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- References [383]
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- Product number
- 20584-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20584-1-AP, RRID:AB_10734439
- Product name
- PI3 Kinase p110 Beta antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PI3 Kinase p110 Beta antibody (Cat. #20584-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior.
Bioinformatics analysis and experimental verification of TIGD1 in non-small cell lung cancer.
Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Regulation of Glucose Metabolism for Cell Energy Supply In Situ via High-Energy Intermediate Fructose Hydrogels.
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking.
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling.
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12.
Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway.
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms.
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM(2.5)-induced inflammatory response in human bronchial epithelial cells.
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Vitamin K1 ameliorates lipopolysaccharide-triggered skeletal muscle damage revealed by faecal bacteria transplantation.
Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice.
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway.
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation.
Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice.
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.
Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling.
Two polysaccharides from Rehmannia glutinosa: isolation, structural characterization, and hypoglycemic activities.
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERK pathways.
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway.
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury.
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling.
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease.
Effects of external environment on promoter methylation of PIK3R5 and related pathway regulation in steroid-induced femoral head necrosis.
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
HnRNP A2/B1 as a potential anti-tumor target for triptolide based on a simplified thermal proteome profiling method using XGBoost.
GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1/PI3K/Akt pathway.
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells.
si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway.
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
The In Vitro Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways.
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers.
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data.
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
Scutellarin-mediated autophagy activates exosome release of rat nucleus pulposus cells by positively regulating Rab8a via the PI3K/PTEN/Akt pathway.
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring.
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Selenium protects against cadmium-induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling.
Anti-fatigue effects of fermented soybean protein peptides in mice.
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway.
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production.
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
The crucial role of thioredoxin interacting protein in the liver insulin resistance induced by di (2-ethylhexyl) phthalates.
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Chronic vitamin D(3) supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway.
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis.
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma.
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation.
Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 Administration.
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism.
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway.
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Dandelion root extract affects ESCC progression via regulating multiple signal pathways.
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
NLRP3 promotes endometrial receptivity by inducing epithelial-mesenchymal transition of the endometrial epithelium.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma.
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression.
LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis.
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway.
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure.
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Velvet antler polypeptide prevents the disruption of hepatic tight junctions via inhibiting oxidative stress in cholestatic mice and liver cell lines.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice.
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Pharmacological actions of neferine in the modulation of human platelet function.
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux.
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
Fang X, Jiang XF, Zhang YP, Zhou CL, Dong YJ, Bo-Li, Lv GY, Chen SH
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior.
Liu X, Zhang WM, Meng N, Lin LJ, Tang GD
Open life sciences 2024;19(1):20220806
Open life sciences 2024;19(1):20220806
Bioinformatics analysis and experimental verification of TIGD1 in non-small cell lung cancer.
Xia L, Yang Z, Xv M, Wang G, Mao Y, Yang Y, Tang J
Frontiers in medicine 2024;11:1374260
Frontiers in medicine 2024;11:1374260
Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Fu ZY, Huang Y, Lian LS, Huang HT, Zhan SF, Cai Y, Li JX, Liu XH
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Zhang H, Hu S, Sanches JGP, Li Y, Wei Y, Pu C, Zhang J
Journal of physiology and biochemistry 2024 May;80(2):381-392
Journal of physiology and biochemistry 2024 May;80(2):381-392
Regulation of Glucose Metabolism for Cell Energy Supply In Situ via High-Energy Intermediate Fructose Hydrogels.
Lu B, Zhao Q, Cai Z, Qian S, Mao J, Zhang L, Mao X, Sun X, Cui W, Zhang Y
Small (Weinheim an der Bergstrasse, Germany) 2024 May;20(19):e2309060
Small (Weinheim an der Bergstrasse, Germany) 2024 May;20(19):e2309060
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Du Y, Xu Y, Guo X, Tan C, Zhu X, Liu G, Lyu X, Bei C
BMC cancer 2024 May 22;24(1):624
BMC cancer 2024 May 22;24(1):624
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Wang C, Xiong ZM, Cong YQ, Li ZY, Xie Y, Wang YX, Zhou HM, Yang YF, Liu JJ, Wu HZ
Scientific reports 2024 May 16;14(1):11240
Scientific reports 2024 May 16;14(1):11240
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking.
Huang XL, Sun Y, Wen P, Pan JC, He WY
The Journal of international medical research 2024 Mar;52(3):3000605241234006
The Journal of international medical research 2024 Mar;52(3):3000605241234006
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Xu X, Li Y, Xu R, Meng Y, Li Z, Zuo D, Wu Y
The FEBS journal 2024 Mar;291(6):1199-1219
The FEBS journal 2024 Mar;291(6):1199-1219
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice.
Lai J, Liang J, Chen K, Guan B, Chen Z, Chen L, Fan J, Zhang Y, Li Q, Su J, Chen Q, Lin J
Chinese journal of natural medicines 2024 Mar;22(3):235-248
Chinese journal of natural medicines 2024 Mar;22(3):235-248
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Zhang S, Cai X, Khan GJ, Cheng J, He J, Zhai K, Mao Y
Journal of ethnopharmacology 2024 Mar 25;322:117572
Journal of ethnopharmacology 2024 Mar 25;322:117572
FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
Wang DX, Bao SY, Song NN, Chen WZ, Ding XQ, Walker RJ, Fang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23436
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23436
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Shi Z, Yang F, Hu Y, Pang Q, Shi L, Du T, Cao Y, Song B, Yu X, Cao Z, Ye Z, Liu C, Yu R, Chen X, Zhu Y, Pang Q
Carbohydrate polymers 2024 Mar 1;327:121666
Carbohydrate polymers 2024 Mar 1;327:121666
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Dong P, Zhou L, Wang X, Xue L, Du Y, Cui R
European journal of medical research 2024 Mar 1;29(1):149
European journal of medical research 2024 Mar 1;29(1):149
Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling.
Que Y, Shi J, Zhang Z, Sun L, Li H, Qin X, Zeng Z, Yang X, Chen Y, Liu C, Liu C, Sun S, Jin Q, Zhang Y, Li X, Lei M, Yang C, Tian H, Tian J, Chang J
Exploration (Beijing, China) 2024 Jun;4(3):20230067
Exploration (Beijing, China) 2024 Jun;4(3):20230067
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.
Wang X, Li X, Ma X, Zhang L, Han T, Zhang D
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4183-4194
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4183-4194
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Bai X, Deng J, Duan Z, Fu R, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12.
Lin J, Gu M, Wang X, Chen Y, Chau NV, Li J, Chu Q, Qing L, Wu W
Journal of ethnopharmacology 2024 Jun 28;328:118125
Journal of ethnopharmacology 2024 Jun 28;328:118125
Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway.
Hu S, Fei Y, Jin C, Yao J, Ding H, Wang J, Liu C
Neuropharmacology 2024 Jun 15;251:109929
Neuropharmacology 2024 Jun 15;251:109929
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
Chen H, Peng L, Wang Z, He Y, Zhang X
Oral diseases 2024 Jul;30(5):3225-3238
Oral diseases 2024 Jul;30(5):3225-3238
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Wang T, Chen S, Wang Z, Li S, Fei X, Wang T, Zhang M
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Li Y, Yang X, Bao T, Sun X, Li X, Zhu H, Zhang B, Ma T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Ma G, Dong Q, Li F, Jin Z, Pi J, Wu W, Li J
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms.
Gu D, Ye M, Zhu G, Bai J, Chen J, Yan L, Yu P, Lu F, Hu C, Zhong Y, Liu P, He Q, Tang Q
Journal of translational medicine 2024 Jan 23;22(1):93
Journal of translational medicine 2024 Jan 23;22(1):93
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Yu S, Xiong W, Xu W, Chen Y
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM(2.5)-induced inflammatory response in human bronchial epithelial cells.
