17049-1-AP

antibody from Proteintech Group

Targeting: LATS1 WARTS

Provider product page for 17049-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [43]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 17049-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17049-1-AP, RRID:AB_2281011
Product name: LATS1 antibody
Antibody type: Polyclonal
Description: KD/KO validated LATS1 antibody (Cat. #17049-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LATS1 protein structure - 17049-1-AP shown in red.

Submitted references Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling.

Liang P, Xie W, Wang X, Du Z, Zheng C, Zhao H, Wang Z, Ji Z
International immunopharmacology 2024 May 10;132:111900

FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.

Wang R, Cheng F, Yang X
Journal of ovarian research 2024 Mar 15;17(1):62

Targeting mechanics-induced trabecular meshwork dysfunction through YAP-TGFβ Ameliorates high myopia-induced ocular hypertension.

Bu Q, Zhu H, Cao G, Gong G, Su Y, Ge Q, Zhu W, Li Z, Pan X
Experimental eye research 2024 Apr;241:109853

A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.

Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032

Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma.

Yan Q, Liu J, Liu Y, Wen Z, Jin D, Wang F, Gao L
Cellular and molecular life sciences : CMLS 2024 Apr 11;81(1):179

Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.

Ma T, Ruan H, Lv L, Wei C, Yu Y, Jia L, Song X, Zhang J, Li Y
Food & function 2023 Nov 13;14(22):9999-10013

KK-LC-1 as a therapeutic target to eliminate ALDH(+) stem cells in triple negative breast cancer.

Bu J, Zhang Y, Wu S, Li H, Sun L, Liu Y, Zhu X, Qiao X, Ma Q, Liu C, Niu N, Xue J, Chen G, Yang Y, Liu C
Nature communications 2023 May 5;14(1):2602

Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of (AGTR1+) CAFs in intrahepatic cholangiocarcinoma.

Li JH, Wu X, Ni X, Li YX, Xu L, Hao XY, Zhao W, Zhu XX, Yin XY
Clinical and translational medicine 2023 Mar;13(3):e1213

PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling.

Chen H, Yang W, Li Y, Ji Z
Cell death & disease 2023 Jul 15;14(7):433

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.

Sun Y, Jin X, Meng J, Guo F, Chen T, Zhao X, Wu H, Ren D
The EMBO journal 2023 Dec 1;42(23):e114558

LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism.

He XY, Fan X, Qu L, Wang X, Jiang L, Sang LJ, Shi CY, Lin S, Yang JC, Yang ZZ, Lei K, Li JH, Ju HQ, Yan Q, Liu J, Wang F, Shao J, Xiong Y, Wang W, Lin A
Nature communications 2023 Apr 20;14(1):2253

KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression.

Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, Lee JR, Salem F, Mariani LH, Gordon RE, Basgen JM, Wen HH, Fu J, Azeloglu EU, He JC, Wong JS, Campbell KN
JCI insight 2023 Apr 10;8(7)

Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway.

Wang M, Zhang Q, Li Y, Jin L, Fang Z
Journal of oncology 2022;2022:5824617

IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells.

Zhu Y, Chen S, Liu W, Xu F, Lu J, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Connective tissue research 2022 Sep;63(5):498-513

N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.

Ma T, Cheng H, Li T, Chen Y, Cai T, Bai J, Wu Z, Xia X, Liang T, Du Y, Fu W
Bioorganic chemistry 2022 Sep;126:105899

A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma.

Zhang J, Tong Y, Lu X, Dong F, Ma X, Yin S, He Y, Liu Y, Liu Q, Fan D
Life sciences 2022 Sep 1;304:120698

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.

Li Y, Yang J, Zhang Q, Xu S, Sun W, Ge S, Xu X, Jager MJ, Jia R, Zhang J, Fan X
Oncogene 2022 Jul;41(27):3539-3553

miR-1307-5p suppresses proliferation and tumorigenesis of bladder cancer via targeting MDM4 and the Hippo signaling pathway.

Huang W, Zhang C, Xiong S, Zhou X, Wang G, Guo J
Discover oncology 2022 Jul 1;13(1):57

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway.

Fu Y, Wan P, Zhang J, Li X, Xing J, Zou Y, Wang K, Peng H, Zhu Q, Cao L, Zhai X
Frontiers in cell and developmental biology 2021;9:741060

Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells.

Hong L, Zha Y, Wang C, Qiao S, An J
Frontiers in molecular biosciences 2021;8:698698

LATS1 exerts tumor suppressor functions via targeting Gli1 in colorectal cancer.

Shen Z, Pan Y, Chen P, Jiang B, Fang X, Jiang Y
Journal of Cancer 2021;12(24):7311-7319

Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway.

