X, Bilegsaikhan E, Guo HY, Wu J, Shen XZ
Cancer management and research 2019;11:8359-8370
Cancer management and research 2019;11:8359-8370
Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.
Tang G, Zeng Z, Sun W, Li S, You C, Tang F, Peng S, Ma S, Luo Y, Xu J, Tian X, Zhang N, Gong Y, Xie C
Journal of Cancer 2019;10(10):2261-2275
Journal of Cancer 2019;10(10):2261-2275
The Capsid Protein VP1 of Coxsackievirus B Induces Cell Cycle Arrest by Up-Regulating Heat Shock Protein 70.
Wang Y, Zhao S, Chen Y, Wang T, Dong C, Wo X, Zhang J, Dong Y, Xu W, Feng X, Qu C, Wang Y, Zhong Z, Zhao W
Frontiers in microbiology 2019;10:1633
Frontiers in microbiology 2019;10:1633
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4
Gastroenterology 2019 Sep;157(3):744-759.e4
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.
Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, Hu Y, Wu G, Dong X
Aging 2019 Sep 8;11(17):6734-6761
Aging 2019 Sep 8;11(17):6734-6761
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Zheng F, Wang M, Li Y, Huang C, Tao D, Xie F, Zhang H, Sun J, Zhang C, Gu C, Wang Z, Jiang G
Cancer letters 2019 Sep 28;460:139-151
Cancer letters 2019 Sep 28;460:139-151
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner.
He J, Hong B, Bian M, Jin H, Chen J, Shao J, Zhang F, Zheng S
International immunopharmacology 2019 Oct;75:105816
International immunopharmacology 2019 Oct;75:105816
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L
International journal of oncology 2019 Oct;55(4):879-895
International journal of oncology 2019 Oct;55(4):879-895
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.
Fu R, Yang P, Sajid A, Li Z
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816
Knockdown of TRIM27 expression suppresses the dysfunction of mesangial cells in lupus nephritis by FoxO1 pathway.
Liu J, Feng X, Tian Y, Wang K, Gao F, Yang L, Li H, Tian Y, Yang R, Zhao L, Miao X, Huang J, Liu Q, Zhang W, Li Y, Wang C, Duan H, Liu S
Journal of cellular physiology 2019 Jul;234(7):11555-11566
Journal of cellular physiology 2019 Jul;234(7):11555-11566
Thyroid hormone (T(3)) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.
Wang C, Zheng P, Adeniran SO, Ma M, Huang F, Adegoke EO, Zhang G
Theriogenology 2019 Jul 15;133:1-9
Theriogenology 2019 Jul 15;133:1-9
Effect of ingredients from Chinese herbs on enterovirus D68 production.
Meng X, Yu X, Liu C, Wang Y, Song F, Huan C, Huo W, Zhang S, Li Z, Zhang J, Zhang W, Yu J
Phytotherapy research : PTR 2019 Jan;33(1):174-186
Phytotherapy research : PTR 2019 Jan;33(1):174-186
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, Wang Q, Su H, Jiang X, Dao R, Qiu X
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2.
Wang R, Liu H, Shao Y, Wang K, Yin S, Qiu Y, Wu H, Liu E, Wang T, Gao X, Yu H
Molecular cancer research : MCR 2019 Dec;17(12):2469-2479
Molecular cancer research : MCR 2019 Dec;17(12):2469-2479
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C
Oncogene 2019 Aug;38(33):6142-6157
Oncogene 2019 Aug;38(33):6142-6157
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.
Zheng M, Tian C, Fan T, Xu B
Experimental eye research 2019 Aug;185:107681
Experimental eye research 2019 Aug;185:107681
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A
Journal of molecular and cellular cardiology 2019 Aug;133:26-35
Journal of molecular and cellular cardiology 2019 Aug;133:26-35
MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.
Zhao F, Zhou LH, Ge YZ, Ping WW, Wu X, Xu ZL, Wang M, Sha ZL, Jia RP
Journal of cellular physiology 2019 Apr;234(4):4910-4923
Journal of cellular physiology 2019 Apr;234(4):4910-4923
Autophagy mediates serum starvation-induced quiescence in nucleus pulposus stem cells by the regulation of P27.
