14824-1-AP

antibody from Proteintech Group

Targeting: LDHB

Provider product page for 14824-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [91]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14824-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14824-1-AP, RRID:AB_2134953
Product name: LDHB antibody
Antibody type: Polyclonal
Description: KD/KO validated LDHB antibody (Cat. #14824-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LDHB protein structure - 14824-1-AP shown in red.

Submitted references Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach.

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Cong J, Zheng S, Zhang H, Li Y, Liu Z
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Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma.

Li J, Xun W, Wang X, Luo R, Hu Q, Zhou Z, Yuan J, Wang Y, Wan X, Zhao T, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e10733

lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation.

Yu L, Zhou N, Zhang XL, Pang XJ, Xing L, Pu YJ, Zhang L, Wu JN, Shu H
Molecular medicine reports 2026 Feb;33(2)

Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.

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MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation.

Chi W, Kang N, Sheng L, Liu S, Tao L, Cao X, Liu Y, Zhu C, Zhang Y, Wu B, Chen R, Cheng L, Wang J, Sun X, Liu X, Deng H, Yang J, Li Z, Liu W, Chen L
Nature communications 2024 Jan 2;15(1):163

Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection.

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LDHA and LDHB overexpression promoted the Warburg effect in malignantly transformed GES-1 cells induced by N-nitroso compounds.

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Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice.

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ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.

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Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P
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Cancer letters 2023 Feb 1;554:216020

Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.

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HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1.

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Cell reports 2023 Aug 29;42(8):112945

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Frontiers in oncology 2022;12:821620

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Comparative Proteomic Analysis of HPV(+) Oropharyngeal Squamous Cell Carcinoma Recurrence.

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Journal of proteome research 2022 Jan 7;21(1):200-208

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Koh JH, Pataky MW, Dasari S, Klaus KA, Vuckovic I, Ruegsegger GN, Kumar AP, Robinson MM, Nair KS
Nature communications 2022 Apr 28;13(1):2324

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Frontiers in pharmacology 2021;12:744826

AMPKα loss promotes KRAS-mediated lung tumorigenesis.

La Montagna M, Shi L, Magee P, Sahoo S, Fassan M, Garofalo M
Cell death and differentiation 2021 Sep;28(9):2673-2689

Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease.

Zhang L, Liu T, Hu C, Zhang X, Zhang Q, Shi K
BMC genomics 2021 Sep 4;22(1):640

Metabolic remodelling during early mouse embryo development.

Zhao J, Yao K, Yu H, Zhang L, Xu Y, Chen L, Sun Z, Zhu Y, Zhang C, Qian Y, Ji S, Pan H, Zhang M, Chen J, Correia C, Weiskittel T, Lin DW, Zhao Y, Chandrasekaran S, Fu X, Zhang D, Fan HY, Xie W, Li H, Hu Z, Zhang J
Nature metabolism 2021 Oct;3(10):1372-1384

Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.

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Respiratory research 2021 Oct 28;22(1):278

ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.

Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059

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Wang S, Yang J, Ding C, Li J, You L, Dai M, Zhao Y
Frontiers in oncology 2020;10:1539

A glycolytic shift in Schwann cells supports injured axons.

Babetto E, Wong KM, Beirowski B
Nature neuroscience 2020 Oct;23(10):1215-1228

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N
Nature communications 2020 Jun 22;11(1):3162

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.

Arra M, Swarnkar G, Ke K, Otero JE, Ying J, Duan X, Maruyama T, Rai MF, O'Keefe RJ, Mbalaviele G, Shen J, Abu-Amer Y
Nature communications 2020 Jul 9;11(1):3427

Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes.

Wen J, Wang GL, Yuan HJ, Zhang J, Xie HL, Gong S, Han X, Tan JH
Scientific reports 2020 Feb 17;10(1):2782

Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.

Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618

Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.

Li H, Hu S, Pang Y, Li M, Chen L, Liu F, Liu M, Wang Z, Cheng X
American journal of cancer research 2018;8(7):1288-1296

The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.

Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B
Stem cell reports 2018 Sep 11;11(3):741-755

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer.

Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, You L, Zheng L, Zhang T, Zhao Y
Journal of experimental & clinical cancer research : CR 2018 Nov 12;37(1):274

The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer.

Jiang W, He T, Liu S, Zheng Y, Xiang L, Pei X, Wang Z, Yang H
Journal of hematology & oncology 2018 Dec 14;11(1):139

A large-scale targeted proteomics assay resource based on an in vitro human proteome.

Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI
Nature methods 2017 Mar;14(3):251-258

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Fu L, Xu Y, Hou Y, Qi X, Zhou L, Liu H, Luan Y, Jing L, Miao Y, Zhao S, Liu H, Li X
Scientific reports 2017 Mar 27;7:45291

miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin.

Jimenez L, Lim J, Burd B, Harris TM, Ow TJ, Kawachi N, Belbin TJ, Angeletti R, Prystowsky MB, Childs G, Segall JE
The American journal of pathology 2017 Jul;187(7):1523-1536

Fructose‑1,6‑bisphosphatase‑1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.

Li H, Li M, Pang Y, Liu F, Sheng D, Cheng X
Molecular medicine reports 2017 Dec;16(6):8563-8571

Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysis.

Wang S, Xie J, Li J, Liu F, Wu X, Wang Z
American journal of cancer research 2016;6(5):1108-17

Probing early tumor response to radiation therapy using hyperpolarized [1-¹³C]pyruvate in MDA-MB-231 xenografts.

Chen AP, Chu W, Gu YP, Cunningham CH
PloS one 2013;8(2):e56551

Laser capture microdissection-directed profiling of glycolytic and mTOR pathways in areas of selectively ablated Müller cells in the murine retina.

Chung SH, Shen W, Gillies MC
Investigative ophthalmology & visual science 2013 Oct 9;54(10):6578-85

Differential redox proteomics allows identification of proteins reversibly oxidized at cysteine residues in endothelial cells in response to acute hypoxia.

Izquierdo-Álvarez A, Ramos E, Villanueva J, Hernansanz-Agustín P, Fernández-Rodríguez R, Tello D, Carrascal M, Martínez-Ruiz A
Journal of proteomics 2012 Sep 18;75(17):5449-62

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.

Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 8;108(10):4129-34

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 14824-1-AP(LDHB antibody) at dilution of 1:2000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using LDHB antibody 14824-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate using 14824-1-AP(LDHB antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate using 14824-1-AP(LDHB antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue