Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 20966-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- LEPR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LEPR antibody (Cat. #20966-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effects of carotid baroreceptor stimulation on aortic remodeling in obese rats.
919 syrup inhibits ROS-mediated leptin-induced anorexia by activating PPARγ and improves gut flora abnormalities.
PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.
Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor-dependent manner.
Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7.
Feasibility of Application of the Newly Developed Nano-Biomaterial, β-TCP/PDLLA, in Maxillofacial Reconstructive Surgery: A Pilot Rat Study.
Leptin, Leptin Receptor, KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1), and Adiponectin in Bone Metastasis from Breast Carcinoma: An Immunohistochemical Study.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression.
JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells.
Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide.
Leptin mediates the effects of melatonin on female reproduction in mammals.
Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis.
Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production.
Yu Q, Shu L, Wang L, Gao K, Wang J, Dai M, Cao Q, Zhang Y, Luo Q, Hu B, Dai D, Chen J, Bao M
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 May 6;31(5):1635-1644
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 May 6;31(5):1635-1644
919 syrup inhibits ROS-mediated leptin-induced anorexia by activating PPARγ and improves gut flora abnormalities.
Xing JW, Chen MM, Tian XY, Pan DQ, Peng XH, Gao PF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111455
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111455
PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.
Yen YT, Chien M, Wu PY, Hung SC
Communications biology 2021 Jun 2;4(1):658
Communications biology 2021 Jun 2;4(1):658
Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor-dependent manner.
Zheng J, Ding J, Liao M, Qiu Z, Yuan Q, Mai W, Dai Y, Zhang H, Wu H, Wang Y, Liao Y, Chen X, Cheng X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21157
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21157
Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7.
Huang H, Zhang J, Ling F, Huang Y, Yang M, Zhang Y, Wei Y, Zhang Q, Wang H, Song L, Wu Y, Yang J, Tang J
Cancer cell international 2021 Jan 4;21(1):4
Cancer cell international 2021 Jan 4;21(1):4
Feasibility of Application of the Newly Developed Nano-Biomaterial, β-TCP/PDLLA, in Maxillofacial Reconstructive Surgery: A Pilot Rat Study.
Toda E, Bai Y, Sha J, Dong QN, Ngo HX, Suyama T, Miyamoto K, Matsuzaki Y, Kanno T
Nanomaterials (Basel, Switzerland) 2021 Jan 25;11(2)
Nanomaterials (Basel, Switzerland) 2021 Jan 25;11(2)
Leptin, Leptin Receptor, KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1), and Adiponectin in Bone Metastasis from Breast Carcinoma: An Immunohistochemical Study.
Maroni P, Luzzati A, Perrucchini G, Cannavò L, Bendinelli P
Biomedicines 2020 Nov 17;8(11)
Biomedicines 2020 Nov 17;8(11)
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cai BB, Lu YN, Xu M
Acta pharmacologica Sinica 2020 May;41(5):650-660
Acta pharmacologica Sinica 2020 May;41(5):650-660
Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression.
Gelsomino L, Naimo GD, Malivindi R, Augimeri G, Panza S, Giordano C, Barone I, Bonofiglio D, Mauro L, Catalano S, Andò S
Cancers 2020 Jul 27;12(8)
Cancers 2020 Jul 27;12(8)
JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells.
Wu W, Fu J, Gu Y, Wei Y, Ma P, Wu J
The Journal of endocrinology 2020 Apr;245(1):141-153
The Journal of endocrinology 2020 Apr;245(1):141-153
Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide.
Sukegawa S, Kawai H, Nakano K, Takabatake K, Kanno T, Nagatsuka H, Furuki Y
Materials (Basel, Switzerland) 2019 Nov 8;12(22)
Materials (Basel, Switzerland) 2019 Nov 8;12(22)
Leptin mediates the effects of melatonin on female reproduction in mammals.
Lv D, Tan T, Zhu T, Wang J, Zhang S, Zhang L, Hu X, Liu G, Xing Y
Journal of pineal research 2019 Apr;66(3):e12559
Journal of pineal research 2019 Apr;66(3):e12559
Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis.
Pan H, Fu C, Huang L, Jiang Y, Deng X, Guo J, Su Z
Marine drugs 2018 Jun 5;16(6)
Marine drugs 2018 Jun 5;16(6)
Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Guo X, Wu L, Lyu Y, Chowanadisai W, Clarke SL, Lucas EA, Smith BJ, He H, Wang W, Medeiros DM, Lin D
The Journal of nutritional biochemistry 2017 Aug;46:74-82
The Journal of nutritional biochemistry 2017 Aug;46:74-82
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production.
Fan Y, Gan Y, Shen Y, Cai X, Song Y, Zhao F, Yao M, Gu J, Tu H
Oncotarget 2015 Jun 30;6(18):16120-34
Oncotarget 2015 Jun 30;6(18):16120-34
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 20966-1-AP(LEPR antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LEPR antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human LEPR. This antibody recognizes human antigen. The LEPR antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate hyperplasia using 20966-1-AP(LEPR antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate hyperplasia using 20966-1-AP(LEPR antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue