11854-1-AP

antibody from Proteintech Group

Targeting: GBP2

Provider product page for 11854-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [75]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11854-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11854-1-AP, RRID:AB_2109336
Product name: GBP2 antibody
Antibody type: Polyclonal
Description: KD/KO validated GBP2 antibody (Cat. #11854-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GBP2 protein structure - 11854-1-AP shown in red.

Submitted references Decoding microglial metabolic cell death and PANoptosis hub genes in subacute phase of traumatic brain injury: a multi-omics and experimental validation study.

Wu Z, Yang BY, Lai JQ, Lin SH, Lin L, Chen JL, Pan JX, Ruan YX, Chen XR
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage.

Boegli A, Bernard EM, Lacante L, Majeux G, Hartenian E, Mack V, Broz P
The EMBO journal 2026 Jan;45(1):30-63

Identifying Crucial Genes Associated with Pyroptosis in Lupus Nephritis.

Shi M, Ma S, An Q, Zhu H, Zeng R, Yao Y
Inflammation 2026 Jan 16;49(1):51

Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during L. major infection and promote host defense to infection.

Fry L, Adhvaryu H, Roys H, Bowlin A, Venugopal G, Bird JT, Washam C, Yamamoto M, Coers J, Byrum S, Voth D, Weinkopff T
mBio 2026 Apr 8;17(4):e0282525

TgJosephin and TgRad23 are important for anti-IFN-γ virulence via deubiquitination of SPM1 in Toxoplasma.

Hashizaki E, Tachibana Y, Fukumoto J, Takashima E, Kosako H, Okuzaki D, Sasai M, Yamamoto M
mSphere 2026 Apr 13;:e0013726

Old drugs with new applications: Tofacitinib-mediated inhibition of M1-like macrophage polarization in acute pancreatitis by the JAK/STAT and emerging NOD-like receptor pathways.

Dai Y, Xiang H, Guo F, Wu Y, Zhao L, Kong X, Xu Y, Shang D, Tao X
International immunopharmacology 2025 Sep 23;162:115135

Identification of novel protein biomarkers of macrophage polarization using comparative proteomic analyses of murine primary macrophages.

Liu B, Nguyen PL, Li P, Naldrett MJ, Alvarez S, Yu J
Journal of immunology (Baltimore, Md. : 1950) 2025 Oct 1;214(10):2730-2742

Scutellarin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting M1 Macrophage Polarization via the GBP2/JAK2/STAT3 Signaling Pathway.

Tang J, Ding Y, Chen W, Shi J, Zhang C, Zhao X, Li J, Han Z, Chen X
Phytotherapy research : PTR 2025 Nov;39(11):5140-5158

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells.

Li Z, Bu Y, Wang C, Yu Y, Han L, Liu C, Chen G, Li C, Zhang Y, Cao H, Ma Z, Yue Z
Redox biology 2025 May;82:103614

Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion.

Ahlgreen OA, Hansen MW, Baake J, Hybel TE, Rossi R, Lai X, Sankaranarayanan I, Pold J, Lin L, Reinert LS, Paludan SS, Price TJ, Pallesen LT, Vægter CB
bioRxiv : the preprint server for biology 2025 May 21;

Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics.

Ye H, Zhang X, Li P, Wang M, Liu R, Yang D
BMC nephrology 2025 Mar 29;26(1):160

Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells.

Fry L, Adhvaryu H, Roys H, Bowlin A, Venugopal G, Bird JT, Washam C, Yamamoto M, Coers J, Byrum S, Voth D, Weinkopff T
bioRxiv : the preprint server for biology 2025 Jun 30;

Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors.

Srivastava J, Yadav VK, Jimenez RV, Phadatare PR, Inamdar NA, Young MM, Bacchiocchi A, Halaban R, Fang B, Pulido AM, Tsai KY, Smalley KSM, Koomen JM, Rodriguez PC, Premi S
Cancer research 2025 Jun 16;85(12):2268-2287

Lipopolysaccharide-induced cytokine signaling activates a temporal innate defense program and represses pancreatic β-cell identity.

Bartosiak JT, Hansen PA, Schumacher EA, Harty KR, Stancill JS, Corbett JA
The Journal of biological chemistry 2025 Dec;301(12):110811

Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion in Toxoplasma gondii.

Lempke SL, DiMare PC, Nichols B, Chaudry AM, Fitzsimmons LF, Reese ML, Ewald SE
bioRxiv : the preprint server for biology 2025 Dec 8;

VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses.

Wang X, Hu R, Chen K, He K, Li Y, Gao J, Tian Y, Du G, Wang Z, Zhao Y, Lai L, Su M
Journal of neuroinflammation 2025 Dec 5;23(1):11

GBP2 condensates promote ferroptosis to sensitize anti-PD-L1 immunotherapy in melanoma.

Liu X, Fang S, Ren X, Hong Y, Guo J, Liu X, Gao L, Nie H, Ning Y, Zhang M, Xu F, Liu L, Fang J, Pang Y, Zhao Q, Wang F, Wang H
Nature communications 2025 Dec 24;17(1):964

Phosphatidic acid production on the vacuole harboring Legionella pneumophila is a signal for recognition of interferon-induced GTPases.

Oide H, Kubori T, Nagai H, Nozawa T, Nakagawa I, Sasai M, Yamamoto M, Arasaki K
Proceedings of the National Academy of Sciences of the United States of America 2025 Aug 12;122(32):e2420096122

Icaritin promotes brain functional rehabilitation in ischemic stroke rats by regulating astrocyte activation and polarization via GPER.

Su G, Yu Z, Liu G, Zhang L, Luo L, Fang S, Zhang Q, Tang S, Cao X, Huang C, Huang Z, Li L
Free radical biology & medicine 2025 Aug 1;235:379-389

GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies.

Torelli F, Butterworth S, Lockyer E, Matias AN, Hildebrandt F, Song OR, Pearson-Farr J, Treeck M
Nature communications 2025 Apr 16;16(1):3570

Isoliquiritigenin alleviates experimental autoimmune encephalomyelitis by modulating inflammatory and neuroprotective reactive astrocytes.

Zhang YL, Qu Y, Song HH, Cheng G, Lu F, Cui TT, Gong Y, Ding XL, Yang Y, Zhang Q, Yang LT, Yan YP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117188

Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1.

Chang T, Alvarez J, Chappidi S, Crockett S, Sorouri M, Orchard RC, Hancks DC
PLoS pathogens 2024 Oct;20(10):e1012673

Extracellular vesicles from neural stem cells safeguard neurons in intracerebral hemorrhage by suppressing reactive astrocyte neurotoxicity.

Li T, Zhang L, Wang P, Yu J, Zhong J, Tang Q, Zhu T, Chen K, Li F, Hong P, Wei J, Sun X, Ji G, Song B, Zhu J
Cell reports 2024 Oct 22;43(10):114854

Small extracellular vesicles derived from acute myeloid leukemia cells promote leukemogenesis by transferring miR-221-3p.

Li M, Sun G, Zhao J, Pu S, Lv Y, Wang Y, Li Y, Zhao X, Wang Y, Yang S, Cheng T, Cheng H
Haematologica 2024 Oct 1;109(10):3209-3221

Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages.

Ihara F, Kyan H, Takashima Y, Ono F, Hayashi K, Matsuo T, Igarashi M, Nishikawa Y, Hikosaka K, Sakamoto H, Nakamura S, Motooka D, Yamauchi K, Ichikawa-Seki M, Fukumoto S, Sasaki M, Ikadai H, Kusakisako K, Ohari Y, Yoshida A, Sasai M, Grigg ME, Yamamoto M
Nature communications 2024 May 22;15(1):4278

iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse.

Zhao XY, Lempke SL, Urbán Arroyo JC, Brown IG, Yin B, Magaj MM, Holness NK, Smiley J, Redemann S, Ewald SE
Nature communications 2024 Mar 27;15(1):2698

CENPA facilitates glioma stem cell stemness and suppress ferroptosis to accelerate glioblastoma multiforme progression by promoting GBP2 transcription.

Li C, Jing J, Wang Y, Jiang H
Pathology, research and practice 2024 Aug;260:155438

GBP2 enhances paclitaxel sensitivity in triple‑negative breast cancer by promoting autophagy in combination with ATG2 and inhibiting the PI3K/AKT/mTOR pathway.

Zhang W, Tang X, Peng Y, Xu Y, Liu L, Liu S
International journal of oncology 2024 Apr;64(4)

A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity.

Clayton BLL, Kristell JD, Allan KC, Cohn EF, Karl M, Jerome AD, Garrison E, Maeno-Hikichi Y, Sturno AM, Kerr A, Shick HE, Sepeda JA, Freundt EC, Sas AR, Segal BM, Miller RH, Tesar PJ
Nature neuroscience 2024 Apr;27(4):656-665

Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway.

Rao Y, Li J, Qiao R, Luo J, Liu Y
International immunopharmacology 2024 Apr 20;131:111686

A five-protein prognostic signature with GBP2 functioning in immune cell infiltration of clear cell renal cell carcinoma.

Meng K, Li YY, Liu DY, Hu LL, Pan YL, Zhang CZ, He QY
Computational and structural biotechnology journal 2023;21:2621-2630

Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction.

Zhu J, Yuan J, Arya S, Du Z, Liu X, Jia J
Frontiers in immunology 2023;14:1265098

GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy.

Li X, Liu J, Zeng M, Yang K, Zhang S, Liu Y, Yin X, Zhao C, Wang W, Xiao L
Frontiers in immunology 2023;14:1127612

Guanylate-Binding Protein 2 Exerts GTPase-Dependent Anti-Ectromelia Virus Effect.

Gao Z, Meng Z, He X, Chen G, Fang Y, Tian H, Zhang H, Jing Z
Microorganisms 2023 Sep 8;11(9)

The Viral Protein Poly(A) Polymerase Catalytic Subunit Interacts with Guanylate-Binding Proteins 2 to Antagonize the Antiviral Ability of Targeting Ectromelia Virus.

Gao Z, He X, Chen G, Fang Y, Meng Z, Tian H, Zhang H, Jing Z
International journal of molecular sciences 2023 Oct 30;24(21)

GBP2 is a prognostic biomarker and associated with immunotherapeutic responses in gastric cancer.

Wang Y, Pan J, An F, Chen K, Chen J, Nie H, Zhu Y, Qian Z, Zhan Q
BMC cancer 2023 Oct 2;23(1):925

Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated T. gondii restriction in murine macrophages via vacuole nitration and intravacuolar network collapse.

Zhao XY, Lempke SL, Urbán Arroyo JC, Yin B, Holness NK, Smiley J, Ewald SE
bioRxiv : the preprint server for biology 2023 Jul 25;

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Cao Q, Ma J, Li W, Hong P, Shen T, Tong M
Genes & genomics 2023 Jan;45(1):1-11

Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.

Korcari A, Nichols AEC, Buckley MR, Loiselle AE
eLife 2023 Jan 19;12

Insight into the Neuroprotective Effect of Genistein-3'-Sodium Sulfonate Against Neonatal Hypoxic-Ischaemic Brain Injury in Rats by Bioinformatics.

Xie T, Shuang L, Liu G, Zhao S, Yuan Z, Cai H, Jiang L, Huang Z
Molecular neurobiology 2023 Feb;60(2):807-819

Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

Hashizaki E, Sasai M, Okuzaki D, Nishi T, Kobayashi T, Iwanaga S, Yamamoto M
mBio 2023 Feb 28;14(1):e0325622

Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.

Li G, Choi JE, Kryczek I, Sun Y, Liao P, Li S, Wei S, Grove S, Vatan L, Nelson R, Schaefer G, Allen SG, Sankar K, Fecher LA, Mendiratta-Lala M, Frankel TL, Qin A, Waninger JJ, Tezel A, Alva A, Lao CD, Ramnath N, Cieslik M, Harms PW, Green MD, Chinnaiyan AM, Zou W
Cancer cell 2023 Feb 13;41(2):304-322.e7

GBP2 acts as a member of the interferon signalling pathway in lupus nephritis.

Zhang Y, Liao Y, Hang Q, Sun D, Liu Y
BMC immunology 2022 Sep 17;23(1):44

Enrichment of Newly Synthesized Proteins following treatment of C2C12 Myotubes with Endotoxin and Interferon-γ.

Coleman CS, Stanley BA, Lang CH
Inflammation 2022 Jun;45(3):1313-1331

GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.

Xu H, Jin J, Chen Y, Wu G, Zhu H, Wang Q, Wang J, Li S, Grigore FN, Ma J, Chen CC, Lan Q, Li M
Oncogene 2022 Jul;41(31):3876-3885

GBP2 serves as a novel prognostic biomarker and potential immune microenvironment indicator in renal cell carcinoma.

Tian Y, Wang H, Guan W, Tu X, Zhang X, Sun Y, Qian C, Song X, Peng B, Cui X
Molecular carcinogenesis 2022 Dec;61(12):1082-1098

Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.

Peng Z, Zhang R, Kuang X, Yu C, Niu S, Du Y, Lu D, Li S, Teng Z, Lu S
Journal of cachexia, sarcopenia and muscle 2022 Dec;13(6):2985-2998

GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma.

Liu B, Huang R, Fu T, He P, Du C, Zhou W, Xu K, Ren T
PeerJ 2021;9:e11423

Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.

Chowdhury D, Gardner JC, Satpati A, Nookala S, Mukundan S, Porollo A, Landero Figueroa JA, Subramanian Vignesh K
Frontiers in immunology 2021;12:755961

Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis.