Li JL, Tan Y, Wang QL, Li CX, Hong JC, Wang HJ, Wu Y, Ni C, Peng XW
Ecotoxicology and environmental safety 2024 Jan 15;270:115778
Ecotoxicology and environmental safety 2024 Jan 15;270:115778
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Xiong M, Chen X, Wang H, Tang X, Wang Q, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
Vitamin K1 ameliorates lipopolysaccharide-triggered skeletal muscle damage revealed by faecal bacteria transplantation.
Xiao Y, Feng J, Jia J, Li J, Zhou Y, Song Z, Guan F, Li X, Liu L
Journal of cachexia, sarcopenia and muscle 2024 Feb;15(1):81-97
Journal of cachexia, sarcopenia and muscle 2024 Feb;15(1):81-97
Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice.
Miao L, Zhang X, Zhang H, Cheong MS, Chen X, Farag MA, Cheang WS, Xiao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155296
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155296
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
Zhao X, Liu D, Zhao Y, Wang Z, Wang Y, Chen Z, Ning S, Wang G, Meng L, Yao J, Tian X
Cell death & disease 2024 Feb 20;15(2):154
Cell death & disease 2024 Feb 20;15(2):154
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.
Yao C, Sun J, Luo W, Chen H, Chen T, Chen C, Zhang B, Zhang Y
Bone & joint research 2024 Feb 1;13(2):52-65
Bone & joint research 2024 Feb 1;13(2):52-65
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Mao Y, Zha Y, Zang Y, Gao Y, Sun J, Liu Y, Wang Z, Wei Z, Wang M, Yang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Wang N, Guo W, Liu T, Chen X, Lin M
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway.
Han X, Ding W, Qu G, Li Y, Wang P, Yu J, Liu M, Chen X, Xie S, Feng J, Xu S
Respiratory physiology & neurobiology 2024 Apr;322:104219
Respiratory physiology & neurobiology 2024 Apr;322:104219
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Chen L, Wang J, Ren Y, Ma Y, Liu J, Jiang H, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Zhang ZT, Liang QF, Wang X, Wang RS, Duan TT, Wang SM, Tang D
Journal of ethnopharmacology 2024 Apr 6;323:117647
Journal of ethnopharmacology 2024 Apr 6;323:117647
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Cheng F, Zhang J, Yang P, Chen Z, Fu Y, Mi J, Xie X, Liu S, Sheng Y
Heliyon 2024 Apr 30;10(8):e29162
Heliyon 2024 Apr 30;10(8):e29162
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Xu K, Liu Z, Pan S, Zhang N, Wu S, Yang G, Song X, Teng Y, Tong X
Brain research 2024 Apr 15;1829:148795
Brain research 2024 Apr 15;1829:148795
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
Fan L, Guo Y, Wu Q, Hu T, Chen X, Guo J, Liu Y, Lu Y, Lin M
Evidence-based complementary and alternative medicine : eCAM 2023;2023:6931644
Evidence-based complementary and alternative medicine : eCAM 2023;2023:6931644
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Ning J, Ding J, Wang S, Jiang Y, Wang D, Jiang S
Journal of immunology research 2023;2023:5532617
Journal of immunology research 2023;2023:5532617
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
Gao HT, Yang Z, Sun H, Zhang Y, Wang Z, Liu WY, Wen HZ, Qu CB, Wang XL
American journal of translational research 2023;15(2):779-798
American journal of translational research 2023;15(2):779-798
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Zhu J, Li Z, Yin F, Yu X, Lu Y, Zhou T, Gong F, Xu Z
Frontiers in pharmacology 2023;14:1143096
Frontiers in pharmacology 2023;14:1143096
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation.
Jin YB, Liang XC, Cai JH, Wang K, Wang CY, Wang WH, Chen XL, Bao S
Frontiers in oncology 2023;13:1205604
Frontiers in oncology 2023;13:1205604
Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.
Jia J, He R, Yao Z, Su J, Deng S, Chen K, Yu B
PeerJ 2023;11:e16121
PeerJ 2023;11:e16121
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Tan C, Shi W, Zhang Y, Liu C, Hu T, Chen D, Huang J
Life science alliance 2023 Sep;6(9)
Life science alliance 2023 Sep;6(9)
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039
International journal of biological macromolecules 2023 Sep 30;249:126039
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Chen YX, Yang H, Wang DS, Yao YT, Chen TT, Tao L, Chen Y, Shen XC
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice.
Bo W, Ma Y, Feng L, Yu M, Zhang L, Cai M, Song W, Xi Y, Tian Z
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Sep 1;135(3):696-705
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Sep 1;135(3):696-705
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Li T, Yang S, Liu X, Li Y, Gu Z, Jiang Z
Journal of advanced research 2023 Oct;52:119-134
Journal of advanced research 2023 Oct;52:119-134
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.
Hu D, Mo X, Luo J, Wang F, Huang C, Xie H, Jin L
International immunopharmacology 2023 Oct;123:110698
International immunopharmacology 2023 Oct;123:110698
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Zhang Z, Peng S, Xu T, Liu J, Zhao L, Xu H, Zhang W, Zhu Y, Yang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2302909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2302909
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.
Xu W, Gong J, Chen Y, Chen Y, Chen S, Wu Y, He Y, Li C, Yu H, Xie L
Nutrients 2023 Oct 25;15(21)
Nutrients 2023 Oct 25;15(21)
Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling.
Su L, Wu S, Huang C, Zhuo X, Chen J, Jiang X, Kong X, Lv C, Xu Q, Han P, Huang X, Wong PP
NPJ precision oncology 2023 Oct 11;7(1):102
NPJ precision oncology 2023 Oct 11;7(1):102
Two polysaccharides from Rehmannia glutinosa: isolation, structural characterization, and hypoglycemic activities.
Chen H, Liu X, Xie M, Zhong X, Yan C, Xian M, Wang S
RSC advances 2023 Oct 11;13(43):30190-30201
RSC advances 2023 Oct 11;13(43):30190-30201
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.
Sun S, Xu Y, Yu N, Zhang M, Wang J, Wan D, Tian Z, Zhu H
Molecular neurobiology 2023 Nov;60(11):6227-6247
Molecular neurobiology 2023 Nov;60(11):6227-6247
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Feng HG, Wu CX, Zhong GC, Gong JP, Miao CM, Xiong B
Journal of cancer research and clinical oncology 2023 Nov;149(17):15879-15898
Journal of cancer research and clinical oncology 2023 Nov;149(17):15879-15898
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Zhou W, Kang S, Wang F, Qin Y, Liu J, Xiao X, Chen X, Zhang D
European journal of pharmacology 2023 Nov 5;958:176043
European journal of pharmacology 2023 Nov 5;958:176043
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Cheng H, Sun Y, Yu X, Zhou D, Ding J, Wang S, Ma F
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Li P, Fang X, Hao G, Li X, Cai Y, Yan Y, Zan L, Yang R, Liu B
Metabolites 2023 Nov 14;13(11)
Metabolites 2023 Nov 14;13(11)
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S
Redox biology 2023 May;61:102635
Redox biology 2023 May;61:102635
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Ai Z, Wang M, Zhou Y, Yuan D, Jian Q, Wu S, Liu B, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Qin R, Zheng F, Qin W, Wang J, Ma N, Tian W, Li J, Liao M, Qin A
Reproductive biomedicine online 2023 Mar;46(3):425-435
Reproductive biomedicine online 2023 Mar;46(3):425-435
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Sui X, Sun Y, Zhang G, Chi N, Guan Y, Wang D, Li X
Cancer medicine 2023 Mar;12(5):5874-5888
Cancer medicine 2023 Mar;12(5):5874-5888
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
Zhu Y, Yang J, Li Y, Xu J, Fang Z
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Zhou B, Zhou X, Zhan C, Jin M, Yan S
Journal of endocrinological investigation 2023 Jun;46(6):1115-1130
Journal of endocrinological investigation 2023 Jun;46(6):1115-1130
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Liu Z, Xiang H, Deng Q, Fu W, Li Y, Yu Z, Qiu Y, Mei Z, Xu L
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Guo M, Zhu C, Fu R, Ma X, Duan Z, Fan D
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Meng P, Zhang X, Liu TT, Liu J, Luo Y, Xie MX, Yang H, Fang R, Guo DW, Zhong ZY, Wang YH, Ge JW
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
Wu Q, Cui Z, Jiang S, Xia H, Liu L, You Y, Sun Y
Cell biochemistry and function 2023 Jul;41(5):599-608
Cell biochemistry and function 2023 Jul;41(5):599-608
Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERK pathways.
Fu S, Song X, Hu Y, Zhu Q, Lv X, Tang X, Zhang M
Chinese journal of natural medicines 2023 Jul;21(7):527-539
Chinese journal of natural medicines 2023 Jul;21(7):527-539
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Li D, Xia L, Huang P, Wang Z, Guo Q, Huang C, Leng W, Qin S
Cell & bioscience 2023 Jul 3;13(1):124
Cell & bioscience 2023 Jul 3;13(1):124
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Liu Y, Chen LJ, Li XW, Yang JZ, Liu JL, Zhang KK, Li JH, Wang Q, Xu JT, Zhi X
Chemico-biological interactions 2023 Jul 1;379:110512
Chemico-biological interactions 2023 Jul 1;379:110512
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway.
Li J, Yang B
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):19-30
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):19-30
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
Wang W, Jiang X, Xia F, Chen X, Li G, Liu L, Xu Q, Zhu M, Chen C
Molecular biology reports 2023 Jan;50(1):453-464
Molecular biology reports 2023 Jan;50(1):453-464
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Zhang L, Zhang X, Che D, Zeng L, Zhang Y, Nan K, Zhang X, Zhang H, Guo Z
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury.
Hu Z, Xuan L, Wu T, Jiang N, Liu X, Chang J, Wang T, Han N, Tian X
International immunopharmacology 2023 Jan;114:109616
International immunopharmacology 2023 Jan;114:109616
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Liu H, Yu L, Ding Y, Peng M, Deng Y
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Li D, Xia L, Huang P, Wang Z, Guo Q, Huang C, Leng W, Qin S
Cell death discovery 2023 Jan 21;9(1):17
Cell death discovery 2023 Jan 21;9(1):17
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Xing F, Gao H, Chen G, Sun L, Sun J, Qiao X, Xue J, Liu C
Molecular cancer 2023 Jan 10;22(1):6
Molecular cancer 2023 Jan 10;22(1):6
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Wang L, Chen X, Meng F, Huang T, Wang S, Zheng Z, Zheng G, Li W, Zhang J, Liu Y
Journal of physiology and biochemistry 2023 Feb;79(1):19-34
Journal of physiology and biochemistry 2023 Feb;79(1):19-34
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q
Translational oncology 2023 Feb;28:101614
Translational oncology 2023 Feb;28:101614
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Chen B, Zheng D, Liu C, Bhandari A, Hirachan S, Shen C, Mainali S, Li H, Jiang W, Xu J, Zhang X, Tang K, Zhang W
Pathology, research and practice 2023 Feb;242:154325
Pathology, research and practice 2023 Feb;242:154325
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Hu C, Li S, Fu X, Zhao X, Peng J
Cytokine 2023 Feb;162:156105
Cytokine 2023 Feb;162:156105
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Xu W, Song X, Qu Q, Gong Z, Xiao W
Food & function 2023 Feb 21;14(4):2059-2073
Food & function 2023 Feb 21;14(4):2059-2073
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Li S, Cui Y, Li M, Zhang W, Sun X, Xin Z, Li J
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2154578
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2154578
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Huang Y, Luo W, Chen S, Su H, Zhu W, Wei Y, Qiu Y, Long Y, Shi Y, Wei J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Cao M, Wang J, Jiang X, Sun Z, Zhao L, Chen G
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.
Liu C, Zhao M, Chen J, Xu L, Wang K, Li G
European journal of pharmacology 2023 Dec 5;960:176121
European journal of pharmacology 2023 Dec 5;960:176121
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling.
Zhang Q, Tang X, Zhou Y, Chen X, Peng K, Jiang R, Liu Z, Song X, Xia H
Cancer biology & therapy 2023 Dec 31;24(1):2198904
Cancer biology & therapy 2023 Dec 31;24(1):2198904
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Chen X, Fu K, Lai Y, Dong C, Chen Z, Huang Y, Li G, Jiang R, Wu H, Wang A, Huang S, Shen L, Gao W, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease.
Li F, Peng J, Lu Y, Zhou M, Liang J, Le C, Ding J, Wang J, Dai J, Wan C, Wang J, Luo P, Xia B
International journal of cardiology 2023 Dec 1;392:131303
International journal of cardiology 2023 Dec 1;392:131303
Effects of external environment on promoter methylation of PIK3R5 and related pathway regulation in steroid-induced femoral head necrosis.
Qin W, Jiang M, Lu S, Hu Y, Gan F, Fang W, Chen D, Bo Z
Environmental research 2023 Dec 1;238(Pt 1):117116
Environmental research 2023 Dec 1;238(Pt 1):117116
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
Wu Y, Shi H, Zheng J, Yang Y, Lei X, Qian X, Zhu J
Heliyon 2023 Aug;9(8):e18449
Heliyon 2023 Aug;9(8):e18449
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P
Biochemical genetics 2023 Aug;61(4):1265-1281
Biochemical genetics 2023 Aug;61(4):1265-1281
HnRNP A2/B1 as a potential anti-tumor target for triptolide based on a simplified thermal proteome profiling method using XGBoost.
Chen P, Zhao P, Hu M, Wang L, Lei T, Liu B, Li L, Shi J, Lu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154929
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154929
GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1/PI3K/Akt pathway.
Wang Y, Gao Y, Wang Y, Zhang H, Qin Q, Xu Z, Liu S, Wang X, Qu Y, Liu Y, Jiang X, He H
Cellular signalling 2023 Aug;108:110721
Cellular signalling 2023 Aug;108:110721
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Wang F, Yao W, Yu D, Hao Y, Wu Y, Zhang X
BMC gastroenterology 2023 Aug 11;23(1):276
BMC gastroenterology 2023 Aug 11;23(1):276
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Zhang PP, Zhuo BY, Duan ZW, Li X, Huang SL, Cao Q, Zhao T, Wei SL, Hu XH, Zhang Y
Journal of ethnopharmacology 2023 Aug 10;312:116523
Journal of ethnopharmacology 2023 Aug 10;312:116523
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Shi Y, Zhang ZW, Du MM, Wu J, Li JX
Journal of ethnopharmacology 2023 Aug 10;312:116458
Journal of ethnopharmacology 2023 Aug 10;312:116458
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Feng H, Zhou P, Liu F, Zhang W, Yang H, Li X, Dong J
Environmental science and pollution research international 2023 Apr;30(19):55200-55213
Environmental science and pollution research international 2023 Apr;30(19):55200-55213
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Chen R, Wang Z, Lu T, Liu Y, Ji Y, Yu Y, Tou F, Guo S
Thoracic cancer 2023 Apr;14(10):893-912
Thoracic cancer 2023 Apr;14(10):893-912
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Tian X, Ou G, Hu S, Wang C, Han F, Gao L
Journal of ethnopharmacology 2023 Apr 6;305:116114
Journal of ethnopharmacology 2023 Apr 6;305:116114
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Xiong W, Huang XL, Li CY, Wang XL, Lan HW, Wang TT, Chen ZL, Yang QP, Hu AL, Xia YF, Zhu FR, Zhou ZZ
Folia histochemica et cytobiologica 2022;60(4):323-334
Folia histochemica et cytobiologica 2022;60(4):323-334
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Li W, Zhang H, Zhang L, Zhang T, Ding H
BioMed research international 2022;2022:7709926
BioMed research international 2022;2022:7709926
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Yang Y, Lai Q, Wang C, Zhou G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells.
Liu X, Yang Y, Tang X, Guo L, Tang X, Zhu T, Zhao T, Zhang W, Zhang P
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6517732
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6517732
si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway.
