26555-1-AP

antibody from Proteintech Group

Targeting: CPT2 CPT1, CPTASE

Provider product page for 26555-1-AP

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ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

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Product number: 26555-1-AP - Provider product page
Provider: Proteintech Group
Product name: CPT2 antibody
Antibody type: Polyclonal
Description: CPT2 antibody (Cat. #26555-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CPT2 protein structure - 26555-1-AP shown in red.

Submitted references Polydatin Targets ACADVL to Combat Obesity by Promoting Adipocyte Browning and Activating Fatty Acid Oxidation.

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Phytotherapy research : PTR 2026 May;40(5):2417-2436

NAT10 regulates heart development and function by maintaining the expression of genes related to fatty acid β-oxidation and heart contraction.

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Cell death and differentiation 2026 Feb;33(2):358-373

Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.

Sun Y, Wei T, Xu H, Li H, Zhou C, Liu X, Li Y, Huang S, Zhang Q, Duan X
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436

Gut microbiota dysbiosis contributes to diabetic nephropathy via affecting renal lipid deposition and inflammatory responses.

Liu P, Hu P, Jin M, Wan Y, Wu J, Sun W, Tang Y, Huang L, Zhang D, Shi D, Xie T, Tong Y, Zheng H, Wang L, He H, Xu X
Journal of translational medicine 2026 Feb 23;24(1)

Palmitoyl-carnitine Regulates Lung Development by Promoting Pulmonary Mesenchyme Proliferation.

Liu X, Lam SM, Zheng Y, Mo L, Li M, Sun T, Long X, Peng S, Zhang X, Mei M, Shui G, Bao S
Research (Washington, D.C.) 2025;8:0620

Aerobic exercise improved liver steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway.

Wu B, Zhang Z, Xu C, Zhao J
PloS one 2025;20(11):e0333872

Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.

Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z
Drug design, development and therapy 2025;19:3611-3630

Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation.

Guo W, Zhang C, Zhou Q, Chen T, Xu X, Zhang J, Yu X, Wu H, Zhang X, Ma L, Qian K, Klionsky DJ, Kang R, Kroemer G, Yu Y, Tang D, Wang J
Developmental cell 2025 Sep 8;60(17):2294-2312.e11

A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.

Sun Y, Ni W, Wang D, Ren J, Zhao D, Yu S, Liu S, Zhang S, Wang S, Wang W, Liu M
Carbohydrate polymers 2025 Sep 1;363:123708

Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.

Zeng S, Wang J, Guan C, Yao Z, Zhang Y, Li Y, Zheng J, Wang H
BMC pharmacology & toxicology 2025 Oct 7;26(1):160

Machine learning analysis facilitates the identification of liver biomarkers in postmortem diagnosis of heat stroke.

Pan M, Liu H, Ma C, Dong Y, Dong H
Legal medicine (Tokyo, Japan) 2025 Nov;79:102739

Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment.

Tao X, Gao Y, Jin Z, Lu S, Li Z, Guo S, Fan Q, Li J, Qiao C, Lei H, Zhang Z, Zhao C, Wu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157185

GSTK1 suppresses HCC aggravation via L-carnitine metabolism by PGAM5/DRP1 complex-mediated mitochondrial quality control.

Shi Y, Zhang J, Song B, Zhang H, He J, Ding K, Wang F, Yu W, Zhangyuan G, Jin K, Zhang W, Sun B
Journal of experimental & clinical cancer research : CR 2025 Nov 24;45(1):1

Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.

Simwela NV, Jaecklein E, Sassetti CM, Russell DG
eLife 2025 Mar 13;13

GLA deficiency causes cardiac hypertrophy via enhanced autophagy.

Ou W, Li X, Tang K, Ding L, Sun T, Li Q, Li T
Science China. Life sciences 2025 Jun;68(6):1689-1702

Qifu Decoction Alleviates Lipopolysaccharide-Induced Myocardial Dysfunction by Inhibiting TLR4/NF-κB/NLRP3 Inflammatory Pathway and Activating PPARα/CPT Pathway.

Zhuo L, Ma M, Zhang J, Zhou J, Zheng Y, Liang A, Sun Q, Liu J, Liao W
Pharmaceuticals (Basel, Switzerland) 2025 Jul 25;18(8)

SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction.

Yang Y, Zheng L, He J, Wu T, Yang H, Zhang B, Zhou S, Lu Y, He X, Li J, Wang N
Cell death & disease 2025 Jul 1;16(1):468

Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.

Lin D, Tang C, Wang J, Yang Y, Yang H, Zhou Y, Yu W, Li B, Huang Q, Wang H, An R, Liang X, Yan Y, Yuan L, Du X, Yuan Y, Li Y, Lu S
MedComm 2025 Jan;6(1):e70013

Repeated Injection of Xylazine Causes Liver Injury Through the PPAR Signaling Pathway in Rats.

Yi S, Mai T, Fang Y, Tian Q, Zhao S
Journal of biochemical and molecular toxicology 2025 Jan;39(1):e70101

Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice.

Geng J, Zhang X, Guo Y, Wen H, Guo D, Liang Q, Pu S, Wang Y, Liu M, Li Z, Hu W, Yang X, Chang P, Hu L, Li Y
Nature communications 2025 Jan 12;16(1):613

Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.

Simwela NV, Jaecklein E, Sassetti CM, Russell DG
bioRxiv : the preprint server for biology 2025 Jan 11;

Immunoregulatory electrospinning fiber mediates Macrophage energy metabolism reprogramming to promote burn wound healing.

Wu H, Wu Q, Liang C, Hua J, Meng L, Nakielski P, Lu C, Pierini F, Xu L, Yu Y, Luo Q
Materials today. Bio 2025 Dec;35:102430

Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells.

Li M, Li D, Wang HY, Zhang W, Zhuo Z, Guo H, Liu J, Zhuo Y, Tang J, He J, Miao L
Oncoimmunology 2025 Dec;14(1):2460281

Gallic Acid Ameliorates Skeletal Muscle Metabolic Inflexibility by Regulating Lactate Metabolism and Promoting Mitochondrial Function.

Wang Y, Wang F, Sun J, Xue L, Sun Y, Zhang K, Fan M, Qian H, Yang B, Du J, Li Y, Wang L
Molecular nutrition & food research 2025 Aug;69(16):e70106

Chlorogenic Acid Improves High-Fat Diet-Induced Skeletal Muscle Metabolic Disorders by Regulating Mitochondrial Function and Lactate Metabolism.

Wang Y, Sun J, Xue L, Sun Y, Zhang K, Fan M, Qian H, Li Y, Wang L
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10347-10357

Downregulation of CPT2 promotes proliferation and migration through the TNFα/NF-κB pathway in cholangiocarcinoma.

Mao J, Yi G, Yu H, Qu Q, Hu Y
Journal of gastrointestinal oncology 2025 Apr 30;16(2):679-698

Pemafibrate modulates peroxisome proliferator-activated receptor alpha and prevents alcohol-associated liver disease in rats.

Saito T, George J, Ozaki K, Tsuchishima M, Tsutsumi M
Molecular medicine (Cambridge, Mass.) 2025 Apr 22;31(1):145

Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.

Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38

Involvement of mitochondrial fatty acid β-oxidation in the antiviral innate immune response in head kidney macrophages of large yellow croaker (Larimichthys crocea).

Liu Q, Chen Z, Zhang J, Pan S, Zhou Y, Tang Y, Wu C, Wang H, Zhao Z, Li Y, Mai K, Ai Q
Fish & shellfish immunology 2024 Oct;153:109829

Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways.

Fang B, Luo J, Cui Z, Liu R, Wang P, Zhang J
Foods (Basel, Switzerland) 2024 Oct 30;13(21)

CPT2-mediated Fatty Acid Oxidation Is Dispensable for Humoral Immunity.

Li M, Zhou X, Li Y, Zhu X, Li Y, Hitosugi T, Zeng H
Journal of immunology (Baltimore, Md. : 1950) 2024 Oct 15;213(8):1139-1149

The ZNF263/CPT1B axis regulates fatty acid β-oxidation to affect cisplatin resistance in lung adenocarcinoma.

Yan R, Zheng C, Qian S, Li K, Kong X, Liao S
The pharmacogenomics journal 2024 Nov 5;24(6):33

Starvation-induced metabolic rewiring affects mTORC1 composition in vivo.

Kaade E, Mausbach S, Erps N, Sylvester M, Shakeri F, Jachimowicz RD, Gieselmann V, Thelen M
Scientific reports 2024 Nov 16;14(1):28296

APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.

Zhao H, Cheng X, Yan L, Mi F, Wang W, Hu Y, Liu X, Fan Y, Min Q, Wang Y, Zhang W, Wu Q, Zhan Q
Cell communication and signaling : CCS 2024 May 23;22(1):283

Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.