Mohammadi N, Lindgren H, Yamamoto M, Martin A, Henry T, Sjöstedt A
Frontiers in cellular and infection microbiology 2021;11:784101

Galectin-3 regulates proinflammatory cytokine function and favours Brucella abortus chronic replication in macrophages and mice.

Tana FL, Guimarães ES, Cerqueira DM, Campos PC, Gomes MTR, Marinho FV, Oliveira SC
Cellular microbiology 2021 Oct;23(10):e13375

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.

Li G, Kryczek I, Nam J, Li X, Li S, Li J, Wei S, Grove S, Vatan L, Zhou J, Du W, Lin H, Wang T, Subramanian C, Moon JJ, Cieslik M, Cohen M, Zou W
Nature cell biology 2021 May;23(5):526-537

Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.

Pradipta A, Sasai M, Motani K, Ma JS, Lee Y, Kosako H, Yamamoto M
Life science alliance 2021 Jul;4(7)

cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.

Yu P, Miao Z, Li Y, Bansal R, Peppelenbosch MP, Pan Q
Gut microbes 2021 Jan-Dec;13(1):1959839

Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

Nyonda MA, Hammoudi PM, Ye S, Maire J, Marq JB, Yamamoto M, Soldati-Favre D
Cellular microbiology 2021 Feb;23(2):e13278

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

Wang X, Lin W, Liu T, Xu Z, Wang Z, Cao Z, Feng X, Gao Y, He J
Translational lung cancer research 2021 Dec;10(12):4423-4444

Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.

Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma JS, Yamamoto M
Frontiers in immunology 2020;11:561948

Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis.

Burke TP, Engström P, Chavez RA, Fonbuena JA, Vance RE, Welch MD
Nature microbiology 2020 May;5(5):688-696

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

Place DE, Briard B, Samir P, Karki R, Bhattacharya A, Guy CS, Peters JL, Frase S, Vogel P, Neale G, Yamamoto M, Kanneganti TD
PLoS pathogens 2020 Mar;16(3):e1008364

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

Yu P, Li Y, Li Y, Miao Z, Peppelenbosch MP, Pan Q
The Journal of biological chemistry 2020 Jun 5;295(23):8036-8047

Lipopolysaccharide restricts murine norovirus infection in macrophages mainly through NF-kB and JAK-STAT signaling pathway.

Yu P, Li Y, Wang Y, Peppelenbosch MP, Pan Q
Virology 2020 Jul;546:109-121

GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway.

Yu S, Yu X, Sun L, Zheng Y, Chen L, Xu H, Jin J, Lan Q, Chen CC, Li M
Oncogene 2020 Jul;39(27):5042-5055

Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.

Lee Y, Yamada H, Pradipta A, Ma JS, Okamoto M, Nagaoka H, Takashima E, Standley DM, Sasai M, Takei K, Yamamoto M
Life science alliance 2020 Jan;3(1)

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD
Nature microbiology 2019 Feb;4(2):316-327

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD
Cell 2018 May 3;173(4):920-933.e13

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P
The EMBO journal 2018 Mar 15;37(6)

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.

Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A
Cell reports 2018 Jul 3;24(1):155-168.e5

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

Costa Franco MM, Marim F, Guimarães ES, Assis NRG, Cerqueira DM, Alves-Silva J, Harms J, Splitter G, Smith J, Kanneganti TD, de Queiroz NMGP, Gutman D, Barber GN, Oliveira SC
Journal of immunology (Baltimore, Md. : 1950) 2018 Jan 15;200(2):607-622

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, Golovliov I, Michal F, Basso P, Djebali S, Provost A, Allatif O, Meunier E, Broz P, Yamamoto M, Py BF, Faudry E, Sjöstedt A, Henry T
PLoS pathogens 2017 Oct;13(10):e1006630

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, Xu J, Xu B, Wang F, Shao F
Nature 2017 Nov 16;551(7680):378-383

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD
Cell 2016 Oct 6;167(2):382-396.e17

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Meunier E, Wallet P, Dreier RF, Costanzo S, Anton L, Rühl S, Dussurgey S, Dick MS, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P
Nature immunology 2015 May;16(5):476-484

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M, Kanneganti TD
Nature immunology 2015 May;16(5):467-75

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4581-90

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Meunier E, Dick MS, Dreier RF, Schürmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P
Nature 2014 May 15;509(7500):366-70

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human lung tissue were subjected to SDS PAGE followed by western blot with 11854-1-AP(GBP2 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GBP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GBP2. This antibody recognizes human, mouse, rat antigen. The GBP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11854-1-AP.pdf

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