Li Y, Yu H, Ma Q, Wei M, Liu X, Qi Y, Li C, Dong L, Zhang H
Oxidative medicine and cellular longevity 2022;2022:5081439
Oxidative medicine and cellular longevity 2022;2022:5081439
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Lei Y, Chan M, Liu H, Lyu W, Chen L, Zhong Y, Gan H, Wang M, Qi M, Guo Y, Liu J, Zhang E
Disease markers 2022;2022:4399334
Disease markers 2022;2022:4399334
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Zuo X, Shi X, Zhang X, Chen Z, Yang Z, Pan X, Lai R, Zhao Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
The In Vitro Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.
Wu Y, Zhang YZ, Li MJ, Yang WQ, Cheng LF
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1952891
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1952891
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Li J, Yang T, Wang Q, Li Y, Wu H, Zhang M, Qi H, Zhang H, Li J
International journal of biological sciences 2022;18(9):3576-3591
International journal of biological sciences 2022;18(9):3576-3591
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ
Drug design, development and therapy 2022;16:843-861
Drug design, development and therapy 2022;16:843-861
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Shu W, Wang Z, Zhao R, Shi R, Zhang J, Zhang W, Wang H
Drug design, development and therapy 2022;16:1847-1863
Drug design, development and therapy 2022;16:1847-1863
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Wang S, Yang XX, Li TJ, Zhao L, Bao YR, Meng XS
Frontiers in pharmacology 2022;13:999935
Frontiers in pharmacology 2022;13:999935
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
Li Y, Deng Y, Zhang X, Fu H, Han X, Guo W, Zhao W, Zhao X, Yu C, Li H, Lei K, Wang T
Frontiers in pharmacology 2022;13:897465
Frontiers in pharmacology 2022;13:897465
ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways.
Wang X, Zhang L, Feng M, Xu Z, Cheng Z, Qian L
Frontiers in pharmacology 2022;13:873614
Frontiers in pharmacology 2022;13:873614
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Lu X, Yao J, Li C, Cui L, Liu Y, Liu X, Wang G, Dong J, Deng Q, Hu Y, Guo D, Wang W, Li C
Frontiers in pharmacology 2022;13:840521
Frontiers in pharmacology 2022;13:840521
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Dong C, Chen Z, Zhu L, Bsoul N, Wu H, Jiang J, Chen X, Lai Y, Yu G, Gu Y, Guo X, Gao W
Frontiers in pharmacology 2022;13:809034
Frontiers in pharmacology 2022;13:809034
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Yu PC, Liu D, Han ZX, Liang F, Hao CY, Lei YT, Guo CR, Wang WH, Li XH, Yang XN, Li CZ, Yu Y, Fan YZ
Frontiers in pharmacology 2022;13:779715
Frontiers in pharmacology 2022;13:779715
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Yin C, Cai J, Gou Y, Li D, Tang H, Wang L, Liu H, Luo B
Frontiers in immunology 2022;13:1078880
Frontiers in immunology 2022;13:1078880
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers.
Li Z, Pu Z, Yang Z, Zhu Y, Deng Y, Li N, Peng F
Frontiers in oncology 2022;12:971618
Frontiers in oncology 2022;12:971618
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Islam MT, Chen FZ, Chen HC, Wahid A
Frontiers in oncology 2022;12:923270
Frontiers in oncology 2022;12:923270
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
Hu S, Ge M, Zhang S, Jiang M, Hu K, Gao L
Frontiers in oncology 2022;12:854596
Frontiers in oncology 2022;12:854596
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Wang H, Chen Y, Yuan Q, Chen L, Dai P, Li X
Frontiers in oncology 2022;12:1053510
Frontiers in oncology 2022;12:1053510
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Wang X, Jian W, Luo Q, Fang L
Cell death & disease 2022 Sep 17;13(9):794
Cell death & disease 2022 Sep 17;13(9):794
Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data.
Chen X, Zhuang J, Chen Q, Xu L, Yue X, Qiao D
The Science of the total environment 2022 Sep 15;839:155984
The Science of the total environment 2022 Sep 15;839:155984
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
Zhang T, Dong Z, Liu F, Pan E, He N, Ma F, Wang G, Wang Y, Dong J
Ecotoxicology and environmental safety 2022 Sep 15;243:113961
Ecotoxicology and environmental safety 2022 Sep 15;243:113961
Scutellarin-mediated autophagy activates exosome release of rat nucleus pulposus cells by positively regulating Rab8a via the PI3K/PTEN/Akt pathway.
Hu SQ, Zou YP, Jiang YQ, Zhang QC, Cheng HX, Wang HR, Li XL
Cell biology international 2022 Oct;46(10):1588-1603
Cell biology international 2022 Oct;46(10):1588-1603
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Yin L, Feng S, Sun Y, Jiang Y, Tang C, Sun D
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Zheng Z, Lei C, Liu H, Jiang M, Zhou Z, Zhao Y, Yu CY, Wei H
Advanced healthcare materials 2022 Oct;11(19):e2200990
Advanced healthcare materials 2022 Oct;11(19):e2200990
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder.
Paul F, Ng C, Mohamad Sahari UB, Nafissi S, Nilipoor Y, Tavasoli AR, Bonnard C, Wong PM, Nabavizadeh N, Altunoğlu U, Estiar MA, Majoie CB, Lee H, Nelson SF, Gan-Or Z, Rouleau GA, Van Veldhoven PP, Massie R, Hennekam RC, Kariminejad A, Reversade B
Human molecular genetics 2022 Oct 28;31(21):3729-3740
Human molecular genetics 2022 Oct 28;31(21):3729-3740
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
Xu H, Chen G, Niu Q, Song K, Feng Z, Han Z
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring.
Zhou K, Cheng R, Zhu M, Yang M, Shen X, Luo X, Ma L, Xu L, Zhang J
Obesity research & clinical practice 2022 Nov-Dec;16(6):500-506
Obesity research & clinical practice 2022 Nov-Dec;16(6):500-506
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Du X, Zhang X, Dong J, Zou N, Guo D, Yao W, Wang X, Li S, Song C, Yan K, Shen W, Zhu S
Journal of translational medicine 2022 Nov 5;20(1):507
Journal of translational medicine 2022 Nov 5;20(1):507
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
He H, Deng J, Yang M, An L, Ye X, Li X
Journal of ethnopharmacology 2022 Nov 15;298:115529
Journal of ethnopharmacology 2022 Nov 15;298:115529
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Zhang Y, Wei Y, Jiang S, Dang Y, Yang Y, Zuo W, Zhu Q, Liu P, Gao Y, Lu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Tian K, Du G, Wang X, Wu X, Li L, Liu W, Wu R
Molecular biology reports 2022 May;49(5):3469-3480
Molecular biology reports 2022 May;49(5):3469-3480
Selenium protects against cadmium-induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling.
Feng J, Yang F, Wu H, Xing C, Xue H, Zhang L, Zhang C, Hu G, Cao H
Environmental toxicology 2022 May;37(5):1185-1197
Environmental toxicology 2022 May;37(5):1185-1197
Anti-fatigue effects of fermented soybean protein peptides in mice.
Fang L, Zhang RX, Wei Y, Ling K, Lu L, Wang J, Pan XC, Cai MY
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H
World journal of gastroenterology 2022 May 7;28(17):1781-1797
World journal of gastroenterology 2022 May 7;28(17):1781-1797
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
Yang G, Lu S, Jiang J, Weng J, Zeng X
International journal of molecular sciences 2022 May 27;23(11)
International journal of molecular sciences 2022 May 27;23(11)
Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway.
Wang F, Zeng Y, Liu X, Cao J, Kang S, Zhou W, Chen X, Liu J, Zhang D
Biochemical and biophysical research communications 2022 May 21;605:162-170
Biochemical and biophysical research communications 2022 May 21;605:162-170
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production.
