HPA000243

antibody from Atlas Antibodies

Targeting: OTC OTCase

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

HPA000243

Provider

Atlas Antibodies

Proper citation

Product name

Anti-OTC

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human OTC, Gene description: ornithine carbamoyltransferase, Validated applications: WB, IHC, ICC, Uniprot ID: P00480, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.3 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress

Eldeeb M, Bayne A, Fallahi A, Goiran T, MacDougall E, Soumbasis A, Zorca C, Jones-Tabah J, Thomas R, Karpilovsky N, Mathur M, Durcan T, Trempe J, Fon E
Proceedings of the National Academy of Sciences 2024;121(10)

---

Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion

Bishop E, Dimitrova M, Froggatt A, Estevez-Cebrero M, Storer L, Mussai F, Paine S, Grundy R, Dandapani M, Prodam F
BioMed Research International 2022;2022(1)

---

Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes

Zabulica M, Srinivasan R, Akcakaya P, Allegri G, Bestas B, Firth M, Hammarstedt C, Jakobsson T, Jakobsson T, Ellis E, Jorns C, Makris G, Scherer T, Rimann N, van Zuydam N, Gramignoli R, Forslöw A, Engberg S, Maresca M, Rooyackers O, Thöny B, Häberle J, Rosen B, Strom S
Molecular Therapy 2021;29(5):1903-1917

---

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

Ginn S, Amaya A, Liao S, Zhu E, Cunningham S, Lee M, Hallwirth C, Logan G, Tay S, Cesare A, Pickett H, Grompe M, Dilworth K, Lisowski L, Alexander I
JHEP Reports 2020;2(1):100065

---

Adult-Derived Human Liver Stem/Progenitor Cells Infused 3 Days Postsurgery Improve Liver Regeneration in a Mouse Model of Extended Hepatectomy

Herrero A, Prigent J, Lombard C, Rosseels V, Daujat-Chavanieu M, Breckpot K, Najimi M, Deblandre G, Sokal E
Cell Transplantation 2017;26(2):351-364

---

Candidate Serological Biomarkers for Cancer Identified from the Secretomes of 23 Cancer Cell Lines and the Human Protein Atlas

Wu C, Hsu C, Chen C, Yu C, Chang K, Tai D, Liu H, Su W, Chang Y, Yu J
Molecular & Cellular Proteomics 2010;9(6):1100-1117

---

A Quantitative Proteomic Approach for Identification of Potential Biomarkers in Hepatocellular Carcinoma

Chaerkady R, Harsha H, Nalli A, Gucek M, Vivekanandan P, Akhtar J, Cole R, Simmers J, Schulick R, Singh S, Torbenson M, Pandey A, Thuluvath P
Journal of Proteome Research 2008;7(10):4289-4298

Immunocytochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Main image

Experimental details

Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.

Sample type

Human

Immunohistochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Enhanced method

Orthogonal validation

Main image

Experimental details

Immunohistochemistry analysis in human liver and kidney tissues using HPA000243 antibody. Corresponding OTC RNA-seq data are presented for the same tissues.

Sample type

Human

Protocol

Protocol

Orthogonal method

Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

Show more