RGS17

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Description

Regulator of G protein signaling 17

Tissue specificity

Tissue enhanced (brain)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (153004459 - 153131282)

Ensembl ID

ENSG00000091844  (ver. 103.38)

Orthologs

Mouse Rgs17: ENSMUSG00000019775

UniProt

Q9UGC6

neXtProt

NX_Q9UGC6

Human splice variants
Mouse splice variants

Protein structure