Fang J, Li M, Zhang G, Du G, Zhou J, Guan X, Chen J
Food & function 2022 May 10;13(9):5089-5101
Food & function 2022 May 10;13(9):5089-5101
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Tu Y, Tan L, Lu T, Wang K, Wang H, Han B, Zhao Y, Chen H, Li Y, Chen H, Chen M, He C
Biochemical pharmacology 2022 Mar;197:114912
Biochemical pharmacology 2022 Mar;197:114912
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Zhang J, Shang L, Jiang W, Wu W
Bioengineered 2022 Mar;13(3):7904-7918
Bioengineered 2022 Mar;13(3):7904-7918
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Huang H, Chen J, Hu X, Chen Y, Xie J, Ao T, Wang H, Xie J, Yu Q
Food & function 2022 Mar 7;13(5):2710-2728
Food & function 2022 Mar 7;13(5):2710-2728
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
Zhao N, Yu H, Xi Y, Dong M, Wang Y, Sun C, Zhang J, Xu N, Liu W
Toxicon : official journal of the International Society on Toxinology 2022 Jun;212:11-18
Toxicon : official journal of the International Society on Toxinology 2022 Jun;212:11-18
The crucial role of thioredoxin interacting protein in the liver insulin resistance induced by di (2-ethylhexyl) phthalates.
Zhang W, Xu P, Li JY
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113045
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113045
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Wu L, Yang FR, Xing ML, Lu SF, Chen HL, Yang QW, Zhang YT, Lu Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
Qiao D, Xing J, Duan Y, Wang S, Yao G, Zhang S, Jin J, Lin Z, Chen L, Piao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154046
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154046
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W
Cells 2022 Jun 14;11(12)
Cells 2022 Jun 14;11(12)
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Niu Z, Lin J, Hao C, Xu X, Wang C, Dai K, Deng X, Deng M, Guo Y, Yao W
International journal of environmental research and public health 2022 Jul 18;19(14)
International journal of environmental research and public health 2022 Jul 18;19(14)
Chronic vitamin D(3) supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Lin J, Niu Z, Xue Y, Gao J, Zhang M, Li M, Peng Y, Zhang S, Li W, Zhang Q, Li X
Neuroscience letters 2022 Jul 13;783:136725
Neuroscience letters 2022 Jul 13;783:136725
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Liu R, Cai D, Li X, Liu B, Chen J, Jiang X, Li H, Li Z, Teerds K, Sun J, Bai W, Jin Y
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Zhou YH, Tang YZ, Guo LY, Zheng LL, Zhang D, Yang CY, Wang W
Microvascular research 2022 Jan;139:104252
Microvascular research 2022 Jan;139:104252
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Liu X, Yang Y, Song J, Li D, Liu X, Li C, Ma Z, Zhong J, Wang L
Bioengineered 2022 Jan;13(1):1320-1334
Bioengineered 2022 Jan;13(1):1320-1334
Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway.
Cheng X, Cao Z, Luo J, Hu R, Cao H, Guo X, Xing C, Yang F, Zhuang Y, Hu G
Poultry science 2022 Jan;101(1):101572
Poultry science 2022 Jan;101(1):101572
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Xu Y, Tang Z, Dai H, Hou J, Li F, Tang Z, Zhang D
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Zheng P, Huang Z, Tong DC, Zhou Q, Tian S, Chen BW, Ning DM, Guo YM, Zhu WH, Long Y, Xiao W, Deng Z, Lei YC, Tian XF
World journal of gastrointestinal oncology 2022 Feb 15;14(2):450-477
World journal of gastrointestinal oncology 2022 Feb 15;14(2):450-477
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Song JX, Zhao YS, Zhen YQ, Yang XY, Chen Q, An JR, Ji ES
Pharmaceutical biology 2022 Dec;60(1):609-620
Pharmaceutical biology 2022 Dec;60(1):609-620
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Zhao Y, Xie Y, Li X, Song J, Guo M, Xian D, Zhong J
Redox report : communications in free radical research 2022 Dec;27(1):200-211
Redox report : communications in free radical research 2022 Dec;27(1):200-211
Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis.
Han H, Qian C, Zong G, Liu H, Wang F, Tao R, Cheng P, Wei Z, Zhao Y, Lu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113897
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Varier KM, Dan G, Liu W, Wu G, Xiao C, Lei H, Ling T, Jiang Y, Chen Y, Ben-David Y, Li Y, Zhang N, Gajendran B, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122
Molecular immunology 2022 Dec;152:111-122
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Sun Y, Li H, Liu L, Bai X, Wu L, Shan J, Sun X, Wang Q, Guo Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
Shen T, Li Y, Wang D, Su Y, Li G, Shang Z, Niu Y, Tan X
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166540
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166540
HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma.
Han N, Li X, Wang Y, Li H, Zhang C, Zhao X, Zhang Z, Ruan M, Zhang C
Oral oncology 2022 Aug;131:105940
Oral oncology 2022 Aug;131:105940
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Huang W, Wen F, Gu P, Liu J, Xia Y, Li Y, Zhou J, Song S, Ruan S, Gu S, Chen X, Shu P
Chinese medicine 2022 Aug 9;17(1):93
Chinese medicine 2022 Aug 9;17(1):93
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Sokouti H, Mohajeri D, Nourazar MA
Physiological research 2022 Aug 31;71(4):551-560
Physiological research 2022 Aug 31;71(4):551-560
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Zhao X, Sun W, Guo B, Cui L
Stem cell research & therapy 2022 Aug 13;13(1):417
Stem cell research & therapy 2022 Aug 13;13(1):417
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Wang Z, Liang M, Li H, Liu B, Yang L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Aihaiti Y, Tuerhong X, Zheng H, Cai Y, Yang M, Xu P
Clinical immunology (Orlando, Fla.) 2022 Apr;237:108964
Clinical immunology (Orlando, Fla.) 2022 Apr;237:108964
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Liu W, Feng Y, Wang X, Ding J, Li H, Guan H, Chen Z
Bioengineered 2022 Apr;13(4):8850-8865
Bioengineered 2022 Apr;13(4):8850-8865
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Li Y, Sun Y, Zhang Q, Liu Y, Niu Y, Li X, Cai D
Journal of ethnopharmacology 2022 Apr 6;287:114937
Journal of ethnopharmacology 2022 Apr 6;287:114937
Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation.
Wang K, Qian R, Li H, Wang C, Ding Y, Gao Z
ACS omega 2022 Apr 5;7(13):11166-11176
ACS omega 2022 Apr 5;7(13):11166-11176
Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 Administration.
Li Y, Lin M, Lin P, Xia N, Li X, Lin L, Yang Y
Frontiers in cell and developmental biology 2021;9:731698
Frontiers in cell and developmental biology 2021;9:731698
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Hua L, Zhou Y, Hou C, Chen J, Wang Y, Zhang S, Zhou H, He S, Jia E
Frontiers in cardiovascular medicine 2021;8:700630
Frontiers in cardiovascular medicine 2021;8:700630
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Qiao D, Jin J, Xing J, Zhang Y, Jia N, Ren X, Lin Z, Jin N, Chen L, Piao Y
The American journal of Chinese medicine 2021;49(2):525-541
The American journal of Chinese medicine 2021;49(2):525-541
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Zhang Y, Chen G, Zhuang X, Guo M
Oxidative medicine and cellular longevity 2021;2021:8807676
Oxidative medicine and cellular longevity 2021;2021:8807676
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
Wang K, Miao X, Kong F, Huang S, Mo J, Jin C, Zheng Y
Drug design, development and therapy 2021;15:3749-3764
Drug design, development and therapy 2021;15:3749-3764
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Deng L, Wu X, Zhu X, Yu Z, Liu Z, Wang J, Zheng Y
American journal of translational research 2021;13(1):57-72
American journal of translational research 2021;13(1):57-72
Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism.
