11796-1-AP

antibody from Proteintech Group

Targeting: KYNU

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

11796-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11796-1-AP, RRID:AB_2133050

Product name

KYNU antibody

Antibody type

Polyclonal

Description

KD/KO validated KYNU antibody (Cat. #11796-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation.

Shi Y, Luo S, Zhai J, Chen Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166929

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Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease.

Noh M, Sim JY, Kim J, Ahn JH, Min HY, Lee JU, Park JS, Jeong JY, Lee JY, Lee SY, Lee HJ, Park CS, Lee HY
Journal of hazardous materials 2024 Feb 15;464:132932

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Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer.

Sun JR, Kong CF, Ye YX, Wang Q, Qu XK, Jia LQ, Wu S
Scientific reports 2024 Apr 1;14(1):7648

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Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.

Xu H, Hu C, Wang Y, Shi Y, Yuan L, Xu J, Zhang Y, Chen J, Wei Q, Qin J, Xu Z, Cheng X
Oncogene 2023 Jun;42(24):1994-2006

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Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006

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De novo NAD(+) synthesis contributes to CD8(+) T cell metabolic fitness and antitumor function.

Wan J, Cheng C, Hu J, Huang H, Han Q, Jie Z, Zou Q, Shi JH, Yu X
Cell reports 2023 Dec 26;42(12):113518

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Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.

Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N
Nature communications 2023 Dec 13;14(1):8095

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Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection.

Song Y, Shou S, Guo H, Gao Z, Liu N, Yang Y, Wang F, Deng Q, Liu J, Xie Y
Virologica Sinica 2022 Aug;37(4):558-568

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Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.

Tan B, Chen J, Qin S, Liao C, Zhang Y, Wang D, Li S, Zhang Z, Zhang P, Xu F
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768

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Downregulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses the PI3K/AKT pathway.

Ci C, Wu C, Lyu D, Chang X, He C, Liu W, Chen L, Ding W
Clinical and experimental dermatology 2020 Mar;45(2):194-201

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Fr‑HMGB1 and ds‑HMGB1 activate the kynurenine pathway via different mechanisms in association with depressive‑like behavior.

Wang B, Lian YJ, Su WJ, Liu LL, Li JM, Jiang CL, Wang YX
Molecular medicine reports 2019 Jul;20(1):359-367

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 11796-1-AP(KYNU antibody) at dilution of 1:2000

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using KYNU antibody 11796-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human ovary tumor using 11796-1-AP(KYNU antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue