Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
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- Product number
- 14115-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14115-1-AP, RRID:AB_2256809
- Product name
- UBE2S antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UBE2S antibody (Cat. #14115-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data.
Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition.
UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc.
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.
BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding.
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway.
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1.
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Yuan Z, Zhu Q, Wu Q, Zhang Z, Guo J, Wu G, Zheng C, Xu Q, Huang D, Cui D
Journal of Cancer 2024;15(9):2580-2600
Journal of Cancer 2024;15(9):2580-2600
Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition.
Gliech CR, Yeow ZY, Tapias-Gomez D, Yang Y, Huang Z, Tijhuis AE, Spierings DC, Foijer F, Chung G, Tamayo N, Bahrami-Nejad Z, Collins P, Nguyen TT, Plata Stapper A, Hughes PE, Payton M, Holland AJ
The EMBO journal 2024 Mar;43(5):666-694
The EMBO journal 2024 Mar;43(5):666-694
UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc.
Gong D, Rao X, Min Z, Liu X, Xin H, Zhou P, Yang L, Li D
American journal of cancer research 2023;13(8):3705-3720
American journal of cancer research 2023;13(8):3705-3720
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
Xiao K, Peng S, Lu J, Zhou T, Hong X, Chen S, Liu G, Li H, Huang J, Chen X, Lin T
Cell death & disease 2023 Jul 8;14(7):408
Cell death & disease 2023 Jul 8;14(7):408
UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.
Peng S, Chen X, Huang C, Yang C, Situ M, Zhou Q, Ling Y, Huang H, Huang M, Zhang Y, Cheng L, Zhang Q, Guo Z, Lai Y, Huang J
International journal of biological sciences 2022;18(8):3528-3543
International journal of biological sciences 2022;18(8):3528-3543
BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding.
Wang M, Zhao K, Liu M, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T, Wang H, Jiang C, Gao S, Chen J
Protein & cell 2022 Aug;13(8):580-601
Protein & cell 2022 Aug;13(8):580-601
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway.
Hu W, Li M, Chen Y, Gu X
Journal of ovarian research 2021 Sep 17;14(1):121
Journal of ovarian research 2021 Sep 17;14(1):121
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Xu W, Huang M, Guo J, Zhang H, Wang D, Liu T, Liu H, Chen S, Gao P, Mu K
International journal of biological sciences 2020;16(8):1388-1402
International journal of biological sciences 2020;16(8):1388-1402
Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1.
Huang L, Liu H, Zhang K, Meng Q, Hu L, Zhang Y, Xiang Z, Li J, Yang Y, Chen Y, Cui S, Tang H, Pei H, Bu Z, Weng C
Cell reports 2020 Aug 18;32(7):108044
Cell reports 2020 Aug 18;32(7):108044
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Yoshimura S, Kasamatsu A, Nakashima D, Iyoda M, Kasama H, Saito T, Takahara T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K
Biochemical and biophysical research communications 2017 Apr 15;485(4):820-825
Biochemical and biophysical research communications 2017 Apr 15;485(4):820-825
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 14115-1-AP(UBE2S antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14115-1-AP(UBE2S antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14115-1-AP(UBE2S antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UBE2S antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UBE2S. This antibody recognizes human,mouse,rat antigen. The UBE2S antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.