Yang Y, Wang Z, Yao M, Xiong W, Wang J, Fang Y, Yang W, Jiang H, Song N, Liu L, Qian J
Frontiers in pharmacology 2021;12:766024
Frontiers in pharmacology 2021;12:766024
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Yu HX, Lin W, Yang K, Wei LJ, Chen JL, Liu XY, Zhong K, Chen X, Pei M, Yang HT
Frontiers in pharmacology 2021;12:741801
Frontiers in pharmacology 2021;12:741801
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Zeng T, Cao Y, Gu T, Chen L, Tian Y, Li G, Shen J, Tao Z, Lu L
Frontiers in genetics 2021;12:693780
Frontiers in genetics 2021;12:693780
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Luo LF, Qin LY, Wang JX, Guan P, Wang N, Ji ES
Frontiers in pharmacology 2021;12:669782
Frontiers in pharmacology 2021;12:669782
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
Liu X, Fan Y, Du L, Mei Z, Fu Y
Frontiers in pharmacology 2021;12:665102
Frontiers in pharmacology 2021;12:665102
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway.
Liu L, Yan M, Yang R, Qin X, Chen L, Li L, Si J, Li X, Ma K
Frontiers in pharmacology 2021;12:644225
Frontiers in pharmacology 2021;12:644225
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184
Frontiers in oncology 2021;11:661184
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
Liu H, Liu C, Wang M, Sun D, Zhu P, Zhang P, Tan X, Shi G
Scientific reports 2021 Sep 29;11(1):19268
Scientific reports 2021 Sep 29;11(1):19268
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Hu B, Qin C, Li L, Wei L, Mo X, Fan H, Lei Y, Wei F, Zou D
Cancer cell international 2021 Sep 23;21(1):509
Cancer cell international 2021 Sep 23;21(1):509
Dandelion root extract affects ESCC progression via regulating multiple signal pathways.
Duan X, Pan L, Deng Y, Liu Y, Han X, Fu H, Li Y, Li M, Wang T
Food & function 2021 Oct 4;12(19):9486-9502
Food & function 2021 Oct 4;12(19):9486-9502
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M
European journal of medicinal chemistry 2021 Oct 15;222:113573
European journal of medicinal chemistry 2021 Oct 15;222:113573
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
NLRP3 promotes endometrial receptivity by inducing epithelial-mesenchymal transition of the endometrial epithelium.
Cheng X, Zhang Y, Ma J, Wang S, Ma R, Ge X, Zhao W, Xue T, Chen L, Yao B
Molecular human reproduction 2021 Nov 2;27(11)
Molecular human reproduction 2021 Nov 2;27(11)
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.
Xue YY, Lu YY, Sun GQ, Fang F, Ji YQ, Tang HF, Qiu PC, Cheng G
Die Pharmazie 2021 May 1;76(5):208-214
Die Pharmazie 2021 May 1;76(5):208-214
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Liu Q, Hao Y, Du R, Hu D, Xie J, Zhang J, Deng G, Liang N, Tian T, Käsmann L, Rades D, Rim CH, Hu P, Zhang J
Translational lung cancer research 2021 Mar;10(3):1424-1443
Translational lung cancer research 2021 Mar;10(3):1424-1443
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Xin C, Zhao M, Wang J, Wang Z
Journal of food biochemistry 2021 Jul;45(7):e13771
Journal of food biochemistry 2021 Jul;45(7):e13771
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Du W, Gao A, Herman JG, Wang L, Zhang L, Jiao S, Guo M
Cancer science 2021 Jul;112(7):2870-2883
Cancer science 2021 Jul;112(7):2870-2883
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
Jing F, Zou Q, Wang Y, Cai Z, Tang Y
The journal of headache and pain 2021 Jul 29;22(1):86
The journal of headache and pain 2021 Jul 29;22(1):86
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Huang F, Zhu P, Wang J, Chen J, Lin W
Pediatric research 2021 Jan;89(1):143-149
Pediatric research 2021 Jan;89(1):143-149
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Zhang L, Zhou S, Zhou T, Yuan K, Li X, Tang J
Oncology reports 2021 Jan;45(1):151-158
Oncology reports 2021 Jan;45(1):151-158
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Liu Y, Zhu D, Dong G, Zeng Y, Jiang P, Xiao Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 Feb;30(2):157-163
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 Feb;30(2):157-163
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
Ha M, Huang X, Li L, Lu D, Liu C
The Science of the total environment 2021 Feb 25;757:143727
The Science of the total environment 2021 Feb 25;757:143727
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
Lv S, Yuan P, Lu C, Dong J, Li M, Qu F, Zhu Y, Zhang J
Aging 2021 Feb 11;13(4):5525-5538
Aging 2021 Feb 11;13(4):5525-5538
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Hou Y, Li FZ
European review for medical and pharmacological sciences 2021 Dec;25(24):7668-7678
European review for medical and pharmacological sciences 2021 Dec;25(24):7668-7678
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Chen X, Tang H, Liang Y, Wu P, Xie L, Ding Y, Yang P, Long B, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma.
Qian Y, Shanbo M, Shaojie H, Long L, Yuhan C, Jin W, Shan M, Xiao-Peng S
Journal of ethnopharmacology 2021 Dec 5;281:114513
Journal of ethnopharmacology 2021 Dec 5;281:114513
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Ji K, Liang H, Ren M, Ge X, Pan L, Yu H
Scientific reports 2021 Dec 13;11(1):23843
Scientific reports 2021 Dec 13;11(1):23843
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Chen X, Zhang W, Xu X
World journal of surgical oncology 2021 Aug 6;19(1):232
World journal of surgical oncology 2021 Aug 6;19(1):232
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
Liao Y, Xu J, Qin B, Shi J, Qin C, Xie F, Ou S, Tang J, Wang W, Wu F, Bai L
Free radical biology & medicine 2021 Aug 20;172:33-47
Free radical biology & medicine 2021 Aug 20;172:33-47
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Jiang X, Wang J, Chen P, He Z, Xu J, Chen Y, Liu X, Jiang J
Cancer cell international 2021 Aug 10;21(1):420
Cancer cell international 2021 Aug 10;21(1):420
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Sun CC, Zhou ZQ, Chen ZL, Zhu RK, Yang D, Peng XY, Zheng L, Tang CF
Biology 2021 Aug 10;10(8)
Biology 2021 Aug 10;10(8)
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Liu J, Han YS, Liu L, Tang L, Yang H, Meng P, Zhao HQ, Wang YH
Neural regeneration research 2021 Apr;16(4):727-733
Neural regeneration research 2021 Apr;16(4):727-733
LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
Zhao WJ, Zhu LL, Yang WQ, Xu SJ, Chen J, Ding XF, Liang Y, Chen G
Cancer science 2021 Apr;112(4):1624-1632
Cancer science 2021 Apr;112(4):1624-1632
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
Xie Y, Zhou X, Li J, Yao XC, Liu WL, Kang FH, Zou ZX, Xu KP, Xu PS, Tan GS
Bioorganic chemistry 2021 Apr;109:104744
Bioorganic chemistry 2021 Apr;109:104744
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
Liu Y, Wang L, Zhang X, Deng Y, Pan L, Li H, Shi X, Wang T
Scientific reports 2021 Apr 26;11(1):8963
Scientific reports 2021 Apr 26;11(1):8963
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Wang Y, Zhao H, Liu Y, Li J, Nie X, Huang P, Xing M
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Chen X, Deng S, Lei Q, He Q, Ren Y, Zhang Y, Nie J, Lu W
Frontiers in cell and developmental biology 2020;8:598020
Frontiers in cell and developmental biology 2020;8:598020
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
Han S, Li X, Liu J, Zou Z, Luo L, Wu R, Zhao Z, Wang C, Shen B
Frontiers in veterinary science 2020;7:529
Frontiers in veterinary science 2020;7:529
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
Li R, Liu W, Ou L, Gao F, Li M, Wang L, Wei P, Miao F
BioMed research international 2020;2020:1562915
BioMed research international 2020;2020:1562915
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
Li L, Li X, Zhang Z, Liu L, Liu T, Li S, Liu S, Zhou Y, Liu F
Current molecular medicine 2020;20(5):396-406
Current molecular medicine 2020;20(5):396-406
Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression.
Du Z, Yin S, Song X, Zhang L, Yue S, Jia X, Zhang Y
Frontiers in molecular neuroscience 2020;13:71
Frontiers in molecular neuroscience 2020;13:71
LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis.
Ma F, Wang Z, Qiang Y, Xu L, Ding P, Wang Y, Ma X
OncoTargets and therapy 2020;13:10221-10230
OncoTargets and therapy 2020;13:10221-10230
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Shi Y, Zhuang Y, Zhang J, Chen M, Wu S
Cancer management and research 2020;12:13173-13184
Cancer management and research 2020;12:13173-13184
Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway.
Chen X, Li S, Li D, Li M, Su Z, Lai X, Zhou C, Chen S, Li S, Yang X, Su J, Zhang Y
Frontiers in pharmacology 2020;11:606
Frontiers in pharmacology 2020;11:606
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Luo H, Peng F, Weng B, Tang X, Chen Y, Yang A, Chen B, Ran M
Frontiers in genetics 2020;11:581593
Frontiers in genetics 2020;11:581593
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Zhou S, Ai Z, Li W, You P, Wu C, Li L, Hu Y, Ba Y
Frontiers in pharmacology 2020;11:425
Frontiers in pharmacology 2020;11:425
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Xu HX, Lin SX, Gong Y, Huo ZX, Zhao CY, Zhu HM, Xi SY
Frontiers in pharmacology 2020;11:245
Frontiers in pharmacology 2020;11:245
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, Zhang N, Qiu F
Journal of ethnopharmacology 2020 Sep 15;259:113015
Journal of ethnopharmacology 2020 Sep 15;259:113015
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Li Y, Zhang M, Li F
Histology and histopathology 2020 Oct;35(10):1171-1180
Histology and histopathology 2020 Oct;35(10):1171-1180
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Wu X, Yu H, Zhou H, Li Z, Huang H, Xiao F, Xu S, Yang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure.
Tan C, Song M, Stamer WD, Qiao Y, Chen X, Sun X, Lei Y, Chen J
Experimental eye research 2020 Nov;200:108197
Experimental eye research 2020 Nov;200:108197
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Li T, Zhang L, Jin C, Xiong Y, Cheng YY, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Velvet antler polypeptide prevents the disruption of hepatic tight junctions via inhibiting oxidative stress in cholestatic mice and liver cell lines.
Li L, Yang F, Jia R, Yan P, Ma L
Food & function 2020 Nov 18;11(11):9752-9763
Food & function 2020 Nov 18;11(11):9752-9763
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X
Life sciences 2020 Nov 1;260:118413
Life sciences 2020 Nov 1;260:118413
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Zhang M, Li F, Wang X, Gong J, Xian Y, Wang G, Zheng Z, Shang C, Wang B, He Y, Wang W, Lin R
Histochemistry and cell biology 2020 May;153(5):357-366
Histochemistry and cell biology 2020 May;153(5):357-366
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
Tan XH, Zhang KK, Xu JT, Qu D, Chen LJ, Li JH, Wang Q, Wang HJ, Xie XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Tang W, Wang D, Shao L, Liu X, Zheng J, Xue Y, Ruan X, Yang C, Liu L, Ma J, Li Z, Liu Y
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
Xu M, Yu X, Meng X, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, Wang T, Chen Z, Fan Y, Liang D, Meng Q
Molecular carcinogenesis 2020 Jun;59(6):575-589
Molecular carcinogenesis 2020 Jun;59(6):575-589
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Zhang Y, Chen L, Cao Y, Chen S, Xu C, Xing J, Zhang K
Journal of gastric cancer 2020 Jun;20(2):139-151
Journal of gastric cancer 2020 Jun;20(2):139-151
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Han B, Jiang L, Jiang P, Zhou D, Jia X, Li X, Ye X
Planta medica 2020 Jul;86(11):767-775
Planta medica 2020 Jul;86(11):767-775
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Chen Y, Cao W, Wang L, Zhong T
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Zhang L, Wu M, Zhu L, Liu S, Zhao D
Journal of ethnopharmacology 2020 Jul 15;257:112796
Journal of ethnopharmacology 2020 Jul 15;257:112796
Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.
Liu P, Zhu C, Luo J, Lan S, Su D, Wang Q, Wei Z, Cui W, Xu C, Yang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1481-1496
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1481-1496
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Li W, Jiang YH, Wang Y, Zhao M, Hou GJ, Hu HZ, Zhou L
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164
Food & function 2020 Jan 29;11(1):1155-1164
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Liu Y, Fan D
Nutrients 2020 Jan 18;12(1)
Nutrients 2020 Jan 18;12(1)
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Ma M, Wang C, Ao Y, He N, Hao F, Liang H, Liu D
Molecular and cellular probes 2020 Feb;49:101491
Molecular and cellular probes 2020 Feb;49:101491
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Wang Y, Zhao H, Guo M, Fei D, Zhang L, Xing M
Journal of hazardous materials 2020 Feb 5;383:121217
Journal of hazardous materials 2020 Feb 5;383:121217
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Liu Y, Zhang M, He T, Yang W, Wang L, Zhang L, Guo M
Clinical epigenetics 2020 Feb 10;12(1):22
Clinical epigenetics 2020 Feb 10;12(1):22
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Zeng Q, Zeng Y, Nie X, Guo Y, Zhan Y
Planta medica 2020 Dec;86(18):1401-1410
Planta medica 2020 Dec;86(18):1401-1410
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Zhang M, Li F, Pokharel S, Ma T, Wang X, Wang Y, Wang W, Lin R
Journal of molecular histology 2020 Dec;51(6):629-637
Journal of molecular histology 2020 Dec;51(6):629-637
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Zhao J, Han Y, Wang Z, Zhang R, Wang G, Mao Y
Biotechnology letters 2020 Dec;42(12):2749-2758
Biotechnology letters 2020 Dec;42(12):2749-2758
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Wang Y, Zhao H, Nie X, Guo M, Jiang G, Xing M
Environmental research 2020 Dec;191:110063
Environmental research 2020 Dec;191:110063
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Qiu C, Su W, Shen N, Qi X, Wu X, Wang K, Li L, Guo Z, Tao H, Wang G, Chen B, Xiang H
BMC cancer 2020 Dec 3;20(1):1187
BMC cancer 2020 Dec 3;20(1):1187
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Zhao Y, Lin Z, Lin Z, Zhou C, Liu G, Lin J, Zhang D, Lin D
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
He W, Zhang J, Liu B, Liu X, Liu G, Xie L, He J, Wei M, Li K, Ma J, Dong R, Ma D, Dong K, Ye M
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Xiao S, Li S, Yuan Z, Zhou L
Annals of translational medicine 2020 Aug;8(15):937
Annals of translational medicine 2020 Aug;8(15):937
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y, Yu J
Life sciences 2020 Aug 1;254:116444
Life sciences 2020 Aug 1;254:116444
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Bu T, Wang C, Jin H, Meng Q, Huo X, Sun H, Sun P, Wu J, Ma X, Liu Z, Liu K
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Li Y, Guo Y, Feng Z, Bergan R, Li B, Qin Y, Zhao L, Zhang Z, Shi M
Nutrition and cancer 2019;71(6):1007-1018
Nutrition and cancer 2019;71(6):1007-1018
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Huang F, Chen J, Wang J, Zhu P, Lin W
BioMed research international 2019;2019:8171989
BioMed research international 2019;2019:8171989
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Zhang D, Ren L, Zhao M, Yang C, Liu X, Zhang H, Jiang Y, Sun X, Li T, Cui L, Hu X
Frontiers in immunology 2019;10:1550
Frontiers in immunology 2019;10:1550
Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice.
