PTPN18

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Description

Protein tyrosine phosphatase non-receptor type 18

Tissue specificity

Low tissue specificity

Subcell location

Intermediate filaments

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (130356045 - 130375405)

Ensembl ID

ENSG00000072135  (ver. 103.38)

Orthologs

Mouse Ptpn18: ENSMUSG00000026126

UniProt

Q99952

neXtProt

NX_Q99952

Human splice variants
Mouse splice variants

Protein structure