SPPL2B

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Signal peptide peptidase like 2B

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane, Centrosome

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (2328615 - 2355095)

Ensembl ID

ENSG00000005206  (ver. 103.38)

Orthologs

Mouse Sppl2b: ENSMUSG00000035206

UniProt

Q8TCT7

neXtProt

NX_Q8TCT7

Human splice variants
Mouse splice variants

Protein structure