11796-1-AP

antibody from Proteintech Group

Targeting: KYNU

Provider product page for 11796-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11796-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11796-1-AP, RRID:AB_2133050
Product name: KYNU antibody
Antibody type: Polyclonal
Description: KD/KO validated KYNU antibody (Cat. #11796-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KYNU protein structure - 11796-1-AP shown in red.

Submitted references Immune Cell Infiltration and Kynurenine Pathway Activation Define Early Injury and Progression in Diabetic Nephropathy.

Tsai YC, Dai CY, Tsai MJ, Hwang SJ, Yu PS, Hung WW, Pan SF, Wu LY, Tsai PH, Tsai HP, Chang WA, Hsu YL
International journal of biological sciences 2026;22(3):1389-1406

Evidence Based on Sleep Disorder Exacerbating Postoperative Pain via Kynureninase.

Huang N, Chen Y, Yang X, Tao C, Zhang Y, Yang Y, Shu B, Duan G, Chen Y
Drug design, development and therapy 2026;20:565401

A novel recombinant peptide, rAnguillin, induces ferroptosis in nasopharyngeal carcinoma by promoting FOXM1 degradation and disrupting the FOXM1-PABPC1L-tryptophan metabolism axis.

Yuan Q, Zhao Y, Zhou F, Zhang Y, Jia X, Yao J, Lv M, Wang J, Lv L
International journal of biological macromolecules 2026 May;361:151988

Integrated network pharmacology and Chinmedomics reveal the molecular mechanisms of aqueous extract of Eleutherococcus senticosus fruit for treating essential hypertension.

Li Z, Yang L, Kong L, Sun H, Sun Y, Yin F, Yan G, Wang X
Journal of ethnopharmacology 2026 Jul 15;366:121619

Targeting Kynureninase Attenuates Radiation-Induced Intestinal Injury via MAPK Signaling Suppression.

Liu Q, Ling Z, Zhu Y, Gong W, Lu G, Li W, Yang W, Xiao W, Wang Y
Mediators of inflammation 2025;2025:7023259

GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism.

Xu J, Weng C, Zhang Y, Zhao Q, Chen J, Pan S, Wang Y, Zhang R, Wang Y, Zhu W, Cao M, Zu D, Zhang S, Xu Z, Hu C, Cheng X
Theranostics 2025;15(12):5826-5845

Targeting the Kynureninase-HDAC6-Complement Axis as a Novel Therapeutic Strategy in Glioblastoma.

Hasan AU, Sato S, Obara M, Kondo Y, Taira E
Epigenomes 2025 Jul 28;9(3)

Integrating multi-omics data of Triple-Negative Breast Cancer to explore the role of Kynurenine pathway and KYNU as a therapeutic target.

Lin M, Zhou J, Xiao J, Li C, Mo Y, Liu Y, Xiao Y, Huang J, Feng X
Biochemical and biophysical research communications 2025 Apr 5;756:151569

Dissecting gastric cancer heterogeneity and exploring therapeutic strategies using bulk and single-cell transcriptomic analysis and experimental validation of tumor microenvironment and metabolic interplay.

Lin X, Yang P, Wang M, Huang X, Wang B, Chen C, Xu A, Cai J, Khan M, Liu S, Lin J
Frontiers in pharmacology 2024;15:1355269

Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.

Lin H, Ma C, Zhuang X, Liu S, Liu D, Zhang M, Lu Y, Zhou G, Zhang C, Wang T, Zhang Z, Lv L, Zhang D, Ruan XZ, Xu Y, Chai R, Yu X, Sun JP, Chu B
Cell metabolism 2024 Nov 5;36(11):2402-2418.e10

A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation.

Shi Y, Luo S, Zhai J, Chen Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166929

Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease.

Noh M, Sim JY, Kim J, Ahn JH, Min HY, Lee JU, Park JS, Jeong JY, Lee JY, Lee SY, Lee HJ, Park CS, Lee HY
Journal of hazardous materials 2024 Feb 15;464:132932

Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer.

Sun JR, Kong CF, Ye YX, Wang Q, Qu XK, Jia LQ, Wu S
Scientific reports 2024 Apr 1;14(1):7648

Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.

Xu H, Hu C, Wang Y, Shi Y, Yuan L, Xu J, Zhang Y, Chen J, Wei Q, Qin J, Xu Z, Cheng X
Oncogene 2023 Jun;42(24):1994-2006

Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006

De novo NAD(+) synthesis contributes to CD8(+) T cell metabolic fitness and antitumor function.

Wan J, Cheng C, Hu J, Huang H, Han Q, Jie Z, Zou Q, Shi JH, Yu X
Cell reports 2023 Dec 26;42(12):113518

Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.

Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N
Nature communications 2023 Dec 13;14(1):8095

Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection.

Song Y, Shou S, Guo H, Gao Z, Liu N, Yang Y, Wang F, Deng Q, Liu J, Xie Y
Virologica Sinica 2022 Aug;37(4):558-568

Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.

Tan B, Chen J, Qin S, Liao C, Zhang Y, Wang D, Li S, Zhang Z, Zhang P, Xu F
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768

Downregulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses the PI3K/AKT pathway.

Ci C, Wu C, Lyu D, Chang X, He C, Liu W, Chen L, Ding W
Clinical and experimental dermatology 2020 Mar;45(2):194-201

Fr‑HMGB1 and ds‑HMGB1 activate the kynurenine pathway via different mechanisms in association with depressive‑like behavior.

Wang B, Lian YJ, Su WJ, Liu LL, Li JM, Jiang CL, Wang YX
Molecular medicine reports 2019 Jul;20(1):359-367

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11796-1-AP(KYNU antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using KYNU antibody 11796-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human ovary tumor using 11796-1-AP(KYNU antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue