15691-1-AP

antibody from Proteintech Group

Targeting: TK1

Provider product page for 15691-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 15691-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15691-1-AP, RRID:AB_2203613
Product name: TK1 antibody
Antibody type: Polyclonal
Description: TK1 antibody (Cat. #15691-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TK1 protein structure - 15691-1-AP shown in red.

Submitted references Thymidine kinase 1 related to Prolif-like T cells promoted GBM through regulation of cell cycle and EMT signals: a comprehensive research based on multi-omics analysis and experimental validation.

Deng W, Chang X, Shang W
Frontiers in immunology 2025;16:1655980

Proteomics analysis and immune profiling reveal regulators of PD-L1 in oesophageal squamous cell carcinoma.

Li Y, Yuan X, Yin XF, Zheng D, Shi F, Liu D, Hu L, Shi X, Wen N, He QY, Yang H, Zhang CZ
British journal of cancer 2025 Sep;133(4):448-463

ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth.

Tao J, Wang Z, Shi R, Lin L, Li M, Meng Y, Luo S, Jiang X, Guo Z, Shang Y, Lu Z
Nature structural & molecular biology 2025 May;32(5):853-863

Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.

Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596

KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism.

Huang H, Ren L, Zhou Y, Chen P, Zhao H, Li S, Wang H, Li X
BMC cancer 2025 Feb 21;25(1):311

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth.

Zuazo-Gaztelu I, Lawrence D, Oikonomidi I, Marsters S, Pechuan-Jorge X, Gaspar CJ, Kan D, Segal E, Clark K, Beresini M, Braun MG, Rudolph J, Modrusan Z, Choi M, Sandoval W, Reichelt M, DeWitt DC, Kujala P, van Dijk S, Klumperman J, Ashkenazi A
PLoS biology 2025 Apr;23(4):e3003086

Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer.

Wang X, Wang G, Xu Q, Li Y, Song W, Liu Z, Tian Y, Wang L, Zhao K, Wang Y
Frontiers in oncology 2024;14:1480028

All Blood Brain Barrier Cell Types Demonstrate Capability to Influence Differential Tenofovir and Emtricitabine Metabolism and Transport in the Brain.

Wilkins HN, Knerler SA, Warshanna A, Colón Ortiz R, Haas K, Orsburn BC, Williams DW
ACS pharmacology & translational science 2024 Nov 8;7(11):3626-3640

Elimination of radiation-induced senescent cancer cells and stromal cells in vitro by near-infrared photoimmunotherapy.

Suzuki M, Kobayashi H, Hara D, Hanaoka H
Cancer medicine 2024 Jun;13(12):e7381

Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.

Sun X, Ye G, Li J, Shou H, Bai G, Zhang J
Clinical and translational medicine 2023 Oct;13(10):e1457

Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners.

Li Q, Zhang L, Yang Q, Li M, Pan X, Xu J, Zhong C, Yao F, Zhang R, Zhou S, Dai X, Shi X, Dai Y, Xu J, Cheng X, Xiao W, She Z, Wang K, Qian X, Pu L, Zhang P, Wang X
Cell metabolism 2023 Jun 6;35(6):912-927.e7

lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.

Liang G, Zeng M, Gao M, Xing W, Jin X, Wang Q, Deng L, Ou H, He Z
Oxidative medicine and cellular longevity 2022;2022:9369035

Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension.

Fang X, Ma L, Wang Y, Ren F, Yu Y, Yuan Z, Wei H, Zhang H, Sun Y
Journal of hypertension 2022 Oct 1;40(10):2045-2057

Thymidine Kinase 1 Mediates the Synergistic Antitumor Activity of Ubenimex and Celecoxib via Regulation of Cell Cycle in Colorectal Cancer.

Wang A, Shang Y, Ni J, Wang W, Wang C, Li G, Chen SZ
The Journal of pharmacology and experimental therapeutics 2022 Aug;382(2):188-198

Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist.

Zhang L, Zhuang X, Kotitalo P, Keller T, Krzyczmonik A, Haaparanta-Solin M, Solin O, Forsback S, Grönroos TJ, Han C, López-Picón FR, Xia H
Theranostics 2021;11(3):1147-1161

rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors.

Lian F, Ye Q, Feng B, Cheng H, Niu S, Fan N, Wang D, Wang Z
Cancer biology & therapy 2020 Dec 1;21(12):1171-1178

Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway.

Jiang X, Wang J
Journal of cellular and molecular medicine 2019 Jul;23(7):4545-4558

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

Schrock MS, Karras JR, Guggenbiller MJ, Druck T, Batar B, Huebner K
Advances in biological regulation 2017 Jan;63:167-176

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 15691-1-AP(TK1 antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using TK1 antibody 15691-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line