ABIN350690

antibody from antibodies-online

Targeting: CDKN1B KIP1, P27KIP1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN350690

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN350690, RRID:AB_10781662

Product name

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (C-Term), (AA 100-170) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from c-terminal region (aa 100-170) of human p27 Kip1 (KIP1, p27Kip1) conjugated to an immunogenic carrier protein was used as the immunogen.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

C-Term,AA 100-170

Isotype

IgG

Vial size

500 μg

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW, Hengst L
Cell 2007 Jan 26;128(2):269-80

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.

Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M
Nature medicine 2002 Oct;8(10):1136-44

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Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

Pietenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask BJ, Roberts JM, Kinzler KW, Rowley JD
Cancer research 1995 Mar 15;55(6):1206-10