22245-1-AP

antibody from Proteintech Group

Targeting: STK4 KRS2, MST1, YSK3

Provider product page for 22245-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 22245-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22245-1-AP, RRID:AB_11182388
Product name: STK4/MST1 antibody
Antibody type: Polyclonal
Description: KD/KO validated STK4/MST1 antibody (Cat. #22245-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

STK4 protein structure - 22245-1-AP shown in red.

Submitted references RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.

Xu C, Fang T, Qu J, Miao Y, Tian L, Zhang M, Zhuang H, Sun B, Chen L
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348

TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway.

Shu B, Zhou Y, Lei G, Peng Y, Ding C, Li Z, He C
Cancer science 2024 May;115(5):1476-1491

FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.

Wang R, Cheng F, Yang X
Journal of ovarian research 2024 Mar 15;17(1):62

Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.

Chen LL, Li YQ, Kang ZH, Zhang X, Gu SY, Wang N, Shen XY
Molecular and cellular endocrinology 2024 Jan 1;579:112073

Targeting mechanics-induced trabecular meshwork dysfunction through YAP-TGFβ Ameliorates high myopia-induced ocular hypertension.

Bu Q, Zhu H, Cao G, Gong G, Su Y, Ge Q, Zhu W, Li Z, Pan X
Experimental eye research 2024 Apr;241:109853

Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.

Ma T, Ruan H, Lv L, Wei C, Yu Y, Jia L, Song X, Zhang J, Li Y
Food & function 2023 Nov 13;14(22):9999-10013

KK-LC-1 as a therapeutic target to eliminate ALDH(+) stem cells in triple negative breast cancer.

Bu J, Zhang Y, Wu S, Li H, Sun L, Liu Y, Zhu X, Qiao X, Ma Q, Liu C, Niu N, Xue J, Chen G, Yang Y, Liu C
Nature communications 2023 May 5;14(1):2602

PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling.

Chen H, Yang W, Li Y, Ji Z
Cell death & disease 2023 Jul 15;14(7):433

Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.

Hu Y, Yan Z, He Y, Li Y, Li M, Li Y, Zhang D, Zhao Y, Ommati MM, Wang J, Huo M, Wang J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647

Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.

Ning S, Chen Y, Wang G, Liu Y, Yang Y, Zhang Z
Frontiers in oncology 2022;12:1031160

A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma.

Zhang J, Tong Y, Lu X, Dong F, Ma X, Yin S, He Y, Liu Y, Liu Q, Fan D
Life sciences 2022 Sep 1;304:120698

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.

Li Y, Yang J, Zhang Q, Xu S, Sun W, Ge S, Xu X, Jager MJ, Jia R, Zhang J, Fan X
Oncogene 2022 Jul;41(27):3539-3553

Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway.

Tong G, Chen X, Lee J, Fan J, Li S, Zhu K, Hu Z, Mei L, Sui Y, Dong Y, Chen R, Jin Z, Zhou B, Li X, Wang X, Cong W, Huang P, Jin L
Pharmacological research 2022 Apr;178:106139

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway.

Fu Y, Wan P, Zhang J, Li X, Xing J, Zou Y, Wang K, Peng H, Zhu Q, Cao L, Zhai X
Frontiers in cell and developmental biology 2021;9:741060

Glycogen accumulation and phase separation drives liver tumor initiation.

Liu Q, Li J, Zhang W, Xiao C, Zhang S, Nian C, Li J, Su D, Chen L, Zhao Q, Shao H, Zhao H, Chen Q, Li Y, Geng J, Hong L, Lin S, Wu Q, Deng X, Ke R, Ding J, Johnson RL, Liu X, Chen L, Zhou D
Cell 2021 Oct 28;184(22):5559-5576.e19

FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.

Zheng YW, Li ZH, Lei L, Liu CC, Wang Z, Fei LR, Yang MQ, Huang WJ, Xu HT
Frontiers in oncology 2020;10:180

Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway.

Meng C, Tian G, Xu C, Li X, Zhang Y, Wang Y, Qin J, Fok EKL, Hinton BT, Mak KK, Shum WW, Chan WY, Xia Y
Cell death and differentiation 2020 Oct;27(10):2797-2809

Gut microbiota transplantation from db/db mice induces diabetes-like phenotypes and alterations in Hippo signaling in pseudo germ-free mice.

Yu F, Jiang R, Han W, Zhan G, Xu X, Jiang X, Wang L, Xiang S, Zhou Q, Liu C, Zhu B, Hua F, Yang C
Aging 2020 Nov 20;12(23):24156-24167

LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas.

Li W, Dai Y, Shi B, Yue F, Zou J, Xu G, Jiang X, Wang F, Zhou X, Liu L
Oncogene 2020 May;39(19):3879-3892

Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.

Xu C, Wang L, Zhang Y, Li W, Li J, Wang Y, Meng C, Qin J, Zheng ZH, Lan HY, Mak KK, Huang Y, Xia Y
Journal of the American Society of Nephrology : JASN 2020 May;31(5):946-961

Differential Levels of Hippo Signaling in Selected Brain and Peripheral Tissues in Streptozotocin-Induced Cognitive Dysfunction in Mice.

Yu F, Han W, Zhan G, Li S, Jiang X, Xiang S, Zhu B, Yang L, Hua D, Luo A, Hua F, Yang C
Neuroscience 2019 Nov 21;421:48-58

Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.

Han Y, Zhang L, Yu X, Wang S, Xu C, Yin H, Wang S
Cell death & disease 2019 May 10;10(5):374

Expression of Hippo signaling pathway components in Hu sheep male reproductive tract and spermatozoa.

Zhang GM, Zhang TT, An SY, El-Samahy MA, Yang H, Wan YJ, Meng FX, Xiao SH, Wang F, Lei ZH
Theriogenology 2019 Mar 1;126:239-248

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation.

Li W, Yue F, Dai Y, Shi B, Xu G, Jiang X, Zhou X, Pfeifer GP, Liu L
Cell death and differentiation 2019 Aug;26(8):1379-1395

REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma.

Chen S, Wang Q, Wang L, Chen H, Gao X, Gong D, Ma J, Kubra S, Yao X, Li X, Li L, Zhai W, Zheng J
Cell death & disease 2018 May 24;9(6):627

Energy restriction affect liver development in Hu sheep ram lambs through Hippo signaling pathway.

Zhang TT, Zhang GM, Jin YH, Guo YX, Wang Z, Fan YX, El-Samahy MA, Wang F
Tissue & cell 2017 Oct;49(5):603-611

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.

Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X, Ye L
Oncogene 2016 Aug 4;35(31):4048-57

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22245-1-AP(STK4 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The STK4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human STK4. This antibody recognizes human,mouse,rat antigen. The STK4 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 22245-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 22245-1-AP(STK4 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 22245-1-AP(STK4 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue