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- Antibody Data
- Antigen structure
- References [30]
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- Product number
- 10477-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10477-1-AP, RRID:AB_2079470
- Product name
- CHMP2A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CHMP2A antibody (Cat. #10477-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.
PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure.
CDK1 controls CHMP7-dependent nuclear envelope reformation.
Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes.
ER-directed TREX1 limits cGAS activation at micronuclei.
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α.
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles.
ESCRT-mediated phagophore sealing during mitophagy.
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.
Studying the Spatial Organization of ESCRTs in Cytokinetic Abscission Using the High-Resolution Imaging Techniques SIM and Cryo-SXT.
Nuclear envelope assembly defects link mitotic errors to chromothripsis.
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival.
Nonenvelopment Role for the ESCRT-III Complex during Human Cytomegalovirus Infection.
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure.
VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis.
CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.
Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.
Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation.
ESCRT-III controls nuclear envelope reformation.
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis.
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
Shao R, Wang X, Xu T, Xia Y, Cui D
Journal of neuroinflammation 2021 Nov 5;18(1):257
Journal of neuroinflammation 2021 Nov 5;18(1):257
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.
Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V
Cell 2021 Nov 24;184(24):5950-5969.e22
Cell 2021 Nov 24;184(24):5950-5969.e22
PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure.
Wang H, Wang Y, Wang X, Huang H, Bao J, Zhong W, Li A
Cell death & disease 2021 Nov 16;12(12):1087
Cell death & disease 2021 Nov 16;12(12):1087
CDK1 controls CHMP7-dependent nuclear envelope reformation.
Gatta AT, Olmos Y, Stoten CL, Chen Q, Rosenthal PB, Carlton JG
eLife 2021 Jul 21;10
eLife 2021 Jul 21;10
Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes.
Hattori T, Takahashi Y, Chen L, Tang Z, Wills CA, Liang X, Wang HG
Cell death and differentiation 2021 Feb;28(2):657-670
Cell death and differentiation 2021 Feb;28(2):657-670
ER-directed TREX1 limits cGAS activation at micronuclei.
Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J
Molecular cell 2021 Feb 18;81(4):724-738.e9
Molecular cell 2021 Feb 18;81(4):724-738.e9
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GPD, Javed R, Gu Y, Allers L, Peters R, Wang F, da Costa LJ, Pallikkuth S, Lidke KA, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze SA, Mari MC, Johansen T, Reggiori F, Deretic V
Nature cell biology 2021 Aug;23(8):846-858
Nature cell biology 2021 Aug;23(8):846-858
AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.
Merigliano C, Burla R, La Torre M, Del Giudice S, Teo H, Liew CW, Chojnowski A, Goh WI, Olmos Y, Maccaroni K, Giubettini M, Chiolo I, Carlton JG, Raimondo D, Vernì F, Stewart CL, Rhodes D, Wright GD, Burke BE, Saggio I
PLoS genetics 2021 Aug;17(8):e1009757
PLoS genetics 2021 Aug;17(8):e1009757
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
Nüchel J, Tauber M, Nolte JL, Mörgelin M, Türk C, Eckes B, Demetriades C, Plomann M
Molecular cell 2021 Aug 19;81(16):3275-3293.e12
Molecular cell 2021 Aug 19;81(16):3275-3293.e12
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU
Nature communications 2021 Aug 11;12(1):4863
Nature communications 2021 Aug 11;12(1):4863
Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
Little JN, McNeely KC, Michel N, Bott CJ, Lettieri KS, Hecht MR, Martin SA, Dwyer ND
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Apr 14;41(15):3344-3365
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Apr 14;41(15):3344-3365
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α.
Saha B, Chisholm D, Kell AM, Mandell MA
PLoS pathogens 2020 Oct;16(10):e1009017
PLoS pathogens 2020 Oct;16(10):e1009017
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles.
Liese S, Wenzel EM, Kjos I, Rojas Molina R, Schultz SW, Brech A, Stenmark H, Raiborg C, Carlson A
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 17;117(46):28614-28624
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 17;117(46):28614-28624
ESCRT-mediated phagophore sealing during mitophagy.
Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H
Autophagy 2020 May;16(5):826-841
Autophagy 2020 May;16(5):826-841
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C
Nature cell biology 2020 Jul;22(7):856-867
Nature cell biology 2020 Jul;22(7):856-867
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.
Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, Roux A
Nature cell biology 2020 Aug;22(8):947-959
Nature cell biology 2020 Aug;22(8):947-959
Studying the Spatial Organization of ESCRTs in Cytokinetic Abscission Using the High-Resolution Imaging Techniques SIM and Cryo-SXT.
Adar-Levor S, Goliand I, Elbaum M, Elia N
Methods in molecular biology (Clifton, N.J.) 2019;1998:129-148
Methods in molecular biology (Clifton, N.J.) 2019;1998:129-148
Nuclear envelope assembly defects link mitotic errors to chromothripsis.
Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D
Nature 2018 Sep;561(7724):551-555
Nature 2018 Sep;561(7724):551-555
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival.
Radulovic M, Schink KO, Wenzel EM, Nähse V, Bongiovanni A, Lafont F, Stenmark H
The EMBO journal 2018 Nov 2;37(21)
The EMBO journal 2018 Nov 2;37(21)
Nonenvelopment Role for the ESCRT-III Complex during Human Cytomegalovirus Infection.
Streck NT, Carmichael J, Buchkovich NJ
Journal of virology 2018 Jun 15;92(12)
Journal of virology 2018 Jun 15;92(12)
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure.
Takahashi Y, He H, Tang Z, Hattori T, Liu Y, Young MM, Serfass JM, Chen L, Gebru M, Chen C, Wills CA, Atkinson JM, Chen H, Abraham T, Wang HG
Nature communications 2018 Jul 20;9(1):2855
Nature communications 2018 Jul 20;9(1):2855
VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis.
Ott C, Nachmias D, Adar S, Jarnik M, Sherman S, Birnbaum RY, Lippincott-Schwartz J, Elia N
Scientific reports 2018 Feb 20;8(1):3353
Scientific reports 2018 Feb 20;8(1):3353
CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Ventimiglia LN, Cuesta-Geijo MA, Martinelli N, Caballe A, Macheboeuf P, Miguet N, Parnham IM, Olmos Y, Carlton JG, Weissenhorn W, Martin-Serrano J
Developmental cell 2018 Dec 3;47(5):547-563.e6
Developmental cell 2018 Dec 3;47(5):547-563.e6
Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.
Goliand I, Adar-Levor S, Segal I, Nachmias D, Dadosh T, Kozlov MM, Elia N
Cell reports 2018 Aug 14;24(7):1756-1764
Cell reports 2018 Aug 14;24(7):1756-1764
Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.
Yang Z, Maciejowski J, de Lange T
Molecular cancer research : MCR 2017 Nov;15(11):1579-1586
Molecular cancer research : MCR 2017 Nov;15(11):1579-1586
Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation.
Olmos Y, Perdrix-Rosell A, Carlton JG
Current biology : CB 2016 Oct 10;26(19):2635-2641
Current biology : CB 2016 Oct 10;26(19):2635-2641
ESCRT-III controls nuclear envelope reformation.
Olmos Y, Hodgson L, Mantell J, Verkade P, Carlton JG
Nature 2015 Jun 11;522(7555):236-9
Nature 2015 Jun 11;522(7555):236-9
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H
Nature 2015 Jun 11;522(7555):231-5
Nature 2015 Jun 11;522(7555):231-5
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis.
Lee S, Chang J, Renvoisé B, Tipirneni A, Yang S, Blackstone C
Molecular biology of the cell 2012 Nov;23(22):4347-61
Molecular biology of the cell 2012 Nov;23(22):4347-61
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
Kuang Z, Seo EJ, Leis J
Journal of virology 2011 Jul;85(14):7153-61
Journal of virology 2011 Jul;85(14):7153-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CHMP2A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CHMP2A. This antibody recognizes human,mouse,rat antigen. The CHMP2A antibody has been validated for the following applications: ELISA, WB analysis.
