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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 367602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#367602, RRID:AB_2565898
- Product name
- Purified anti-human MERTK
- Antibody type
- Monoclonal
- Antigen
- MERTK extracellular domain/Fc fusion.
- Description
- MERTK plays a role in the retinal pigment epithelium as a regulator of rod outer segments fragments phagocytosis. MERTK also plays a role in the inhibition of Toll-like receptor-mediated innate immune responses through the activation of STAT1. Upregulation of MERTK seems to also promote the survival of certain cancer cells, such as t(1;19)-positive acute lymphoblastic leukemias (ALL). MERTK also has a role in cellular migration, as MERTK KO macrophages demonstrate cytoskeletal disruptions that impacts its shape and directional migration. MERTK is a possible therapeutic target for melanoma due to increased expression of MERTK in melanoma cells.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 590H11G1E3
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- : Human monocytes were stimulated and cultured with M-CSF for seven days and stained with CD11b APC and purified human MERTK (clone 590H11G1E3, top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG PE antibody.
- Conjugate
- Unconjugated
