DIRAS3

This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

Description

DIRAS family GTPase 3

Tissue specificity

Tissue enhanced (brain, ovary, pituitary gland)

Subcell location

Nuclear membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (68045886 - 68051631)

Ensembl ID

ENSG00000162595  (ver. 103.38)

Orthologs

-

UniProt

O95661

neXtProt

NX_O95661

Human splice variants

Protein structure