12372-1-AP

antibody from Proteintech Group

Targeting: IL33 C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV

Provider product page for 12372-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [52]
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Validations
Western blot [1]

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Product number: 12372-1-AP - Provider product page
Provider: Proteintech Group
Product name: IL-33 antibody
Antibody type: Polyclonal
Description: KD/KO validated IL-33 antibody (Cat. #12372-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IL33 protein structure - 12372-1-AP shown in red.

Submitted references Ameliorative effects of total glycosides from Aralia elata on airway inflammation and mucus hypersecretion in asthmatic mice.

Li S, Long Y, Chen S, Zhou Q, Yuan Y, Xu S, Zhang D, Tang B, Wang T, Li Y, Dong F, He H, Tong X, Huang F, Li B
Journal of ethnopharmacology 2026 Jun 28;365:121458

The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.

Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743

Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation.

Peng J, Chang Z, Wang J, Liao Z, Yang Y, Mu L, Wang S, Huang J, Xia J, Hu M
Frontiers in physiology 2025;16:1608268

Intratumoral IL-33 + CD4 + FoxP3 + regulatory T cell infiltration determines poor clinical outcomes and intensive immunoevasive contexture in patients with pancreatic cancer after surgical resection: a cohort study.

Pu N, Chen Q, Han J, Xu Z, Jiang Z, He T, An Y, Xu Y, Gan W, Wang H, Wang W, Wu W, Jin Y, Yu J, Lou W, Yin H, Liu L
International journal of surgery (London, England) 2025 Sep 1;111(9):6245-6259

Slow-Release Prostacyclin Agonist-Immersed Sheet Implantation Suppresses Liver Fibrosis via Hippo Signaling Pathway Activation.

Fujii W, Tomimaru Y, Kobayashi S, Torigata K, Hasegawa K, Harada A, Sasaki K, Hasegawa S, Yamada D, Akita H, Noda T, Takahashi H, Imamura H, Kodama T, Terai S, Sawa Y, Miyagawa S, Doki Y, Eguchi H
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Oct;55(10):1353-1366

Notoginsenoside R1 attenuates idiopathic pulmonary fibrosis through neuropilin-1/type 2 innate lymphoid cells pathway.

Yang M, Fang Y, Li X, Yang B, Ma Q, Cui X, Jiang L, Ge F
International immunopharmacology 2025 Oct 30;164:115385

Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2-CXCL1 Axis.

Yoo H, Choi A, Kim M, Gye Y, Jo H, Kwok SK, Park Y, Lee JJ
Cells 2025 Oct 2;14(19)

Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice.

Chen H, Gao C, Mo L, Yin X, Chen L, Wu B, Zhao Y, Cheng X, Liang C, Xu B, Li D, Li Y, Yao P, Tang Y
Diabetes & metabolism journal 2025 Nov;49(6):1204-1218

Targeting of the IL-33/Wnt axis restricts breast cancer stemness and metastasis.

Fan G, Zuo S, Wang Z, Zhang S, Liu L, Luo H, Xie Y, Zhang Y, Li D
Scientific reports 2025 May 25;15(1):18172

Therapeutic potential of a systemically applied humanized monoclonal antibody targeting Toll‑like receptor 2 in atopic‑dermatitis‑like skin lesions in a mouse model.

Yeo H, Jung E, Kim TY, Shin SY
Biomedical reports 2025 Mar;22(3):41

Prognostic implications and characterization of tumor-associated tertiary lymphoid structures genes in pancreatic cancer.

Zhang E, Ma Y, Liu Z, Zhang J, Liu W, Chen Y, Liu G, Liu X, Zhang F, Zhu Y, Yang Y, Tian X
Journal of translational medicine 2025 Mar 10;23(1):301

Increased ocular plasma cells induce damaging α-synuclein(+) microglia in autoimmune uveitis.

Li M, Feng M, Liu T, Duan S, Man X, Yuan X, Wang L, Sun Y, Wei X, Fu Q, Sun B, Lin W
Mucosal immunology 2025 Jun;18(3):668-684

Inhibition of ZFP281/ZNF281-RIPK1/RIPK3/MLKL signaling in hepatocytes by pterostilbene relieves hepatic lipometabolic disorder and inflammation in non-alcoholic steatohepatitis.

Lu C, Zhang Y, Miao J, Wei W, Wang Y, Han Y, Li Y, Tong Y, Wang T, Bao X
International immunopharmacology 2025 Jan 27;146:113936

Hyperactivity of the IL-33-ILC2s-IL-13-M-MDSCs axis promotes cervical cancer progression.

Wang B, Zhu Y, Zhang Y, Ru Z, Chen L, Zhang M, Wu Y, Ding J, Chen Z
International immunopharmacology 2025 Jan 10;144:113693

Effect of improved Yupingfeng powder prescription on interleukin-33/suppression of tumorigenicity 2 pathway in mice with ovalbumins-induced allergic rhinitis.

Xiaochun L, Cuizhen L, Xiujuan L, Xiangyu X, Wei KE, Zhenwen Q, Hongmei T, Yushen H, Lijuan Z, Baoyuan H, Xin W, Detang LI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1215-1227

Etoposide activates CD8(+) T cell anti-tumor immunity in osteosarcoma through MHC I upregulation via tumor-secreted IL-33 mediated signaling.

He X, Li H, Wang H, Zuo D, Dong H, Mu H, Yang B, Tao Y, Yang X, Zhao B, Zhang T, Jiang Y, Wang Z, Wang H, Yang L, Hua Y, Cai Z, Wang C, Sun M, Gui J, Sun W
Journal for immunotherapy of cancer 2025 Dec 21;13(12)

Single-cell sequencing reveals the role of IL-33 (+) endothelial subsets in promoting early gastric cancer progression.

Zhou L, Yang M, Deng C, Hu M, Wu S, Lai K, Zhang L, Chen Z, Tang Q, Wang Q, Chen L, Zha R, Chen Y, Tan Y, He S, Zhou Z
iMeta 2025 Aug;4(4):e70050

Carbon Monoxide Alleviates Cardiomyocyte Pyroptosis in Diabetic Cardiomyopathy by Downregulating the IL-33/ST2L Axis.

Jiang C, Zhu P, Yao P, Bi X, Gao C
Immunity, inflammation and disease 2025 Aug;13(8):e70231

Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.

Li Y, Tian L, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y
Free radical biology & medicine 2024 Sep;222:106-121

WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33.

Cheng Y, Xiao S, Lan L, Liu D, Tang R, Gu J, Ma L, He Z, Chen X, Geng L, Chen P, Li H, Ren L, Zhu Y, Cheng Y, Gong S
Journal of molecular medicine (Berlin, Germany) 2024 Oct;102(10):1199-1215

Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors.

Liu L, Zhang L, Hao X, Wang Y, Zhang X, Ge L, Wang P, Tian B, Zhang M
Nature communications 2024 Oct 8;15(1):8708

Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.

Chen L, Gao C, Yin X, Mo L, Cheng X, Chen H, Jiang C, Wu B, Zhao Y, Li H, Li Y, Li J, Chen L, Deng Q, Yao P, Tang Y
MedComm 2024 Nov;5(11):e742

Ultrasmall Nanoparticles Regulate Immune Microenvironment by Activating IL-33/ST2 to Alleviate Renal Ischemia-Reperfusion Injury.

Xu L, Xing Z, Yuan J, Han Y, Jiang Z, Han M, Hou X, Xing W, Li Z
Advanced healthcare materials 2024 May;13(13):e2303276

MiR-548t-5p regulates pancreatic ductal adenocarcinoma metastasis through an IL-33-dependent crosstalk between cancer cells and M2 macrophages.

Wang Y, Ge WL, Wang SJ, Liu YY, Zhang ZH, Hua Y, Zhang XF, Zhang JJ
Cell cycle (Georgetown, Tex.) 2024 Jan;23(2):169-187

Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.

Ma Z, Chen X, Xiong M, Wang H, Sun C, Tang W, Li J, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Dec 5;335:118644

CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis.

Zhou J, Pathak JL, Cao T, Chen B, Wei W, Hu S, Mao T, Wu X, Watanabe N, Li X, Li J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167121

Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca(2+)/NFAT pathway.

Peng M, Li J, Zhou J, Zhang B, Liao J, Yang D, Wang Y, Yang Y, Li R, Tang X, Lu Q, Zhao Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154946

RORα overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis.

Yu W, Du J, Peng L, Zhang T
Immunity, inflammation and disease 2023 Oct;11(10):e1017

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.

Wu Q, Liang Z, Jiang J, Feng X, Liu J, Zhang Z, Wang H, Wang N, Gou Y, Li Z, Cao Y
Cell death & disease 2023 Oct 11;14(10):668

Nicotine exposure exacerbates silica-induced pulmonary fibrosis via STAT3-BDNF-TrkB-mediated epithelial-mesenchymal transition in alveolar type II cells.

Chen H, Tao X, Cao H, Li B, Sun Q, Wang W, Zou Y, Mu M, Tao H, Zhao Y, Ge D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113694

The association of serum IL-33/ST2 expression with hepatocellular carcinoma.

Pan X, Liu J, Li M, Liang Y, Liu Z, Lao M, Fang M
BMC cancer 2023 Jul 28;23(1):704

Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.