Wang F, Lei X, Zhao Y, Yu Q, Li Q, Zhao H, Pei Z
Experimental and therapeutic medicine 2019 Sep;18(3):1985-1992
Experimental and therapeutic medicine 2019 Sep;18(3):1985-1992
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, Zhao H, Ke J, Wu S, Wang X, Wu F
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Guan P, Sun ZM, Wang N, Zhou J, Luo LF, Zhao YS, Ji ES
Life sciences 2019 Sep 15;233:116748
Life sciences 2019 Sep 15;233:116748
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Zhao H, Wang Y, Fei D, Guo M, Yang X, Mu M, Yu H, Xing M
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Zheng R, Huang S, Zhu J, Lin W, Xu H, Zheng X
Cell and tissue research 2019 Oct;378(1):113-125
Cell and tissue research 2019 Oct;378(1):113-125
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Zhao H, Wang Y, Liu J, Guo M, Fei D, Yu H, Xing M
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Wang Y, He G, Wang F, Zhang C, Ge Z, Zheng X, Deng H, Yuan C, Zhou B, Tao X, Zhang J, Tang K
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Pharmacological actions of neferine in the modulation of human platelet function.
Yang RP, Zhou YJ, Song W, Yin Z, He AD, Ming ZY
European journal of pharmacology 2019 Nov 5;862:172626
European journal of pharmacology 2019 Nov 5;862:172626
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
Wu YJ, Lin SH, Din ZH, Su JH, Liu CI
Marine drugs 2019 Nov 27;17(12)
Marine drugs 2019 Nov 27;17(12)
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Xie L, Dai H, Li M, Yang W, Yu G, Wang X, Wang P, Liu W, Hu X, Zhao M
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux.
Ren Z, Xiao W, Zeng Y, Liu MH, Li GH, Tang ZH, Qu SL, Hao YM, Yuan HQ, Jiang ZS
International journal of molecular medicine 2019 Mar;43(3):1321-1330
International journal of molecular medicine 2019 Mar;43(3):1321-1330
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
Zhou T, Sun Y, Wang Y, Chen X, Zhuo L, Bu L, Xu S, Han J, Li X, Shi J
Inflammation 2019 Jun;42(3):987-993
Inflammation 2019 Jun;42(3):987-993
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Liao Y, Liang X, Liang W, Li Z, Wang Y, Wang L, Zhen S, Tang B, Wang Z
Oncology letters 2019 Jun;17(6):5159-5168
Oncology letters 2019 Jun;17(6):5159-5168
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Xie L, Li M, Liu D, Wang X, Wang P, Dai H, Yang W, Liu W, Hu X, Zhao M
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Zhu BL, Long Y, Luo W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ, Wang XF, Sun F, Chen GJ
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, Zhao X
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
He S, Yu Q, He Y, Hu R, Xia S, He J
Poultry science 2019 Dec 1;98(12):6378-6387
Poultry science 2019 Dec 1;98(12):6378-6387
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Wu XT, Ansari AR, Pang XX, Li HZ, Zhang ZW, Luo Y, Arshad M, Song H
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Wang L, Shi H, Liu Y, Zhang W, Duan X, Li M, Shi X, Wang T
International journal of oncology 2019 Aug;55(2):473-487
International journal of oncology 2019 Aug;55(2):473-487
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation.
Zhang B, Liu P, Zhou Y, Chen Z, He Y, Mo M, Dai G, Xia W, Du Y, Liu Y, Chen X
Life sciences 2019 Apr 15;223:29-37
Life sciences 2019 Apr 15;223:29-37
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Jiang T, Zhou ML, Fan J
OncoTargets and therapy 2018;11:7865-7872
OncoTargets and therapy 2018;11:7865-7872
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):3013-3021
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):3013-3021
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Zou W, Ding F, Niu C, Fu Z, Liu S
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
Guo S, Liang X, Guo M, Zhang X, Li Z
International journal of biological macromolecules 2018 Nov;119:669-676
International journal of biological macromolecules 2018 Nov;119:669-676
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729
Molecular medicine reports 2018 Jun;17(6):7721-7729
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Feng J, Niu P, Chen K, Wu L, Liu T, Xu S, Li J, Li S, Wang W, Lu X, Yu Q, Liu N, Xu L, Wang F, Dai W, Xia Y, Fan X, Guo C
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X, Zhan Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
Deng T, Zhang Y, Wu Y, Ma P, Duan J, Qin W, Yang X, Chen M
Toxicology letters 2018 Jun 15;290:1-9
Toxicology letters 2018 Jun 15;290:1-9
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Sun S, Wu Y, Guo W, Yu F, Kong L, Ren Y, Wang Y, Yao X, Jing C, Zhang C, Liu M, Zhang Y, Zhao M, Li Z, Wu C, Qiao Y, Yang J, Wang X, Zhang L, Li M, Zhou X
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jun 1;24(11):2665-2677
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jun 1;24(11):2665-2677
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, Xue Y, Xing M
Journal of inorganic biochemistry 2018 Jan;178:54-62
Journal of inorganic biochemistry 2018 Jan;178:54-62
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, Li Z, Ye X, Li X
Life sciences 2018 Jan 1;192:259-269
Life sciences 2018 Jan 1;192:259-269
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Yin N, Wang Y, Lu X, Liu R, Zhang L, Zhao W, Yuan W, Luo Q, Wu H, Luan X, Zhang H
Stem cell research & therapy 2018 Feb 14;9(1):37
Stem cell research & therapy 2018 Feb 14;9(1):37
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Cen B, Wei Y, Huang W, Teng M, He S, Li J, Wang W, He G, Bai X, Liu X, Yuan Y, Pan X, Ji A
Molecular therapy. Nucleic acids 2018 Dec 7;13:220-232
Molecular therapy. Nucleic acids 2018 Dec 7;13:220-232
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Sun D, Zhang F, Qian J, Shen W, Fan H, Tan J, Li L, Xu C, Yang Y, Cheng H
Chemico-biological interactions 2018 Dec 25;296:26-33
Chemico-biological interactions 2018 Dec 25;296:26-33
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Zhang H, Cao Y, Chen Y, Li G, Yu H
Oncology letters 2018 Apr;15(4):5739-5743
Oncology letters 2018 Apr;15(4):5739-5743
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Lou J, Teng Z, Zhang L, Yang J, Ma L, Wang F, Tian X, An R, Yang M, Zhang Q, Xu L, Dong Z
Frontiers in pharmacology 2017;8:2
Frontiers in pharmacology 2017;8:2
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, Sun H, Peng J
Frontiers in pharmacology 2017;8:120
Frontiers in pharmacology 2017;8:120
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, Li Z, Liu Y
Frontiers in molecular neuroscience 2017;10:68
Frontiers in molecular neuroscience 2017;10:68
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Xu S, Wu L, Zhang Q, Feng J, Li S, Li J, Liu T, Mo W, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Life sciences 2017 Sep 15;185:103-113
Life sciences 2017 Sep 15;185:103-113
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
Ren K, Lu YJ, Mo ZC, -Liu X, Tang ZL, Jiang Y, Peng XS, Li L, Zhang QH, Yi GH
Journal of physiology and biochemistry 2017 May;73(2):287-296
Journal of physiology and biochemistry 2017 May;73(2):287-296
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Wang LL, Xiu YL, Chen X, Sun KX, Chen S, Wu DD, Liu BL, Zhao Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Yin K, Zhu R, Wang S, Zhao RC
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MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
Yang YL, Wang FS, Li SC, Tiao MM, Huang YH
International journal of molecular sciences 2017 Jan 18;18(1)
International journal of molecular sciences 2017 Jan 18;18(1)
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, Ye X, Li X
Scientific reports 2017 Feb 6;7:38524
Scientific reports 2017 Feb 6;7:38524
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Sun KX, Wu DD, Chen S, Zhao Y, Zong ZH
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Scientific reports 2017 Aug 24;7(1):9289
Scientific reports 2017 Aug 24;7(1):9289
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
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Lab on a chip 2016 Aug 7;16(15):2911-20
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
Wu DM, Zhang P, Liu RY, Sang YX, Zhou C, Xu GC, Yang JL, Tong AP, Wang CT
FEBS letters 2014 May 21;588(10):1921-9
FEBS letters 2014 May 21;588(10):1921-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 20584-1-AP(PIK3CB antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PIK3CB antibody 20584-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
