NLRP4

The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]

Description

NLR family pyrin domain containing 4

Tissue specificity

Group enriched (lymphoid tissue, testis)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

19 (55836540 - 55881855)

Ensembl ID

ENSG00000160505  (ver. 103.38)

Orthologs

-

UniProt

Q96MN2

neXtProt

NX_Q96MN2

Human splice variants

Protein structure