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- References [18]
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- Product number
- 12651-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SIAH2 antibody
- Antibody type
- Polyclonal
- Description
- SIAH2 antibody (Cat. #12651-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Siah2 regulates lipid uptake in adipose tissue macrophages.
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.
The E3 ubiquitin ligase SIAH1 targets a bacterial pore-forming toxin to facilitate xenophagy.
Efferocytosis-related signatures identified via Single-cell analysis and machine learning predict TNBC outcomes and immunotherapy response.
Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression.
Virtual Screening, Molecular Dynamics, and Mechanism Study of Homeodomain-Interacting Protein Kinase 2 Inhibitor in Renal Fibroblasts.
SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells.
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.
Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments.
P-TEFb is degraded by Siah1/2 in quiescent cells.
SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression.
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis.
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation.
Ghosh B, Panta PR, Scott MC, Taylor J, Beyl R, Stadler K, Floyd ZE
The Journal of biological chemistry 2026 Mar 18;302(5):111380
The Journal of biological chemistry 2026 Mar 18;302(5):111380
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.
Dai X, Xu Z, Lv X, Li C, Jiang R, Wang D, Xi M, Li T
International journal of biological sciences 2025;21(2):874-892
International journal of biological sciences 2025;21(2):874-892
The E3 ubiquitin ligase SIAH1 targets a bacterial pore-forming toxin to facilitate xenophagy.
Wu M, Hu X, Iibushi J, Murase K, Nozawa T, Nakagawa I
Cell reports 2025 Sep 23;44(9):116257
Cell reports 2025 Sep 23;44(9):116257
Efferocytosis-related signatures identified via Single-cell analysis and machine learning predict TNBC outcomes and immunotherapy response.
Wei L, Wen S, Dang T, Zeng T, Yang S, You Y, Tang J, Sun H, Zhang L, Li Q, Li X, Sun M, He X, Zhao L, Zhu X, Zhang Y
Scientific reports 2025 Nov 6;15(1):38955
Scientific reports 2025 Nov 6;15(1):38955
Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression.
Chen H, Hu Q, Lu Z, Zhao J, Liu A, Liu Z, Luo J, Ye Q, Zhong Z
Translational research : the journal of laboratory and clinical medicine 2025 Mar;277:1-12
Translational research : the journal of laboratory and clinical medicine 2025 Mar;277:1-12
Virtual Screening, Molecular Dynamics, and Mechanism Study of Homeodomain-Interacting Protein Kinase 2 Inhibitor in Renal Fibroblasts.
Hu X, Wu Y, Ouyang H, Wu J, Yao M, Chen Z, Li Q
Pharmaceuticals (Basel, Switzerland) 2024 Oct 23;17(11)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 23;17(11)
SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells.
Jing LP, Li M, Xia XY, Zheng X, Chen JY, He J, Zhuang XW
Heliyon 2024 Jun 15;10(11):e31487
Heliyon 2024 Jun 15;10(11):e31487
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.
Dong J, Che J, Wu Y, Deng Y, Jiang X, He Z, Zhang J
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1459-1474
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1459-1474
Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments.
Ou G, Che J, Dong J, Deng Y, Jiang X, Sun Y, He Z, Chen W, Zhang J
International immunopharmacology 2023 Jul;120:110349
International immunopharmacology 2023 Jul;120:110349
P-TEFb is degraded by Siah1/2 in quiescent cells.
Huang F, Feng Y, Peterlin BM, Fujinaga K
Nucleic acids research 2022 May 20;50(9):5000-5013
Nucleic acids research 2022 May 20;50(9):5000-5013
SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression.
Schmitz ML, Dreute J, Pfisterer M, Günther S, Kracht M, Chillappagari S
Heliyon 2022 Mar;8(3):e09029
Heliyon 2022 Mar;8(3):e09029
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, Zhao T, Lei H, Mu C, Chen L, Meng Y, Zhang J, Long Y, Su J, Chen G, Li Y, Hu G, Liao X, Chen Q, Zhu Y
eLife 2022 Aug 1;11
eLife 2022 Aug 1;11
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis.
Zheng QW, Ding XF, Cao HJ, Ni QZ, Zhu B, Ma N, Zhang FK, Wang YK, Xu S, Chen TW, Xia J, Qiu XS, Yu DZ, Xie D, Li JJ
Toxins 2021 Nov 13;13(11)
Toxins 2021 Nov 13;13(11)
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Wang Q, Shi W, Zhang Q, Feng W, Wang J, Zhai C, Yan X, Li M
Life sciences 2020 Feb 1;242:117159
Life sciences 2020 Feb 1;242:117159
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL
Nature cell biology 2020 Dec;22(12):1447-1459
Nature cell biology 2020 Dec;22(12):1447-1459
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034
Nature communications 2019 Mar 4;10(1):1034
PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation.
Zhang Y, Zheng X, Tan H, Lu Y, Tao D, Liu Y, Ma Y
Cell death & disease 2018 Apr 1;9(4):423
Cell death & disease 2018 Apr 1;9(4):423
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12651-1-AP( SIAH2 Antibody) at dilution of 1:300
- Other comments
- WB
