Antibody data
- Antibody Data
- Antigen structure
- References [28]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14346-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14346-1-AP, RRID:AB_2214314
- Product name
- USP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP1 antibody (Cat. #14346-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Variety in the USP deubiquitinase catalytic mechanism.
CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice.
The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.
The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion.
Detection of endogenous translesion DNA synthesis in single mammalian cells.
Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway.
USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.
CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.
H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway.
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC.
Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.
FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value.
USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.
USP1 Promotes GC Metastasis via Stabilizing ID2.
USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1.
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma.
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Keijzer N, Priyanka A, Stijf-Bultsma Y, Fish A, Gersch M, Sixma TK
Life science alliance 2024 Apr;7(4)
Life science alliance 2024 Apr;7(4)
CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice.
Alfano L, Iannuzzi CA, Barone D, Forte IM, Ragosta MC, Cuomo M, Mazzarotti G, Dell'Aquila M, Altieri A, Caporaso A, Roma C, Marra L, Boffo S, Indovina P, De Laurentiis M, Giordano A
Oncogene 2024 Apr;43(17):1263-1273
Oncogene 2024 Apr;43(17):1263-1273
The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.
Wang Z, Li T, Liu D, Li M, Liu S, Yu X, Li H, Song H, Zhao W, Liu Z, Chen X, Lu G, Chen ZJ, Huang T, Liu H
iScience 2024 Apr 19;27(4):109456
iScience 2024 Apr 19;27(4):109456
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.
Li Y, Huang X, Jin J, Zhang H, Yang K, Han J, Lv Y, Sun Y, Yao C, Lin T, Zhu C, Liu H
Cell & bioscience 2023 May 6;13(1):80
Cell & bioscience 2023 May 6;13(1):80
The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion.
Huang J, Zhou H, He L, Zhong L, Zhou D, Yin Z
Journal of orthopaedic surgery and research 2023 Mar 2;18(1):152
Journal of orthopaedic surgery and research 2023 Mar 2;18(1):152
Detection of endogenous translesion DNA synthesis in single mammalian cells.
Egger T, Aze A, Maiorano D
Cell reports methods 2023 Jun 26;3(6):100501
Cell reports methods 2023 Jun 26;3(6):100501
Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway.
Kupculak M, Bai F, Luo Q, Yoshikawa Y, Lopez-Martinez D, Xu H, Uphoff S, Cohn MA
Cell reports 2023 Jul 25;42(7):112721
Cell reports 2023 Jul 25;42(7):112721
USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.
Liu S, Xiang Y, Wang B, Gao C, Chen Z, Xie S, Wu J, Liu Y, Zhao X, Yang C, Yue Z, Wang L, Wen X, Zhang R, Zhang F, Xu H, Zhai X, Zheng H, Zhang H, Qian M
Blood advances 2023 Jul 11;7(13):3099-3112
Blood advances 2023 Jul 11;7(13):3099-3112
CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.
Tyagi A, Kaushal K, Chandrasekaran AP, Sarodaya N, Das S, Park CH, Hong SH, Kim KS, Ramakrishna S
Theranostics 2022;12(13):5949-5970
Theranostics 2022;12(13):5949-5970
H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.
Sun Z, Zhu Y, Feng X, Liu X, Zhou K, Wang Q, Zhang H, Shi H
Cancers 2022 Oct 3;14(19)
Cancers 2022 Oct 3;14(19)
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
Hunter JE, Campbell AE, Hannaway NL, Kerridge S, Luli S, Butterworth JA, Sellier H, Mukherjee R, Dhillon N, Sudhindar PD, Shukla R, Brownridge PJ, Bell HL, Coxhead J, Taylor L, Leary P, Hasoon MSR, Collins I, Garrett MD, Eyers CE, Perkins ND
The Biochemical journal 2022 Oct 14;479(19):2063-2086
The Biochemical journal 2022 Oct 14;479(19):2063-2086
HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway.
