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- Product number
- 20584-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20584-1-AP, RRID:AB_10734439
- Product name
- PI3 Kinase p110 Beta antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PI3 Kinase p110 Beta antibody (Cat. #20584-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Zengwei Chengqi Decoction Reduces Inflammation in Acute Intestinal Obstruction.
Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.
Gastrodia elata fermentation alleviates methamphetamine-induced neuroinflammation and anxiety- and depression-like behaviors by regulating the PI3K-AKT signaling pathway.
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.
IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8(+) T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression.
Taohong siwu decoction alleviates hand-foot skin reaction by regulating RAGE-mediated keratinocyte apoptosis and autophagy.
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments.
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.
Multiscale analysis of resolvin D1 biosynthesis and its neuroprotective role in intracerebral hemorrhage.
Novel Ce/Cu-modified black ceramics disrupted mitochondrial dysfunction and tricarboxylic acid cycle to induce cuproptosis in osteosarcoma cells.
Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway.
Fasting-induced physiological remodeling alleviated fatty liver in laying hens through regulating hepatic lipid metabolism.
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Resveratrol triggers autophagy-dependent apoptosis via suppressing the PI3K/AKT/mTOR pathway in Chlamydia psittaci-infected cells.
Dimethyl bisphenolate inhibits ovarian cancer growth by regulating the PI3K/AKT/mTOR signaling pathway.
Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progression.
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Linoleic acid promotes osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates ovariectomy (OVX)-induced osteoporosis in mice through the PI3K/AKT pathway.
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex.
Identifying C1orf122 as a potential HCC exacerbated biomarker dependently of SRPK1 regulates PI3K/AKT/GSK3β signaling pathway.
Mechanistic insights into myricetin-regulated autophagy via the PI3K/Akt and PINK1/Parkin pathway in diabetic kidney disease treatment.
Poria cocos Attenuates LPS/D-Galactosamine-Induced Acute Liver Failure in Rats: An Integrative Exploratory Study Combining Network Pharmacology and In Vivo Validation.
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.
Role of gut microbiota in lead-induced neural damage in diabetic mice.
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway.
Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration.
Exploring the mechanism of the Lianshi Jianpi formula in treating impaired glucose tolerance: a network pharmacology, molecular docking, and experimental validation study.
Identification of a Potential Biomarker PDGFRA for Endometriosis Based on Comprehensive Analysis of Multiple Omics Data.
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Construction of Curcumin-Loaded Mesenchymal Stem Cell-Derived Exosomes and Their Mechanism in Inhibiting Pyroptosis During Hepatic Ischemia-Reperfusion Injury.
Piperlongumine Inhibits Malignant Progression of Esophageal Squamous Cells Through the PI3K/AKT Signaling Pathway.
Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells.
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect.
HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke.
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Tongnao Decoction Exerts a Treatment Effect on Ischemic Stroke by IL-6/PI3K/Akt/GSK-3β Pathway: Based on the Network Pharmacology and Molecular Docking.
Mettl3-Mediated m6A Methylation of Pdgfrb Regulates the Angiogenesis-Dependent Bone Formation.
Structural characterization and hypoglycemic mechanisms of a Hericium coralloides heteropolysaccharide (HCP-2b) via gut microbiota modulation and PI3K/Akt signaling.
Wenweishu Granule Plays a Protective Role against Stress-Induced Gastric Ulcers by Inhibiting the PI3K/AKT Signaling Pathway.
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
GRB14: A prognostic biomarker driving tumor progression in gastric cancer through the PI3K/AKT signaling pathway by interacting with COBLL1.
Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.
Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.
Erianin inhibits endometrial cancer cell proliferation and migration by modulating glutamine metabolism through the ERK signaling pathway.
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma.
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway.
Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells.
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.
DDX49 as a novel prognostic biomarker regulates colorectal cancer cell proliferation through the TIMM44-PI3K-AKT pathway.
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H(2)S axis.
Exploration of the Mechanism of Action of Dendrobium officinale in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.
Insight into the mechanisms of milk protein synthesis via peptides derived from Micropterus salmoides.
IAV NS1 carried by exosomes promotes IL-10 production by the PI3K-AKT-GSK3β-CREB pathway.
Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway.
MiR-2779-x, a key microRNA that is related to the tumorigenicity of the MDCK cell line.
Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.
Investigation of the anti-inflammatory mechanisms of fermented Chinese herbal residue solution in an APEC-Infected HD11 cell model through the PI3K/AKT and NF-κB pathways.
Corydalis rhizoma attenuates primary dysmenorrhea in rats by inhibiting the FAK/PI3K-AKT/NF-κB signaling pathway.
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment.
Endothelial LRP1 activation mitigates microthrombosis after traumatic brain injury in mice.
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Anti-inflammatory lathyrane diterpenoids from the aerial parts of Euphorbia wallichii.
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Lactate Dehydrogenase C4 Accelerates Triple-Negative Breast Cancer Progression by Promoting Acetyl-CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation.
USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF.
Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
ACSS2 promotes proliferation and invasiveness of SKOV-3 and PA-1 ovarian cancer cell lines under hypoxia.
Ursolic acid sensitizes bladder cancer to gemcitabine chemotherapy by concurrently targeting PI3K/AKT and JNK pathways.
Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation.
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Rap2B-mediated reprogramming of the PI3K/AKT signaling axis drives resistance to cetuximab-targeted therapy in colorectal carcinoma.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Prolactin impairs erectile function via eNOS suppression independently of testosterone.
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Osteocyte Neuropeptide Y Aggravates Bone Loss in OVX Mice by Inhibiting Preosteoclast Proliferation and PDGF-BB-Induced Type H Vessel Formation Through PI3K/Akt Signaling Pathway.
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging.
Network pharmacology, molecular docking, and experimental validation-based approach to explore the mechanism of action of ginsenoside Rh4 on acute myeloid leukemia cells.
Phytochemicals from Stellera chamaejasme alleviate psoriasis by modulating the immune microenvironment via the JAK2/PI3K/AKT pathway.
Exosomal lncRNA MIR210HG derived from hypoxic TAMs promotes the metastasis of triple negative breast cancer.
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats.
Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway.
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways.
Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro.
Bardoxolone methyl suppressed colorectal cancer cells in vitro by inhibiting the PI3K signaling pathway.
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.
Dendrobium nobile lindl extract modulates integrin αIIbβ3-mediated signaling pathways to inhibit platelet activation and thrombosis.
MicroRNA‑96 promotes the proliferation and migration of breast cancer cells by inhibiting Smad7 expression.
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione mediates the effect of ROS-enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer.
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
MiR-101-3p targets the PI3K-AKT signaling pathway via Birc5 to inhibit invasion, proliferation, and epithelial-mesenchymal transition in hepatocellular carcinoma.
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor-Suppressive Effects on Colorectal Cancer by Regulating Autophagy via the mTOR Pathway.
The miR-146a-associated HDAC2 regulation of PI3K is involved in pancreatitis in vitro.
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
S100 A16 promotes the progression of osteosarcoma by activating the PI3 K/AKT signaling pathway through ANXA2.
MiR-124-3p/EIF3B Regulates Host Cell Apoptosis Induced by Chlamydia psittaci Through PI3K/AKT Signaling Pathway.
NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway.
Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights.
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Guyuan Jiannao decoction improves neurovascular unit dysfunction by regulating PI3K/AKT/NF-κB signaling pathway in cerebral small vessel disease rats.
Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson's disease.
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Synergic effect of the combination of isoliquiritigenin and arsenic trioxide in HepG2 liver cancer cells.
hnRNPA2B1 restrains granulosa cell ferroptosis by m(6)A/SLC7A11 in premature ovarian failure.
Qingrehuoxue formula enhances anti-PD-1 immunotherapy in NSCLC by remodeling the tumor immune microenvironment via TREM2 signaling.
Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression.
Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair.
The mechanism of Bletilla striata inhibiting glioma proliferation through the PI3K/AKT/mTOR signaling pathway based on network Pharmacology analysis.
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway.
Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration.
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway.
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis.
TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway.
Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin-Resistant Gastric Cancer Cells.
NCAPD3-mediated AKT activation regulates prostate cancer progression.
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p.
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Network pharmacology and molecular docking reveal the mechanism of action of Bergapten against non‑small cell lung cancer.
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke.
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.
RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway.
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Microenvironment-Responsive Hydrogels Comprising Engineering Zeolitic Imidazolate Framework-8-Anchored Parathyroid Hormone-Related Peptide-1 for Osteoarthritis Therapy.
Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway.
Dissecting the mechanisms of velvet antler extract against diabetic osteoporosis via network pharmacology and proteomics.
Endostatin-expressing endometrial mesenchymal stem cells inhibit angiogenesis in endometriosis through the miRNA-21-5p/TIMP3/PI3K/Akt/mTOR pathway.
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
Flavonols interrupt internalized bacteria hijacking cellular responses via suppressing oxidative stress induced cellular apoptotic death.
USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.
Dietary urolithin A suppresses lung cancer via gut microbiota-mediated autophagy activation.
Therapeutic Potential of 6-Gingerol in Glioma: Mechanistic Insights and Experimental Validation.
Sestrin2 Knockdown Impairs Proliferation, Migration, Invasion, and Apoptosis in OSCC Cells via PI3K/AKT/mTOR and MAPK Pathways.
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
Synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241.
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.
TFAP4 Regulation of MCM5 Activates the PI3K/AKT Pathway to Promote Invasion and Metastasis of Gastric Cancer.
TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway.
Prunus mume Alleviates Hyperuricemic Renal Injury: Insights From Network Pharmacology and Experimental Models.
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Proteomic Analysis of Human Follicular Fluid-Derived Exosomes Reveals That Insufficient Folliculogenesis in Aging Women is Associated With Infertility.
Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species-Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway.
p16(INK4a) Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Network pharmacology-based exploration of the mechanism of Wenweishu granule in treating chronic atrophic gastritis with spleen-stomach cold deficiency syndrome.
Orbital mesenchymal chondrosarcoma and its specific fusion gene HEY1-NCOA2.
Comprehensive characterisation of bioactive compounds in Boletus edulis as functional foods to improve muscle atrophy; through whole plant targeted metabolomics, network pharmacology, in vivo and in vitro experiments, molecular docking and molecular dynamics analysis.
BPIFB4 rs4339026 A > G polymorphism impacts COPD susceptibility in the Kashi population, China.
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth.
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
The Mechanism of Action and Experimental Verification of Narenmandula in the Treatment of Postmenopausal Osteoporosis.
Network Analysis and Basic Experiments on the Inhibition of Renal Cancer Proliferation and Migration by Alpinetin through PI3K/AKT/ mTOR Pathway.
Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior.
Yishen paidu pills attenuates 5/6 nephrectomy induced kidney disease via inhibiting the PI3K/AKT/mTOR signaling pathway.
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Bioinformatics analysis and experimental verification of TIGD1 in non-small cell lung cancer.
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease.
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo.
Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.
Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.
Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism.
Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation.
Epidermal Growth Factor Receptor Emerges as a Viable Target for Reducing Tumorigenicity of MDCK Cells.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-κB signaling pathways to promote wound healing.
Miltefosine induces reproductive toxicity during sperm capacitation by altering PI3K/AKT signaling pathway.
Milk-Derived Extracellular Vesicles Carrying ssc-let-7c Alleviate Early Intestinal Inflammation and Regulate Macrophage Polarization via Targeting the PTEN-Mediated PI3K/Akt Pathway.
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Ouabain Ameliorates Alzheimer's Disease-Associated Neuropathology and Cognitive Impairment in FAD(4T) Mice.
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress.
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
NONRATT000538.2 promotes vascular smooth muscle cell phenotypic switch and in-stent restenosis.
The effect of repetitive magnetic stimulation on neuronal apoptosis and PI3K/Akt protein expression in rats with incomplete spinal cord injury.
Rational Design of Human Hair Keratin-Driven Proteins for Hair Growth Promotion.
Taurine Inhibits Lung Metastasis in Triple-Negative Breast Cancer by Modulating Macrophage Polarization Through PTEN-PI3K/Akt/mTOR Pathway.
Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways.
2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways.
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway.
Regulation of Glucose Metabolism for Cell Energy Supply In Situ via High-Energy Intermediate Fructose Hydrogels.
miR-122-5p Promotes Cowshed Particulate Matter2.5-Induced Apoptosis in NR8383 by Targeting COL4A1.
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Efficacy and Safety of Asparagusic Acid against Echinococcus multilocularis In Vitro and in a Murine Infection Model.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking.
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling.
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway.
Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12.
NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway.
Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects.
Anthrahydroquinone‑2,6‑disulfonate attenuates PQ‑induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of the PI3K/AKT/eNOS pathway.
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
Echistatin/BYL-719 impedes epithelial-mesenchymal transition in pulmonary fibrosis induced by silica through modulation of the Integrin β1/ILK/PI3K signaling pathway.
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway.
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms.
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM(2.5)-induced inflammatory response in human bronchial epithelial cells.
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Vitamin K1 ameliorates lipopolysaccharide-triggered skeletal muscle damage revealed by faecal bacteria transplantation.
Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice.
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.
In silico and in vivo verification of the mechanism of formononetin in treating hepatocellular carcinoma.
Auranofin Suppresses the Growth of Canine Mammary Tumour Cells and Induces Apoptosis via the PI3K/AKT Pathway.
New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions.
Gnetupendin A protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway.
Astragaloside IV and cycloastragenol promote liver regeneration through regulation of hepatic oxidative homeostasis and glucose/lipid metabolism.
Quercetin-primed BMSC-derived extracellular vesicles ameliorate chronic liver damage through miR-136-5p and GNAS/STAT3 signaling pathways.
The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway.
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.
Nirmatrelvir has detrimental effects on sperm function by altering the PI3K/PDK1/AKT signaling pathway.
Quercetin inhibits hypertonicity-induced inflammatory injury in human corneal epithelial cells via the PTEN/PI3K/AKT pathway.
Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology.
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Identification of epithelial-related artificial neural network prognostic models for the prediction of bladder cancer prognosis through comprehensive analysis of single-cell and bulk RNA sequencing.
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway.
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation.
Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10.
FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice.
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.
Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling.
Two polysaccharides from Rehmannia glutinosa: isolation, structural characterization, and hypoglycemic activities.
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERK pathways.
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway.
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury.
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Lead and cadmium co-exposure modified PC12 viability and ER stress: study from a 3 × 3 factorial design.
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling.
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease.
Effects of external environment on promoter methylation of PIK3R5 and related pathway regulation in steroid-induced femoral head necrosis.
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
HnRNP A2/B1 as a potential anti-tumor target for triptolide based on a simplified thermal proteome profiling method using XGBoost.
GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1/PI3K/Akt pathway.
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Aloe-Emodin Suppresses Oxidative Stress and Inflammation via a PI3K-Dependent Mechanism in a Murine Model of Sepsis.
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells.
si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway.
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
The In Vitro Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.
TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways.
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers.
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data.
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
Scutellarin-mediated autophagy activates exosome release of rat nucleus pulposus cells by positively regulating Rab8a via the PI3K/PTEN/Akt pathway.
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring.
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Selenium protects against cadmium-induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling.
Anti-fatigue effects of fermented soybean protein peptides in mice.
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway.
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production.
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
The crucial role of thioredoxin interacting protein in the liver insulin resistance induced by di (2-ethylhexyl) phthalates.
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Chronic vitamin D(3) supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway.
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis.
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma.
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation.
Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 Administration.
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism.
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway.
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Dandelion root extract affects ESCC progression via regulating multiple signal pathways.
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
NLRP3 promotes endometrial receptivity by inducing epithelial-mesenchymal transition of the endometrial epithelium.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma.
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression.
LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis.
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway.
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure.
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Velvet antler polypeptide prevents the disruption of hepatic tight junctions via inhibiting oxidative stress in cholestatic mice and liver cell lines.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice.
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Pharmacological actions of neferine in the modulation of human platelet function.
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux.
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
Gong Y, Xuan ZH, Dong Y, Zhang CB, Liu YC, Zhang JH, Li Q, Liu CB, Xie DM
Mediators of inflammation 2026;2026(1):e8826129
Mediators of inflammation 2026;2026(1):e8826129
Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.
Xiao Y, Zhang T, Chen Q, Zhang Y, Chen B, Wang M, Zhang Y, Huang M, Su Y, Guo J
Frontiers in immunology 2026;17:1761558
Frontiers in immunology 2026;17:1761558
Gastrodia elata fermentation alleviates methamphetamine-induced neuroinflammation and anxiety- and depression-like behaviors by regulating the PI3K-AKT signaling pathway.
Liu Y, Yang H, Li H, Zhang S, Yang H, Luo Y, Hu T, Zhang Z, Peng X, Wang Y, Wei S, Xia B, Luo P
Frontiers in medicine 2026;13:1768944
Frontiers in medicine 2026;13:1768944
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.
Luo Y, Jiang P, Huang D, Li H, He J, Shen R, Jiang Y, Rong L, Liu B
Bioactive materials 2026 May;59:370-395
Bioactive materials 2026 May;59:370-395
IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8(+) T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression.
Wu F, Guo Z, Guan J, Xu J, Chen Y, Chen Z
Journal of gastroenterology and hepatology 2026 May;41(5):1600-1613
Journal of gastroenterology and hepatology 2026 May;41(5):1600-1613
Taohong siwu decoction alleviates hand-foot skin reaction by regulating RAGE-mediated keratinocyte apoptosis and autophagy.
Dong H, Liu Z, Yu F, Li J, Zheng Y, Shen Y, Wang A, Wu D, Wang X, Cui H, Peng Y
Journal of ethnopharmacology 2026 May 23;363:121401
Journal of ethnopharmacology 2026 May 23;363:121401
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments.
Lei L, Guo Q, Cheng Y, Gui Y, Li W, Zhao Y, Xu Z, Luo Y, Wu G, Wang JZ, Liu R, Li HL, Wang X
Journal of advanced research 2026 Mar;81:393-408
Journal of advanced research 2026 Mar;81:393-408
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.
Xia Q, Dong S, Xu W, Lai Q, Song H, Zhang W
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168128
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168128
Multiscale analysis of resolvin D1 biosynthesis and its neuroprotective role in intracerebral hemorrhage.
Xiaoyu L, Ziyou Z, Zhenlin L, Zhuang L, Kai S, Siqi W, Tong L, Yunfei L, Weixiu Z, Yifan W, Chun S, Bensi Z
Prostaglandins & other lipid mediators 2026 Mar;183:107063
Prostaglandins & other lipid mediators 2026 Mar;183:107063
Novel Ce/Cu-modified black ceramics disrupted mitochondrial dysfunction and tricarboxylic acid cycle to induce cuproptosis in osteosarcoma cells.
Zhang R, Yin X, Xu Z, Yan Q
Biomaterials advances 2026 Mar;180:214576
Biomaterials advances 2026 Mar;180:214576
Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.
Yang T, Gao Z, Huang H, Zhang C, Tang Y, Qu Q, Li H, Ke J, Chen Z, Feng M, Zhou H, Shu Y, Yuan W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e14269
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e14269
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Guan B, Tang H, Yuan Z, Yao J, Cui D, Hao Z, Li X
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway.
Wu J, Ge Y, Zhang L, Huang J, Huang N, Luo Y
Stem cell research & therapy 2026 Mar 17;17(1)
Stem cell research & therapy 2026 Mar 17;17(1)
Fasting-induced physiological remodeling alleviated fatty liver in laying hens through regulating hepatic lipid metabolism.
Gong Y, Zeng Q, Geng X, Zhang J, Kang X, Tian Y, Jiang R
Poultry science 2026 Mar 13;105(6):106775
Poultry science 2026 Mar 13;105(6):106775
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Fu Z, Li M, Dong K, Feng J, Wang W
International journal of oncology 2026 Jun;68(6)
International journal of oncology 2026 Jun;68(6)
Resveratrol triggers autophagy-dependent apoptosis via suppressing the PI3K/AKT/mTOR pathway in Chlamydia psittaci-infected cells.
Zeng X, Li Y, Wang X, Luo X, Wang C, Li Z, Bai Q, Chen S, Chen L
Microbial pathogenesis 2026 Jun;215:108442
Microbial pathogenesis 2026 Jun;215:108442
Dimethyl bisphenolate inhibits ovarian cancer growth by regulating the PI3K/AKT/mTOR signaling pathway.
Liu M, Liu Y, Xue P, Chen R, Zhang H, Hao M, Wang Z, Zhang X, Xu L, Li R, An J, Qu G, Song S, Cao Q
Bioorganic chemistry 2026 Jun 15;174:109769
Bioorganic chemistry 2026 Jun 15;174:109769
Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progression.
Peng X, Han J, Tian Y, Li X, Zhang X, Li S, Yang J, Chen L, Zhou S, Su N, Mao X, Zhang B, Chen H, Yang J, Jin M, Li C, Jiang W, Liu P, Xie Y, Kuang L, Chen L
Journal of orthopaedic translation 2026 Jan;56:101037
Journal of orthopaedic translation 2026 Jan;56:101037
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Gao S, Yao W, Yang J, Liu Y, Pei Z
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Xu Q, Su J, Lei Q, Liu J, Wang J, Yang M, Song J, Chen H, Lu J
Brain research bulletin 2026 Jan;234:111687
Brain research bulletin 2026 Jan;234:111687
Linoleic acid promotes osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates ovariectomy (OVX)-induced osteoporosis in mice through the PI3K/AKT pathway.
Liao H, Luo X, Jiang L
The international journal of biochemistry & cell biology 2026 Jan;190:106878
The international journal of biochemistry & cell biology 2026 Jan;190:106878
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Zhang S, Xie Y, Zhang L, Qi Y, Liao Q, Xu C, Yang S, Zhou H, Tan Q, Qi S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex.
Kuang S, Liu T, Wei Z, Xu J, Han J, Wang J, Zhai F, Tian Y, Liang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e04316
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e04316
Identifying C1orf122 as a potential HCC exacerbated biomarker dependently of SRPK1 regulates PI3K/AKT/GSK3β signaling pathway.
Cai J, Rong L, Wang R, Zhang Z, Sun H, Chen J, Weng D, Li X, Feng X, Lin P, Xu S, Jiang Z, Xie Y, Zhou Q
Genes & diseases 2026 Jan;13(1):101721
Genes & diseases 2026 Jan;13(1):101721
Mechanistic insights into myricetin-regulated autophagy via the PI3K/Akt and PINK1/Parkin pathway in diabetic kidney disease treatment.
Liu X, Wang PY, Tang SQ, Zhang ML, Fan XF, Sun SQ, Guo Y, Wu JX, Su ZH, Zheng H
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120613
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120613
Poria cocos Attenuates LPS/D-Galactosamine-Induced Acute Liver Failure in Rats: An Integrative Exploratory Study Combining Network Pharmacology and In Vivo Validation.
Wen P, Jian X, Ren X, Zhao S, Yang Y, Ge H, Li L, Wang H, Li M, Wang L
International journal of molecular sciences 2026 Jan 30;27(3)
International journal of molecular sciences 2026 Jan 30;27(3)
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.
Fang Y, Mou C, Yu X, Zhang J, Zhu W, Zhou C, Jiang B, Chen Y
Hereditas 2026 Jan 27;163(1):31
Hereditas 2026 Jan 27;163(1):31
Role of gut microbiota in lead-induced neural damage in diabetic mice.
Ding WJ, Liu CQ, Tang XY, Shang ZB, Liang X, Tao T, Liu RX, Jiang QY, Qiu YF, Sun Y
World journal of diabetes 2026 Jan 15;17(1):112885
World journal of diabetes 2026 Jan 15;17(1):112885
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway.
Liu ZH, Chen WB, Li JZ, Wang XS, Liu L, Liu HW, Chen GZ, Pan C, Yuan MZ
Asian journal of andrology 2026 Jan 1;28(1):57-63
Asian journal of andrology 2026 Jan 1;28(1):57-63
Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration.
Chen L, Wu H, Ren R, Zhang Y, Zhu Z, Chen X, Wang L, Gan X, Kang H, Pu H, Xiong W
International immunopharmacology 2026 Jan 1;168(Pt 1):115831
International immunopharmacology 2026 Jan 1;168(Pt 1):115831
Exploring the mechanism of the Lianshi Jianpi formula in treating impaired glucose tolerance: a network pharmacology, molecular docking, and experimental validation study.
Mingqian J, Tong W, Bowei H, Chen Q, Yanbin L, Binhua YE
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2026 Feb;46(1):160-171
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2026 Feb;46(1):160-171
Identification of a Potential Biomarker PDGFRA for Endometriosis Based on Comprehensive Analysis of Multiple Omics Data.
Chen S, Jiang Y, Chai X, Wu X
Reproductive sciences (Thousand Oaks, Calif.) 2026 Feb;33(2):358-371
Reproductive sciences (Thousand Oaks, Calif.) 2026 Feb;33(2):358-371
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Li Q, Bao Q, Wei C, Xie Y, Zhao S, Yan H, Wu F, Li W, Liu X, Gao H
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Construction of Curcumin-Loaded Mesenchymal Stem Cell-Derived Exosomes and Their Mechanism in Inhibiting Pyroptosis During Hepatic Ischemia-Reperfusion Injury.
Dong X, Sun L, Hu D, He W, Pan Y, Wang R, Lin X, Jiang Z, Xing X
Pharmaceuticals (Basel, Switzerland) 2026 Feb 10;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 10;19(2)
Piperlongumine Inhibits Malignant Progression of Esophageal Squamous Cells Through the PI3K/AKT Signaling Pathway.
Wang J, Chu Y, Hu G, Liang S, Cui Y, Zuo J, Luo Z, Chen X, Wang X, Yu Z, Zhang Z, Wang X
Biochemical genetics 2026 Apr;64(2):2254-2271
Biochemical genetics 2026 Apr;64(2):2254-2271
Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells.
Fu W, Lin L, Li J, Qin F, Chen C, Cai Y, Cai Y, Huang Y, Yang W, Zhu S
Oncology reports 2026 Apr;55(4)
Oncology reports 2026 Apr;55(4)
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect.
Wang Y, Zhang S, Ma X, Hu D, Liu J, Wei L, Lei X, Hu Y, Li F, Gao Y
Materials today. Bio 2026 Apr;37:102789
Materials today. Bio 2026 Apr;37:102789
HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke.
Feng Z, Liu Z, Tang S, Pan M, Zhu K, Liu Y, Wang C, Yao R, Wei X, Liu H
Journal of cellular and molecular medicine 2026 Apr;30(7):e71121
Journal of cellular and molecular medicine 2026 Apr;30(7):e71121
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Xu B, Ji X, Li L, Zhu L, Wang L, Kang J, Yang S, Fan T
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
Tongnao Decoction Exerts a Treatment Effect on Ischemic Stroke by IL-6/PI3K/Akt/GSK-3β Pathway: Based on the Network Pharmacology and Molecular Docking.
Gan J, Cong Y, Li L, Ma F, Yang X, Deng Y, Liu Y, Wu Y, Jiang H, Chen Z, Li W, Zhu Y, Wu M
Assay and drug development technologies 2026 Apr 7;:1540658X261438876
Assay and drug development technologies 2026 Apr 7;:1540658X261438876
Mettl3-Mediated m6A Methylation of Pdgfrb Regulates the Angiogenesis-Dependent Bone Formation.
Zhou S, Zhu Y, Yun L, Li M, Zhang T, Wumiti T, Zhou Q, Chen S, Hu Y, Han Z, Zhang C, Tong K, Zhang Y, Ma Y, Guo Y, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71817
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71817
Structural characterization and hypoglycemic mechanisms of a Hericium coralloides heteropolysaccharide (HCP-2b) via gut microbiota modulation and PI3K/Akt signaling.
Wang M, Fu H, Lv G, Zhao R, Cai W, Pi X, Zhang Z
Carbohydrate polymers 2026 Apr 15;378:124879
Carbohydrate polymers 2026 Apr 15;378:124879
Wenweishu Granule Plays a Protective Role against Stress-Induced Gastric Ulcers by Inhibiting the PI3K/AKT Signaling Pathway.
Zheng J, Jiao Z, Yang X, Ruan Q, Huang Y, Jin C, Gui S, Xuan Z, Jia X
Biological & pharmaceutical bulletin 2025;48(6):849-859
Biological & pharmaceutical bulletin 2025;48(6):849-859
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Qi M, Wang Q, Sun R, Cheng Z, Li M, Fan X, Bai F, Yu J
Cardiovascular therapeutics 2025;2025:9549175
Cardiovascular therapeutics 2025;2025:9549175
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Wang Y, Liao Q, Mei X, Xu H, Luo L, Huang R, Tang Y, Zhou C
PloS one 2025;20(6):e0326687
PloS one 2025;20(6):e0326687
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Wei S, Sun J, Wen J, Yu J, Xuan Y, Huang J, Yang J, Zhang J
PloS one 2025;20(5):e0323965
PloS one 2025;20(5):e0323965
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Tong W, Qin N, Lu T, Liu L, Liu R, Chen J, Luo N
PloS one 2025;20(4):e0302766
PloS one 2025;20(4):e0302766
GRB14: A prognostic biomarker driving tumor progression in gastric cancer through the PI3K/AKT signaling pathway by interacting with COBLL1.
Gu CB, Wang C
Open life sciences 2025;20(1):20251084
Open life sciences 2025;20(1):20251084
Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.
Lin L, Shen B, Cui J, Gao Y, Wang L, Yang T, Weng J, Lai C, Tang X, Xiao C, Shen X, Gao Y
Drug design, development and therapy 2025;19:9151-9167
Drug design, development and therapy 2025;19:9151-9167
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Sun J, Qi X, Yang C, Wang S, Jiang J, Wang L, Song J, Yu B, Sun M
Drug design, development and therapy 2025;19:2959-2977
Drug design, development and therapy 2025;19:2959-2977
Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.
Liu Y, Sun D, Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B
Drug design, development and therapy 2025;19:2609-2628
Drug design, development and therapy 2025;19:2609-2628
Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.
Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265
Erianin inhibits endometrial cancer cell proliferation and migration by modulating glutamine metabolism through the ERK signaling pathway.
Huang Q, Xu Y, Li H, Zhang T
American journal of translational research 2025;17(11):8964-8972
American journal of translational research 2025;17(11):8964-8972
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Yuan Q, Jiang H, Zhu M, Chu Y, Zhang Y, Bie J, Li L
Journal of Cancer 2025;16(3):765-783
Journal of Cancer 2025;16(3):765-783
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Wei J, Xie J, He Z, Feng X
Frontiers in pharmacology 2025;16:1742401
Frontiers in pharmacology 2025;16:1742401
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Zhang C, Hu B, Wang C, Hou S, Lin N
Frontiers in immunology 2025;16:1662351
Frontiers in immunology 2025;16:1662351
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Wang J, Wang C, Jia Y, Chen F, Wang Y, Du J
Frontiers in pharmacology 2025;16:1654108
Frontiers in pharmacology 2025;16:1654108
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Wu X, Chen T, Zhang Z, Wang D, Zhou K, Li J, Xu L, Meng C, Pan H, Huang J, Gao Y, Li S
Frontiers in pharmacology 2025;16:1612726
Frontiers in pharmacology 2025;16:1612726
Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma.
Shi L, Yuan D, Zhu F, He Y, Zuo R, Chen L, Luo Y, Wang Y, Huang D, Chen P, Guo H
Frontiers in pharmacology 2025;16:1577232
Frontiers in pharmacology 2025;16:1577232
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Jin Q, Li Q, Yang L, Ma F, Mao H, Wang Y, Liu T, Peng L, Li P, Zhan Y
Frontiers in pharmacology 2025;16:1538061
Frontiers in pharmacology 2025;16:1538061
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway.
Wu Y, Wang B, Mao X, Chen W, Akber Aisa H
Frontiers in pharmacology 2025;16:1526952
Frontiers in pharmacology 2025;16:1526952
Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells.
Yang Q, Zhao D, Ju L, Cao P, Wei J, Liu Z
Frontiers in pharmacology 2025;16:1524277
Frontiers in pharmacology 2025;16:1524277
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Tang Q, Dong J, Zhang F, Zhao D, Yang Q, Wen J, Sun Y, Wei J, Liu Z
Frontiers in pharmacology 2025;16:1489210
Frontiers in pharmacology 2025;16:1489210
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.
Li J, Zhou Z, Wu Y, Zhao J, Duan H, Peng Y, Wang X, Fan Z, Yin L, Li M, Liu F, Yang Y, Du L, Li J, Zhong H, Hou W, Zhang F, Ma H, Zhang X
Theranostics 2025;15(4):1376-1398
Theranostics 2025;15(4):1376-1398
DDX49 as a novel prognostic biomarker regulates colorectal cancer cell proliferation through the TIMM44-PI3K-AKT pathway.
Huang B, Yin Z, Gao G, Li L, Yang M
Frontiers in oncology 2025;15:1707092
Frontiers in oncology 2025;15:1707092
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
Yao L, Gu C, Ge R, Zhang X, Meng X, Wang L, Peng D, Li G
Frontiers in oncology 2025;15:1529868
Frontiers in oncology 2025;15:1529868
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H(2)S axis.
Liu S, Wei B, Wei H, Xu A, Sheng L, Sun X, Dong Y, Yang H
Frontiers in cell and developmental biology 2025;13:1679330
Frontiers in cell and developmental biology 2025;13:1679330
Exploration of the Mechanism of Action of Dendrobium officinale in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.
Zhan S, Lu X, Guo H, Liu Y, Li Z, Xu W, Xia F, Tang H, Tian Y, Chen J, Lin X
Journal of hepatocellular carcinoma 2025;12:1973-1990
Journal of hepatocellular carcinoma 2025;12:1973-1990
Insight into the mechanisms of milk protein synthesis via peptides derived from Micropterus salmoides.
Liu B, Wu X, Zhang X, Hao G, Li X, Cai Y, Lv D, Li P, Yan Y, Zan L, Pan F
International journal of biological macromolecules 2025 Sep;322(Pt 4):147039
International journal of biological macromolecules 2025 Sep;322(Pt 4):147039
IAV NS1 carried by exosomes promotes IL-10 production by the PI3K-AKT-GSK3β-CREB pathway.
Huang HM, Yang HH, Qin YC, Luo JY, Jiang ZS, Zhang ZR, Ning LJ, Li L, Wu Y
Microbial pathogenesis 2025 Sep;206:107777
Microbial pathogenesis 2025 Sep;206:107777
Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway.
Wang Y, Zhang X, Zhang W, Han M, Jia Q, Bo C, Shao H, Sai L, Peng C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115600
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115600
MiR-2779-x, a key microRNA that is related to the tumorigenicity of the MDCK cell line.
Yang D, Huang L, Shi J, Liu Z, Wang J, Ma Z, Abudureyimu A, Qiao Z, Chen J
Biochimica et biophysica acta. General subjects 2025 Sep;1869(10):130843
Biochimica et biophysica acta. General subjects 2025 Sep;1869(10):130843
Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.
Liu L, Wang C, Chen Z, Yin M, Zhang K, Zhang C, Peng S, Li M, Jiang S, Chen H
Bioorganic chemistry 2025 Sep;164:108886
Bioorganic chemistry 2025 Sep;164:108886
Investigation of the anti-inflammatory mechanisms of fermented Chinese herbal residue solution in an APEC-Infected HD11 cell model through the PI3K/AKT and NF-κB pathways.
Huang B, Mo S, He C, Zhu J, Tan Z, Chen L, Wang Y, Ma H
Poultry science 2025 Sep;104(9):105383
Poultry science 2025 Sep;104(9):105383
Corydalis rhizoma attenuates primary dysmenorrhea in rats by inhibiting the FAK/PI3K-AKT/NF-κB signaling pathway.
Zhang J, Dang M, Wu Y, Dong A, Wang H, Li D, Zhang Q, Zhang X, Zhang M, Zhao C, Sun J
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120420
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120420
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Sun L, Wang Y, Zhang K, Chen X, Shi H
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment.
Xie W, Li XJ, Zhong YS, Fang J, Qi H, Yang M, Ying HZ, Yu CH
World journal of gastrointestinal oncology 2025 Sep 15;17(9):108892
World journal of gastrointestinal oncology 2025 Sep 15;17(9):108892
Endothelial LRP1 activation mitigates microthrombosis after traumatic brain injury in mice.
Yan R, Wang J, Wu J, Qiu X, Yang L, Yang J, Jiang Y, Peng J
Experimental neurology 2025 Oct;392:115324
Experimental neurology 2025 Oct;392:115324
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Yaxian L, Xiaodong W, Futao M, Huizhen W, Chuansheng W, Mengdi M, Bo Y, Yida L, Xin X, Ziqing F, Mingdian L, Yuxian S, Yongxiang L
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
Anti-inflammatory lathyrane diterpenoids from the aerial parts of Euphorbia wallichii.
Ma RF, Zhuang XC, Wu Q, Zhang H
Fitoterapia 2025 Oct;186:106855
Fitoterapia 2025 Oct;186:106855
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Zhao L, Wang J, Han Y, Wang Q, Yang W, Zhang Y, Lin Z, Zhu L, Piao J
Bioorganic chemistry 2025 Oct;165:109002
Bioorganic chemistry 2025 Oct;165:109002
Lactate Dehydrogenase C4 Accelerates Triple-Negative Breast Cancer Progression by Promoting Acetyl-CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation.
Cui Z, Zheng C, Lin Y, Xiao Z, Li Y, Peng W, He S, Li A, Wu X, Chen Y, Sun Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e11849
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e11849
USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF.
Zhang W, Chen L, Zhao J, Ma A, Shi W, Zhang Y, Tang Z, Guo J, Xu Z, Zhou J, Tang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e03106
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e03106
Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.
Su Q, Wang J, Song Y, Zhang Z, Cai B, Xiaohalati X, Liu J, Li H, Wang Z, Chang J, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e07241
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e07241
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Huo N, Xu G, Zhou H, Liu Y, Li S, Yang X, Liu J, Wang W, Yang N, Zhou N
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
ACSS2 promotes proliferation and invasiveness of SKOV-3 and PA-1 ovarian cancer cell lines under hypoxia.
Mroweh O, Karam L, Hammoud R, Al Achcar J, Sobh R, Nasser SM, Garcia JA, Kobeissy PH
Journal of ovarian research 2025 Oct 31;18(1):232
Journal of ovarian research 2025 Oct 31;18(1):232
Ursolic acid sensitizes bladder cancer to gemcitabine chemotherapy by concurrently targeting PI3K/AKT and JNK pathways.
Huang X, Sun Y, Tong H, Zhu J, Pan J, Wen P, He W
Translational andrology and urology 2025 Oct 31;14(10):2902-2916
Translational andrology and urology 2025 Oct 31;14(10):2902-2916
Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation.
Wu X, Li X, Wu Y, Yang H, Wu J, He L
BMC pregnancy and childbirth 2025 Oct 3;25(1):1007
BMC pregnancy and childbirth 2025 Oct 3;25(1):1007
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Ma X, Han L, Xu M, Feng Y, Liu C, Zhao Y, Zhang M, Xu G, Sun X
Current issues in molecular biology 2025 Oct 28;47(11)
Current issues in molecular biology 2025 Oct 28;47(11)
Rap2B-mediated reprogramming of the PI3K/AKT signaling axis drives resistance to cetuximab-targeted therapy in colorectal carcinoma.
Zhang S, Wei Y, Liu T, Sun C, Ge X, Ni Y, Tang X, Roy M, Chang T, Kang X
Biological procedures online 2025 Oct 15;27(1):39
Biological procedures online 2025 Oct 15;27(1):39
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
Prolactin impairs erectile function via eNOS suppression independently of testosterone.
Cheng X, Xiao Y, Qiu D, Li L, Peng Q, Liu Y, Tian Y, Zhou E, Zhou H
Toxicology and applied pharmacology 2025 Nov;504:117532
Toxicology and applied pharmacology 2025 Nov;504:117532
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Zhang Q, Yang Z, Ou X, Zhang M, Ji R, Wu G
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Osteocyte Neuropeptide Y Aggravates Bone Loss in OVX Mice by Inhibiting Preosteoclast Proliferation and PDGF-BB-Induced Type H Vessel Formation Through PI3K/Akt Signaling Pathway.
Chen Q, Zhang Y
Calcified tissue international 2025 Nov 4;116(1):134
Calcified tissue international 2025 Nov 4;116(1):134
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hu HM, Deng JL, Pan Y, Wang ZH, Zhang J, Yu Gu X, Fan SX, Zhao JZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging.
Yang D, Le J, Xiao S, Cui Y, Zhu W, Otsuki K, Li W, Xu J, Feng F, Zhang J
Antioxidants (Basel, Switzerland) 2025 Nov 25;14(12)
Antioxidants (Basel, Switzerland) 2025 Nov 25;14(12)
Network pharmacology, molecular docking, and experimental validation-based approach to explore the mechanism of action of ginsenoside Rh4 on acute myeloid leukemia cells.
Zhang X, Sun P, Liang X, Shen Y, Lin J, Guo JK, Chang F
Medical oncology (Northwood, London, England) 2025 Nov 20;43(1):8
Medical oncology (Northwood, London, England) 2025 Nov 20;43(1):8
Phytochemicals from Stellera chamaejasme alleviate psoriasis by modulating the immune microenvironment via the JAK2/PI3K/AKT pathway.
Xi RF, Nie YW, Lu HZ, Liu X, Feng ZG, Wang Y, Guo DJ, Guo WJ, Nian H, Li FL, Zhu JY
International immunopharmacology 2025 Nov 14;165:115540
International immunopharmacology 2025 Nov 14;165:115540
Exosomal lncRNA MIR210HG derived from hypoxic TAMs promotes the metastasis of triple negative breast cancer.
Feng L, Wang Y, Wang X, Li B, Liu Y, Zhang W, Ji J, Shao L, Guo X
International immunopharmacology 2025 Nov 14;165:115416
International immunopharmacology 2025 Nov 14;165:115416
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats.
Mu Y, Li W, Wei D, Zhang X, Yao L, Xu X, Wang X, Zhang Z, Chen T
Life sciences in space research 2025 May;45:158-169
Life sciences in space research 2025 May;45:158-169
Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway.
Pan S, Wen Y, Liu Z, Xu K, Zhang N, Tong X, Teng Y, Song X, Tong X
Brain research bulletin 2025 May;224:111326
Brain research bulletin 2025 May;224:111326
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways.
Shan L, Gu GJ, Xiang CC, Zuo ED, Lian L, Cheng X
BioFactors (Oxford, England) 2025 May-Jun;51(3):e70023
BioFactors (Oxford, England) 2025 May-Jun;51(3):e70023
Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro.
Fan W, Xu Z, Zhong M, Wu X, Chen P, Chen Z, Su W, Wu H, Li P
Cells 2025 May 8;14(10)
Cells 2025 May 8;14(10)
Bardoxolone methyl suppressed colorectal cancer cells in vitro by inhibiting the PI3K signaling pathway.
Zhang L, Huang Q, Yang J, Hu Y
Scientific reports 2025 May 5;15(1):15710
Scientific reports 2025 May 5;15(1):15710
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.
Qin F, Wang Y, Yang C, Ren Y, Wei Q, Tang Y, Xu J, Wang H, Luo F, Luo Q, Luo X, Liu X, Yang D, Zuo X, Yang Y, Cheng C, Xu J, Wang W, Liu T, Yi P
Nature communications 2025 May 24;16(1):4828
Nature communications 2025 May 24;16(1):4828
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.
Ma T, Guo WW, Zhang M, He W, Dongzhi C, Gongye X, Xia P, Chai Y, Chen Z, Zhu Y, Qu C, Liu J, Yang Z, Ma W, Tian M, Yuan Y
Cell death & disease 2025 May 15;16(1):382
Cell death & disease 2025 May 15;16(1):382
Dendrobium nobile lindl extract modulates integrin αIIbβ3-mediated signaling pathways to inhibit platelet activation and thrombosis.
Hua C, Wu M, Xiao Y, Zhang R, Yuan Y, Zhang L, Guo F, Liu J, Yang Z, Liu G
Journal of ethnopharmacology 2025 May 12;347:119728
Journal of ethnopharmacology 2025 May 12;347:119728
MicroRNA‑96 promotes the proliferation and migration of breast cancer cells by inhibiting Smad7 expression.
Zhang X, Cong L, Yu R, Yu Q, Hou X, Zhou Y
Oncology letters 2025 Mar;29(3):151
Oncology letters 2025 Mar;29(3):151
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione mediates the effect of ROS-enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer.
Chen L, Chen M, Xie Y, Zhang Y, Mo S, He Y, Liang T, Liao Y, Huang R, Huang G, Han C, Pham TTH
FEBS open bio 2025 Mar;15(3):474-489
FEBS open bio 2025 Mar;15(3):474-489
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Lu Q, Liu J, Xiong Y, Jian J, Wang J, Chen Z, Wan S, Liu X, Wang L
Scientific reports 2025 Mar 28;15(1):10695
Scientific reports 2025 Mar 28;15(1):10695
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
Xu Y, Liang H, Xia K, Yao J, Chen Y, Hou B, Hao Z
International immunopharmacology 2025 Mar 26;150:114250
International immunopharmacology 2025 Mar 26;150:114250
Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.
Gao Q, Zhang M, Chen R, Teng P, Dai X, Wu B, Hong L, Ma L, Liu L, Wu S, Li M
Scientific reports 2025 Mar 24;15(1):10132
Scientific reports 2025 Mar 24;15(1):10132
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Liao Q, Chen J, Liu G
Scientific reports 2025 Mar 20;15(1):9644
Scientific reports 2025 Mar 20;15(1):9644
MiR-101-3p targets the PI3K-AKT signaling pathway via Birc5 to inhibit invasion, proliferation, and epithelial-mesenchymal transition in hepatocellular carcinoma.
Zhu W, Ni Q, Wang Z, Zhang R, Liu F, Chang H
Clinical and experimental medicine 2025 Mar 19;25(1):88
Clinical and experimental medicine 2025 Mar 19;25(1):88
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.
Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y
World journal of gastrointestinal oncology 2025 Mar 15;17(3):102187
World journal of gastrointestinal oncology 2025 Mar 15;17(3):102187
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor-Suppressive Effects on Colorectal Cancer by Regulating Autophagy via the mTOR Pathway.
Wang Z, Chen H, Xiong S, Chen X, Gao X, Huang P, Zou J, Cao H
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5931-5946
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5931-5946
The miR-146a-associated HDAC2 regulation of PI3K is involved in pancreatitis in vitro.
Zhong DW, Zeng XT, Chen WH, Huang XY, Liu JX, Liao YH
Biochemistry and biophysics reports 2025 Jun;42:102057
Biochemistry and biophysics reports 2025 Jun;42:102057
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Luo B, Cai M, Huang H, Zhang Y, Chen P, Ji R, Wang F, Liao P, Xian M
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
Li W, Yin Q, Qiu Y, Liu J, Wang J, Li C, Zhang D, Zhang P, Lv H, Lv Y, Wang Y
Cancer genetics 2025 Jun;294-295:156-170
Cancer genetics 2025 Jun;294-295:156-170
S100 A16 promotes the progression of osteosarcoma by activating the PI3 K/AKT signaling pathway through ANXA2.
Xiang YY, Liu JH, Yi X, Luo JY, Yu Y, Yi GL
Scientific reports 2025 Jun 6;15(1):19962
Scientific reports 2025 Jun 6;15(1):19962
MiR-124-3p/EIF3B Regulates Host Cell Apoptosis Induced by Chlamydia psittaci Through PI3K/AKT Signaling Pathway.
Tong T, Li Y, Zhou Y, Zeng X, Xiao C, Cao S, Wang C, Li Z, Zhou Z, Bai Q, Chen S, Yan S, Chen L
The Journal of infectious diseases 2025 Jun 2;231(5):1165-1175
The Journal of infectious diseases 2025 Jun 2;231(5):1165-1175
NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway.
Fan L, Xu F, Liu S, Wu D, Wang S, Pan X, Zhou Y, Qu L, Zhou W
European journal of histochemistry : EJH 2025 Jun 17;69(3)
European journal of histochemistry : EJH 2025 Jun 17;69(3)
Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights.
Zhou YL, Ogura S, Ma H, Liang RB, Fang SY, Wang YM, Wo Y, Wang WJ, Liu DW
Stem cell research & therapy 2025 Jun 15;16(1):304
Stem cell research & therapy 2025 Jun 15;16(1):304
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Yu S, Liu K, Zhou F, Yang X, Zhang J, Yu K, Zhu Y, Qin L, Peng T, Zhang C, He Y
Journal of ethnopharmacology 2025 Jun 12;349:119965
Journal of ethnopharmacology 2025 Jun 12;349:119965
Guyuan Jiannao decoction improves neurovascular unit dysfunction by regulating PI3K/AKT/NF-κB signaling pathway in cerebral small vessel disease rats.
Zhong Z, Long H, Li N, Liu T, Wu M, Wang J, Liu M, Zhang X, Mei Z, Fang R, Ge J, Meng P
Journal of ethnopharmacology 2025 Jun 12;349:119942
Journal of ethnopharmacology 2025 Jun 12;349:119942
Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson's disease.
Li Y, Man M, Tian Y, Zhao G, Liu F, Zhao J, Huang S, Xue J, Chang W
Inflammopharmacology 2025 Jul;33(7):4063-4076
Inflammopharmacology 2025 Jul;33(7):4063-4076
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Wang H, Cheng G, Zhang S, Qu H, Zhao X, Yang A, Sun X, Pan H
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Synergic effect of the combination of isoliquiritigenin and arsenic trioxide in HepG2 liver cancer cells.
Li J, Gu J, Pan S, Deng N, Khan M, Li L, Wu X, Li Y
Cellular signalling 2025 Jul;131:111752
Cellular signalling 2025 Jul;131:111752
hnRNPA2B1 restrains granulosa cell ferroptosis by m(6)A/SLC7A11 in premature ovarian failure.
Xiong J, He L, Zhang Y, Zhao X
Journal of ovarian research 2025 Jul 26;18(1):165
Journal of ovarian research 2025 Jul 26;18(1):165
Qingrehuoxue formula enhances anti-PD-1 immunotherapy in NSCLC by remodeling the tumor immune microenvironment via TREM2 signaling.
Li BB, Jiang YY, Li X, Yu MM, Meng Q, Wang DN, Zang JM, Xu F
BMC complementary medicine and therapies 2025 Jul 16;25(1):270
BMC complementary medicine and therapies 2025 Jul 16;25(1):270
Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.
Zang S, Chen H, Han Y, Cui D, Yu J
Scientific reports 2025 Jul 11;15(1):25065
Scientific reports 2025 Jul 11;15(1):25065
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Ye Y, Shen F, Yan M, Zhan C, Lv J, Zou M, Wang Z, Ning S, Gao Y, Wu J, Li W
Cell death & disease 2025 Jul 10;16(1):509
Cell death & disease 2025 Jul 10;16(1):509
Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression.
Chen X, Wang S, Lei Q, Liu J, Lu W
Metabolic brain disease 2025 Jul 1;40(6):238
Metabolic brain disease 2025 Jul 1;40(6):238
Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair.
Li Z, Tang X, Yang H, Lu L, Zhang J, Liu Y
Acta biomaterialia 2025 Jul 1;201:171-186
Acta biomaterialia 2025 Jul 1;201:171-186
The mechanism of Bletilla striata inhibiting glioma proliferation through the PI3K/AKT/mTOR signaling pathway based on network Pharmacology analysis.
Ren F, Wang Y, He C, Zheng X, Zhou C, Zhong X
Scientific reports 2025 Jul 1;15(1):20415
Scientific reports 2025 Jul 1;15(1):20415
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Ji M, Weng S, Li X, Xiao Q, Tong Y, Zhou Y, Luo T, Liu Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Ren X, Zhou N, Li D, Li L, Wang Y, Li L, Ma Y, Gao X, Zhao Y, Sun Y, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119278
Journal of ethnopharmacology 2025 Jan 31;340:119278
Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.
Zhang J, Peng J, Wang S, Wang L, Sun Y, Xia J, Cheng B, Hu Q
Cell death discovery 2025 Jan 28;11(1):30
Cell death discovery 2025 Jan 28;11(1):30
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.
Tu Y, Pan C, Huang Y, Ye Y, Zheng Y, Cao D, Lv Y
Lasers in medical science 2025 Jan 23;40(1):34
Lasers in medical science 2025 Jan 23;40(1):34
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway.
Shu W, Hua T, Xin X, Zhang J, Lin J, Shi R, Zhao R, Zhang W, Dong KJ, Wang H, Zhou X
Carcinogenesis 2025 Jan 20;46(1)
Carcinogenesis 2025 Jan 20;46(1)
Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration.
Li Z, Zhang C, Wang L, Zhang Q, Dong Y, Sha X, Wang B, Zhu Z, Wang W, Wang Y, Zhou Y, Zhang Y
Scientific reports 2025 Jan 2;15(1):556
Scientific reports 2025 Jan 2;15(1):556
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Zhang RH, Chen T, Xiong QQ, Wang S, Chen GQ, Zhang WL, Yuan HF, Zhao YL, Liu T, Huang Y, Zhou M, Yang CL, Liao SG, Li YJ
European journal of medicinal chemistry 2025 Jan 15;282:117059
European journal of medicinal chemistry 2025 Jan 15;282:117059
GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway.
Luo C, Xiao Z, Yang W
Scientific reports 2025 Jan 13;15(1):1787
Scientific reports 2025 Jan 13;15(1):1787
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis.
Li K, Liu X, Lu R, Zhao P, Tian Y, Li J
Ecotoxicology and environmental safety 2025 Jan 1;289:117451
Ecotoxicology and environmental safety 2025 Jan 1;289:117451
TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway.
Tang S, Xing W, Yan J, Wang L, Li Z, Wang Y, Gu N, Sun X
Brain research 2025 Jan 1;1846:149235
Brain research 2025 Jan 1;1846:149235
Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin-Resistant Gastric Cancer Cells.
Wu Q, Zhu C, Zhao T, Liu T, Da M
Drug development research 2025 Feb;86(1):e70048
Drug development research 2025 Feb;86(1):e70048
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Zhang Y, Xie W, Zong X, Fang Y, Ren J, Jing Z, Wei Y, Lu S, Zhu Q, Liu P
FASEB bioAdvances 2025 Feb;7(2):e1488
FASEB bioAdvances 2025 Feb;7(2):e1488
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Bin Y, Liu M, He R, Tang P, Qu W, Wu D, Tan L, Wang Q, Jiang P, Hu H
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p.
Jiang X, Liu Z, You H, Tang Z, Ma Y, Nie R, Yang Z, Che N, Liu W
Molecular and cellular biochemistry 2025 Feb;480(2):951-969
Molecular and cellular biochemistry 2025 Feb;480(2):951-969
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.
Song Y, Wang X, Zhang H, Ma R, Kang Y, Di X, Feng Z, Ni C, Zhao F, Zhuang H, Zhang J
Ecotoxicology and environmental safety 2025 Feb;291:117833
Ecotoxicology and environmental safety 2025 Feb;291:117833
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Xu M, Chen J, Gao L, Cai S, Dong H
Ecotoxicology and environmental safety 2025 Feb;291:117828
Ecotoxicology and environmental safety 2025 Feb;291:117828
Network pharmacology and molecular docking reveal the mechanism of action of Bergapten against non‑small cell lung cancer.
Chen Y, Fu Y, Zou H, Wang P, Xu Y, Xie Q
Oncology letters 2025 Feb;29(2):87
Oncology letters 2025 Feb;29(2):87
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke.
Zhang K, Wu G, Chen Y, Hu Q, Li Y, Jiang X, Gu C, Zhang N, Zhao F
Nitric oxide : biology and chemistry 2025 Feb;154:115-127
Nitric oxide : biology and chemistry 2025 Feb;154:115-127
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.
Fan X, Yan Q, Xu W, Chen H, Xu Y, Lu S, Xu C, Tan J, Yu C, Lai Y, Fan M, Tao L, Li L, Shen W, Cheng H, Sun D
Journal of ethnopharmacology 2025 Feb 27;342:119361
Journal of ethnopharmacology 2025 Feb 27;342:119361
RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway.
Sheng T, Su H, Yao L, Qu Z, Liu H, Shao W, Zhang X
BMC cancer 2025 Feb 26;25(1):354
BMC cancer 2025 Feb 26;25(1):354
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Zhang R, Zhang Z, Xie L, Yu Z, Gao R, Zhang ZR, Zhang Y, Wei X, Chen Y, Jiao S, Gao Y, Guo JP
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
Microenvironment-Responsive Hydrogels Comprising Engineering Zeolitic Imidazolate Framework-8-Anchored Parathyroid Hormone-Related Peptide-1 for Osteoarthritis Therapy.
Shi G, Wu Z, Hao Z, Zhu M, Shu F, Yang Z, Wang J, Wang C, Chen R, Li Z, Wei R, Li J
ACS nano 2025 Feb 18;19(6):6529-6553
ACS nano 2025 Feb 18;19(6):6529-6553
Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway.
He Y, Huang C, Chen J, Shen W
Heliyon 2025 Feb 15;11(3):e42159
Heliyon 2025 Feb 15;11(3):e42159
Dissecting the mechanisms of velvet antler extract against diabetic osteoporosis via network pharmacology and proteomics.
Wang M, Zhou Z, Wei Y, He R, Yang J, Zhang X, Li X, Zhao D, Li Z, Leng X, Dong H
Journal of ethnopharmacology 2025 Feb 11;341:119334
Journal of ethnopharmacology 2025 Feb 11;341:119334
Endostatin-expressing endometrial mesenchymal stem cells inhibit angiogenesis in endometriosis through the miRNA-21-5p/TIMP3/PI3K/Akt/mTOR pathway.
Cheng Y, Guo Q, Cheng Y, Wang D, Sun L, Liang T, Wang J, Wu H, Peng Z, Zhang G
Stem cells translational medicine 2025 Feb 11;14(2)
Stem cells translational medicine 2025 Feb 11;14(2)
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
Lu J, Wang C
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
Li X, Weng SQ, Li QH, Ji M, Zhou Y, Xiao Q, Luo T, Liu ZX
Cell biochemistry and biophysics 2025 Dec;83(4):4781-4792
Cell biochemistry and biophysics 2025 Dec;83(4):4781-4792
Flavonols interrupt internalized bacteria hijacking cellular responses via suppressing oxidative stress induced cellular apoptotic death.
Lv R, Cai Z, Sun Z, Zhang W, Wang J, Bian Y, Li Z, Liu X
International journal of antimicrobial agents 2025 Dec;66(6):107595
International journal of antimicrobial agents 2025 Dec;66(6):107595
USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.
Chen Y, Hong S, Wu F, Xu S, Yang Y, Xu J
Biochemical pharmacology 2025 Dec;242(Pt 2):117196
Biochemical pharmacology 2025 Dec;242(Pt 2):117196
Dietary urolithin A suppresses lung cancer via gut microbiota-mediated autophagy activation.
Zhang J, Li X, Sun L, Chen B, Zhang R, Duan J
The Journal of nutritional biochemistry 2025 Dec;146:110080
The Journal of nutritional biochemistry 2025 Dec;146:110080
Therapeutic Potential of 6-Gingerol in Glioma: Mechanistic Insights and Experimental Validation.
Miao S, Hua W, Wang J, Li L, Sun Y, Shi X, Ma S
Chemical biology & drug design 2025 Dec;106(6):e70217
Chemical biology & drug design 2025 Dec;106(6):e70217
Sestrin2 Knockdown Impairs Proliferation, Migration, Invasion, and Apoptosis in OSCC Cells via PI3K/AKT/mTOR and MAPK Pathways.
Yang W, Wang W, Zhang Z, Zhao Z, Li K, Liu Z, Xu L, Shi M, Li Y, Wang H
Current issues in molecular biology 2025 Dec 26;48(1)
Current issues in molecular biology 2025 Dec 26;48(1)
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN
World journal of stem cells 2025 Dec 26;17(12):112207
World journal of stem cells 2025 Dec 26;17(12):112207
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
Han L, Zhai H, Ma X, Li H, Ren Q, Liu J, Zhang Z, Li X, Zhang Q, Sun X
Current issues in molecular biology 2025 Dec 20;48(1)
Current issues in molecular biology 2025 Dec 20;48(1)
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
Zhang L, Gao A, Peng K
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
Ha H, Wang J, Zhang X, Du Y, Xiong W, Li S, Shang P
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
Synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241.
Chu PY, Pan YC, Hsu WY, Chuang DW, Yang JC, Chen GY, Jang YJ, Wu YC
RSC medicinal chemistry 2025 Aug 28;16(11):5364-81
RSC medicinal chemistry 2025 Aug 28;16(11):5364-81
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.
Lan TH, Li W, Wang X, Geng YJ, Pang B, Kang LF, Li DY, Pang LY, Zhang XX, Zhang CQ, Wang GQ, Li ZX, Zhou CM, Jiang X, Zhao ZR
iScience 2025 Aug 15;28(8):113165
iScience 2025 Aug 15;28(8):113165
TFAP4 Regulation of MCM5 Activates the PI3K/AKT Pathway to Promote Invasion and Metastasis of Gastric Cancer.
Yuan YW, Yue ZQ, Zhou Q, Sheng J, Zou YH, Fan LJ, Xu H, Xin L
Digestive diseases and sciences 2025 Apr;70(4):1411-1427
Digestive diseases and sciences 2025 Apr;70(4):1411-1427
TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway.
Zhou Q, You Y, Zhao Y, Xiao S, Song Z, Huang C, Qian J, Lu W, Tong H, Zhang Y, Wang Z, Li W, Zhang C, Guo X, Luo R, Hou Y, Cui J, Lu L, Zhou Y
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):455-470
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):455-470
Prunus mume Alleviates Hyperuricemic Renal Injury: Insights From Network Pharmacology and Experimental Models.
Zheng S, Li S, Diao X, Chen N
Biomedical chromatography : BMC 2025 Apr;39(4):e70035
Biomedical chromatography : BMC 2025 Apr;39(4):e70035
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Yang H, Wang Z, Xiong W, Zhou L, Yu S
Experimental neurology 2025 Apr;386:115175
Experimental neurology 2025 Apr;386:115175
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Ma YN, Jiang XM, Hu XQ, Wang L, Gao JJ, Liu H, Qi FH, Song PP, Tang W
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Proteomic Analysis of Human Follicular Fluid-Derived Exosomes Reveals That Insufficient Folliculogenesis in Aging Women is Associated With Infertility.
Liu Z, Zhou Q, Zan J, Tian J, Zhang Y, Wu F, Zhao H, Peng Q, Liu S, Chen Q, Liu E, Liao Z, Zou P, Mei L, Wang W, Dong S, Niu L, Wu S, He L, Zhou X, Jin Y, Li P, Yang S
Molecular & cellular proteomics : MCP 2025 Apr;24(4):100930
Molecular & cellular proteomics : MCP 2025 Apr;24(4):100930
Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species-Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway.
Han H, Wen Z, Yang M, Wang C, Ma Y, Chen Q, Jiang D, Xu Y, Fazal A, Jie W, Lv X, Yin T, Lin H, Lu G, Qi J, Yang Y, Xu G
Chemistry & biodiversity 2025 Apr;22(4):e202403291
Chemistry & biodiversity 2025 Apr;22(4):e202403291
p16(INK4a) Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.
Li B, Wang K, Wang X, Zhang Z, Huang G, Ma Y, Du Y, Gu X, Hui J
Journal of cardiovascular translational research 2025 Apr;18(2):375-391
Journal of cardiovascular translational research 2025 Apr;18(2):375-391
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Network pharmacology-based exploration of the mechanism of Wenweishu granule in treating chronic atrophic gastritis with spleen-stomach cold deficiency syndrome.
Zheng J, Jiao Z, Yang X, Ruan Q, Huang Y, Jin C, Gui S, Xuan Z, Jia X
Journal of ethnopharmacology 2025 Apr 9;345:119591
Journal of ethnopharmacology 2025 Apr 9;345:119591
Orbital mesenchymal chondrosarcoma and its specific fusion gene HEY1-NCOA2.
Lin JQ, Liu X, Zhao JZ, Wang Q, Zhu LM, Lin TT
BMC ophthalmology 2025 Apr 29;25(1):258
BMC ophthalmology 2025 Apr 29;25(1):258
Comprehensive characterisation of bioactive compounds in Boletus edulis as functional foods to improve muscle atrophy; through whole plant targeted metabolomics, network pharmacology, in vivo and in vitro experiments, molecular docking and molecular dynamics analysis.
Zhang M, Chen M, Yan Y, Lu J, Sheng J, Gui M, Ma X
Journal of ethnopharmacology 2025 Apr 25;346:119685
Journal of ethnopharmacology 2025 Apr 25;346:119685
BPIFB4 rs4339026 A > G polymorphism impacts COPD susceptibility in the Kashi population, China.
Xu J, Tao L, Shi Y, Gong H, Abudureheman Z, Zheng A, Zhong X, Xue L, Zou X, Li L
Scientific reports 2025 Apr 25;15(1):14515
Scientific reports 2025 Apr 25;15(1):14515
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.
Wang H, Liang Q, Wen Z, Ma W, Ji S, Zhang H, Zhang X
Scientific reports 2025 Apr 23;15(1):14214
Scientific reports 2025 Apr 23;15(1):14214
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth.
Rao K, Zhang X, Luo Y, Xia Q, Jin Y, He J
Cell reports 2025 Apr 22;44(4):115441
Cell reports 2025 Apr 22;44(4):115441
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
Fang X, Jiang XF, Zhang YP, Zhou CL, Dong YJ, Bo-Li, Lv GY, Chen SH
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
The Mechanism of Action and Experimental Verification of Narenmandula in the Treatment of Postmenopausal Osteoporosis.
Xiao J, Yu Z, Han Q, Guo Y, Ye J, Lian H, Wang L, Ma Y, Liu M
Combinatorial chemistry & high throughput screening 2024;27(15):2249-2259
Combinatorial chemistry & high throughput screening 2024;27(15):2249-2259
Network Analysis and Basic Experiments on the Inhibition of Renal Cancer Proliferation and Migration by Alpinetin through PI3K/AKT/ mTOR Pathway.
Guo Y, Jiang L, Luo S, Hu D, Zhao X, Zhao G, Tang W
Current molecular medicine 2024;24(1):134-144
Current molecular medicine 2024;24(1):134-144
Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.
Sun J, Yao C, Luo W, Ge X, Zheng W, Sun C, Zhang Y
Journal of tissue engineering and regenerative medicine 2024;2024:3870988
Journal of tissue engineering and regenerative medicine 2024;2024:3870988
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior.
Liu X, Zhang WM, Meng N, Lin LJ, Tang GD
Open life sciences 2024;19(1):20220806
Open life sciences 2024;19(1):20220806
Yishen paidu pills attenuates 5/6 nephrectomy induced kidney disease via inhibiting the PI3K/AKT/mTOR signaling pathway.
Liu S, Cao Y, Yuan Q, Xie Y, Zhu Y, Yao L, Zhang C
Frontiers in pharmacology 2024;15:1510098
Frontiers in pharmacology 2024;15:1510098
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
Luo Y, Gao H, Zhao J, Chen L, Shao J, Ju L
Frontiers in immunology 2024;15:1469740
Frontiers in immunology 2024;15:1469740
Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.
Zhong Y, Chang X, Zhao Z, Zheng L, Kuang G, Li P, Liu C, Fan Y, Liang Z, Zhuang K, Xie Q, Liu Y
Frontiers in pharmacology 2024;15:1402465
Frontiers in pharmacology 2024;15:1402465
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Cai W, Xiao Y, Yan J, Peng H, Tu C
Frontiers in cell and developmental biology 2024;12:1489774
Frontiers in cell and developmental biology 2024;12:1489774
Bioinformatics analysis and experimental verification of TIGD1 in non-small cell lung cancer.
Xia L, Yang Z, Xv M, Wang G, Mao Y, Yang Y, Tang J
Frontiers in medicine 2024;11:1374260
Frontiers in medicine 2024;11:1374260
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Zhang W, Yu L, Xu C, Tang T, Cao J, Chen L, Pang X, Ren W
Cell biology international 2024 Sep;48(9):1285-1300
Cell biology international 2024 Sep;48(9):1285-1300
Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Fu ZY, Huang Y, Lian LS, Huang HT, Zhan SF, Cai Y, Li JX, Liu XH
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Zhu C, Zhang M, Gong S, Du J, Ma L, Liu Y, Li Y, Yu J, Liu N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease.
Zhang Y, Qu X, Xu N, He H, Li Q, Wei X, Chen Y, Xu Y, Li X, Zhang R, Zhong R, Liu C, Xiang P, Zhu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155818
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155818
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Luo Z, Zheng S, Liu J, Qi F
Cellular signalling 2024 Sep;121:111275
Cellular signalling 2024 Sep;121:111275
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Qin Y, Li W, Liu J, Wang F, Zhou W, Xiao L, Zhou P, Wu F, Chen X, Xu S, Liu L, Xiao X, Zhang D
International immunopharmacology 2024 Sep 30;139:112719
International immunopharmacology 2024 Sep 30;139:112719
Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo.
Wang Z, Ma J, Sun Y, Jin Z, Zheng R, Li Y, Yu H, Ye H, Wu Y, Ge X, Chen Z
International immunopharmacology 2024 Sep 30;139:112717
International immunopharmacology 2024 Sep 30;139:112717
Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.
Sun B, Shen K, Zhao R, Li Y, Lin J
International immunopharmacology 2024 Sep 30;139:112624
International immunopharmacology 2024 Sep 30;139:112624
Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.
Wang YN, Chen XL, Yang J, Gong XX, Zhang HF, Zhang YM, Zeng DF, Chen PS, Chen HB
Placenta 2024 Sep 26;155:32-41
Placenta 2024 Sep 26;155:32-41
Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism.
Liu Z, Yang Y, Xu Y, Zhang Z, Tang R, Liu J, Jiang H, Zhao R
Food & function 2024 Sep 16;15(18):9272-9283
Food & function 2024 Sep 16;15(18):9272-9283
Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation.
Li R, Ke H, Liu P, Yang Q, Li Y, Ke L, Wang X, Wu C, Zhang Y
Heliyon 2024 Sep 15;10(17):e36579
Heliyon 2024 Sep 15;10(17):e36579
Epidermal Growth Factor Receptor Emerges as a Viable Target for Reducing Tumorigenicity of MDCK Cells.
Yang D, Liao Y, Huang L, Shi J, Wang J, Qiao Z, Ma Z, Yu S
Genes 2024 Sep 14;15(9)
Genes 2024 Sep 14;15(9)
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-κB signaling pathways to promote wound healing.
Zhang X, Hu F, Li J, Chen L, Mao YF, Li QB, Nie CY, Lin C, Xiao J
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Sep 1;200:106847
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Sep 1;200:106847
Miltefosine induces reproductive toxicity during sperm capacitation by altering PI3K/AKT signaling pathway.
Jung EJ, Lee WJ, Bae JW, Kwon WS
Environmental toxicology and pharmacology 2024 Oct;111:104565
Environmental toxicology and pharmacology 2024 Oct;111:104565
Milk-Derived Extracellular Vesicles Carrying ssc-let-7c Alleviate Early Intestinal Inflammation and Regulate Macrophage Polarization via Targeting the PTEN-Mediated PI3K/Akt Pathway.
Lu D, Zhang X, Ye H, Wang J, Han D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22092-22104
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22092-22104
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Yang J, Cong N, Shi D, Chen S, Zhang Z, Zhao P
Journal of ethnopharmacology 2024 Oct 5;332:118366
Journal of ethnopharmacology 2024 Oct 5;332:118366
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Yang Y, Liu X, Liu W, Zhou X, Zhang Z, Hu Y, Liu P, Li X, Liu H, Li S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Ouabain Ameliorates Alzheimer's Disease-Associated Neuropathology and Cognitive Impairment in FAD(4T) Mice.
Wang D, Liu J, Zhu Q, Wei X, Zhang X, Chen Q, Zhao Y, Tang H, Xu W
Nutrients 2024 Oct 20;16(20)
Nutrients 2024 Oct 20;16(20)
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress.
Gu L, Wang X, Wu Z, Chen J
Journal of molecular neuroscience : MN 2024 Oct 16;74(4):97
Journal of molecular neuroscience : MN 2024 Oct 16;74(4):97
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Li X, Zheng K, Chen H, Li W
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
NONRATT000538.2 promotes vascular smooth muscle cell phenotypic switch and in-stent restenosis.
Zhao J, Cheng Y, Zhou M
Experimental cell research 2024 Oct 1;442(2):114260
Experimental cell research 2024 Oct 1;442(2):114260
The effect of repetitive magnetic stimulation on neuronal apoptosis and PI3K/Akt protein expression in rats with incomplete spinal cord injury.
Su J, Zhou F, Hu M, Xu Q, Huang Y, Chen S, Zhou H, Chen H
Journal of neurophysiology 2024 Oct 1;132(4):1211-1222
Journal of neurophysiology 2024 Oct 1;132(4):1211-1222
Rational Design of Human Hair Keratin-Driven Proteins for Hair Growth Promotion.
Zhang H, Qing R, Li W, Yuan Y, Pan Y, Tang N, Huang Q, Wang B, Hao S
Advanced healthcare materials 2024 Nov;13(29):e2401378
Advanced healthcare materials 2024 Nov;13(29):e2401378
Taurine Inhibits Lung Metastasis in Triple-Negative Breast Cancer by Modulating Macrophage Polarization Through PTEN-PI3K/Akt/mTOR Pathway.
Lin Y, Huang Y, Zheng Y, Chen W, Zhang Y, Yang Y, Huang W
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Nov-Dec 01;47(9):369-377
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Nov-Dec 01;47(9):369-377
Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways.
Chen L, Chen LJ, Shen HW, Hsu C, Zeng JH, Li JH, Liu JL, Yang JZ, Liu Y, Li XW, Xie XL, Wang Q, Zhao D
Ecotoxicology and environmental safety 2024 Nov 1;286:117185
Ecotoxicology and environmental safety 2024 Nov 1;286:117185
2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways.
Hsu C, Zeng JH, Chen L, Chen LJ, Li XW, Yang JZ, Liu Y, Liu JL, Li JH, Li JH, Xie XL, Wang Q
Ecotoxicology and environmental safety 2024 Nov 1;286:117173
Ecotoxicology and environmental safety 2024 Nov 1;286:117173
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Zhang H, Hu S, Sanches JGP, Li Y, Wei Y, Pu C, Zhang J
Journal of physiology and biochemistry 2024 May;80(2):381-392
Journal of physiology and biochemistry 2024 May;80(2):381-392
Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway.
Si J, Chen X, Qi K, Li D, Liu B, Zheng Y, Ji E, Yang S
Chinese journal of natural medicines 2024 May;22(5):426-440
Chinese journal of natural medicines 2024 May;22(5):426-440
Regulation of Glucose Metabolism for Cell Energy Supply In Situ via High-Energy Intermediate Fructose Hydrogels.
Lu B, Zhao Q, Cai Z, Qian S, Mao J, Zhang L, Mao X, Sun X, Cui W, Zhang Y
Small (Weinheim an der Bergstrasse, Germany) 2024 May;20(19):e2309060
Small (Weinheim an der Bergstrasse, Germany) 2024 May;20(19):e2309060
miR-122-5p Promotes Cowshed Particulate Matter2.5-Induced Apoptosis in NR8383 by Targeting COL4A1.
Sun Y, Sun K, Ma Z, Zhang X, Du X, Jia Y, Zhu Y, Inam M, Gao Y, Basang W
Toxics 2024 May 25;12(6)
Toxics 2024 May 25;12(6)
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Du Y, Xu Y, Guo X, Tan C, Zhu X, Liu G, Lyu X, Bei C
BMC cancer 2024 May 22;24(1):624
BMC cancer 2024 May 22;24(1):624
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Wang C, Xiong ZM, Cong YQ, Li ZY, Xie Y, Wang YX, Zhou HM, Yang YF, Liu JJ, Wu HZ
Scientific reports 2024 May 16;14(1):11240
Scientific reports 2024 May 16;14(1):11240
Efficacy and Safety of Asparagusic Acid against Echinococcus multilocularis In Vitro and in a Murine Infection Model.
Lu Z, Wang Y, Liu C, Fan H
Tropical medicine and infectious disease 2024 May 11;9(5)
Tropical medicine and infectious disease 2024 May 11;9(5)
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking.
Huang XL, Sun Y, Wen P, Pan JC, He WY
The Journal of international medical research 2024 Mar;52(3):3000605241234006
The Journal of international medical research 2024 Mar;52(3):3000605241234006
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Xu X, Li Y, Xu R, Meng Y, Li Z, Zuo D, Wu Y
The FEBS journal 2024 Mar;291(6):1199-1219
The FEBS journal 2024 Mar;291(6):1199-1219
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice.
Lai J, Liang J, Chen K, Guan B, Chen Z, Chen L, Fan J, Zhang Y, Li Q, Su J, Chen Q, Lin J
Chinese journal of natural medicines 2024 Mar;22(3):235-248
Chinese journal of natural medicines 2024 Mar;22(3):235-248
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Zhang S, Cai X, Khan GJ, Cheng J, He J, Zhai K, Mao Y
Journal of ethnopharmacology 2024 Mar 25;322:117572
Journal of ethnopharmacology 2024 Mar 25;322:117572
FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
Wang DX, Bao SY, Song NN, Chen WZ, Ding XQ, Walker RJ, Fang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23436
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23436
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Shi Z, Yang F, Hu Y, Pang Q, Shi L, Du T, Cao Y, Song B, Yu X, Cao Z, Ye Z, Liu C, Yu R, Chen X, Zhu Y, Pang Q
Carbohydrate polymers 2024 Mar 1;327:121666
Carbohydrate polymers 2024 Mar 1;327:121666
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Dong P, Zhou L, Wang X, Xue L, Du Y, Cui R
European journal of medical research 2024 Mar 1;29(1):149
European journal of medical research 2024 Mar 1;29(1):149
Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling.
Que Y, Shi J, Zhang Z, Sun L, Li H, Qin X, Zeng Z, Yang X, Chen Y, Liu C, Liu C, Sun S, Jin Q, Zhang Y, Li X, Lei M, Yang C, Tian H, Tian J, Chang J
Exploration (Beijing, China) 2024 Jun;4(3):20230067
Exploration (Beijing, China) 2024 Jun;4(3):20230067
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.
Wang X, Li X, Ma X, Zhang L, Han T, Zhang D
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4183-4194
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4183-4194
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Bai X, Deng J, Duan Z, Fu R, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway.
Lin Y, Li Y, Chen X, Jin X, Jiang M, Xiao H, Chen L, Chen M, Zhang W, Chen H, Nie Q, Guo R, Guo W, Fu F, Wang C
Biology direct 2024 Jun 3;19(1):42
Biology direct 2024 Jun 3;19(1):42
Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12.
Lin J, Gu M, Wang X, Chen Y, Chau NV, Li J, Chu Q, Qing L, Wu W
Journal of ethnopharmacology 2024 Jun 28;328:118125
Journal of ethnopharmacology 2024 Jun 28;328:118125
NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
Gu W, Li C, Shen T, Tong L, Yuan W, Zheng X, Wang T, Wang S, Zhu B, Zhang C, Zhang C
Aging 2024 Jun 24;16(12):10546-10562
Aging 2024 Jun 24;16(12):10546-10562
Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway.
Hu S, Fei Y, Jin C, Yao J, Ding H, Wang J, Liu C
Neuropharmacology 2024 Jun 15;251:109929
Neuropharmacology 2024 Jun 15;251:109929
Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects.
Yu B, Wang Q, Zhang L, Lin J, Feng Z, Wang Z, Gu L, Tian X, Luan S, Li C, Zhao G
Redox biology 2024 Jul;73:103206
Redox biology 2024 Jul;73:103206
Anthrahydroquinone‑2,6‑disulfonate attenuates PQ‑induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of the PI3K/AKT/eNOS pathway.
Li N, Yi Y, Chen J, Huang Y, Peng J, Li Z, Wang Y, Zhang J, Xu C, Liu H, Li J, Liu X
International journal of molecular medicine 2024 Jul;54(1)
International journal of molecular medicine 2024 Jul;54(1)
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
Chen H, Peng L, Wang Z, He Y, Zhang X
Oral diseases 2024 Jul;30(5):3225-3238
Oral diseases 2024 Jul;30(5):3225-3238
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Su S, Liu L, Fu Q, Ma M, Yang N, Pan T, Geng S, Yu XF, Zhu J
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
Duan H, Li H, Liu T, Chen Y, Luo M, Shi Y, Zhou J, Rashed MMA, Zhai K, Li L, Wei Z
ACS omega 2024 Jul 30;9(30):32920-32930
ACS omega 2024 Jul 30;9(30):32920-32930
Echistatin/BYL-719 impedes epithelial-mesenchymal transition in pulmonary fibrosis induced by silica through modulation of the Integrin β1/ILK/PI3K signaling pathway.
Li H, Wang P, Hu M, Xu S, Li X, Xu D, Feng K, Zhou Q, Chang M, Yao S
International immunopharmacology 2024 Jul 30;136:112368
International immunopharmacology 2024 Jul 30;136:112368
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
Liu D, Yang K, Li T, Tang T, Wang Y, Wang W, Li J, Zhou P, Wang X, Zhao C, Guo D, Xie Y, Cheng J, Wang M, Sun J, Zhang X
Heliyon 2024 Jul 15;10(13):e34214
Heliyon 2024 Jul 15;10(13):e34214
LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway.
Luo B, Zhuang L, Huang J, Shi L, Zhang L, Zhu M, Lu Y, Zhu Q, Sun D, Wang H, Fang H
Journal of cancer research and clinical oncology 2024 Jul 13;150(7):351
Journal of cancer research and clinical oncology 2024 Jul 13;150(7):351
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Wang T, Chen S, Wang Z, Li S, Fei X, Wang T, Zhang M
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Li Y, Yang X, Bao T, Sun X, Li X, Zhu H, Zhang B, Ma T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.
Liu H, Li Z, Xu B, Li Z, Yang X, Luo J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241308082
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241308082
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Ma G, Dong Q, Li F, Jin Z, Pi J, Wu W, Li J
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms.
Gu D, Ye M, Zhu G, Bai J, Chen J, Yan L, Yu P, Lu F, Hu C, Zhong Y, Liu P, He Q, Tang Q
Journal of translational medicine 2024 Jan 23;22(1):93
Journal of translational medicine 2024 Jan 23;22(1):93
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Yu S, Xiong W, Xu W, Chen Y
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM(2.5)-induced inflammatory response in human bronchial epithelial cells.
Li JL, Tan Y, Wang QL, Li CX, Hong JC, Wang HJ, Wu Y, Ni C, Peng XW
Ecotoxicology and environmental safety 2024 Jan 15;270:115778
Ecotoxicology and environmental safety 2024 Jan 15;270:115778
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Xiong M, Chen X, Wang H, Tang X, Wang Q, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
Vitamin K1 ameliorates lipopolysaccharide-triggered skeletal muscle damage revealed by faecal bacteria transplantation.
Xiao Y, Feng J, Jia J, Li J, Zhou Y, Song Z, Guan F, Li X, Liu L
Journal of cachexia, sarcopenia and muscle 2024 Feb;15(1):81-97
Journal of cachexia, sarcopenia and muscle 2024 Feb;15(1):81-97
Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice.
Miao L, Zhang X, Zhang H, Cheong MS, Chen X, Farag MA, Cheang WS, Xiao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155296
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155296
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
Zhao X, Liu D, Zhao Y, Wang Z, Wang Y, Chen Z, Ning S, Wang G, Meng L, Yao J, Tian X
Cell death & disease 2024 Feb 20;15(2):154
Cell death & disease 2024 Feb 20;15(2):154
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.
Yao C, Sun J, Luo W, Chen H, Chen T, Chen C, Zhang B, Zhang Y
Bone & joint research 2024 Feb 1;13(2):52-65
Bone & joint research 2024 Feb 1;13(2):52-65
In silico and in vivo verification of the mechanism of formononetin in treating hepatocellular carcinoma.
Ma G, Pang X, Ran Y, Chen W, Zhou Y, Li X, Liu B, Li F, Hu S
Annals of medicine 2024 Dec;56(1):2404550
Annals of medicine 2024 Dec;56(1):2404550
Auranofin Suppresses the Growth of Canine Mammary Tumour Cells and Induces Apoptosis via the PI3K/AKT Pathway.
Lin Z, Chen R, Wang J, Zheng Y, He Z, Yan Y, Zhang L, Huang X, Zhang H
Veterinary and comparative oncology 2024 Dec;22(4):555-565
Veterinary and comparative oncology 2024 Dec;22(4):555-565
New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions.
Kuang QX, Huang YQ, Ruan YQ, Lai HZ, Long J, Yan CY, Lei HR, Guo DL, Deng Y, You FM, Jiang YF
Bioorganic chemistry 2024 Dec;153:107899
Bioorganic chemistry 2024 Dec;153:107899
Gnetupendin A protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway.
Mu D, Liu J, Mi Y, Wang D, Xu L, Yang Y, Liu Y, Liang D, Hou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156233
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156233
Astragaloside IV and cycloastragenol promote liver regeneration through regulation of hepatic oxidative homeostasis and glucose/lipid metabolism.
Li Y, Yang X, Li X, Wang S, Chen P, Ma T, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156165
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156165
Quercetin-primed BMSC-derived extracellular vesicles ameliorate chronic liver damage through miR-136-5p and GNAS/STAT3 signaling pathways.
Jiang X, Liu Z, You H, Tang Z, Ma Y, Nie R, Yang Z, Che N, Liu W
International immunopharmacology 2024 Dec 5;142(Pt B):113162
International immunopharmacology 2024 Dec 5;142(Pt B):113162
The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway.
Wang S, Duan Z, Li Z, Yang D, Lu H, Zhang Y, Fu Y, Guan Y, Li G, Qian F, Xu T
BMC musculoskeletal disorders 2024 Dec 30;25(1):1081
BMC musculoskeletal disorders 2024 Dec 30;25(1):1081
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.
Xiaoyu L, Dandan L, Tianzhao O, Ziyou Z, Zhenlin L, Zhuang L, Mingrui L, Yusong H, Yangyang Z, Yanjiao L, Chun S, Siqi W, Tong L, Bensi Z
Scientific reports 2024 Dec 28;14(1):31447
Scientific reports 2024 Dec 28;14(1):31447
Nirmatrelvir has detrimental effects on sperm function by altering the PI3K/PDK1/AKT signaling pathway.
Jung EJ, Jo JH, Uwamahoro C, Jang SI, Hwang JM, Lee WJ, Bae JW, Ryu DY, Kwon WS
Toxicology in vitro : an international journal published in association with BIBRA 2024 Aug;99:105848
Toxicology in vitro : an international journal published in association with BIBRA 2024 Aug;99:105848
Quercetin inhibits hypertonicity-induced inflammatory injury in human corneal epithelial cells via the PTEN/PI3K/AKT pathway.
Huang Y, Xia X, Li M, Li D, Xie S, Li J, Yang Y, Peng Q
Tissue & cell 2024 Aug;89:102465
Tissue & cell 2024 Aug;89:102465
Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology.
Pei C, Yu J, Wang G, Jia YR, Shi X, Zhang L
Biomedical chromatography : BMC 2024 Aug;38(8):e5893
Biomedical chromatography : BMC 2024 Aug;38(8):e5893
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.
Tang X, Huang Y, Fu W, Wang P, Feng L, Yang J, Zhu H, Huang X, Ming Q, Li P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117046
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117046
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Mao Y, Zha Y, Zang Y, Gao Y, Sun J, Liu Y, Wang Z, Wei Z, Wang M, Yang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Liu T, Zhu C, Duan Z, Ma P, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Identification of epithelial-related artificial neural network prognostic models for the prediction of bladder cancer prognosis through comprehensive analysis of single-cell and bulk RNA sequencing.
Zhao F, Zhang K, Ma L, Huang Y
Heliyon 2024 Aug 15;10(15):e34632
Heliyon 2024 Aug 15;10(15):e34632
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Wang N, Guo W, Liu T, Chen X, Lin M
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway.
Han X, Ding W, Qu G, Li Y, Wang P, Yu J, Liu M, Chen X, Xie S, Feng J, Xu S
Respiratory physiology & neurobiology 2024 Apr;322:104219
Respiratory physiology & neurobiology 2024 Apr;322:104219
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Chen L, Wang J, Ren Y, Ma Y, Liu J, Jiang H, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Zhang ZT, Liang QF, Wang X, Wang RS, Duan TT, Wang SM, Tang D
Journal of ethnopharmacology 2024 Apr 6;323:117647
Journal of ethnopharmacology 2024 Apr 6;323:117647
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Cheng F, Zhang J, Yang P, Chen Z, Fu Y, Mi J, Xie X, Liu S, Sheng Y
Heliyon 2024 Apr 30;10(8):e29162
Heliyon 2024 Apr 30;10(8):e29162
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Wang J, Yin H, Li G, Wu D, Xu Y, Chen Y, Wang X, Xing Y, Zhang T, Fei D, Yang P, Fang F, Tao Y, Li X, Yu J, Yang Y, Li Z, Shi L, Zhang Z, Pan J
Cell death discovery 2024 Apr 22;10(1):186
Cell death discovery 2024 Apr 22;10(1):186
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Xu K, Liu Z, Pan S, Zhang N, Wu S, Yang G, Song X, Teng Y, Tong X
Brain research 2024 Apr 15;1829:148795
Brain research 2024 Apr 15;1829:148795
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
Fan L, Guo Y, Wu Q, Hu T, Chen X, Guo J, Liu Y, Lu Y, Lin M
Evidence-based complementary and alternative medicine : eCAM 2023;2023:6931644
Evidence-based complementary and alternative medicine : eCAM 2023;2023:6931644
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Ning J, Ding J, Wang S, Jiang Y, Wang D, Jiang S
Journal of immunology research 2023;2023:5532617
Journal of immunology research 2023;2023:5532617
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
Gao HT, Yang Z, Sun H, Zhang Y, Wang Z, Liu WY, Wen HZ, Qu CB, Wang XL
American journal of translational research 2023;15(2):779-798
American journal of translational research 2023;15(2):779-798
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Zhu J, Li Z, Yin F, Yu X, Lu Y, Zhou T, Gong F, Xu Z
Frontiers in pharmacology 2023;14:1143096
Frontiers in pharmacology 2023;14:1143096
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation.
Jin YB, Liang XC, Cai JH, Wang K, Wang CY, Wang WH, Chen XL, Bao S
Frontiers in oncology 2023;13:1205604
Frontiers in oncology 2023;13:1205604
Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.
Jia J, He R, Yao Z, Su J, Deng S, Chen K, Yu B
PeerJ 2023;11:e16121
PeerJ 2023;11:e16121
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Tan C, Shi W, Zhang Y, Liu C, Hu T, Chen D, Huang J
Life science alliance 2023 Sep;6(9)
Life science alliance 2023 Sep;6(9)
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039
International journal of biological macromolecules 2023 Sep 30;249:126039
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Chen YX, Yang H, Wang DS, Yao YT, Chen TT, Tao L, Chen Y, Shen XC
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10.
Li C, Zhang Q, Luo H, Liu R, Feng S, Geng Y, Wang L, Yang Z, Zhang Y, Wang X
Radiation research 2023 Sep 1;200(3):307-319
Radiation research 2023 Sep 1;200(3):307-319
FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice.
Bo W, Ma Y, Feng L, Yu M, Zhang L, Cai M, Song W, Xi Y, Tian Z
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Sep 1;135(3):696-705
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Sep 1;135(3):696-705
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Li T, Yang S, Liu X, Li Y, Gu Z, Jiang Z
Journal of advanced research 2023 Oct;52:119-134
Journal of advanced research 2023 Oct;52:119-134
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.
Hu D, Mo X, Luo J, Wang F, Huang C, Xie H, Jin L
International immunopharmacology 2023 Oct;123:110698
International immunopharmacology 2023 Oct;123:110698
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Zhang Z, Peng S, Xu T, Liu J, Zhao L, Xu H, Zhang W, Zhu Y, Yang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2302909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2302909
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.
Xu W, Gong J, Chen Y, Chen Y, Chen S, Wu Y, He Y, Li C, Yu H, Xie L
Nutrients 2023 Oct 25;15(21)
Nutrients 2023 Oct 25;15(21)
Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling.
Su L, Wu S, Huang C, Zhuo X, Chen J, Jiang X, Kong X, Lv C, Xu Q, Han P, Huang X, Wong PP
NPJ precision oncology 2023 Oct 11;7(1):102
NPJ precision oncology 2023 Oct 11;7(1):102
Two polysaccharides from Rehmannia glutinosa: isolation, structural characterization, and hypoglycemic activities.
Chen H, Liu X, Xie M, Zhong X, Yan C, Xian M, Wang S
RSC advances 2023 Oct 11;13(43):30190-30201
RSC advances 2023 Oct 11;13(43):30190-30201
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.
Sun S, Xu Y, Yu N, Zhang M, Wang J, Wan D, Tian Z, Zhu H
Molecular neurobiology 2023 Nov;60(11):6227-6247
Molecular neurobiology 2023 Nov;60(11):6227-6247
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Feng HG, Wu CX, Zhong GC, Gong JP, Miao CM, Xiong B
Journal of cancer research and clinical oncology 2023 Nov;149(17):15879-15898
Journal of cancer research and clinical oncology 2023 Nov;149(17):15879-15898
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Zhou W, Kang S, Wang F, Qin Y, Liu J, Xiao X, Chen X, Zhang D
European journal of pharmacology 2023 Nov 5;958:176043
European journal of pharmacology 2023 Nov 5;958:176043
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Cheng H, Sun Y, Yu X, Zhou D, Ding J, Wang S, Ma F
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Li P, Fang X, Hao G, Li X, Cai Y, Yan Y, Zan L, Yang R, Liu B
Metabolites 2023 Nov 14;13(11)
Metabolites 2023 Nov 14;13(11)
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S
Redox biology 2023 May;61:102635
Redox biology 2023 May;61:102635
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Ai Z, Wang M, Zhou Y, Yuan D, Jian Q, Wu S, Liu B, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Qin R, Zheng F, Qin W, Wang J, Ma N, Tian W, Li J, Liao M, Qin A
Reproductive biomedicine online 2023 Mar;46(3):425-435
Reproductive biomedicine online 2023 Mar;46(3):425-435
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Sui X, Sun Y, Zhang G, Chi N, Guan Y, Wang D, Li X
Cancer medicine 2023 Mar;12(5):5874-5888
Cancer medicine 2023 Mar;12(5):5874-5888
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
Zhu Y, Yang J, Li Y, Xu J, Fang Z
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Zhou B, Zhou X, Zhan C, Jin M, Yan S
Journal of endocrinological investigation 2023 Jun;46(6):1115-1130
Journal of endocrinological investigation 2023 Jun;46(6):1115-1130
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Liu Z, Xiang H, Deng Q, Fu W, Li Y, Yu Z, Qiu Y, Mei Z, Xu L
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Guo M, Zhu C, Fu R, Ma X, Duan Z, Fan D
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Meng P, Zhang X, Liu TT, Liu J, Luo Y, Xie MX, Yang H, Fang R, Guo DW, Zhong ZY, Wang YH, Ge JW
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
Wu Q, Cui Z, Jiang S, Xia H, Liu L, You Y, Sun Y
Cell biochemistry and function 2023 Jul;41(5):599-608
Cell biochemistry and function 2023 Jul;41(5):599-608
Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERK pathways.
Fu S, Song X, Hu Y, Zhu Q, Lv X, Tang X, Zhang M
Chinese journal of natural medicines 2023 Jul;21(7):527-539
Chinese journal of natural medicines 2023 Jul;21(7):527-539
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Li D, Xia L, Huang P, Wang Z, Guo Q, Huang C, Leng W, Qin S
Cell & bioscience 2023 Jul 3;13(1):124
Cell & bioscience 2023 Jul 3;13(1):124
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Liu Y, Chen LJ, Li XW, Yang JZ, Liu JL, Zhang KK, Li JH, Wang Q, Xu JT, Zhi X
Chemico-biological interactions 2023 Jul 1;379:110512
Chemico-biological interactions 2023 Jul 1;379:110512
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway.
Li J, Yang B
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):19-30
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):19-30
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
Wang W, Jiang X, Xia F, Chen X, Li G, Liu L, Xu Q, Zhu M, Chen C
Molecular biology reports 2023 Jan;50(1):453-464
Molecular biology reports 2023 Jan;50(1):453-464
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Zhang L, Zhang X, Che D, Zeng L, Zhang Y, Nan K, Zhang X, Zhang H, Guo Z
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury.
Hu Z, Xuan L, Wu T, Jiang N, Liu X, Chang J, Wang T, Han N, Tian X
International immunopharmacology 2023 Jan;114:109616
International immunopharmacology 2023 Jan;114:109616
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Liu H, Yu L, Ding Y, Peng M, Deng Y
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Li D, Xia L, Huang P, Wang Z, Guo Q, Huang C, Leng W, Qin S
Cell death discovery 2023 Jan 21;9(1):17
Cell death discovery 2023 Jan 21;9(1):17
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Xing F, Gao H, Chen G, Sun L, Sun J, Qiao X, Xue J, Liu C
Molecular cancer 2023 Jan 10;22(1):6
Molecular cancer 2023 Jan 10;22(1):6
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Wang L, Chen X, Meng F, Huang T, Wang S, Zheng Z, Zheng G, Li W, Zhang J, Liu Y
Journal of physiology and biochemistry 2023 Feb;79(1):19-34
Journal of physiology and biochemistry 2023 Feb;79(1):19-34
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q
Translational oncology 2023 Feb;28:101614
Translational oncology 2023 Feb;28:101614
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Chen B, Zheng D, Liu C, Bhandari A, Hirachan S, Shen C, Mainali S, Li H, Jiang W, Xu J, Zhang X, Tang K, Zhang W
Pathology, research and practice 2023 Feb;242:154325
Pathology, research and practice 2023 Feb;242:154325
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Hu C, Li S, Fu X, Zhao X, Peng J
Cytokine 2023 Feb;162:156105
Cytokine 2023 Feb;162:156105
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Xu W, Song X, Qu Q, Gong Z, Xiao W
Food & function 2023 Feb 21;14(4):2059-2073
Food & function 2023 Feb 21;14(4):2059-2073
The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
Wang Y, Li Y, Ran C, Le W, Dong J, Wang X, Chen B, Jiang X
Neoplasma 2023 Dec;70(6):722-732
Neoplasma 2023 Dec;70(6):722-732
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Li S, Cui Y, Li M, Zhang W, Sun X, Xin Z, Li J
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2154578
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2154578
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Huang Y, Luo W, Chen S, Su H, Zhu W, Wei Y, Qiu Y, Long Y, Shi Y, Wei J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Lead and cadmium co-exposure modified PC12 viability and ER stress: study from a 3 × 3 factorial design.
Su X, Wang R, Wu Y, Yang M, Ba Y, Huang H
Toxicology research 2023 Dec;12(6):1135-1142
Toxicology research 2023 Dec;12(6):1135-1142
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Cao M, Wang J, Jiang X, Sun Z, Zhao L, Chen G
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.
Liu C, Zhao M, Chen J, Xu L, Wang K, Li G
European journal of pharmacology 2023 Dec 5;960:176121
European journal of pharmacology 2023 Dec 5;960:176121
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling.
Zhang Q, Tang X, Zhou Y, Chen X, Peng K, Jiang R, Liu Z, Song X, Xia H
Cancer biology & therapy 2023 Dec 31;24(1):2198904
Cancer biology & therapy 2023 Dec 31;24(1):2198904
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Chen X, Fu K, Lai Y, Dong C, Chen Z, Huang Y, Li G, Jiang R, Wu H, Wang A, Huang S, Shen L, Gao W, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease.
Li F, Peng J, Lu Y, Zhou M, Liang J, Le C, Ding J, Wang J, Dai J, Wan C, Wang J, Luo P, Xia B
International journal of cardiology 2023 Dec 1;392:131303
International journal of cardiology 2023 Dec 1;392:131303
Effects of external environment on promoter methylation of PIK3R5 and related pathway regulation in steroid-induced femoral head necrosis.
Qin W, Jiang M, Lu S, Hu Y, Gan F, Fang W, Chen D, Bo Z
Environmental research 2023 Dec 1;238(Pt 1):117116
Environmental research 2023 Dec 1;238(Pt 1):117116
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
Wu Y, Shi H, Zheng J, Yang Y, Lei X, Qian X, Zhu J
Heliyon 2023 Aug;9(8):e18449
Heliyon 2023 Aug;9(8):e18449
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P
Biochemical genetics 2023 Aug;61(4):1265-1281
Biochemical genetics 2023 Aug;61(4):1265-1281
HnRNP A2/B1 as a potential anti-tumor target for triptolide based on a simplified thermal proteome profiling method using XGBoost.
Chen P, Zhao P, Hu M, Wang L, Lei T, Liu B, Li L, Shi J, Lu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154929
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154929
GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1/PI3K/Akt pathway.
Wang Y, Gao Y, Wang Y, Zhang H, Qin Q, Xu Z, Liu S, Wang X, Qu Y, Liu Y, Jiang X, He H
Cellular signalling 2023 Aug;108:110721
Cellular signalling 2023 Aug;108:110721
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Wang F, Yao W, Yu D, Hao Y, Wu Y, Zhang X
BMC gastroenterology 2023 Aug 11;23(1):276
BMC gastroenterology 2023 Aug 11;23(1):276
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Zhang PP, Zhuo BY, Duan ZW, Li X, Huang SL, Cao Q, Zhao T, Wei SL, Hu XH, Zhang Y
Journal of ethnopharmacology 2023 Aug 10;312:116523
Journal of ethnopharmacology 2023 Aug 10;312:116523
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Shi Y, Zhang ZW, Du MM, Wu J, Li JX
Journal of ethnopharmacology 2023 Aug 10;312:116458
Journal of ethnopharmacology 2023 Aug 10;312:116458
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Feng H, Zhou P, Liu F, Zhang W, Yang H, Li X, Dong J
Environmental science and pollution research international 2023 Apr;30(19):55200-55213
Environmental science and pollution research international 2023 Apr;30(19):55200-55213
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Chen R, Wang Z, Lu T, Liu Y, Ji Y, Yu Y, Tou F, Guo S
Thoracic cancer 2023 Apr;14(10):893-912
Thoracic cancer 2023 Apr;14(10):893-912
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Tian X, Ou G, Hu S, Wang C, Han F, Gao L
Journal of ethnopharmacology 2023 Apr 6;305:116114
Journal of ethnopharmacology 2023 Apr 6;305:116114
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Xiong W, Huang XL, Li CY, Wang XL, Lan HW, Wang TT, Chen ZL, Yang QP, Hu AL, Xia YF, Zhu FR, Zhou ZZ
Folia histochemica et cytobiologica 2022;60(4):323-334
Folia histochemica et cytobiologica 2022;60(4):323-334
Aloe-Emodin Suppresses Oxidative Stress and Inflammation via a PI3K-Dependent Mechanism in a Murine Model of Sepsis.
Gao H, Ren Y, Liu C
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9697887
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9697887
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Li W, Zhang H, Zhang L, Zhang T, Ding H
BioMed research international 2022;2022:7709926
BioMed research international 2022;2022:7709926
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Yang Y, Lai Q, Wang C, Zhou G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells.
Liu X, Yang Y, Tang X, Guo L, Tang X, Zhu T, Zhao T, Zhang W, Zhang P
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6517732
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6517732
si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway.
Li Y, Yu H, Ma Q, Wei M, Liu X, Qi Y, Li C, Dong L, Zhang H
Oxidative medicine and cellular longevity 2022;2022:5081439
Oxidative medicine and cellular longevity 2022;2022:5081439
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Lei Y, Chan M, Liu H, Lyu W, Chen L, Zhong Y, Gan H, Wang M, Qi M, Guo Y, Liu J, Zhang E
Disease markers 2022;2022:4399334
Disease markers 2022;2022:4399334
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Zuo X, Shi X, Zhang X, Chen Z, Yang Z, Pan X, Lai R, Zhao Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
The In Vitro Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.
Wu Y, Zhang YZ, Li MJ, Yang WQ, Cheng LF
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1952891
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1952891
TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
Liu H, Zhang H, Fan H, Tang S, Weng J
Disease markers 2022;2022:1217918
Disease markers 2022;2022:1217918
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Li J, Yang T, Wang Q, Li Y, Wu H, Zhang M, Qi H, Zhang H, Li J
International journal of biological sciences 2022;18(9):3576-3591
International journal of biological sciences 2022;18(9):3576-3591
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ
Drug design, development and therapy 2022;16:843-861
Drug design, development and therapy 2022;16:843-861
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Shu W, Wang Z, Zhao R, Shi R, Zhang J, Zhang W, Wang H
Drug design, development and therapy 2022;16:1847-1863
Drug design, development and therapy 2022;16:1847-1863
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Wang S, Yang XX, Li TJ, Zhao L, Bao YR, Meng XS
Frontiers in pharmacology 2022;13:999935
Frontiers in pharmacology 2022;13:999935
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
Li Y, Deng Y, Zhang X, Fu H, Han X, Guo W, Zhao W, Zhao X, Yu C, Li H, Lei K, Wang T
Frontiers in pharmacology 2022;13:897465
Frontiers in pharmacology 2022;13:897465
ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways.
Wang X, Zhang L, Feng M, Xu Z, Cheng Z, Qian L
Frontiers in pharmacology 2022;13:873614
Frontiers in pharmacology 2022;13:873614
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Lu X, Yao J, Li C, Cui L, Liu Y, Liu X, Wang G, Dong J, Deng Q, Hu Y, Guo D, Wang W, Li C
Frontiers in pharmacology 2022;13:840521
Frontiers in pharmacology 2022;13:840521
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Dong C, Chen Z, Zhu L, Bsoul N, Wu H, Jiang J, Chen X, Lai Y, Yu G, Gu Y, Guo X, Gao W
Frontiers in pharmacology 2022;13:809034
Frontiers in pharmacology 2022;13:809034
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Yu PC, Liu D, Han ZX, Liang F, Hao CY, Lei YT, Guo CR, Wang WH, Li XH, Yang XN, Li CZ, Yu Y, Fan YZ
Frontiers in pharmacology 2022;13:779715
Frontiers in pharmacology 2022;13:779715
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Yin C, Cai J, Gou Y, Li D, Tang H, Wang L, Liu H, Luo B
Frontiers in immunology 2022;13:1078880
Frontiers in immunology 2022;13:1078880
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers.
Li Z, Pu Z, Yang Z, Zhu Y, Deng Y, Li N, Peng F
Frontiers in oncology 2022;12:971618
Frontiers in oncology 2022;12:971618
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Islam MT, Chen FZ, Chen HC, Wahid A
Frontiers in oncology 2022;12:923270
Frontiers in oncology 2022;12:923270
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
Hu S, Ge M, Zhang S, Jiang M, Hu K, Gao L
Frontiers in oncology 2022;12:854596
Frontiers in oncology 2022;12:854596
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Wang H, Chen Y, Yuan Q, Chen L, Dai P, Li X
Frontiers in oncology 2022;12:1053510
Frontiers in oncology 2022;12:1053510
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Wang X, Jian W, Luo Q, Fang L
Cell death & disease 2022 Sep 17;13(9):794
Cell death & disease 2022 Sep 17;13(9):794
Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data.
Chen X, Zhuang J, Chen Q, Xu L, Yue X, Qiao D
The Science of the total environment 2022 Sep 15;839:155984
The Science of the total environment 2022 Sep 15;839:155984
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
Zhang T, Dong Z, Liu F, Pan E, He N, Ma F, Wang G, Wang Y, Dong J
Ecotoxicology and environmental safety 2022 Sep 15;243:113961
Ecotoxicology and environmental safety 2022 Sep 15;243:113961
Scutellarin-mediated autophagy activates exosome release of rat nucleus pulposus cells by positively regulating Rab8a via the PI3K/PTEN/Akt pathway.
Hu SQ, Zou YP, Jiang YQ, Zhang QC, Cheng HX, Wang HR, Li XL
Cell biology international 2022 Oct;46(10):1588-1603
Cell biology international 2022 Oct;46(10):1588-1603
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Yin L, Feng S, Sun Y, Jiang Y, Tang C, Sun D
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Zheng Z, Lei C, Liu H, Jiang M, Zhou Z, Zhao Y, Yu CY, Wei H
Advanced healthcare materials 2022 Oct;11(19):e2200990
Advanced healthcare materials 2022 Oct;11(19):e2200990
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder.
Paul F, Ng C, Mohamad Sahari UB, Nafissi S, Nilipoor Y, Tavasoli AR, Bonnard C, Wong PM, Nabavizadeh N, Altunoğlu U, Estiar MA, Majoie CB, Lee H, Nelson SF, Gan-Or Z, Rouleau GA, Van Veldhoven PP, Massie R, Hennekam RC, Kariminejad A, Reversade B
Human molecular genetics 2022 Oct 28;31(21):3729-3740
Human molecular genetics 2022 Oct 28;31(21):3729-3740
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
Xu H, Chen G, Niu Q, Song K, Feng Z, Han Z
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring.
Zhou K, Cheng R, Zhu M, Yang M, Shen X, Luo X, Ma L, Xu L, Zhang J
Obesity research & clinical practice 2022 Nov-Dec;16(6):500-506
Obesity research & clinical practice 2022 Nov-Dec;16(6):500-506
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Du X, Zhang X, Dong J, Zou N, Guo D, Yao W, Wang X, Li S, Song C, Yan K, Shen W, Zhu S
Journal of translational medicine 2022 Nov 5;20(1):507
Journal of translational medicine 2022 Nov 5;20(1):507
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
He H, Deng J, Yang M, An L, Ye X, Li X
Journal of ethnopharmacology 2022 Nov 15;298:115529
Journal of ethnopharmacology 2022 Nov 15;298:115529
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Zhang Y, Wei Y, Jiang S, Dang Y, Yang Y, Zuo W, Zhu Q, Liu P, Gao Y, Lu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Tian K, Du G, Wang X, Wu X, Li L, Liu W, Wu R
Molecular biology reports 2022 May;49(5):3469-3480
Molecular biology reports 2022 May;49(5):3469-3480
Selenium protects against cadmium-induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling.
Feng J, Yang F, Wu H, Xing C, Xue H, Zhang L, Zhang C, Hu G, Cao H
Environmental toxicology 2022 May;37(5):1185-1197
Environmental toxicology 2022 May;37(5):1185-1197
Anti-fatigue effects of fermented soybean protein peptides in mice.
Fang L, Zhang RX, Wei Y, Ling K, Lu L, Wang J, Pan XC, Cai MY
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H
World journal of gastroenterology 2022 May 7;28(17):1781-1797
World journal of gastroenterology 2022 May 7;28(17):1781-1797
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
Yang G, Lu S, Jiang J, Weng J, Zeng X
International journal of molecular sciences 2022 May 27;23(11)
International journal of molecular sciences 2022 May 27;23(11)
Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway.
Wang F, Zeng Y, Liu X, Cao J, Kang S, Zhou W, Chen X, Liu J, Zhang D
Biochemical and biophysical research communications 2022 May 21;605:162-170
Biochemical and biophysical research communications 2022 May 21;605:162-170
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production.
Fang J, Li M, Zhang G, Du G, Zhou J, Guan X, Chen J
Food & function 2022 May 10;13(9):5089-5101
Food & function 2022 May 10;13(9):5089-5101
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Tu Y, Tan L, Lu T, Wang K, Wang H, Han B, Zhao Y, Chen H, Li Y, Chen H, Chen M, He C
Biochemical pharmacology 2022 Mar;197:114912
Biochemical pharmacology 2022 Mar;197:114912
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Zhang J, Shang L, Jiang W, Wu W
Bioengineered 2022 Mar;13(3):7904-7918
Bioengineered 2022 Mar;13(3):7904-7918
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Huang H, Chen J, Hu X, Chen Y, Xie J, Ao T, Wang H, Xie J, Yu Q
Food & function 2022 Mar 7;13(5):2710-2728
Food & function 2022 Mar 7;13(5):2710-2728
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
Zhao N, Yu H, Xi Y, Dong M, Wang Y, Sun C, Zhang J, Xu N, Liu W
Toxicon : official journal of the International Society on Toxinology 2022 Jun;212:11-18
Toxicon : official journal of the International Society on Toxinology 2022 Jun;212:11-18
The crucial role of thioredoxin interacting protein in the liver insulin resistance induced by di (2-ethylhexyl) phthalates.
Zhang W, Xu P, Li JY
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113045
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113045
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Wu L, Yang FR, Xing ML, Lu SF, Chen HL, Yang QW, Zhang YT, Lu Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
Qiao D, Xing J, Duan Y, Wang S, Yao G, Zhang S, Jin J, Lin Z, Chen L, Piao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154046
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154046
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W
Cells 2022 Jun 14;11(12)
Cells 2022 Jun 14;11(12)
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Niu Z, Lin J, Hao C, Xu X, Wang C, Dai K, Deng X, Deng M, Guo Y, Yao W
International journal of environmental research and public health 2022 Jul 18;19(14)
International journal of environmental research and public health 2022 Jul 18;19(14)
Chronic vitamin D(3) supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Lin J, Niu Z, Xue Y, Gao J, Zhang M, Li M, Peng Y, Zhang S, Li W, Zhang Q, Li X
Neuroscience letters 2022 Jul 13;783:136725
Neuroscience letters 2022 Jul 13;783:136725
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Liu R, Cai D, Li X, Liu B, Chen J, Jiang X, Li H, Li Z, Teerds K, Sun J, Bai W, Jin Y
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Zhou YH, Tang YZ, Guo LY, Zheng LL, Zhang D, Yang CY, Wang W
Microvascular research 2022 Jan;139:104252
Microvascular research 2022 Jan;139:104252
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Liu X, Yang Y, Song J, Li D, Liu X, Li C, Ma Z, Zhong J, Wang L
Bioengineered 2022 Jan;13(1):1320-1334
Bioengineered 2022 Jan;13(1):1320-1334
Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway.
Cheng X, Cao Z, Luo J, Hu R, Cao H, Guo X, Xing C, Yang F, Zhuang Y, Hu G
Poultry science 2022 Jan;101(1):101572
Poultry science 2022 Jan;101(1):101572
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Xu Y, Tang Z, Dai H, Hou J, Li F, Tang Z, Zhang D
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Zheng P, Huang Z, Tong DC, Zhou Q, Tian S, Chen BW, Ning DM, Guo YM, Zhu WH, Long Y, Xiao W, Deng Z, Lei YC, Tian XF
World journal of gastrointestinal oncology 2022 Feb 15;14(2):450-477
World journal of gastrointestinal oncology 2022 Feb 15;14(2):450-477
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Song JX, Zhao YS, Zhen YQ, Yang XY, Chen Q, An JR, Ji ES
Pharmaceutical biology 2022 Dec;60(1):609-620
Pharmaceutical biology 2022 Dec;60(1):609-620
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Zhao Y, Xie Y, Li X, Song J, Guo M, Xian D, Zhong J
Redox report : communications in free radical research 2022 Dec;27(1):200-211
Redox report : communications in free radical research 2022 Dec;27(1):200-211
Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis.
Han H, Qian C, Zong G, Liu H, Wang F, Tao R, Cheng P, Wei Z, Zhao Y, Lu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113897
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Varier KM, Dan G, Liu W, Wu G, Xiao C, Lei H, Ling T, Jiang Y, Chen Y, Ben-David Y, Li Y, Zhang N, Gajendran B, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122
Molecular immunology 2022 Dec;152:111-122
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Sun Y, Li H, Liu L, Bai X, Wu L, Shan J, Sun X, Wang Q, Guo Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
Shen T, Li Y, Wang D, Su Y, Li G, Shang Z, Niu Y, Tan X
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166540
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166540
HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma.
Han N, Li X, Wang Y, Li H, Zhang C, Zhao X, Zhang Z, Ruan M, Zhang C
Oral oncology 2022 Aug;131:105940
Oral oncology 2022 Aug;131:105940
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Huang W, Wen F, Gu P, Liu J, Xia Y, Li Y, Zhou J, Song S, Ruan S, Gu S, Chen X, Shu P
Chinese medicine 2022 Aug 9;17(1):93
Chinese medicine 2022 Aug 9;17(1):93
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Sokouti H, Mohajeri D, Nourazar MA
Physiological research 2022 Aug 31;71(4):551-560
Physiological research 2022 Aug 31;71(4):551-560
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Zhao X, Sun W, Guo B, Cui L
Stem cell research & therapy 2022 Aug 13;13(1):417
Stem cell research & therapy 2022 Aug 13;13(1):417
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Wang Z, Liang M, Li H, Liu B, Yang L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Aihaiti Y, Tuerhong X, Zheng H, Cai Y, Yang M, Xu P
Clinical immunology (Orlando, Fla.) 2022 Apr;237:108964
Clinical immunology (Orlando, Fla.) 2022 Apr;237:108964
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Liu W, Feng Y, Wang X, Ding J, Li H, Guan H, Chen Z
Bioengineered 2022 Apr;13(4):8850-8865
Bioengineered 2022 Apr;13(4):8850-8865
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Li Y, Sun Y, Zhang Q, Liu Y, Niu Y, Li X, Cai D
Journal of ethnopharmacology 2022 Apr 6;287:114937
Journal of ethnopharmacology 2022 Apr 6;287:114937
Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation.
Wang K, Qian R, Li H, Wang C, Ding Y, Gao Z
ACS omega 2022 Apr 5;7(13):11166-11176
ACS omega 2022 Apr 5;7(13):11166-11176
Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 Administration.
Li Y, Lin M, Lin P, Xia N, Li X, Lin L, Yang Y
Frontiers in cell and developmental biology 2021;9:731698
Frontiers in cell and developmental biology 2021;9:731698
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Hua L, Zhou Y, Hou C, Chen J, Wang Y, Zhang S, Zhou H, He S, Jia E
Frontiers in cardiovascular medicine 2021;8:700630
Frontiers in cardiovascular medicine 2021;8:700630
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Qiao D, Jin J, Xing J, Zhang Y, Jia N, Ren X, Lin Z, Jin N, Chen L, Piao Y
The American journal of Chinese medicine 2021;49(2):525-541
The American journal of Chinese medicine 2021;49(2):525-541
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Zhang Y, Chen G, Zhuang X, Guo M
Oxidative medicine and cellular longevity 2021;2021:8807676
Oxidative medicine and cellular longevity 2021;2021:8807676
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
Wang K, Miao X, Kong F, Huang S, Mo J, Jin C, Zheng Y
Drug design, development and therapy 2021;15:3749-3764
Drug design, development and therapy 2021;15:3749-3764
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Deng L, Wu X, Zhu X, Yu Z, Liu Z, Wang J, Zheng Y
American journal of translational research 2021;13(1):57-72
American journal of translational research 2021;13(1):57-72
Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism.
Yang Y, Wang Z, Yao M, Xiong W, Wang J, Fang Y, Yang W, Jiang H, Song N, Liu L, Qian J
Frontiers in pharmacology 2021;12:766024
Frontiers in pharmacology 2021;12:766024
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Yu HX, Lin W, Yang K, Wei LJ, Chen JL, Liu XY, Zhong K, Chen X, Pei M, Yang HT
Frontiers in pharmacology 2021;12:741801
Frontiers in pharmacology 2021;12:741801
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Zeng T, Cao Y, Gu T, Chen L, Tian Y, Li G, Shen J, Tao Z, Lu L
Frontiers in genetics 2021;12:693780
Frontiers in genetics 2021;12:693780
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Luo LF, Qin LY, Wang JX, Guan P, Wang N, Ji ES
Frontiers in pharmacology 2021;12:669782
Frontiers in pharmacology 2021;12:669782
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
Liu X, Fan Y, Du L, Mei Z, Fu Y
Frontiers in pharmacology 2021;12:665102
Frontiers in pharmacology 2021;12:665102
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway.
Liu L, Yan M, Yang R, Qin X, Chen L, Li L, Si J, Li X, Ma K
Frontiers in pharmacology 2021;12:644225
Frontiers in pharmacology 2021;12:644225
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184
Frontiers in oncology 2021;11:661184
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Zhang L, Xie Z, Yu H, Du H, Wang X, Cai J, Qiu Y, Chen R, Jiang X, Liu Z, Li Y, Chen T
Annals of translational medicine 2021 Sep;9(18):1429
Annals of translational medicine 2021 Sep;9(18):1429
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
Liu H, Liu C, Wang M, Sun D, Zhu P, Zhang P, Tan X, Shi G
Scientific reports 2021 Sep 29;11(1):19268
Scientific reports 2021 Sep 29;11(1):19268
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Hu B, Qin C, Li L, Wei L, Mo X, Fan H, Lei Y, Wei F, Zou D
Cancer cell international 2021 Sep 23;21(1):509
Cancer cell international 2021 Sep 23;21(1):509
Dandelion root extract affects ESCC progression via regulating multiple signal pathways.
Duan X, Pan L, Deng Y, Liu Y, Han X, Fu H, Li Y, Li M, Wang T
Food & function 2021 Oct 4;12(19):9486-9502
Food & function 2021 Oct 4;12(19):9486-9502
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M
European journal of medicinal chemistry 2021 Oct 15;222:113573
European journal of medicinal chemistry 2021 Oct 15;222:113573
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
NLRP3 promotes endometrial receptivity by inducing epithelial-mesenchymal transition of the endometrial epithelium.
Cheng X, Zhang Y, Ma J, Wang S, Ma R, Ge X, Zhao W, Xue T, Chen L, Yao B
Molecular human reproduction 2021 Nov 2;27(11)
Molecular human reproduction 2021 Nov 2;27(11)
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.
Xue YY, Lu YY, Sun GQ, Fang F, Ji YQ, Tang HF, Qiu PC, Cheng G
Die Pharmazie 2021 May 1;76(5):208-214
Die Pharmazie 2021 May 1;76(5):208-214
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Liu Q, Hao Y, Du R, Hu D, Xie J, Zhang J, Deng G, Liang N, Tian T, Käsmann L, Rades D, Rim CH, Hu P, Zhang J
Translational lung cancer research 2021 Mar;10(3):1424-1443
Translational lung cancer research 2021 Mar;10(3):1424-1443
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Xin C, Zhao M, Wang J, Wang Z
Journal of food biochemistry 2021 Jul;45(7):e13771
Journal of food biochemistry 2021 Jul;45(7):e13771
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Du W, Gao A, Herman JG, Wang L, Zhang L, Jiao S, Guo M
Cancer science 2021 Jul;112(7):2870-2883
Cancer science 2021 Jul;112(7):2870-2883
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
Jing F, Zou Q, Wang Y, Cai Z, Tang Y
The journal of headache and pain 2021 Jul 29;22(1):86
The journal of headache and pain 2021 Jul 29;22(1):86
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Huang F, Zhu P, Wang J, Chen J, Lin W
Pediatric research 2021 Jan;89(1):143-149
Pediatric research 2021 Jan;89(1):143-149
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Zhang L, Zhou S, Zhou T, Yuan K, Li X, Tang J
Oncology reports 2021 Jan;45(1):151-158
Oncology reports 2021 Jan;45(1):151-158
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Liu Y, Zhu D, Dong G, Zeng Y, Jiang P, Xiao Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 Feb;30(2):157-163
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 Feb;30(2):157-163
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
Ha M, Huang X, Li L, Lu D, Liu C
The Science of the total environment 2021 Feb 25;757:143727
The Science of the total environment 2021 Feb 25;757:143727
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
Lv S, Yuan P, Lu C, Dong J, Li M, Qu F, Zhu Y, Zhang J
Aging 2021 Feb 11;13(4):5525-5538
Aging 2021 Feb 11;13(4):5525-5538
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Hou Y, Li FZ
European review for medical and pharmacological sciences 2021 Dec;25(24):7668-7678
European review for medical and pharmacological sciences 2021 Dec;25(24):7668-7678
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Chen X, Tang H, Liang Y, Wu P, Xie L, Ding Y, Yang P, Long B, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma.
Qian Y, Shanbo M, Shaojie H, Long L, Yuhan C, Jin W, Shan M, Xiao-Peng S
Journal of ethnopharmacology 2021 Dec 5;281:114513
Journal of ethnopharmacology 2021 Dec 5;281:114513
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Ji K, Liang H, Ren M, Ge X, Pan L, Yu H
Scientific reports 2021 Dec 13;11(1):23843
Scientific reports 2021 Dec 13;11(1):23843
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Chen X, Zhang W, Xu X
World journal of surgical oncology 2021 Aug 6;19(1):232
World journal of surgical oncology 2021 Aug 6;19(1):232
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
Liao Y, Xu J, Qin B, Shi J, Qin C, Xie F, Ou S, Tang J, Wang W, Wu F, Bai L
Free radical biology & medicine 2021 Aug 20;172:33-47
Free radical biology & medicine 2021 Aug 20;172:33-47
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Jiang X, Wang J, Chen P, He Z, Xu J, Chen Y, Liu X, Jiang J
Cancer cell international 2021 Aug 10;21(1):420
Cancer cell international 2021 Aug 10;21(1):420
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Sun CC, Zhou ZQ, Chen ZL, Zhu RK, Yang D, Peng XY, Zheng L, Tang CF
Biology 2021 Aug 10;10(8)
Biology 2021 Aug 10;10(8)
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Liu J, Han YS, Liu L, Tang L, Yang H, Meng P, Zhao HQ, Wang YH
Neural regeneration research 2021 Apr;16(4):727-733
Neural regeneration research 2021 Apr;16(4):727-733
LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
Zhao WJ, Zhu LL, Yang WQ, Xu SJ, Chen J, Ding XF, Liang Y, Chen G
Cancer science 2021 Apr;112(4):1624-1632
Cancer science 2021 Apr;112(4):1624-1632
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
Xie Y, Zhou X, Li J, Yao XC, Liu WL, Kang FH, Zou ZX, Xu KP, Xu PS, Tan GS
Bioorganic chemistry 2021 Apr;109:104744
Bioorganic chemistry 2021 Apr;109:104744
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
Liu Y, Wang L, Zhang X, Deng Y, Pan L, Li H, Shi X, Wang T
Scientific reports 2021 Apr 26;11(1):8963
Scientific reports 2021 Apr 26;11(1):8963
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Wang Y, Zhao H, Liu Y, Li J, Nie X, Huang P, Xing M
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Chen X, Deng S, Lei Q, He Q, Ren Y, Zhang Y, Nie J, Lu W
Frontiers in cell and developmental biology 2020;8:598020
Frontiers in cell and developmental biology 2020;8:598020
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
Han S, Li X, Liu J, Zou Z, Luo L, Wu R, Zhao Z, Wang C, Shen B
Frontiers in veterinary science 2020;7:529
Frontiers in veterinary science 2020;7:529
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
Li R, Liu W, Ou L, Gao F, Li M, Wang L, Wei P, Miao F
BioMed research international 2020;2020:1562915
BioMed research international 2020;2020:1562915
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
Li L, Li X, Zhang Z, Liu L, Liu T, Li S, Liu S, Zhou Y, Liu F
Current molecular medicine 2020;20(5):396-406
Current molecular medicine 2020;20(5):396-406
Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression.
Du Z, Yin S, Song X, Zhang L, Yue S, Jia X, Zhang Y
Frontiers in molecular neuroscience 2020;13:71
Frontiers in molecular neuroscience 2020;13:71
LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis.
Ma F, Wang Z, Qiang Y, Xu L, Ding P, Wang Y, Ma X
OncoTargets and therapy 2020;13:10221-10230
OncoTargets and therapy 2020;13:10221-10230
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Shi Y, Zhuang Y, Zhang J, Chen M, Wu S
Cancer management and research 2020;12:13173-13184
Cancer management and research 2020;12:13173-13184
Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway.
Chen X, Li S, Li D, Li M, Su Z, Lai X, Zhou C, Chen S, Li S, Yang X, Su J, Zhang Y
Frontiers in pharmacology 2020;11:606
Frontiers in pharmacology 2020;11:606
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Luo H, Peng F, Weng B, Tang X, Chen Y, Yang A, Chen B, Ran M
Frontiers in genetics 2020;11:581593
Frontiers in genetics 2020;11:581593
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Zhou S, Ai Z, Li W, You P, Wu C, Li L, Hu Y, Ba Y
Frontiers in pharmacology 2020;11:425
Frontiers in pharmacology 2020;11:425
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Xu HX, Lin SX, Gong Y, Huo ZX, Zhao CY, Zhu HM, Xi SY
Frontiers in pharmacology 2020;11:245
Frontiers in pharmacology 2020;11:245
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, Zhang N, Qiu F
Journal of ethnopharmacology 2020 Sep 15;259:113015
Journal of ethnopharmacology 2020 Sep 15;259:113015
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Li Y, Zhang M, Li F
Histology and histopathology 2020 Oct;35(10):1171-1180
Histology and histopathology 2020 Oct;35(10):1171-1180
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Wu X, Yu H, Zhou H, Li Z, Huang H, Xiao F, Xu S, Yang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure.
Tan C, Song M, Stamer WD, Qiao Y, Chen X, Sun X, Lei Y, Chen J
Experimental eye research 2020 Nov;200:108197
Experimental eye research 2020 Nov;200:108197
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Li T, Zhang L, Jin C, Xiong Y, Cheng YY, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Velvet antler polypeptide prevents the disruption of hepatic tight junctions via inhibiting oxidative stress in cholestatic mice and liver cell lines.
Li L, Yang F, Jia R, Yan P, Ma L
Food & function 2020 Nov 18;11(11):9752-9763
Food & function 2020 Nov 18;11(11):9752-9763
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X
Life sciences 2020 Nov 1;260:118413
Life sciences 2020 Nov 1;260:118413
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Zhang M, Li F, Wang X, Gong J, Xian Y, Wang G, Zheng Z, Shang C, Wang B, He Y, Wang W, Lin R
Histochemistry and cell biology 2020 May;153(5):357-366
Histochemistry and cell biology 2020 May;153(5):357-366
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
Tan XH, Zhang KK, Xu JT, Qu D, Chen LJ, Li JH, Wang Q, Wang HJ, Xie XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Tang W, Wang D, Shao L, Liu X, Zheng J, Xue Y, Ruan X, Yang C, Liu L, Ma J, Li Z, Liu Y
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
Xu M, Yu X, Meng X, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, Wang T, Chen Z, Fan Y, Liang D, Meng Q
Molecular carcinogenesis 2020 Jun;59(6):575-589
Molecular carcinogenesis 2020 Jun;59(6):575-589
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Zhang Y, Chen L, Cao Y, Chen S, Xu C, Xing J, Zhang K
Journal of gastric cancer 2020 Jun;20(2):139-151
Journal of gastric cancer 2020 Jun;20(2):139-151
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Han B, Jiang L, Jiang P, Zhou D, Jia X, Li X, Ye X
Planta medica 2020 Jul;86(11):767-775
Planta medica 2020 Jul;86(11):767-775
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Chen Y, Cao W, Wang L, Zhong T
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Zhang L, Wu M, Zhu L, Liu S, Zhao D
Journal of ethnopharmacology 2020 Jul 15;257:112796
Journal of ethnopharmacology 2020 Jul 15;257:112796
Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.
Liu P, Zhu C, Luo J, Lan S, Su D, Wang Q, Wei Z, Cui W, Xu C, Yang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1481-1496
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1481-1496
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Li W, Jiang YH, Wang Y, Zhao M, Hou GJ, Hu HZ, Zhou L
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164
Food & function 2020 Jan 29;11(1):1155-1164
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Liu Y, Fan D
Nutrients 2020 Jan 18;12(1)
Nutrients 2020 Jan 18;12(1)
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Ma M, Wang C, Ao Y, He N, Hao F, Liang H, Liu D
Molecular and cellular probes 2020 Feb;49:101491
Molecular and cellular probes 2020 Feb;49:101491
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Wang Y, Zhao H, Guo M, Fei D, Zhang L, Xing M
Journal of hazardous materials 2020 Feb 5;383:121217
Journal of hazardous materials 2020 Feb 5;383:121217
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Liu Y, Zhang M, He T, Yang W, Wang L, Zhang L, Guo M
Clinical epigenetics 2020 Feb 10;12(1):22
Clinical epigenetics 2020 Feb 10;12(1):22
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Zeng Q, Zeng Y, Nie X, Guo Y, Zhan Y
Planta medica 2020 Dec;86(18):1401-1410
Planta medica 2020 Dec;86(18):1401-1410
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Zhang M, Li F, Pokharel S, Ma T, Wang X, Wang Y, Wang W, Lin R
Journal of molecular histology 2020 Dec;51(6):629-637
Journal of molecular histology 2020 Dec;51(6):629-637
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Zhao J, Han Y, Wang Z, Zhang R, Wang G, Mao Y
Biotechnology letters 2020 Dec;42(12):2749-2758
Biotechnology letters 2020 Dec;42(12):2749-2758
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Wang Y, Zhao H, Nie X, Guo M, Jiang G, Xing M
Environmental research 2020 Dec;191:110063
Environmental research 2020 Dec;191:110063
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Qiu C, Su W, Shen N, Qi X, Wu X, Wang K, Li L, Guo Z, Tao H, Wang G, Chen B, Xiang H
BMC cancer 2020 Dec 3;20(1):1187
BMC cancer 2020 Dec 3;20(1):1187
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Zhao Y, Lin Z, Lin Z, Zhou C, Liu G, Lin J, Zhang D, Lin D
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
He W, Zhang J, Liu B, Liu X, Liu G, Xie L, He J, Wei M, Li K, Ma J, Dong R, Ma D, Dong K, Ye M
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Xiao S, Li S, Yuan Z, Zhou L
Annals of translational medicine 2020 Aug;8(15):937
Annals of translational medicine 2020 Aug;8(15):937
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y, Yu J
Life sciences 2020 Aug 1;254:116444
Life sciences 2020 Aug 1;254:116444
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Bu T, Wang C, Jin H, Meng Q, Huo X, Sun H, Sun P, Wu J, Ma X, Liu Z, Liu K
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Li Y, Guo Y, Feng Z, Bergan R, Li B, Qin Y, Zhao L, Zhang Z, Shi M
Nutrition and cancer 2019;71(6):1007-1018
Nutrition and cancer 2019;71(6):1007-1018
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Huang F, Chen J, Wang J, Zhu P, Lin W
BioMed research international 2019;2019:8171989
BioMed research international 2019;2019:8171989
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Qu L, Chen C, He W, Chen Y, Li Y, Wen Y, Zhou S, Jiang Y, Yang X, Zhang R, Shen L
American journal of translational research 2019;11(4):2042-2055
American journal of translational research 2019;11(4):2042-2055
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Zhang D, Ren L, Zhao M, Yang C, Liu X, Zhang H, Jiang Y, Sun X, Li T, Cui L, Hu X
Frontiers in immunology 2019;10:1550
Frontiers in immunology 2019;10:1550
Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice.
Wang F, Lei X, Zhao Y, Yu Q, Li Q, Zhao H, Pei Z
Experimental and therapeutic medicine 2019 Sep;18(3):1985-1992
Experimental and therapeutic medicine 2019 Sep;18(3):1985-1992
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, Zhao H, Ke J, Wu S, Wang X, Wu F
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Guan P, Sun ZM, Wang N, Zhou J, Luo LF, Zhao YS, Ji ES
Life sciences 2019 Sep 15;233:116748
Life sciences 2019 Sep 15;233:116748
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Zhao H, Wang Y, Fei D, Guo M, Yang X, Mu M, Yu H, Xing M
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Zheng R, Huang S, Zhu J, Lin W, Xu H, Zheng X
Cell and tissue research 2019 Oct;378(1):113-125
Cell and tissue research 2019 Oct;378(1):113-125
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Zhao H, Wang Y, Liu J, Guo M, Fei D, Yu H, Xing M
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Wang Y, He G, Wang F, Zhang C, Ge Z, Zheng X, Deng H, Yuan C, Zhou B, Tao X, Zhang J, Tang K
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Pharmacological actions of neferine in the modulation of human platelet function.
Yang RP, Zhou YJ, Song W, Yin Z, He AD, Ming ZY
European journal of pharmacology 2019 Nov 5;862:172626
European journal of pharmacology 2019 Nov 5;862:172626
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
Wu YJ, Lin SH, Din ZH, Su JH, Liu CI
Marine drugs 2019 Nov 27;17(12)
Marine drugs 2019 Nov 27;17(12)
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Xie L, Dai H, Li M, Yang W, Yu G, Wang X, Wang P, Liu W, Hu X, Zhao M
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux.
Ren Z, Xiao W, Zeng Y, Liu MH, Li GH, Tang ZH, Qu SL, Hao YM, Yuan HQ, Jiang ZS
International journal of molecular medicine 2019 Mar;43(3):1321-1330
International journal of molecular medicine 2019 Mar;43(3):1321-1330
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
Zhou T, Sun Y, Wang Y, Chen X, Zhuo L, Bu L, Xu S, Han J, Li X, Shi J
Inflammation 2019 Jun;42(3):987-993
Inflammation 2019 Jun;42(3):987-993
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Liao Y, Liang X, Liang W, Li Z, Wang Y, Wang L, Zhen S, Tang B, Wang Z
Oncology letters 2019 Jun;17(6):5159-5168
Oncology letters 2019 Jun;17(6):5159-5168
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Xie L, Li M, Liu D, Wang X, Wang P, Dai H, Yang W, Liu W, Hu X, Zhao M
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Zhu BL, Long Y, Luo W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ, Wang XF, Sun F, Chen GJ
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, Zhao X
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
He S, Yu Q, He Y, Hu R, Xia S, He J
Poultry science 2019 Dec 1;98(12):6378-6387
Poultry science 2019 Dec 1;98(12):6378-6387
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Wu XT, Ansari AR, Pang XX, Li HZ, Zhang ZW, Luo Y, Arshad M, Song H
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Wang L, Shi H, Liu Y, Zhang W, Duan X, Li M, Shi X, Wang T
International journal of oncology 2019 Aug;55(2):473-487
International journal of oncology 2019 Aug;55(2):473-487
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation.
Zhang B, Liu P, Zhou Y, Chen Z, He Y, Mo M, Dai G, Xia W, Du Y, Liu Y, Chen X
Life sciences 2019 Apr 15;223:29-37
Life sciences 2019 Apr 15;223:29-37
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Jiang T, Zhou ML, Fan J
OncoTargets and therapy 2018;11:7865-7872
OncoTargets and therapy 2018;11:7865-7872
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):3013-3021
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):3013-3021
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Zou W, Ding F, Niu C, Fu Z, Liu S
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
Guo S, Liang X, Guo M, Zhang X, Li Z
International journal of biological macromolecules 2018 Nov;119:669-676
International journal of biological macromolecules 2018 Nov;119:669-676
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729
Molecular medicine reports 2018 Jun;17(6):7721-7729
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Feng J, Niu P, Chen K, Wu L, Liu T, Xu S, Li J, Li S, Wang W, Lu X, Yu Q, Liu N, Xu L, Wang F, Dai W, Xia Y, Fan X, Guo C
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X, Zhan Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
Deng T, Zhang Y, Wu Y, Ma P, Duan J, Qin W, Yang X, Chen M
Toxicology letters 2018 Jun 15;290:1-9
Toxicology letters 2018 Jun 15;290:1-9
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Sun S, Wu Y, Guo W, Yu F, Kong L, Ren Y, Wang Y, Yao X, Jing C, Zhang C, Liu M, Zhang Y, Zhao M, Li Z, Wu C, Qiao Y, Yang J, Wang X, Zhang L, Li M, Zhou X
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jun 1;24(11):2665-2677
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jun 1;24(11):2665-2677
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, Xue Y, Xing M
Journal of inorganic biochemistry 2018 Jan;178:54-62
Journal of inorganic biochemistry 2018 Jan;178:54-62
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, Li Z, Ye X, Li X
Life sciences 2018 Jan 1;192:259-269
Life sciences 2018 Jan 1;192:259-269
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Yin N, Wang Y, Lu X, Liu R, Zhang L, Zhao W, Yuan W, Luo Q, Wu H, Luan X, Zhang H
Stem cell research & therapy 2018 Feb 14;9(1):37
Stem cell research & therapy 2018 Feb 14;9(1):37
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Cen B, Wei Y, Huang W, Teng M, He S, Li J, Wang W, He G, Bai X, Liu X, Yuan Y, Pan X, Ji A
Molecular therapy. Nucleic acids 2018 Dec 7;13:220-232
Molecular therapy. Nucleic acids 2018 Dec 7;13:220-232
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Sun D, Zhang F, Qian J, Shen W, Fan H, Tan J, Li L, Xu C, Yang Y, Cheng H
Chemico-biological interactions 2018 Dec 25;296:26-33
Chemico-biological interactions 2018 Dec 25;296:26-33
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Zhang H, Cao Y, Chen Y, Li G, Yu H
Oncology letters 2018 Apr;15(4):5739-5743
Oncology letters 2018 Apr;15(4):5739-5743
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Lou J, Teng Z, Zhang L, Yang J, Ma L, Wang F, Tian X, An R, Yang M, Zhang Q, Xu L, Dong Z
Frontiers in pharmacology 2017;8:2
Frontiers in pharmacology 2017;8:2
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, Sun H, Peng J
Frontiers in pharmacology 2017;8:120
Frontiers in pharmacology 2017;8:120
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, Li Z, Liu Y
Frontiers in molecular neuroscience 2017;10:68
Frontiers in molecular neuroscience 2017;10:68
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Xu S, Wu L, Zhang Q, Feng J, Li S, Li J, Liu T, Mo W, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Life sciences 2017 Sep 15;185:103-113
Life sciences 2017 Sep 15;185:103-113
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
Ren K, Lu YJ, Mo ZC, -Liu X, Tang ZL, Jiang Y, Peng XS, Li L, Zhang QH, Yi GH
Journal of physiology and biochemistry 2017 May;73(2):287-296
Journal of physiology and biochemistry 2017 May;73(2):287-296
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Wang LL, Xiu YL, Chen X, Sun KX, Chen S, Wu DD, Liu BL, Zhao Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Yin K, Zhu R, Wang S, Zhao RC
Stem cells and development 2017 May 15;26(10):762-775
Stem cells and development 2017 May 15;26(10):762-775
MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
Yang YL, Wang FS, Li SC, Tiao MM, Huang YH
International journal of molecular sciences 2017 Jan 18;18(1)
International journal of molecular sciences 2017 Jan 18;18(1)
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, Ye X, Li X
Scientific reports 2017 Feb 6;7:38524
Scientific reports 2017 Feb 6;7:38524
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Sun KX, Wu DD, Chen S, Zhao Y, Zong ZH
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Scientific reports 2017 Aug 24;7(1):9289
Scientific reports 2017 Aug 24;7(1):9289
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
Wu DM, Zhang P, Liu RY, Sang YX, Zhou C, Xu GC, Yang JL, Tong AP, Wang CT
FEBS letters 2014 May 21;588(10):1921-9
FEBS letters 2014 May 21;588(10):1921-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 20584-1-AP(PIK3CB antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PIK3CB antibody 20584-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
