ULBP2

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

Description

UL16 binding protein 2

Tissue specificity

Tissue enhanced (esophagus)

Subcell location

Vesicles, Plasma membrane

Predicted location

Membrane, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

6 (149942014 - 149949235)

Ensembl ID

ENSG00000131015  (ver. 103.38)

Orthologs

-

UniProt

Q9BZM5

neXtProt

NX_Q9BZM5

Human splice variants

Protein structure