14-9230-80

antibody from Invitrogen Antibodies
Targeting: PRNP AltPrP, CD230, CJD, GSS, PRIP, PRP
Provider product page for 14-9230-80

Antibody data

Product number
14-9230-80 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD230 (PrP) Monoclonal Antibody (4D5), eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: CD230 (prion protein; PrP^C) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrP^C form is converted to the scrapie PrP^Sc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.
Antibody clone number
4D5
Concentration
0.5 mg/mL
PRNP protein structure - 14-9230-80 shown in red.