Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-L1448 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Human LATS1 monoclonal antibody, clone 3I54M7
- Antibody type
- Monoclonal
- Description
- LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3I54M7
- Concentration
- 0.5 mg/ml
- Storage
- -20°C, Avoid Freeze/Thaw Cycles
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