Antibody data

Product number
BS60042 - Provider product page
Provider
Bioworld Technology, Inc
Product name
LATS1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human LATS1.
Description
The Drosophila tumor suppressor protein lats (for large tumor suppressor) is a putative protein kinase that shares homology with three proteins in Neurospora and budding yeast that are involved in cell cycle and growth regulation: S. cerevisiae Dbf2 and Dbf20, and Neurospora cot-1. Mosaic screens in Drosophila have identified the lats gene as a tumor suppressor in this species. The human homolog, designated LATS1, was shown to inhibit tumor growth in lats-deficient Drosophila. Human LATS1 binds to Cdc2 in early mitosis and appears to negatively regulate the kinase activity of Cdc2. LATS1-deficient mice are highly sensitive to carcinogenic treatments and develop soft-tissue sarcomas and ovarian stromal cell tumors, indicating a role for mammalian LATS1 in tumorigenesis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
LATS1 protein structure - BS60042 shown in red.