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Learn10359-1-AP
antibody from Proteintech Group
Targeting: HBS1L
DKFZp434g247, EF-1a, eRF3c, ERFS, HBS1, HSPC276, KIAA1038
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 10359-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10359-1-AP, RRID:AB_2114730
- Product name
- HBS1L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HBS1L antibody (Cat. #10359-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Translation regulation of ATF4 by the termination complex Hbs1-Pelo is required for visual system development and function.
Synthetic lethality of mRNA quality control complexes in cancer.
Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt.
HBS1L deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells.
Genetic deficiency of ribosomal rescue factor HBS1L causes retinal dystrophy associated with Pelota and EDF1 depletion.
Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.
Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.
RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism.
Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.
Deep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomes.
Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.
Querry K, Lago-Baldaia I, Nampoothiri V P N, Garbark C, Carney AJ, Fernandes VM, Vasudevan D
bioRxiv : the preprint server for biology 2025 Oct 8;
bioRxiv : the preprint server for biology 2025 Oct 8;
Synthetic lethality of mRNA quality control complexes in cancer.
Prindle V, Richardson AE, Sher KR, Kongpachith S, Kentala K, Petiwala S, Cheng D, Widomski D, Le P, Torrent M, Chen A, Walker S, Palczewski MB, Mitra D, Manaves V, Shi X, Lu C, Sandoval S, Dezso Z, Buchanan FG, Verduzco D, Bierie B, Meulbroek JA, Pappano WN, Plotnik JP
Nature 2025 Feb;638(8052):1095-1103
Nature 2025 Feb;638(8052):1095-1103
Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt.
Miluzio A, Scagliola A, Ferrari I, Yilmaz H, D'Andrea G, Cassina L, Oliveto S, Ricciardi S, Boletta A, Biffo S
Molecular cell 2025 Dec 4;85(23):4410-4425.e11
Molecular cell 2025 Dec 4;85(23):4410-4425.e11
HBS1L deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells.
Luo S, Alwattar B, Li Q, Bora K, Blomfield AK, Lin J, Fulton A, Chen J, Agrawal PB
Disease models & mechanisms 2024 Aug 1;17(8)
Disease models & mechanisms 2024 Aug 1;17(8)
Genetic deficiency of ribosomal rescue factor HBS1L causes retinal dystrophy associated with Pelota and EDF1 depletion.
Luo S, Alwattar B, Li Q, Bora K, Blomfield AK, Lin J, Fulton A, Chen J, Agrawal PB
bioRxiv : the preprint server for biology 2023 Oct 20;
bioRxiv : the preprint server for biology 2023 Oct 20;
Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.
Wu X, Yang ZH, Wu J, Han J
Immunity 2023 May 9;56(5):926-943.e7
Immunity 2023 May 9;56(5):926-943.e7
Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.
Terrey M, Adamson SI, Chuang JH, Ackerman SL
eLife 2021 Apr 26;10
eLife 2021 Apr 26;10
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.
O'Connell AE, Gerashchenko MV, O'Donohue MF, Rosen SM, Huntzinger E, Gleeson D, Galli A, Ryder E, Cao S, Murphy Q, Kazerounian S, Morton SU, Schmitz-Abe K, Gladyshev VN, Gleizes PE, Séraphin B, Agrawal PB
PLoS genetics 2019 Feb;15(2):e1007917
PLoS genetics 2019 Feb;15(2):e1007917
RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism.
Aly HH, Suzuki J, Watashi K, Chayama K, Hoshino S, Hijikata M, Kato T, Wakita T
The Journal of biological chemistry 2016 Jul 29;291(31):15958-74
The Journal of biological chemistry 2016 Jul 29;291(31):15958-74
Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.
Knight JR, Bastide A, Roobol A, Roobol J, Jackson TJ, Utami W, Barrett DA, Smales CM, Willis AE
The Biochemical journal 2015 Jan 15;465(2):227-38
The Biochemical journal 2015 Jan 15;465(2):227-38
Deep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomes.
Slevin MK, Meaux S, Welch JD, Bigler R, Miliani de Marval PL, Su W, Rhoads RE, Prins JF, Marzluff WF
Molecular cell 2014 Mar 20;53(6):1020-30
Molecular cell 2014 Mar 20;53(6):1020-30
Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.
Baandrup JD, Markvardsen LH, Peters CD, Schou UK, Jensen JL, Magnusson NE, Ørntoft TF, Kruhøffer M, Simonsen U
PloS one 2011 Jan 5;6(1):e15859
PloS one 2011 Jan 5;6(1):e15859
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 10359-1-AP(HBS1L antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HBS1L antibody 10359-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 10359-1-AP(HBS1L antibody) at dilution of 1:50 (under 25x lens)
- Sample type
- tissue
