13618-1-AP

antibody from Proteintech Group

Targeting: TTL MGC46235

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

13618-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13618-1-AP, RRID:AB_2256858

Product name

TTL antibody

Antibody type

Polyclonal

Description

KD/KO validated TTL antibody (Cat. #13618-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function.

Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L
bioRxiv : the preprint server for biology 2024 Feb 7;

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MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.

Kumar A, Larrea D, Pero ME, Infante P, Conenna M, Shin GJ, Grueber WB, Di Marcotullio L, Area-Gomez E, Bartolini F
bioRxiv : the preprint server for biology 2023 Mar 16;

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Altered Posttranslational Modification of Microtubules Contributes to Disturbed Enterocyte Morphology in Celiac Disease.

Stricker S, Müller M, Zimmer KP, Jacob R
International journal of molecular sciences 2023 Jan 30;24(3)

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α-Tubulin detyrosination links the suppression of MCAK activity with taxol cytotoxicity.

Lopes D, Seabra AL, Orr B, Maiato H
The Journal of cell biology 2023 Feb 6;222(2)

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Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons.

Hotta T, Plemmons A, Gebbie M, Ziehm TA, Blasius TL, Johnson C, Verhey KJ, Pearring JN, Ohi R
Biomolecules 2023 Feb 12;13(2)

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Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.

Martínez-Hernández J, Parato J, Sharma A, Soleilhac JM, Qu X, Tein E, Sproul A, Andrieux A, Goldberg Y, Moutin MJ, Bartolini F, Peris L
Frontiers in cell and developmental biology 2022;10:926914

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Tubulin expression and modification in heart failure with preserved ejection fraction (HFpEF).

Schulz L, Werner S, Böttner J, Adams V, Lurz P, Besler C, Thiele H, Büttner P
Scientific reports 2022 Sep 21;12(1):15734

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Posttranslational modification of microtubules by the MATCAP detyrosinase.

Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, Song JY, Bleijerveld OB, Nieuwenhuis J, Heidebrecht T, Henneman L, Moutin MJ, Barisic M, Taraviras S, Perrakis A, Brummelkamp TR
Science (New York, N.Y.) 2022 May 20;376(6595):eabn6020

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Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.

Peris L, Parato J, Qu X, Soleilhac JM, Lanté F, Kumar A, Pero ME, Martínez-Hernández J, Corrao C, Falivelli G, Payet F, Gory-Fauré S, Bosc C, Blanca Ramirez M, Sproul A, Brocard J, Di Cara B, Delagrange P, Buisson A, Goldberg Y, Moutin MJ, Bartolini F, Andrieux A
Brain : a journal of neurology 2022 Jul 29;145(7):2486-2506

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Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy.

Tian J, Shan XL, Wang SN, Chen HH, Zhao P, Qian DD, Xu M, Guo W, Zhang C, Lu R
European journal of pharmacology 2022 Jan 5;914:174687

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RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration.

Moriarty RA, Mili S, Stroka KM
iScience 2022 Feb 18;25(2):103845

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Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.

Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660

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Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms.

Vite A, Caporizzo MA, Corbin EA, Brandimarto J, McAfee Q, Livingston CE, Prosser BL, Margulies KB
Basic research in cardiology 2022 Aug 25;117(1):41

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TTL-Expression Modulates Epithelial Morphogenesis.

Müller M, Ringer K, Hub F, Kamm N, Worzfeld T, Jacob R
Frontiers in cell and developmental biology 2021;9:635723

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MARK4 controls ischaemic heart failure through microtubule detyrosination.

Yu X, Chen X, Amrute-Nayak M, Allgeyer E, Zhao A, Chenoweth H, Clement M, Harrison J, Doreth C, Sirinakis G, Krieg T, Zhou H, Huang H, Tokuraku K, Johnston DS, Mallat Z, Li X
Nature 2021 Jun;594(7864):560-565

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Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.

Pero ME, Meregalli C, Qu X, Shin GJ, Kumar A, Shorey M, Rolls MM, Tanji K, Brannagan TH, Alberti P, Fumagalli G, Monza L, Grueber WB, Cavaletti G, Bartolini F
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)

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Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.

Bora G, Hensel N, Rademacher S, Koyunoğlu D, Sunguroğlu M, Aksu-Mengeş E, Balcı-Hayta B, Claus P, Erdem-Yurter H
Human molecular genetics 2021 Feb 25;29(24):3935-3944

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Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.

Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL
Circulation research 2020 Jul 3;127(2):e14-e27

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α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity.

Ferreira LT, Orr B, Rajendraprasad G, Pereira AJ, Lemos C, Lima JT, Guasch Boldú C, Ferreira JG, Barisic M, Maiato H
The Journal of cell biology 2020 Apr 6;219(4)

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Tubulin detyrosination promotes human trophoblast syncytium formation.

Wang R, Yu R, Zhu C, Lin HY, Lu X, Wang H
Journal of molecular cell biology 2019 Dec 23;11(11):967-978

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Dissecting the role of the tubulin code in mitosis.

Ferreira LT, Figueiredo AC, Orr B, Lopes D, Maiato H
Methods in cell biology 2018;144:33-74

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PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.

Kath C, Goni-Oliver P, Müller R, Schultz C, Haucke V, Eickholt B, Schmoranzer J
PloS one 2018;13(4):e0193257

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Nuclear envelope assembly defects link mitotic errors to chromothripsis.

Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D
Nature 2018 Sep;561(7724):551-555

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Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.

Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL
Nature medicine 2018 Aug;24(8):1225-1233

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The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.

Chen HH, Zhao P, Tian J, Guo W, Xu M, Zhang C, Lu R
Evidence-based complementary and alternative medicine : eCAM 2017;2017:2915247

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Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration.

Wang T, Hamilla S, Cam M, Aranda-Espinoza H, Mili S
Nature communications 2017 Oct 12;8(1):896

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Vasohibins encode tubulin detyrosinating activity.

Nieuwenhuis J, Adamopoulos A, Bleijerveld OB, Mazouzi A, Stickel E, Celie P, Altelaar M, Knipscheer P, Perrakis A, Blomen VA, Brummelkamp TR
Science (New York, N.Y.) 2017 Dec 15;358(6369):1453-1456

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AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.

Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Rupérez C, Fernández-Vidal A, Ferguson C, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A
Nature communications 2015 May 27;6:7176

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Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

Barisic M, Silva e Sousa R, Tripathy SK, Magiera MM, Zaytsev AV, Pereira AL, Janke C, Grishchuk EL, Maiato H
Science (New York, N.Y.) 2015 May 15;348(6236):799-803

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Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon Regeneration.

Song W, Cho Y, Watt D, Cavalli V
The Journal of biological chemistry 2015 Jun 5;290(23):14765-75

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Structural basis of tubulin tyrosination by tubulin tyrosine ligase.

Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO
The Journal of cell biology 2013 Feb 4;200(3):259-70

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Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells.

Zink S, Grosse L, Freikamp A, Bänfer S, Müksch F, Jacob R
Journal of cell science 2012 Dec 15;125(Pt 24):5998-6008

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The TTL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TTL. This antibody recognizes human,mouse,rat antigen. The TTL antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

13618-1-AP.pdf

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