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- Antigen structure
- References [26]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11854-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11854-1-AP, RRID:AB_2109336
- Product name
- GBP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GBP2 antibody (Cat. #11854-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma.
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
Galectin-3 regulates proinflammatory cytokine function and favours Brucella abortus chronic replication in macrophages and mice.
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.
Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.
Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis.
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.
Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.
Lipopolysaccharide restricts murine norovirus infection in macrophages mainly through NF-kB and JAK-STAT signaling pathway.
GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway.
Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.
IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Liu B, Huang R, Fu T, He P, Du C, Zhou W, Xu K, Ren T
PeerJ 2021;9:e11423
PeerJ 2021;9:e11423
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
Chowdhury D, Gardner JC, Satpati A, Nookala S, Mukundan S, Porollo A, Landero Figueroa JA, Subramanian Vignesh K
Frontiers in immunology 2021;12:755961
Frontiers in immunology 2021;12:755961
Galectin-3 regulates proinflammatory cytokine function and favours Brucella abortus chronic replication in macrophages and mice.
Tana FL, Guimarães ES, Cerqueira DM, Campos PC, Gomes MTR, Marinho FV, Oliveira SC
Cellular microbiology 2021 Oct;23(10):e13375
Cellular microbiology 2021 Oct;23(10):e13375
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.
Li G, Kryczek I, Nam J, Li X, Li S, Li J, Wei S, Grove S, Vatan L, Zhou J, Du W, Lin H, Wang T, Subramanian C, Moon JJ, Cieslik M, Cohen M, Zou W
Nature cell biology 2021 May;23(5):526-537
Nature cell biology 2021 May;23(5):526-537
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.
Pradipta A, Sasai M, Motani K, Ma JS, Lee Y, Kosako H, Yamamoto M
Life science alliance 2021 Jul;4(7)
Life science alliance 2021 Jul;4(7)
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.
Yu P, Miao Z, Li Y, Bansal R, Peppelenbosch MP, Pan Q
Gut microbes 2021 Jan-Dec;13(1):1959839
Gut microbes 2021 Jan-Dec;13(1):1959839
Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.
Nyonda MA, Hammoudi PM, Ye S, Maire J, Marq JB, Yamamoto M, Soldati-Favre D
Cellular microbiology 2021 Feb;23(2):e13278
Cellular microbiology 2021 Feb;23(2):e13278
Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma JS, Yamamoto M
Frontiers in immunology 2020;11:561948
Frontiers in immunology 2020;11:561948
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis.
Burke TP, Engström P, Chavez RA, Fonbuena JA, Vance RE, Welch MD
Nature microbiology 2020 May;5(5):688-696
Nature microbiology 2020 May;5(5):688-696
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.
Place DE, Briard B, Samir P, Karki R, Bhattacharya A, Guy CS, Peters JL, Frase S, Vogel P, Neale G, Yamamoto M, Kanneganti TD
PLoS pathogens 2020 Mar;16(3):e1008364
PLoS pathogens 2020 Mar;16(3):e1008364
Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.
Yu P, Li Y, Li Y, Miao Z, Peppelenbosch MP, Pan Q
The Journal of biological chemistry 2020 Jun 5;295(23):8036-8047
The Journal of biological chemistry 2020 Jun 5;295(23):8036-8047
Lipopolysaccharide restricts murine norovirus infection in macrophages mainly through NF-kB and JAK-STAT signaling pathway.
Yu P, Li Y, Wang Y, Peppelenbosch MP, Pan Q
Virology 2020 Jul;546:109-121
Virology 2020 Jul;546:109-121
GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway.
Yu S, Yu X, Sun L, Zheng Y, Chen L, Xu H, Jin J, Lan Q, Chen CC, Li M
Oncogene 2020 Jul;39(27):5042-5055
Oncogene 2020 Jul;39(27):5042-5055
Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
Lee Y, Yamada H, Pradipta A, Ma JS, Okamoto M, Nagaoka H, Takashima E, Standley DM, Sasai M, Takei K, Yamamoto M
Life science alliance 2020 Jan;3(1)
Life science alliance 2020 Jan;3(1)
Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.
Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD
Nature microbiology 2019 Feb;4(2):316-327
Nature microbiology 2019 Feb;4(2):316-327
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD
Cell 2018 May 3;173(4):920-933.e13
Cell 2018 May 3;173(4):920-933.e13
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P
The EMBO journal 2018 Mar 15;37(6)
The EMBO journal 2018 Mar 15;37(6)
Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.
Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A
Cell reports 2018 Jul 3;24(1):155-168.e5
Cell reports 2018 Jul 3;24(1):155-168.e5
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.
Costa Franco MM, Marim F, Guimarães ES, Assis NRG, Cerqueira DM, Alves-Silva J, Harms J, Splitter G, Smith J, Kanneganti TD, de Queiroz NMGP, Gutman D, Barber GN, Oliveira SC
Journal of immunology (Baltimore, Md. : 1950) 2018 Jan 15;200(2):607-622
Journal of immunology (Baltimore, Md. : 1950) 2018 Jan 15;200(2):607-622
IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.
Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, Golovliov I, Michal F, Basso P, Djebali S, Provost A, Allatif O, Meunier E, Broz P, Yamamoto M, Py BF, Faudry E, Sjöstedt A, Henry T
PLoS pathogens 2017 Oct;13(10):e1006630
PLoS pathogens 2017 Oct;13(10):e1006630
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.
Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, Xu J, Xu B, Wang F, Shao F
Nature 2017 Nov 16;551(7680):378-383
Nature 2017 Nov 16;551(7680):378-383
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD
Cell 2016 Oct 6;167(2):382-396.e17
Cell 2016 Oct 6;167(2):382-396.e17
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Meunier E, Wallet P, Dreier RF, Costanzo S, Anton L, Rühl S, Dussurgey S, Dick MS, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P
Nature immunology 2015 May;16(5):476-484
Nature immunology 2015 May;16(5):476-484
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M, Kanneganti TD
Nature immunology 2015 May;16(5):467-75
Nature immunology 2015 May;16(5):467-75
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4581-90
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4581-90
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Meunier E, Dick MS, Dreier RF, Schürmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P
Nature 2014 May 15;509(7500):366-70
Nature 2014 May 15;509(7500):366-70
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human lung tissue were subjected to SDS PAGE followed by western blot with 11854-1-AP(GBP2 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GBP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GBP2. This antibody recognizes human, mouse, rat antigen. The GBP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
