Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN2839618 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (pSer10) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pSer10
- Antibody clone number
- RB7323
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation.
Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition.
The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma.
The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27.
Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.
Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X
The Journal of biological chemistry 2012 Jan 13;287(3):2090-8
The Journal of biological chemistry 2012 Jan 13;287(3):2090-8
Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition.
Lee MS, Kim HP, Kim TY, Lee JW
Biochimica et biophysica acta 2012 Feb;1823(2):514-23
Biochimica et biophysica acta 2012 Feb;1823(2):514-23
The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr
Journal of the National Cancer Institute 2011 Sep 21;103(18):1403-22
Journal of the National Cancer Institute 2011 Sep 21;103(18):1403-22
Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma.
Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, Claret FX, Medeiros LJ, Amin HM
Blood 2005 Jan 15;105(2):827-9
Blood 2005 Jan 15;105(2):827-9
The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27.
Wingate H, Zhang N, McGarhen MJ, Bedrosian I, Harper JW, Keyomarsi K
The Journal of biological chemistry 2005 Apr 15;280(15):15148-57
The Journal of biological chemistry 2005 Apr 15;280(15):15148-57
Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.
Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J
The Journal of biological chemistry 2005 Apr 1;280(13):12339-43
The Journal of biological chemistry 2005 Apr 1;280(13):12339-43
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Supportive validation
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- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC