NBP2-47786-0.1mg

antibody from Novus Biologicals

Targeting: FBXO5 EMI1, FBX5, Fbxo31

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Validation data

Product number: NBP2-47786-0.1mg - Provider product page
Provider: Novus Biologicals
Product name: Mouse Monoclonal EMI1 Antibody
Antibody type: Monoclonal
Description: Protein A or G purified. It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Reactivity: Human
Host: Mouse
Isotype: IgG
Vial size: 0.1 mg
Concentration: 1.0 mg/ml
Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

FBXO5 protein structure - NBP2-47786-0.1mg shown in red.