21601-1-AP

antibody from Proteintech Group

Targeting: LRRC8C AD158

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

21601-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#21601-1-AP, RRID:AB_10733648

Product name

LRRC8C antibody

Antibody type

Polyclonal

Description

LRRC8C antibody (Cat. #21601-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channels.

Chandler ML, Sprague AD, Nalwalk JW, Mongin AA
American journal of physiology. Cell physiology 2026 Apr 1;330(4):C842-C860

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Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.

Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900

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LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis.

Tranter JD, Mikami RT, Kumar A, Brown G, Abd El-Aziz TM, Zhao Y, Abraham N, Meyer C, Ajanel A, Xie L, Ashworth K, Hong J, Zhang H, Kumari T, Balutowski A, Liu A, Bark D, Nair VK, Lasky NM, Feng Y, Stitziel NO, Lerner DJ, Campbell RA, Paola JD, Cho J, Sah R
bioRxiv : the preprint server for biology 2024 Sep 26;

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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism.

Kumar A, Zhao Y, Xie L, Chadda R, Abraham N, Hong J, Feng E, Tranter JD, Rawnsley D, Liu H, Henry KM, Meyer G, Hu M, Xu H, Hinton A, Grueter CE, Abel ED, Norris AW, Diwan A, Sah R
bioRxiv : the preprint server for biology 2024 Sep 23;

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2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.

Deng Y, Hahn Q, Yu L, Zhu Z, Boyer JA, Wang J, Kong D, Carey LM, Hepperla AJ, Simon JM, Temple B, Zhang Z, Zhang Y, Santos C, Frank JE, Herring LE, Wang X, Dokholyan NV, Campbell SL, Baldwin AS, Damania B, Zhang Q, Liu P
Science advances 2024 Oct 18;10(42):eado7024

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TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer.

Lv H, Zong Q, Chen C, Lv G, Xiang W, Xing F, Jiang G, Yan B, Sun X, Ma Y, Wang L, Wu Z, Cui X, Wang H, Yang W
Nature communications 2024 Jan 4;15(1):6

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Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy.

Feldman LER, Mohapatra S, Jones RT, Scholtes M, Tilton CB, Orman MV, Joshi M, Deiter CS, Broneske TP, Qu F, Gutierrez C, Ye H, Clambey ET, Parker S, Mahmoudi T, Zuiverloon T, Costello JC, Theodorescu D
Science advances 2024 Dec 13;10(50):eadr9364

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Astrocytes-Derived Small Extracellular Vesicles Hinder Glioma Growth.

Serpe C, Michelucci A, Monaco L, Rinaldi A, De Luca M, Familiari P, Relucenti M, Di Pietro E, Di Castro MA, D'Agnano I, Catacuzzeno L, Limatola C, Catalano M
Biomedicines 2022 Nov 17;10(11)

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using LRRC8C antibody 21601-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 21601-1-AP(LRRC8C antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue