RA0460

antibody from Oursmab

Targeting: LEPR CD295, OBR

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0460

Provider

Oursmab

Product name

Mibavademab (Biosimilar Reference Antibody) (LEPR)

Antibody type

Monoclonal

Description

Mibavademab (also known as REGN-4461) is an investigational, fully human monoclonal antibody that targets leptin receptor (LEPR), a key receptor involved in the regulation of energy homeostasis and metabolism. By binding to LEPR, mibavademab functions as a leptin receptor agonist, mimicking the action of the hormone leptin. This activation is intended to restore leptin signaling in individuals with congenital leptin receptor deficiency or other forms of leptin receptor dysfunction, thereby reducing hyperphagia (extreme hunger), improving metabolic parameters, and promoting weight loss. It is being developed as a potential therapy for severe, early-onset obesity due to LEPR deficiency and related metabolic disorders.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Mibavademab (Biosimilar Reference Antibody) (LEPR)-RA0460-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Mibavademab (Biosimilar Reference Antibody) (LEPR)-RA0460 in a linear range of 3.91¨C31 ng/mL.