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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 367603 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#367603, RRID:AB_2566396
- Product name
- Brilliant Violet 421™ anti-human MERTK
- Antibody type
- Monoclonal
- Antigen
- MERTK extracellular domain/Fc fusion.
- Description
- MERTK plays a role in the retinal pigment epithelium as a regulator of rod outer segments fragments phagocytosis. MERTK also plays a role in the inhibition of Toll-like receptor-mediated innate immune responses through the activation of STAT1. Upregulation of MERTK seems to also promote the survival of certain cancer cells, such as t(1;19)-positive acute lymphoblastic leukemias (ALL). MERTK also has a role in cellular migration, as MERTK KO macrophages demonstrate cytoskeletal disruptions that impacts its shape and directional migration. Melanoma cells express high levels of MERTK, which makes this molecule an attractive therapeutic target.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Blue dye
- Antibody clone number
- 590H11G1E3
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood monocytes were stimulated and cultured with M-CSF for seven days then stained with human MERTK (clone 590H11G1E3) Brilliant Violet 421™ (filled histogram) or mouse IgG1, κ Brilliant Violet 421™ isotype control (open histogram).
- Conjugate
- Blue dye
