Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 12651-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SIAH2 antibody
- Antibody type
- Polyclonal
- Description
- SIAH2 antibody (Cat. #12651-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.
Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments.
P-TEFb is degraded by Siah1/2 in quiescent cells.
SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression.
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis.
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation.
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.
Dong J, Che J, Wu Y, Deng Y, Jiang X, He Z, Zhang J
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1459-1474
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1459-1474
Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments.
Ou G, Che J, Dong J, Deng Y, Jiang X, Sun Y, He Z, Chen W, Zhang J
International immunopharmacology 2023 Jul;120:110349
International immunopharmacology 2023 Jul;120:110349
P-TEFb is degraded by Siah1/2 in quiescent cells.
Huang F, Feng Y, Peterlin BM, Fujinaga K
Nucleic acids research 2022 May 20;50(9):5000-5013
Nucleic acids research 2022 May 20;50(9):5000-5013
SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression.
Schmitz ML, Dreute J, Pfisterer M, Günther S, Kracht M, Chillappagari S
Heliyon 2022 Mar;8(3):e09029
Heliyon 2022 Mar;8(3):e09029
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, Zhao T, Lei H, Mu C, Chen L, Meng Y, Zhang J, Long Y, Su J, Chen G, Li Y, Hu G, Liao X, Chen Q, Zhu Y
eLife 2022 Aug 1;11
eLife 2022 Aug 1;11
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis.
Zheng QW, Ding XF, Cao HJ, Ni QZ, Zhu B, Ma N, Zhang FK, Wang YK, Xu S, Chen TW, Xia J, Qiu XS, Yu DZ, Xie D, Li JJ
Toxins 2021 Nov 13;13(11)
Toxins 2021 Nov 13;13(11)
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Wang Q, Shi W, Zhang Q, Feng W, Wang J, Zhai C, Yan X, Li M
Life sciences 2020 Feb 1;242:117159
Life sciences 2020 Feb 1;242:117159
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL
Nature cell biology 2020 Dec;22(12):1447-1459
Nature cell biology 2020 Dec;22(12):1447-1459
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034
Nature communications 2019 Mar 4;10(1):1034
PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation.
Zhang Y, Zheng X, Tan H, Lu Y, Tao D, Liu Y, Ma Y
Cell death & disease 2018 Apr 1;9(4):423
Cell death & disease 2018 Apr 1;9(4):423
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12651-1-AP( SIAH2 Antibody) at dilution of 1:300
- Other comments
- WB