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- Antibody Data
- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 10771-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10771-1-AP, RRID:AB_2170496
- Product name
- PACT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PACT antibody (Cat. #10771-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prkra dimer senses double-stranded RNAs to dictate global translation efficiency.
Biomimetic targeted self-adaptive nanodrug for inflammation optimization and AT2 cell modulation in precise ARDS therapy.
Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA.
A frameshift mutation in the murine Prkra gene causes dystonia and exhibits abnormal cerebellar development and reduced eIF2α phosphorylation.
Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape.
PRKRA promotes pancreatic cancer progression by upregulating MMP1 transcription via the NF-κB pathway.
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
L-bodies are RNA-protein condensates driving RNA localization in Xenopus oocytes.
The dynamic recruitment of TRBP to neuronal membranes mediates dendritogenesis during development.
KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.
Proteomic analysis of early HIV-1 nucleoprotein complexes.
Hepato-specific microRNA-122 facilitates accumulation of newly synthesized miRNA through regulating PRKRA.
Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain.
Lu T, Ma P, Fang H, Chen A, Xu J, Kuang X, Wang M, Su L, Wang S, Zhang Y, Wang J, Yang B, Shi DL, Zhou Y, Gong Q, Liu X, Mao B, Shao M
Molecular cell 2025 May 15;85(10):2032-2047.e9
Molecular cell 2025 May 15;85(10):2032-2047.e9
Biomimetic targeted self-adaptive nanodrug for inflammation optimization and AT2 cell modulation in precise ARDS therapy.
Chen C, He D, Li X, Ou Z, Wang H, Shou Z, Wang L, Mao Z, Qi X, Deng J
Science advances 2025 Aug;11(31):eadw5133
Science advances 2025 Aug;11(31):eadw5133
Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA.
Burnett SB, Culver AM, Simon TA, Rowson T, Frederick K, Palmer K, Murray SA, Davis SW, Patel RC
Disease models & mechanisms 2024 Nov 1;17(11)
Disease models & mechanisms 2024 Nov 1;17(11)
A frameshift mutation in the murine Prkra gene causes dystonia and exhibits abnormal cerebellar development and reduced eIF2α phosphorylation.
Burnett SB, Culver AM, Simon TA, Rowson T, Frederick K, Palmer K, Murray SA, Davis SW, Patel RC
bioRxiv : the preprint server for biology 2024 Jun 4;
bioRxiv : the preprint server for biology 2024 Jun 4;
Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape.
Cao Y, Wu J, Hu Y, Chai Y, Song J, Duan J, Zhang S, Xu X
Cell reports 2023 Oct 31;42(10):113262
Cell reports 2023 Oct 31;42(10):113262
PRKRA promotes pancreatic cancer progression by upregulating MMP1 transcription via the NF-κB pathway.
Qiu J, Feng M, Yang G, Su D, Zhao F, Liu Y, Tao J, Luo W, Zhang T
Heliyon 2023 Jun;9(6):e17194
Heliyon 2023 Jun;9(6):e17194
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.
Zhang N, Liu X, Huang L, Zeng J, Ma C, Han L, Li W, Yu J, Yang M
Cell reports 2023 Dec 26;42(12):113479
Cell reports 2023 Dec 26;42(12):113479
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE, Gottlieb RA, Erbay E
The Journal of biological chemistry 2022 Jul;298(7):102050
The Journal of biological chemistry 2022 Jul;298(7):102050
L-bodies are RNA-protein condensates driving RNA localization in Xenopus oocytes.
Neil CR, Jeschonek SP, Cabral SE, O'Connell LC, Powrie EA, Otis JP, Wood TR, Mowry KL
Molecular biology of the cell 2021 Dec 1;32(22):ar37
Molecular biology of the cell 2021 Dec 1;32(22):ar37
The dynamic recruitment of TRBP to neuronal membranes mediates dendritogenesis during development.
Antoniou A, Khudayberdiev S, Idziak A, Bicker S, Jacob R, Schratt G
EMBO reports 2018 Mar;19(3)
EMBO reports 2018 Mar;19(3)
KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.
Sharma NR, Majerciak V, Kruhlak MJ, Zheng ZM
PLoS pathogens 2017 Oct;13(10):e1006677
PLoS pathogens 2017 Oct;13(10):e1006677
Proteomic analysis of early HIV-1 nucleoprotein complexes.
Schweitzer CJ, Jagadish T, Haverland N, Ciborowski P, Belshan M
Journal of proteome research 2013 Feb 1;12(2):559-72
Journal of proteome research 2013 Feb 1;12(2):559-72
Hepato-specific microRNA-122 facilitates accumulation of newly synthesized miRNA through regulating PRKRA.
Li S, Zhu J, Fu H, Wan J, Hu Z, Liu S, Li J, Tie Y, Xing R, Zhu J, Sun Z, Zheng X
Nucleic acids research 2012 Jan;40(2):884-91
Nucleic acids research 2012 Jan;40(2):884-91
Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain.
Lugli G, Torvik VI, Larson J, Smalheiser NR
Journal of neurochemistry 2008 Jul;106(2):650-61
Journal of neurochemistry 2008 Jul;106(2):650-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 10771-1-AP(PRKRA antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PRKRA antibody 10771-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 10771-1-AP(PRKRA antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
