22245-1-AP

antibody from Proteintech Group

Targeting: STK4 KRS2, MST1, YSK3

Provider product page for 22245-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 22245-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22245-1-AP, RRID:AB_11182388
Product name: STK4/MST1 antibody
Antibody type: Polyclonal
Description: KD/KO validated STK4/MST1 antibody (Cat. #22245-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

STK4 protein structure - 22245-1-AP shown in red.

Submitted references Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway.

Fu Y, Wan P, Zhang J, Li X, Xing J, Zou Y, Wang K, Peng H, Zhu Q, Cao L, Zhai X
Frontiers in cell and developmental biology 2021;9:741060

Glycogen accumulation and phase separation drives liver tumor initiation.

Liu Q, Li J, Zhang W, Xiao C, Zhang S, Nian C, Li J, Su D, Chen L, Zhao Q, Shao H, Zhao H, Chen Q, Li Y, Geng J, Hong L, Lin S, Wu Q, Deng X, Ke R, Ding J, Johnson RL, Liu X, Chen L, Zhou D
Cell 2021 Oct 28;184(22):5559-5576.e19

FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.

Zheng YW, Li ZH, Lei L, Liu CC, Wang Z, Fei LR, Yang MQ, Huang WJ, Xu HT
Frontiers in oncology 2020;10:180

Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway.

Meng C, Tian G, Xu C, Li X, Zhang Y, Wang Y, Qin J, Fok EKL, Hinton BT, Mak KK, Shum WW, Chan WY, Xia Y
Cell death and differentiation 2020 Oct;27(10):2797-2809

Gut microbiota transplantation from db/db mice induces diabetes-like phenotypes and alterations in Hippo signaling in pseudo germ-free mice.

Yu F, Jiang R, Han W, Zhan G, Xu X, Jiang X, Wang L, Xiang S, Zhou Q, Liu C, Zhu B, Hua F, Yang C
Aging 2020 Nov 20;12(23):24156-24167

LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas.

Li W, Dai Y, Shi B, Yue F, Zou J, Xu G, Jiang X, Wang F, Zhou X, Liu L
Oncogene 2020 May;39(19):3879-3892

Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.

Xu C, Wang L, Zhang Y, Li W, Li J, Wang Y, Meng C, Qin J, Zheng ZH, Lan HY, Mak KK, Huang Y, Xia Y
Journal of the American Society of Nephrology : JASN 2020 May;31(5):946-961

Differential Levels of Hippo Signaling in Selected Brain and Peripheral Tissues in Streptozotocin-Induced Cognitive Dysfunction in Mice.

Yu F, Han W, Zhan G, Li S, Jiang X, Xiang S, Zhu B, Yang L, Hua D, Luo A, Hua F, Yang C
Neuroscience 2019 Nov 21;421:48-58

Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.

Han Y, Zhang L, Yu X, Wang S, Xu C, Yin H, Wang S
Cell death & disease 2019 May 10;10(5):374

Expression of Hippo signaling pathway components in Hu sheep male reproductive tract and spermatozoa.

Zhang GM, Zhang TT, An SY, El-Samahy MA, Yang H, Wan YJ, Meng FX, Xiao SH, Wang F, Lei ZH
Theriogenology 2019 Mar 1;126:239-248

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation.

Li W, Yue F, Dai Y, Shi B, Xu G, Jiang X, Zhou X, Pfeifer GP, Liu L
Cell death and differentiation 2019 Aug;26(8):1379-1395

REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma.

Chen S, Wang Q, Wang L, Chen H, Gao X, Gong D, Ma J, Kubra S, Yao X, Li X, Li L, Zhai W, Zheng J
Cell death & disease 2018 May 24;9(6):627

Energy restriction affect liver development in Hu sheep ram lambs through Hippo signaling pathway.

Zhang TT, Zhang GM, Jin YH, Guo YX, Wang Z, Fan YX, El-Samahy MA, Wang F
Tissue & cell 2017 Oct;49(5):603-611

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.

Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X, Ye L
Oncogene 2016 Aug 4;35(31):4048-57

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22245-1-AP(STK4 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The STK4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human STK4. This antibody recognizes human,mouse,rat antigen. The STK4 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 22245-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 22245-1-AP(STK4 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 22245-1-AP(STK4 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue