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- Antigen structure
- References [14]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 20861-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20861-1-AP, RRID:AB_10696446
- Product name
- CCDC93 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CCDC93 antibody (Cat. #20861-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma.
Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion.
WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.
Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes.
Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins.
Regulation of murine copper homeostasis by members of the COMMD protein family.
COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages.
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Healy MD, McNally KE, Butkovič R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ
Cell 2023 May 11;186(10):2219-2237.e29
Cell 2023 May 11;186(10):2219-2237.e29
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K
Science immunology 2023 Mar 31;8(81):eadc9324
Science immunology 2023 Mar 31;8(81):eadc9324
COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma.
Wang S, Liu Y, Li S, Chen Y, Liu Y, Yan J, Wu J, Li J, Wang L, Xiang R, Shi Y, Qin X, Yang S
Molecular cancer research : MCR 2023 Mar 1;21(3):199-213
Molecular cancer research : MCR 2023 Mar 1;21(3):199-213
Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion.
Yang L, Fye MA, Yang B, Tang Z, Zhang Y, Haigh S, Covington BA, Bracey K, Taraska JW, Kaverina I, Qu S, Chen W
Molecular metabolism 2022 Sep;63:101541
Molecular metabolism 2022 Sep;63:101541
WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.
Hong Y, Sun H, Hong X, Yang CP, Billadeau DD, Wang T, Deng ZH
Molecular biology reports 2022 Sep;49(9):8349-8357
Molecular biology reports 2022 Sep;49(9):8349-8357
Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes.
Giridharan SSP, Luo G, Rivero-Rios P, Steinfeld N, Tronchere H, Singla A, Burstein E, Billadeau DD, Sutton MA, Weisman LS
eLife 2022 Jan 18;11
eLife 2022 Jan 18;11
Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins.
Healy MD, Sacharz J, McNally KE, McConville C, Tillu VA, Hall RJ, Chilton M, Cullen PJ, Mobli M, Ghai R, Stroud DA, Collins BM
Structure (London, England : 1993) 2022 Dec 1;30(12):1590-1602.e6
Structure (London, England : 1993) 2022 Dec 1;30(12):1590-1602.e6
Regulation of murine copper homeostasis by members of the COMMD protein family.
Singla A, Chen Q, Suzuki K, Song J, Fedoseienko A, Wijers M, Lopez A, Billadeau DD, van de Sluis B, Burstein E
Disease models & mechanisms 2021 Jan 1;14(1)
Disease models & mechanisms 2021 Jan 1;14(1)
COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages.
Ben Shlomo S, Mouhadeb O, Cohen K, Varol C, Gluck N
iScience 2019 Apr 26;14:147-163
iScience 2019 Apr 26;14:147-163
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.
Hunter MR, Hesketh GG, Benedyk TH, Gingras AC, Graham SC
Journal of molecular biology 2018 Jul 6;430(14):2153-2163
Journal of molecular biology 2018 Jul 6;430(14):2153-2163
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ
Nature cell biology 2017 Oct;19(10):1214-1225
Nature cell biology 2017 Oct;19(10):1214-1225
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B
Nature communications 2016 Mar 11;7:10961
Nature communications 2016 Mar 11;7:10961
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.
Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E
The Journal of cell biology 2015 Nov 9;211(3):605-17
The Journal of cell biology 2015 Nov 9;211(3):605-17
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis Bv, Billadeau DD, Burstein E
Molecular biology of the cell 2015 Jan 1;26(1):91-103
Molecular biology of the cell 2015 Jan 1;26(1):91-103
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 20861-1-AP(CCDC93 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon using 20861-1-AP(CCDC93 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CCDC93 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CCDC93. This antibody recognizes human, mouse, rat antigen. The CCDC93 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