Li B, Sun C, Sun J, Yang MH, Zuo R, Liu C, Lan WR, Liu MH, Huang B, Zhou Y
Stem cell research & therapy 2019 Apr 15;10(1):118
Stem cell research & therapy 2019 Apr 15;10(1):118
EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma.
Li Z, Qiu R, Qiu X, Tian T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1856-1869
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1856-1869
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
Xie F, Li Y, Wang M, Huang C, Tao D, Zheng F, Zhang H, Zeng F, Xiao X, Jiang G
Molecular cancer 2018 Oct 3;17(1):144
Molecular cancer 2018 Oct 3;17(1):144
WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4.
Taniuchi K, Furihata M, Naganuma S, Saibara T
Cancer medicine 2018 Nov;7(11):5733-5751
Cancer medicine 2018 Nov;7(11):5733-5751
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ.
Zhang JR, Lu QB, Feng WB, Wang HP, Tang ZH, Cheng H, Du Q, Wang YB, Li KX, Sun HJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:711-717
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:711-717
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
Yang X, Qu S, Wang L, Zhang H, Yang Z, Wang J, Dai B, Tao K, Shang R, Liu Z, Li X, Zhang Z, Xia C, Ma B, Liu W, Li H, Dou K
Oncogene 2018 Dec;37(50):6399-6413
Oncogene 2018 Dec;37(50):6399-6413
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854
Cell research 2018 Aug;28(8):833-854
Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade.
Lu QB, Wan MY, Wang PY, Zhang CX, Xu DY, Liao X, Sun HJ
Redox biology 2018 Apr;14:656-668
Redox biology 2018 Apr;14:656-668
Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A, Galderisi U
Neoplasia (New York, N.Y.) 2017 Oct;19(10):781-790
Neoplasia (New York, N.Y.) 2017 Oct;19(10):781-790
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
Lin G, Zhu S, Wu Y, Song C, Wang W, Zhang Y, Chen YL, He Z
Scientific reports 2017 Jun 7;7(1):2929
Scientific reports 2017 Jun 7;7(1):2929
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, Zhang H, Zhang W, Han Y
Oncotarget 2017 Jun 20;8(25):40501-40513
Oncotarget 2017 Jun 20;8(25):40501-40513
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Hu YH, Chen Q, Lu YX, Zhang JM, Lin C, Zhang F, Zhang WJ, Li XM, Zhang W, Li XN
Oncotarget 2017 Jul 11;8(28):46191-46203
Oncotarget 2017 Jul 11;8(28):46191-46203
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Ma H, Li L, Dou G, Wang C, Li J, He H, Wu M, Qi H
Oncotarget 2017 Apr 25;8(17):29328-29345
Oncotarget 2017 Apr 25;8(17):29328-29345
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro.
Shi L, Song R, Yao X, Ren Y
Theriogenology 2017 Apr 15;93:24-32
Theriogenology 2017 Apr 15;93:24-32
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
Zhao Y, Zhang B, Lei Y, Sun J, Zhang Y, Yang S, Zhang X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
Yin J, Sheng B, Han B, Pu A, Yang K, Li P, Wang Q, Xiao W, Yang H
Cell biology international 2016 May;40(5):560-8
Cell biology international 2016 May;40(5):560-8
[Corrigendum] Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells.
Xu D, Wang J, Zhou Z, He Z, Zhao Q
Molecular medicine reports 2016 Jan;13(1):1054
Molecular medicine reports 2016 Jan;13(1):1054
Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells.
Li W, Cao F, Li J, Wang Z, Ren Y, Liang Z, Liu P
Molecular medicine reports 2016 Dec;14(6):5334-5342
Molecular medicine reports 2016 Dec;14(6):5334-5342
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Zhang L, Liu L, He X, Shen Y, Liu X, Wei J, Yu F, Tian J
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92
Oncotarget 2015 Oct 13;6(31):32177-92
Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells.
Xu D, Wang J, Zhou Z, He Z, Zhao Q
Molecular medicine reports 2015 Dec;12(6):7963-70
Molecular medicine reports 2015 Dec;12(6):7963-70
Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis.
Kamar N, Izopet J, Cintas P, Garrouste C, Uro-Coste E, Cointault O, Rostaing L
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 May;10(5):1321-4
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 May;10(5):1321-4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The P27; KIP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human P27; KIP1. This antibody recognizes human, mouse antigen. The P27; KIP1 antibody has been validated for the following applications: ELISA, WB analysis.
