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- References [21]
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- Product number
- 17939-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17939-1-AP, RRID:AB_2285290
- Product name
- RPE65 antibody
- Antibody type
- Polyclonal
- Description
- RPE65 antibody (Cat. #17939-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tropism and Retinal Transduction Efficiency of Adeno-Associated Virus Serotypes in Mice.
Superoxide Activates Ferroptosis via the Haber-Weiss Reaction and Enhances Age-Related Macular Degeneration.
Disulfide-Appended siRNA Nanoeyedrops: Noninvasive Gene Therapy for Targeting Retinal Angiogenesis.
RPE65 variant p.(E519K) causes a novel dominant adult-onset maculopathy in 83 affected individuals.
The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium.
Klotho attenuates epithelial‑mesenchymal transition of retinal pigment epithelial cells in subretinal fibrosis by suppressing the ERK1/2 and Wnt/β‑catenin signaling pathways.
AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway.
Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy.
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.
A Nucleic Acid-Based LYTAC Plus Platform to Simultaneously Mediate Disease-Driven Protein Downregulation.
Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE-Choroid.
CRISPR-cas9 screening identified lethal genes enriched in Hippo kinase pathway and of predictive significance in primary low-grade glioma.
Region-resolved multi-omics of the mouse eye.
Prph2 disease mutations lead to structural and functional defects in the RPE.
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4(-/-)/Bco2(-/-) double knockout mice.
The Construction of Retinal Pigment Epithelium Sheets with Enhanced Characteristics and Cilium Assembly Using iPS Conditioned Medium and Small Incision Lenticule Extraction Derived Lenticules.
Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal.
Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina.
Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy.
Wu W, McRae J, Brown A, Agbaga MP
Investigative ophthalmology & visual science 2025 Sep 2;66(12):18
Investigative ophthalmology & visual science 2025 Sep 2;66(12):18
Superoxide Activates Ferroptosis via the Haber-Weiss Reaction and Enhances Age-Related Macular Degeneration.
Huang Y, Zhou Z, Huan M, Guo Q, Zhang X, Lu R, Chen L, Li X, Yao J, Jiang Q, Xu Y
Aging cell 2025 Oct;24(10):e70195
Aging cell 2025 Oct;24(10):e70195
Disulfide-Appended siRNA Nanoeyedrops: Noninvasive Gene Therapy for Targeting Retinal Angiogenesis.
Liu S, Wang D, Ye S, Zhang J, Du B, Lian Z, Yang W, Zhou J, Chen Q, Li J, Li J, Yang H
ACS nano 2025 Oct 14;19(40):35333-35347
ACS nano 2025 Oct 14;19(40):35333-35347
RPE65 variant p.(E519K) causes a novel dominant adult-onset maculopathy in 83 affected individuals.
Vooren EV, den Broeck FV, Mahieu Q, Geens E, Heetvelde MV, De Bruyne M, de Sompele SV, Uppal S, Poliakov E, Dhaenens CM, Gregory-Evans CY, Hoefsloot L, Gonzalez AI, Kohl S, Zuleger T, Demaret T, Dominant RPE65-p.(E519K) Consortium, Tuupanen S, Ruys J, Os LV, Platteau E, Jacob J, Vermeer S, Postelmans L, Dahan K, Maystadt I, Rasquin F, Thiadens AAHJ, Stephenson KAJ, Sheri N, Smirnov V, MacDonald IM, Gregory-Evans K, Redmond TM, De Zaeytijd J, Leroy BP, Bauwens M, De Baere E
Research square 2025 May 5;
Research square 2025 May 5;
The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium.
Ji C, Wang Y, Ju Y, Liu S, Chen X, Wang J, Sun N, Tang Z, Gu P, Ji J
Scientific reports 2025 May 29;15(1):18949
Scientific reports 2025 May 29;15(1):18949
Klotho attenuates epithelial‑mesenchymal transition of retinal pigment epithelial cells in subretinal fibrosis by suppressing the ERK1/2 and Wnt/β‑catenin signaling pathways.
Jiang Y, Wen X, Jian X, Chen Q, Li Y
International journal of molecular medicine 2025 Mar;55(3)
International journal of molecular medicine 2025 Mar;55(3)
AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway.