Huang Z, Chen Y, Chen R, Zhou B, Wang Y, Hong L, Wang Y, Wang J, Xu X, Huang Z, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov 16;10(1):e2202437
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov 16;10(1):e2202437
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC.
Wang L, Hu T, Shen Z, Zheng Y, Geng Q, Li L, Sha B, Li M, Sun Y, Guo Y, Xue W, Xuan D, Chen P, Zhao J
Cell death & disease 2022 Nov 10;13(11):951
Cell death & disease 2022 Nov 10;13(11):951
Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.
Chen Z, Ma Y, Guo Z, Song D, Chen Z, Sun M
Annals of hepatology 2022 Mar-Apr;27(2):100669
Annals of hepatology 2022 Mar-Apr;27(2):100669
FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value.
Zheng C, Ren Z, Chen H, Yuan X, Suye S, Yin H, Zhou Z, Fu C
Experimental cell research 2022 Dec 15;421(2):113388
Experimental cell research 2022 Dec 15;421(2):113388
USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.
Sun D, Peng Y, Ge S, Fu Q
Journal of musculoskeletal & neuronal interactions 2022 Dec 1;22(4):536-545
Journal of musculoskeletal & neuronal interactions 2022 Dec 1;22(4):536-545
USP1 Promotes GC Metastasis via Stabilizing ID2.
Li N, Wu L, Zuo X, Luo H, Sheng Y, Yan J
Disease markers 2021;2021:3771990
Disease markers 2021;2021:3771990
USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
Han D, Wang L, Chen B, Zhao W, Liang Y, Li Y, Zhang H, Liu Y, Wang X, Chen T, Li C, Song X, Luo D, Li Z, Yang Q
Cell cycle (Georgetown, Tex.) 2021 Feb;20(3):320-331
Cell cycle (Georgetown, Tex.) 2021 Feb;20(3):320-331
USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1.
Li Y, Xu Y, Gao C, Sun Y, Zhou K, Wang P, Cheng J, Guo W, Ya C, Fan J, Yang X
Frontiers in oncology 2020;10:554809
Frontiers in oncology 2020;10:554809
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.
Zhao Y, Xue C, Xie Z, Ouyang X, Li L
Cell proliferation 2020 Oct;53(10):e12908
Cell proliferation 2020 Oct;53(10):e12908
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma.
Herviou P, Le Bras M, Dumas L, Hieblot C, Gilhodes J, Cioci G, Hugnot JP, Ameadan A, Guillonneau F, Dassi E, Cammas A, Millevoi S
Nature communications 2020 May 27;11(1):2661
Nature communications 2020 May 27;11(1):2661
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A, Cohen S
EMBO reports 2020 Apr 3;21(4):e48791
EMBO reports 2020 Apr 3;21(4):e48791
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
Huang X, Zhang Q, Lou Y, Wang J, Zhao X, Wang L, Zhang X, Li S, Zhao Y, Chen Q, Liang T, Bai X
Cancer immunology research 2019 Oct;7(10):1580-1590
Cancer immunology research 2019 Oct;7(10):1580-1590
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
Ma A, Tang M, Zhang L, Wang B, Yang Z, Liu Y, Xu G, Wu L, Jing T, Xu X, Yang S, Liu Y
Oncogene 2019 Mar;38(13):2405-2419
Oncogene 2019 Mar;38(13):2405-2419
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P
Nature communications 2017 Jun 12;8:15751
Nature communications 2017 Jun 12;8:15751
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
Xiao H, Tian Y, Yang Y, Hu F, Xie X, Mei J, Ding F
Biochemical and biophysical research communications 2015 May 8;460(3):703-8
Biochemical and biophysical research communications 2015 May 8;460(3):703-8
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z
Nature chemical biology 2014 Apr;10(4):298-304
Nature chemical biology 2014 Apr;10(4):298-304
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ
Molecular cell 2012 Aug 10;47(3):396-409
Molecular cell 2012 Aug 10;47(3):396-409
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 14346-1-AP(USP1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP1. This antibody recognizes human,mouse,rat antigen. The USP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 14346-1-AP(USP1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue