13126-1-AP

antibody from Proteintech Group

Targeting: USP24 KIAA1057

Provider product page for 13126-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 13126-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13126-1-AP, RRID:AB_2212761
Product name: USP24 antibody
Antibody type: Polyclonal
Description: KD/KO validated USP24 antibody (Cat. #13126-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

USP24 protein structure - 13126-1-AP shown in red.

Submitted references USP24 inhibits autophagy in diabetic myocardial disorder by regulating TRAF6-mediated ubiquitination of Beclin-1.

Wu S, Zhou Y, Shu M, Zhang H, Situ Q, Bao Z, Hu Z, Zhu J
Life sciences 2026 May 1;392:124296

LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis.

Bacchiocchi A, Mak M, Khan ZM, Gong X, Sznol M, Na Z, Su H, Chan LH, Yan Q, Zhao D, Mortlock RD, Knight J, Slavoff SA, Halaban R
Oncogene 2025 Oct;44(41):3974-3984

ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration.

Xiang Q, Lu Y, Wang H, Chen H, Chen P, Zhao X, Cortes Morales L, Yang Y, Yang J, Zhang T, Wang J
Science advances 2025 Oct 24;11(43):eado4330

Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop.

Yu ST, Sun ZY, Li N, Qu ZZ, Wang CH, Ju TT, Liu YQ, Mei ZT, Liu KW, Lu MX, Huang M, Li Y, Dou SK, Jiang JH, Zhang YZ, Huang CH, Pang XC, Jia YQ, Dong XH, Wu F, Zhang Y, Li WH, Yang BF, Du WJ
Acta pharmacologica Sinica 2025 Mar;46(3):592-605

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.

Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X
Cell death & disease 2025 Jul 26;16(1):564

Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma.

Li C, Wu P, Xie X, Chen X, Chen L, Zhu L, Xuan Z, Liu T, Tan W, Zhang S, Lin D, Wu C
Signal transduction and targeted therapy 2025 Jul 22;10(1):233

TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.

Chen C, Chen Z, Zhao J, Wen X, Yao H, Weng Z, Xiong H, Zheng Z, Wu J
Cell death discovery 2025 Feb 5;11(1):47

USP24 promotes hepatocellular carcinoma progression by deubiquitinating and stabilizing YAP1.

Shan H, Yuan J, Xian L, Li W, Ge Y, Zhang L, Lin T, Lan M, Liu J, Luo Y, Wu Y, Xiao X
Cancer cell international 2025 Apr 26;25(1):164

USP26 suppresses type I interferon signaling by targeting TRAF3 for deubiquitination.

Sheng CL, Jiang BD, Zhang CQ, Huang JH, Wang Z, Xu C
PloS one 2024;19(7):e0307776

NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells.

Wang SA, Wu YC, Yang FM, Hsu FL, Zhang K, Hung JJ
Molecular oncology 2024 Sep;18(9):2255-2276

USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2.

Zhou N, Guo C, Li X, Tu L, Du J, Qian Q, Li J, Huang D, Xu Q, Zheng X
Biochemical pharmacology 2024 Nov;229:116473

USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy.

Young MJ, Wang SA, Chen YC, Liu CY, Hsu KC, Tang SW, Tseng YL, Wang YC, Lin SM, Hung JJ
Cell death and differentiation 2024 May;31(5):574-591

USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase.

Chen Y, Feng X, Wu Z, Yang Y, Rao X, Meng R, Zhang S, Dong X, Xu S, Wu G, Jie X
Journal of biomedical science 2024 May 28;31(1):55

Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.

Wu S, Zhou Y, Liang J, Ying P, Situ Q, Tan X, Zhu J
Free radical biology & medicine 2024 Jan;210:352-366

Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1.

Zang L, Gu J, Yang X, Yuan Y, Guo H, Zhou W, Ma J, Chen Y, Wu Y, Zheng H, Shi W
Virologica Sinica 2023 Feb;38(1):75-83

LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer.

Sun Z, Zhang R, Zhang X, Sun Y, Liu P, Francoeur N, Han L, Lam WY, Yi Z, Sebra R, Walsh M, Yu J, Zhang W
Molecular cancer 2022 Jul 16;21(1):147

USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.

He H, Yi L, Zhang B, Yan B, Xiao M, Ren J, Zi D, Zhu L, Zhong Z, Zhao X, Jin X, Xiong W
International journal of biological sciences 2021;17(10):2417-2429

USP24 promotes drug resistance during cancer therapy.

Wang SA, Young MJ, Wang YC, Chen SH, Liu CY, Lo YA, Jen HH, Hsu KC, Hung JJ
Cell death and differentiation 2021 Sep;28(9):2690-2707

USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.

Wang SA, Young MJ, Jeng WY, Liu CY, Hung JJ
Scientific reports 2020 Nov 30;10(1):20870

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.

Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH
Nature communications 2020 May 8;11(1):2289

The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.

Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM
Autophagy 2020 Jan;16(1):140-153

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L
Nature communications 2019 Jul 24;10(1):3304

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.

Wang YC, Wu YS, Hung CY, Wang SA, Young MJ, Hsu TI, Hung JJ
Nature communications 2018 Sep 28;9(1):3996

Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism.

Sun Y, Bao Q, Xuan B, Xu W, Pan D, Li Q, Qian Z
Journal of virology 2018 Jul 1;92(13)

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma.

Engel K, Rudelius M, Slawska J, Jacobs L, Ahangarian Abhari B, Altmann B, Kurutz J, Rathakrishnan A, Fernández-Sáiz V, Brunner A, Targosz BS, Loewecke F, Gloeckner CJ, Ueffing M, Fulda S, Pfreundschuh M, Trümper L, Klapper W, Keller U, Jost PJ, Rosenwald A, Peschel C, Bassermann F
EMBO molecular medicine 2016 Aug;8(8):851-62

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse lung tissue were subjected to SDS PAGE followed by western blot with 13126-1-AP(USP24 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using USP24 antibody 13126-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line