Zuo W, Liu N, Zeng Y, Xiao Z, Wu K, Yang F, Li B, Song Q, Xiao Y, Liu Q
Frontiers in pharmacology 2021;12:663551

Tetramethylpyrazine Ameliorates Peritoneal Angiogenesis by Regulating VEGF/Hippo/YAP Signaling.

Zhu X, Shan Y, Yu M, Shi J, Tang L, Cao H, Sheng M
Frontiers in pharmacology 2021;12:649581

NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression.

Wang L, Li J, Wang R, Chen H, Wang R, Wang W, Yang X
Frontiers in oncology 2021;11:688794

A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.

Li RH, Tian T, Ge QW, He XY, Shi CY, Li JH, Zhang Z, Liu FZ, Sang LJ, Yang ZZ, Liu YZ, Xiong Y, Yan Q, Li X, Ju HQ, Liu J, Wang LJ, Shao JZ, Wang W, Zhou T, Lin A
Cell research 2021 Oct;31(10):1088-1105

KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.

Xu D, Chen PP, Zheng PQ, Yin F, Cheng Q, Zhou ZL, Xie HY, Li JY, Ni JY, Wang YZ, Chen SJ, Zhou L, Wang XX, Liu J, Zhang W, Lu LM
Acta pharmacologica Sinica 2021 Mar;42(3):436-450

miR-582-5p Is a Tumor Suppressor microRNA Targeting the Hippo-YAP/TAZ Signaling Pathway in Non-Small Cell Lung Cancer.

Zhu B, V M, Finch-Edmondson M, Lee Y, Wan Y, Sudol M, DasGupta R
Cancers 2021 Feb 11;13(4)

Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway.

Kong D, Jiang Y, Miao X, Wu Z, Liu H, Gong W
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166267

Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia.

Liao J, Liu W, Zhang L, Li Q, Hou F, Zou P
International journal of clinical and experimental pathology 2020;13(1):81-88

CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.

Chen L, Long X, Duan S, Liu X, Chen J, Lan J, Liu X, Huang W, Geng J, Zhou J
Theranostics 2020;10(24):11063-11079

FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.

Zheng YW, Li ZH, Lei L, Liu CC, Wang Z, Fei LR, Yang MQ, Huang WJ, Xu HT
Frontiers in oncology 2020;10:180

The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma.

Li J, Shi C, Zhou R, Han Y, Xu S, Ma H, Zhang Z
Cancer science 2020 Sep;111(9):3222-3235

Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.

Faizah Z, Amanda B, Ashari FY, Triastuti E, Oxtoby R, Rahaju AS, Aziz MA, Lusida MI, Oceandy D
Molecules (Basel, Switzerland) 2020 Sep 24;25(19)

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling.

Chen Z, Li S, Mo J, Hawley E, Wang Y, He Y, Brosseau JP, Shipman T, Clapp DW, Carroll TJ, Le LQ
JCI insight 2020 Oct 15;5(20)

TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.

Zhou S, Liu S, Lin C, Li Y, Ye L, Wu X, Jian Y, Dai Y, Ouyang Y, Zhao L, Liu M, Song L, Xi M
Oncogene 2020 Apr;39(18):3710-3725

Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.

Han Y, Zhang L, Yu X, Wang S, Xu C, Yin H, Wang S
Cell death & disease 2019 May 10;10(5):374

Expression of Hippo signaling pathway components in Hu sheep male reproductive tract and spermatozoa.

Zhang GM, Zhang TT, An SY, El-Samahy MA, Yang H, Wan YJ, Meng FX, Xiao SH, Wang F, Lei ZH
Theriogenology 2019 Mar 1;126:239-248

Heat-shock protein B1 upholds the cytoplasm reduced state to inhibit activation of the Hippo pathway in H9c2 cells.

Liu X, Liu K, Li C, Cai J, Huang L, Chen H, Wang H, Zou J, Liu M, Wang K, Tan S, Zhang H
Journal of cellular physiology 2019 Apr;234(4):5117-5133

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Li M, Chen J, Yu X, Xu S, Li D, Zheng Q, Yin Y
Cells 2019 Apr 17;8(4)

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.

Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216

Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.

Zhang X, Fan Q, Li Y, Yang Z, Yang L, Zong Z, Wang B, Meng X, Li Q, Liu J, Li H
Oncotarget 2017 May 2;8(18):29785-29794

Knockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells.

Wang C, Zhu ZM, Liu CL, He XJ, Zhang HY, Dong JH
Molecular medicine reports 2015 Jun;11(6):4101-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse testis tissue were subjected to SDS PAGE followed by western blot with 17049-1-AP(LATS1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The LATS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LATS1. This antibody recognizes human,mouse,rat antigen. The LATS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 17049-1-AP.pdf

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