STXBP5

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

Syntaxin binding protein 5

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (147204425 - 147390476)

Ensembl ID

ENSG00000164506  (ver. 103.38)

Orthologs

Mouse Stxbp5: ENSMUSG00000019790

UniProt

Q5T5C0

neXtProt

NX_Q5T5C0

Human splice variants
Mouse splice variants

Protein structure