Sitzia C, Vianello E, Dozio E, Kalousová M, Zima T, Brizzola S, Roccabianca P, Tedeschi G, Lamont J, Tacchini L, Corsi-Romanelli MM
International journal of molecular sciences 2023 Jan 19;24(3)

IL-33/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea.

Dandan-Zong, Shen C, Liu X, Liu T, Ou Y, Ouyang R
International immunopharmacology 2023 Feb;115:109604

Seven oxidative stress-related genes predict the prognosis of hepatocellular carcinoma.

Miao C, He X, Chen G, Kahlert UD, Yao C, Shi W, Su D, Hu L, Zhang Z
Aging 2023 Dec 14;15(24):15050-15063

Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.

Zhu X, Lu J, Rao J, Ru D, Gao M, Shi D, Cao K, Wen S, Dai C, Wang X, Mi W, Liu L, Zhou H
The American journal of pathology 2023 Aug;193(8):1029-1045

Hypoxia induces the production of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis with nasal polyps.

Zhang M, Tang B, Huang L, Xiong Y, Tu J, Jia Y, Jiang F, Shen L, Luo Q, Ye J
International immunopharmacology 2023 Aug;121:110559

Topical application of imatinib mesylate suppresses vitamin D3 analog-induced dermatitis in Balb/c mice.

Seshimo H, Egusa C, Maeda T, Numata T, Okubo Y, Harada K, Ito T
Experimental dermatology 2023 Apr;32(4):413-424

IL-33 Participates in the Development of Esophageal Adenocarcinoma.

Liu J, Liu L, Su Y, Wang Y, Zhu Y, Sun X, Guo Y, Shan J
Pathology oncology research : POR 2022;28:1610474

Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis.

He B, Teng XM, Hao F, Zhao M, Chen ZQ, Li KM, Yan Q
Frontiers in endocrinology 2022;13:928024

Akkermansia muciniphila Alters Gut Microbiota and Immune System to Improve Cardiovascular Diseases in Murine Model.

He X, Bai Y, Zhou H, Wu K
Frontiers in microbiology 2022;13:906920

Clinical implications of interleukins-31, 32, and 33 in gastric cancer.

Liu QH, Zhang JW, Xia L, Wise SG, Hambly BD, Tao K, Bao SS
World journal of gastrointestinal oncology 2022 Sep 15;14(9):1808-1822

Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes.

Chen X, Zhang Y, Pei J, Zeng X, Yang Y, Zhang Y, Li F, Deng Y
International immunopharmacology 2022 Nov;112:109270

Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.

Zhu S, Zhang J, Jiang X, Wang W, Chen YQ
EBioMedicine 2022 Jun;80:104060

Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-α/NF-κB axis mediated transactivation of IL-17A and IL-33 in keratinocytes.

Yang Y, Zhang Y, Chen X, Su Z, Deng Y, Zhao Q
Journal of ethnopharmacology 2022 Jun 28;292:115124

Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet.

Kai Y, Gao J, Liu H, Wang Y, Tian C, Guo S, He L, Li M, Tian Z, Song X
International immunopharmacology 2021 Dec;101(Pt A):108209

Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway.

Xie C, Zhu J, Wang X, Chen J, Geng S, Wu J, Zhong C, Li X
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):39

Increased Type 2 Innate Lymphoid Cells in Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome.

Tsai YG, Liou JH, Hung SI, Chen CB, Chiu TM, Wang CW, Chung WH
The Journal of investigative dermatology 2019 Aug;139(8):1722-1731

Decreased IL-33 Production Contributes to Trophoblast Cell Dysfunction in Pregnancies with Preeclampsia.

Chen H, Zhou X, Han TL, Baker PN, Qi H, Zhang H
Mediators of inflammation 2018;2018:9787239

Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.

Xiang H, Tao X, Xia S, Qu J, Song H, Liu J, Shang D
Frontiers in immunology 2017;8:1488

Overexpression of interleukin-33 is associated with poor prognosis of patients with glioma.

Zhang J, Wang P, Ji W, Ding Y, Lu X
The International journal of neuroscience 2017 Mar;127(3):210-217

Interleukin-33 affects cytokine production by keratinocytes in vitiligo.

Li P, Ma H, Han D, Mou K
Clinical and experimental dermatology 2015 Mar;40(2):163-70

Global secretome characterization of A549 human alveolar epithelial carcinoma cells during Mycoplasma pneumoniae infection.

Li S, Li X, Wang Y, Yang J, Chen Z, Shan S
BMC microbiology 2014 Feb 7;14:27

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IL33 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IL33. This antibody recognizes human antigen. The IL33 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12372-1-AP.pdf

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