Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS8438 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- USP1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human USP1.
- Description
- The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP1 (ubiquitin specific peptidase 1), also known as UBP, ubiquitin carboxyl-terminal hydrolase 1, ubiquitin thioesterase 1 or deubiquitinating enzyme 1, is a 785 amino acid that belongs to the peptidase C19 family of ubiquitin carboxy-terminal hydrolases. A negative regulator of DNA damage repair, USP1 specifically deubiquitinates FANCD2 in the DNA repair pathway. Following DNA damage, autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA and the recruitment of POL H. Multiple isoforms of USP1 exist due to alternative splicing events.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
No validations: Submit validation data