Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- AF891 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Mer Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Mer in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse Mer and less than 1% cross-reactivity with recombinant human (rh) Axl and rhDtk is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target.
Protein S and Gas6 induce efferocytosis of HIV-1-infected cells.
Human Sertoli cells support high levels of Zika virus replication and persistence.
Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses.
Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma.
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.
IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages.
Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells.
Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells.
Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, Coll M, Colell A, Gausdal G, Lorens JB, García de Frutos P, Morales A, Marí M
Cellular and molecular gastroenterology and hepatology 2020;9(3):349-368
Cellular and molecular gastroenterology and hepatology 2020;9(3):349-368
Protein S and Gas6 induce efferocytosis of HIV-1-infected cells.
Chua BA, Ngo JA, Situ K, Ramirez CM, Nakano H, Morizono K
Virology 2018 Feb;515:176-190
Virology 2018 Feb;515:176-190
Human Sertoli cells support high levels of Zika virus replication and persistence.
Kumar A, Jovel J, Lopez-Orozco J, Limonta D, Airo AM, Hou S, Stryapunina I, Fibke C, Moore RB, Hobman TC
Scientific reports 2018 Apr 3;8(1):5477
Scientific reports 2018 Apr 3;8(1):5477
Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 15;199(8):2885-2895
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 15;199(8):2885-2895
AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses.
Richard AS, Shim BS, Kwon YC, Zhang R, Otsuka Y, Schmitt K, Berri F, Diamond MS, Choe H
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 21;114(8):2024-2029
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 21;114(8):2024-2029
Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma.
Dantas-Barbosa C, Lesluyes T, Loarer FL, Chibon F, Treilleux I, Coindre JM, Meeus P, Brahmi M, Bally O, Ray-Coquard I, Sunyach MP, Cesne AL, Mir O, Bonvalot S, Toulmonde M, Italiano A, Saintigny P, Jean-Denis M, Ducimetiere F, Ranchere D, El Sayadi H, Alberti L, Blay JY
British journal of cancer 2017 Dec 5;117(12):1787-1797
British journal of cancer 2017 Dec 5;117(12):1787-1797
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.
Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 7;113(23):6526-31
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 7;113(23):6526-31
IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
Zizzo G, Cohen PL
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5237-46
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5237-46
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
Bauer T, Zagórska A, Jurkin J, Yasmin N, Köffel R, Richter S, Gesslbauer B, Lemke G, Strobl H
The Journal of experimental medicine 2012 Oct 22;209(11):2033-47
The Journal of experimental medicine 2012 Oct 22;209(11):2033-47
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Zizzo G, Hilliard BA, Monestier M, Cohen PL
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 1;189(7):3508-20
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 1;189(7):3508-20
Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages.
Eken C, Martin PJ, Sadallah S, Treves S, Schaller M, Schifferli JA
The Journal of biological chemistry 2010 Dec 17;285(51):39914-21
The Journal of biological chemistry 2010 Dec 17;285(51):39914-21
Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells.
Uehara H, Shacter E
Journal of immunology (Baltimore, Md. : 1950) 2008 Feb 15;180(4):2522-30
Journal of immunology (Baltimore, Md. : 1950) 2008 Feb 15;180(4):2522-30
Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells.
Uehara H, Shacter E
Journal of immunology (Baltimore, Md. : 1950) 2008 Feb 15;180(4):2522-30
Journal of immunology (Baltimore, Md. : 1950) 2008 Feb 15;180(4):2522-30
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human Mer by Western Blot. Detection of Human Mer by Western Blot.