Yang Y, Shen J, Li Y, Chen X, Liu G, Lu P
Investigative ophthalmology & visual science 2025 Apr 1;66(4):83
Investigative ophthalmology & visual science 2025 Apr 1;66(4):83
Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy.
Li B, Chang FY, Wan Z, Giauque NA, Addo EK, Bernstein PS
Experimental eye research 2024 Oct;247:110043
Experimental eye research 2024 Oct;247:110043
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.
Kothurkar AA, Patient GS, Noel NCL, Krzywańska AM, Carr BJ, Chu CJ, MacDonald RB
Journal of cell science 2024 Dec 1;137(23)
Journal of cell science 2024 Dec 1;137(23)
A Nucleic Acid-Based LYTAC Plus Platform to Simultaneously Mediate Disease-Driven Protein Downregulation.
Huang Y, Zhou X, Zhang Y, Xie M, Wang F, Qin J, Ye H, Zhang H, Zhang C, Hong J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(13):e2306248
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(13):e2306248
Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE-Choroid.
Wang Y, Tseng Y, Chen K, Chen K, Chen K, Huang Z, Mao Z, Li X
Investigative ophthalmology & visual science 2023 Sep 1;64(12):39
Investigative ophthalmology & visual science 2023 Sep 1;64(12):39
CRISPR-cas9 screening identified lethal genes enriched in Hippo kinase pathway and of predictive significance in primary low-grade glioma.
Mijiti M, Maimaiti A, Chen X, Tuersun M, Dilixiati M, Dilixiati Y, Zhu G, Wu H, Li Y, Turhon M, Abulaiti A, Maimaitiaili N, Yiming N, Kasimu M, Wang Y
Molecular medicine (Cambridge, Mass.) 2023 May 14;29(1):64
Molecular medicine (Cambridge, Mass.) 2023 May 14;29(1):64
Region-resolved multi-omics of the mouse eye.
Xiang H, Zhang B, Wang Y, Xu N, Zhang F, Luo R, Ji M, Ding C
Cell reports 2023 Feb 28;42(2):112121
Cell reports 2023 Feb 28;42(2):112121
Prph2 disease mutations lead to structural and functional defects in the RPE.
Tebbe L, Sakthivel H, Makia MS, Kakakhel M, Conley SM, Al-Ubaidi MR, Naash MI
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22284
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22284
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.
Ren X, Lv J, Wang N, Liu J, Gao C, Wu X, Yu Y, Teng Q, Dong W, Kong H, Kong L
Diabetes research and clinical practice 2022 Mar;185:109788
Diabetes research and clinical practice 2022 Mar;185:109788
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L
Redox biology 2022 Jun;52:102292
Redox biology 2022 Jun;52:102292
Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4(-/-)/Bco2(-/-) double knockout mice.
Arunkumar R, Gorusupudi A, Li B, Blount JD, Nwagbo U, Kim HJ, Sparrow JR, Bernstein PS
Experimental eye research 2021 Aug;209:108680
Experimental eye research 2021 Aug;209:108680
The Construction of Retinal Pigment Epithelium Sheets with Enhanced Characteristics and Cilium Assembly Using iPS Conditioned Medium and Small Incision Lenticule Extraction Derived Lenticules.
Gu J, Wang Y, Cui Z, Li H, Li S, Yang X, Yan X, Ding C, Tang S, Chen J
Acta biomaterialia 2019 Jul 1;92:115-131
Acta biomaterialia 2019 Jul 1;92:115-131
Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal.
Liao Y, Zhang H, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, Wu Y
Investigative ophthalmology & visual science 2019 Jul 1;60(8):3034-3045
Investigative ophthalmology & visual science 2019 Jul 1;60(8):3034-3045
Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina.
Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, Wu Y
The Journal of biological chemistry 2018 Sep 14;293(37):14507-14519
The Journal of biological chemistry 2018 Sep 14;293(37):14507-14519
Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy.
Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX
The American journal of pathology 2017 Oct;187(10):2222-2231
The American journal of pathology 2017 Oct;187(10):2222-2231
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RPE65 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RPE65. This antibody recognizes human,mouse,rat antigen. The RPE65 antibody has been validated for the following applications: ELISA, WB analysis.
