ALX-804-840-C100
antibody from Enzo Life Sciences
Targeting: IL33
C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV
Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-804-840-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Product name
- IL-33 monoclonal antibody (Nessy-1)
- Antibody type
- Monoclonal
- Antigen
- Recombinant protein fragment
- Description
- Protein G-affinity purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- Nessy-1
- Vial size
- 100 μg
- Storage
- -20°C
Submitted references An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer.
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice.
Experimentally induced psoriatic lesions associate with rapid but transient decrease in interleukin-33 immunostaining in epidermis.
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease.
Unique temporal and spatial expression patterns of IL-33 in ovaries during ovulation and estrous cycle are associated with ovarian tissue homeostasis.
Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension.
IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment.
Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.
Interleukin 33 as a mechanically responsive cytokine secreted by living cells.
Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques.
IL-33 exacerbates acute kidney injury.
Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription.
The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis.
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.
Interleukin-33 is biologically active independently of caspase-1 cleavage.
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.
O'Donnell C, Mahmoud A, Keane J, Murphy C, White D, Carey S, O'Riordain M, Bennett MW, Brint E, Houston A
British journal of cancer 2016 Jan 12;114(1):37-43
British journal of cancer 2016 Jan 12;114(1):37-43
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice.
Chen H, Sun Y, Lai L, Wu H, Xiao Y, Ming B, Gao M, Zou H, Xiong P, Xu Y, Tan Z, Gong F, Zheng F
Neuroscience 2015 Nov 12;308:157-68
Neuroscience 2015 Nov 12;308:157-68
Experimentally induced psoriatic lesions associate with rapid but transient decrease in interleukin-33 immunostaining in epidermis.
Suttle MM, Enoksson M, Zoltowska A, Chatterjee M, Nilsson G, Harvima IT
Acta dermato-venereologica 2015 May;95(5):536-41
Acta dermato-venereologica 2015 May;95(5):536-41
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease.
Millar NL, Gilchrist DS, Akbar M, Reilly JH, Kerr SC, Campbell AL, Murrell GA, Liew FY, Kurowska-Stolarska M, McInnes IB
Nature communications 2015 Apr 10;6:6774
Nature communications 2015 Apr 10;6:6774
Unique temporal and spatial expression patterns of IL-33 in ovaries during ovulation and estrous cycle are associated with ovarian tissue homeostasis.
Carlock CI, Wu J, Zhou C, Tatum K, Adams HP, Tan F, Lou Y
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):161-9
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):161-9
Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension.
Shao D, Perros F, Caramori G, Meng C, Dormuller P, Chou PC, Church C, Papi A, Casolari P, Welsh D, Peacock A, Humbert M, Adcock IM, Wort SJ
Biochemical and biophysical research communications 2014 Aug 15;451(1):8-14
Biochemical and biophysical research communications 2014 Aug 15;451(1):8-14
IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment.
Roussel L, Farias R, Rousseau S
The Journal of allergy and clinical immunology 2013 Mar;131(3):913-6
The Journal of allergy and clinical immunology 2013 Mar;131(3):913-6
Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishii KJ, Yoshimoto T, Akira S, Nakanishi K
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3451-6
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3451-6
Interleukin 33 as a mechanically responsive cytokine secreted by living cells.
Kakkar R, Hei H, Dobner S, Lee RT
The Journal of biological chemistry 2012 Feb 24;287(9):6941-8
The Journal of biological chemistry 2012 Feb 24;287(9):6941-8
Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques.
Demyanets S, Konya V, Kastl SP, Kaun C, Rauscher S, Niessner A, Pentz R, Pfaffenberger S, Rychli K, Lemberger CE, de Martin R, Heinemann A, Huk I, Gröger M, Maurer G, Huber K, Wojta J
Arteriosclerosis, thrombosis, and vascular biology 2011 Sep;31(9):2080-9
Arteriosclerosis, thrombosis, and vascular biology 2011 Sep;31(9):2080-9
IL-33 exacerbates acute kidney injury.
Akcay A, Nguyen Q, He Z, Turkmen K, Won Lee D, Hernando AA, Altmann C, Toker A, Pacic A, Ljubanovic DG, Jani A, Faubel S, Edelstein CL
Journal of the American Society of Nephrology : JASN 2011 Nov;22(11):2057-67
Journal of the American Society of Nephrology : JASN 2011 Nov;22(11):2057-67
Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Louten J, Rankin AL, Li Y, Murphy EE, Beaumont M, Moon C, Bourne P, McClanahan TK, Pflanz S, de Waal Malefyt R
International immunology 2011 May;23(5):307-15
International immunology 2011 May;23(5):307-15
The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription.
Ali S, Mohs A, Thomas M, Klare J, Ross R, Schmitz ML, Martin MU
Journal of immunology (Baltimore, Md. : 1950) 2011 Aug 15;187(4):1609-16
Journal of immunology (Baltimore, Md. : 1950) 2011 Aug 15;187(4):1609-16
The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis.
Manetti M, Ibba-Manneschi L, Liakouli V, Guiducci S, Milia AF, Benelli G, Marrelli A, Conforti ML, Romano E, Giacomelli R, Matucci-Cerinic M, Cipriani P
Annals of the rheumatic diseases 2010 Mar;69(3):598-605
Annals of the rheumatic diseases 2010 Mar;69(3):598-605
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.
Préfontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, Olivenstein R, Halayko AJ, Lemière C, Martin JG, Hamid Q
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 15;183(8):5094-103
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 15;183(8):5094-103
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
Kurowska-Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan CJ, Ying S, Pitman N, Mirchandani A, Rana B, van Rooijen N, Shepherd M, McSharry C, McInnes IB, Xu D, Liew FY
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6469-77
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6469-77
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.
Cayrol C, Girard JP
Proceedings of the National Academy of Sciences of the United States of America 2009 Jun 2;106(22):9021-6
Proceedings of the National Academy of Sciences of the United States of America 2009 Jun 2;106(22):9021-6
Interleukin-33 is biologically active independently of caspase-1 cleavage.
Talabot-Ayer D, Lamacchia C, Gabay C, Palmer G
The Journal of biological chemistry 2009 Jul 17;284(29):19420-6
The Journal of biological chemistry 2009 Jul 17;284(29):19420-6
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):7890-7
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):7890-7
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.
Küchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, De Angelis PM, Scott H, Haraldsen G
The American journal of pathology 2008 Oct;173(4):1229-42
The American journal of pathology 2008 Oct;173(4):1229-42
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Immunohistochemical staining of endogenous human IL-33 in different human tissues (paraffin sections) using MAb to IL-33 (Nessy-1) (Prod. No. ALX-804-840). Method: Different human normal tissues (A: Stomach; B: Bronchus; C: Vulva/Anal skin; D: Nasopharynx) or cancer tissues (E: Colorectal cancer; F: Malignant glioma) were stained with MAb to lL-33 (Nessy-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (http://www.proteinatlas.org/).