Zhang Z, Xu X, Zhang D, Zhao S, Wang C, Zhang G, Chen W, Liu J, Gong H, Rixiati Y, Li S, Shen T, Li J
Cell metabolism 2024 Mar 5;36(3):541-556.e9

5-Heptadecylresorcinol Improves Aging-Associated Hepatic Fatty Acid Oxidation Dysfunction via Regulating Adipose Sirtuin 3.

Zhang K, Jiang L, Xue L, Wang Y, Sun Y, Fan M, Qian H, Wang L, Li Y
Nutrients 2024 Mar 27;16(7)

Integration of Proteomic and Metabolomic Data Reveals the Lipid Metabolism Disorder in the Liver of Rats Exposed to Simulated Microgravity.

Ru M, He J, Bai Y, Zhang K, Shi Q, Gao F, Wang Y, Li B, Shen L
Biomolecules 2024 Jun 12;14(6)

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.

Dong S, Zhang M, Cheng Z, Zhang X, Liang W, Li S, Li L, Xu Q, Song S, Liu Z, Yang G, Zhao X, Tao Z, Liang S, Wang K, Zhang G, Hu S
Redox biology 2024 Jul;73:103207

Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation.

Wu M, Tan J, Cao Z, Cai Y, Huang Z, Chen Z, He W, Liu X, Jiang Y, Gao Q, Deng B, Wang J, Yuan W, Zhang H, Chen Y
Redox biology 2024 Jul;73:103184

Circular RNA circMYLK4 shifts energy metabolism from glycolysis to OXPHOS by binding to the calcium channel auxiliary subunit CACNA2D2.

Cao H, Li C, Sun X, Yang J, Li X, Yang G, Jin J, Shi X
The Journal of biological chemistry 2024 Jul;300(7):107426

Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction.

Wang Q, Ge L, Guo J, Zhang H, Chen T, Lian F, Li L, Xu Y, Xu J, Chen N, Zhang Y, Ruan Z, Xiao J, Zhang H, Yang L
ACS biomaterials science & engineering 2024 Jul 8;10(7):4480-4495

Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.

Yin Y, Wang Z, Yang Y, Shen M, Hu H, Chen C, Zhou H, Li Z, Wu S
iScience 2024 Jul 19;27(7):110331

Endogenous Coriobacteriaceae enriched by a high-fat diet promotes colorectal tumorigenesis through the CPT1A-ERK axis.

Tang Q, Huang H, Xu H, Xia H, Zhang C, Ye D, Bi F
NPJ biofilms and microbiomes 2024 Jan 20;10(1):5

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance.

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The Journal of cell biology 2024 Dec 2;223(12)

Proteomics Analysis Provides Insights into the Role of Lipid Metabolism in T2DM-Related Sarcopenia.

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ACS omega 2024 Aug 6;9(31):34056-34069

Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose Diet.

Gonzalez K, Merlin AC, Roye E, Ju B, Lee Y, Chicco AJ, Chung E
Medicine and science in sports and exercise 2024 Aug 1;56(8):1378-1389

Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data.

Zhao S, Zhang P, Niu S, Xie J, Liu Y, Liu Y, Zhao N, Cheng C, Lu P
Functional & integrative genomics 2024 Apr 10;24(2):72

Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.

Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370

Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling.

Zhong J, He X, Gao X, Liu Q, Zhao Y, Hong Y, Zhu W, Yan J, Li Y, Li Y, Zheng N, Bao Y, Wang H, Ma J, Huang W, Liu Z, Lyu Y, Ke X, Jia W, Xie C, Hu Y, Sheng L, Li H
Nature communications 2023 Sep 6;14(1):5451

Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice.

Elmansi AM, Miller RA
GeroScience 2023 Oct;45(5):2967-2981

The Enhancement of Acylcarnitine Metabolism by 5-Heptadecylresorcinol in Brown Adipose Tissue Contributes to Improving Glucose and Lipid Levels in Aging Male Mice.

Zhang K, Jiang L, Xue L, Wang Y, Sun Y, Fan M, Qian H, Wang L, Li Y
Nutrients 2023 Oct 29;15(21)

Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.

Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131

Chitobiose exhibited a lipid-lowering effect in ob/ob(-/-) mice via butyric acid enrolled liver-gut crosstalk.

Zhuang X, Zhao M, Ji X, Yang S, Yin H, Zhao L
Bioresources and bioprocessing 2023 Nov 9;10(1):79

Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice.

Guo B, Shu H, Luo L, Liu X, Ma Y, Zhang J, Liu Z, Zhang Y, Fu L, Song T, Qiao Y, Zhang C
Nutrients 2023 Nov 20;15(22)

Apolipoprotein A4 Elevates Sympathetic Activity and Thermogenesis in Male Mice.

Kuo HN, LaRussa Z, Xu FM, West K, Consitt L, Davidson WS, Liu M, Coschigano KT, Shi H, Lo CC
Nutrients 2023 May 26;15(11)

Complementary hepatic metabolomics and proteomics reveal the adaptive mechanisms of dairy cows to the transition period.

Zhang J, Gaowa N, Wang Y, Li H, Cao Z, Yang H, Zhang X, Li S
Journal of dairy science 2023 Mar;106(3):2071-2088

Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.

Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229

Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.

Landowski M, Bhute VJ, Grindel S, Haugstad Z, Gyening YK, Tytanic M, Brush RS, Moyer LJ, Nelson DW, Davis CR, Yen CE, Ikeda S, Agbaga MP, Ikeda A
Communications biology 2023 Jan 4;6(1):8

An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration.

Cao Z, Lin J, Fu G, Niu L, Yang Z, Cai W
Frontiers in immunology 2022;13:959967

Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.

Li R, Li X, Zhao J, Meng F, Yao C, Bao E, Sun N, Chen X, Cheng W, Hua H, Li X, Wang B, Wang H, Pan X, You H, Yang J, Ikezoe T
Theranostics 2022;12(2):976-998

CD147 Mediates 5-Fluorouracil Resistance in Colorectal Cancer by Reprogramming Glycolipid Metabolism.

Dong S, Li S, Wang X, Liang S, Zhang W, Li L, Xu Q, Shi B, Cheng Z, Zhang X, Zhong M, Zhang G, Hu S
Frontiers in oncology 2022;12:813852

The Role and Mechanism of CREBH Regulating SIRT3 in Metabolic Associated Fatty Liver Disease.

Junli Z, Shuhan W, Yajuan Z, Xiaoling D, Jiahuan L, Keshu X
Life sciences 2022 Oct 1;306:120838

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S
iScience 2022 Nov 18;25(11):105214

Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice.

Huo Y, Zhao G, Li J, Wang R, Ren F, Li Y, Wang X
Nutrients 2022 Jan 29;14(3)

Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.

Zhang L, Shi J, Du D, Niu N, Liu S, Yang X, Lu P, Shen X, Shi N, Yao L, Zhang R, Hu G, Lu G, Zhu Q, Zeng T, Liu T, Xia Q, Huang W, Xue J
EBioMedicine 2022 Apr;78:103959

A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.

Du J, Zheng L, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu X, Wu H, Chen Z, Chen L, Wei K, Zhang Z, Zhu X, Zhang X, Tu Q, Zhao SM, Lei X, Xiong JW
Cell stem cell 2022 Apr 7;29(4):545-558.e13

Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice.

Ranea-Robles P, Portman K, Bender A, Lee K, He JC, Mulholland DJ, Argmann C, Houten SM
Kidney360 2021 Sep;2(9):1441-1454

Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy.

Luo L, Qin B, Jiang M, Xie L, Luo Z, Guo X, Zhang J, Li X, Zhu C, Du Y, Peng L, You J
Journal of nanobiotechnology 2021 Sep 30;19(1):297

CLN6 deficiency causes selective changes in the lysosomal protein composition.

Tuermer A, Mausbach S, Kaade E, Damme M, Sylvester M, Gieselmann V, Thelen M
Proteomics 2021 Oct;21(19):e2100043

The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis.

Ranea-Robles P, Chen H, Stauffer B, Yu C, Bhattacharya D, Friedman SL, Puchowicz M, Houten SM
Journal of inherited metabolic disease 2021 Nov;44(6):1419-1433

Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).

Nakano D, Kawaguchi T, Iwamoto H, Hayakawa M, Koga H, Torimura T
PloS one 2020;15(4):e0232283

Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.

Li Y, Zou S, Ding H, Hao N, Huang Y, Tang J, Cheng J, Feng S, Li J, Wang X, Wu J
Animals : an open access journal from MDPI 2020 Mar 27;10(4)

Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division.

Ow JR, Caldez MJ, Zafer G, Foo JC, Li HY, Ghosh S, Wollmann H, Cazenave-Gassiot A, Ong CB, Wenk MR, Han W, Choi H, Kaldis P
eLife 2020 Dec 21;9

UPLC-QTOF/MS-based metabolomics analysis of plasma reveals an effect of Xue-Fu-Zhu-Yu capsules on blood-stasis syndrome in CHD rats.

Zhao Y, Nie S, Yi M, Wu N, Wang W, Zhang Z, Yao Y, Wang D
Journal of ethnopharmacology 2019 Sep 15;241:111908

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