BS60298
antibody from Bioworld Technology, Inc
Targeting: IL37
FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H4, IL-1RP1, IL1F7
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS60298 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL37 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human IL37.
- Description
- IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NF°ÙB and AP-1, thereby promoting host response to injury or infection. The IL-1 superfamily is comprised of several ligands and receptors. IL-1F7, also known as IL-1ø, IL-1 homolog 4 (IL-1H4) or IL-1 related protein 1 (IL-1rp1), is a secreted ligand belonging to this superfamily. It is expressed in the cytoplasm of peripheral monocytic cells localizing to the inner surface of the plasma membrane and surrounding the nuclear membrane suggesting that IL-1F7 may play a role in immune regulation. Five isoforms exist for this protein due to alternative splicing and they are designated IL-1F7a through IL-1F7e. Isoform a has a distinct N-terminus while isoforms c-d are truncated. Isoform b is the mature functional isoform that binds to the IL-18RÏ«-chain and the IL-18 binding protein (IL-18BP) acting as an IL-18 antagonist. IL-1F7 is closely related to IL-1ra, sharing 36% sequence identity.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of IL37 pAb at 1:500 dilutionLane1:Hela cell lysateLane2:NIH-3T3 cell lysateLane3:H9C2 cell lysate