Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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Validation data
Reference
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- Product number
- 14341-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14341-1-AP, RRID:AB_10548408
- Product name
- MAVS; VISA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MAVS; VISA antibody (Cat. #14341-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS.
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3.
Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
STING1 is essential for an RNA-virus triggered autophagy.
Induction of autophagy and suppression of type I IFN secretion by CSFV.
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy.
The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS.
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation.
Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.
MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation.
MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1.
RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.
Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-β expression.
Li W, Qiao J, You Q, Zong S, Peng Q, Liu Y, Hu S, Liu W, Li S, Shu X, Sun B
Frontiers in immunology 2021;12:750969
Frontiers in immunology 2021;12:750969
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Yang B, Zhang G, Qin X, Huang Y, Ren X, Sun J, Ma S, Liu Y, Song D, Liu Y, Cui Y, Wang H, Wang J
Frontiers in immunology 2021;12:730483
Frontiers in immunology 2021;12:730483
Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3.
Ekanayaka P, Lee BH, Weerawardhana A, Chathuranga K, Park JH, Lee JS
Viruses 2021 Sep 6;13(9)
Viruses 2021 Sep 6;13(9)
Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.
Zheng J, Xu Y, Khan A, Sun P, Sun Y, Fan K, Yin W, Wang S, Li H, Sun N
BMC veterinary research 2021 Sep 30;17(1):318
BMC veterinary research 2021 Sep 30;17(1):318
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, Ke Y, Wu T, Sun R, Qian J, Du Y
Cell reports 2021 Jun 22;35(12):109272
Cell reports 2021 Jun 22;35(12):109272
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
Rebendenne A, Valadão ALC, Tauziet M, Maarifi G, Bonaventure B, McKellar J, Planès R, Nisole S, Arnaud-Arnould M, Moncorgé O, Goujon C
Journal of virology 2021 Jan 29;
Journal of virology 2021 Jan 29;
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F
Cell reports 2021 Jan 19;34(3):108631
Cell reports 2021 Jan 19;34(3):108631
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H
Autophagy 2021 Feb;17(2):496-511
Autophagy 2021 Feb;17(2):496-511
STING1 is essential for an RNA-virus triggered autophagy.
Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2021 Aug 2;:1-13
Autophagy 2021 Aug 2;:1-13
Induction of autophagy and suppression of type I IFN secretion by CSFV.
Xie B, Zhao M, Song D, Wu K, Yi L, Li W, Li X, Wang K, Chen J
Autophagy 2021 Apr;17(4):925-947
Autophagy 2021 Apr;17(4):925-947
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR
Theranostics 2020;10(20):9032-9049
Theranostics 2020;10(20):9032-9049
Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.
Luo Z, Liu LF, Jiang YN, Tang LP, Li W, Ouyang SH, Tu LF, Wu YP, Gong HB, Yan CY, Jiang S, Lu YH, Liu T, Jiang Z, Kurihara H, Yu Y, Yao XS, Li YF, He RR
Signal transduction and targeted therapy 2020 Sep 18;5(1):202
Signal transduction and targeted therapy 2020 Sep 18;5(1):202
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy.
Szymura SJ, Bernal GM, Wu L, Zhang Z, Crawley CD, Voce DJ, Campbell PA, Ranoa DE, Weichselbaum RR, Yamini B
BMC biology 2020 Mar 24;18(1):32
BMC biology 2020 Mar 24;18(1):32
The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS.
Zhou D, Li Q, Jia F, Zhang L, Wan S, Li Y, Song Y, Chen H, Cao S, Ye J
Journal of immunology (Baltimore, Md. : 1950) 2020 Mar 1;204(5):1287-1298
Journal of immunology (Baltimore, Md. : 1950) 2020 Mar 1;204(5):1287-1298
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y
The Journal of experimental medicine 2020 Jul 6;217(7)
The Journal of experimental medicine 2020 Jul 6;217(7)
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation.
Wang Y, Wang P, Zhang Y, Xu J, Li Z, Li Z, Zhou Z, Liu L, Cao X
Immunity 2020 Dec 15;53(6):1168-1181.e7
Immunity 2020 Dec 15;53(6):1168-1181.e7
Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro.
Luo Z, Liu LF, Wang XH, Li W, Jie C, Chen H, Wei FQ, Lu DH, Yan CY, Liu B, Kurihara H, Li YF, He RR
Frontiers in pharmacology 2019;10:78
Frontiers in pharmacology 2019;10:78
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.
Igase M, Shousu K, Fujiki N, Sakurai M, Bonkobara M, Hwang CC, Coffey M, Noguchi S, Nemoto Y, Mizuno T
Veterinary and comparative oncology 2019 Jun;17(2):184-193
Veterinary and comparative oncology 2019 Jun;17(2):184-193
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y
Nature communications 2018 Mar 28;9(1):1243
Nature communications 2018 Mar 28;9(1):1243
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.
Xing J, Zhang A, Minze LJ, Li XC, Zhang Z
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):183-192
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):183-192
MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells.
Hou P, Wang H, Zhao G, Hu G, Xia X, He H
BMC microbiology 2018 Dec 27;18(1):224
BMC microbiology 2018 Dec 27;18(1):224
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
Jie C, Luo Z, Chen H, Wang M, Yan C, Mao ZF, Xiao GK, Kurihara H, Li YF, He RR
Oncotarget 2017 Dec 1;8(62):105615-105629
Oncotarget 2017 Dec 1;8(62):105615-105629
GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation.
Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J
PLoS pathogens 2017 Apr;13(4):e1006321
PLoS pathogens 2017 Apr;13(4):e1006321
MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).
Wan S, Ashraf U, Ye J, Duan X, Zohaib A, Wang W, Chen Z, Zhu B, Li Y, Chen H, Cao S
Oncotarget 2016 Nov 22;7(47):76667-76683
Oncotarget 2016 Nov 22;7(47):76667-76683
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G
Journal of virology 2016 Nov 15;90(22):10259-10270
Journal of virology 2016 Nov 15;90(22):10259-10270
Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1.
Hwang KY, Choi YB
Journal of virology 2016 Jan 1;90(1):506-20
Journal of virology 2016 Jan 1;90(1):506-20
RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.
Gu M, Liu Z, Lai R, Liu S, Lin W, Ouyang C, Ye S, Huang H, Wang X
The EMBO journal 2016 Dec 1;35(23):2553-2565
The EMBO journal 2016 Dec 1;35(23):2553-2565
Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-β expression.
Dong J, Xu S, Wang J, Luo R, Wang D, Xiao S, Fang L, Chen H, Jiang Y
The Journal of general virology 2015 Oct;96(10):3049-3058
The Journal of general virology 2015 Oct;96(10):3049-3058
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 14341-1-AP(MAVS; VISA antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using MAVS antibody 14341-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MAVS; VISA (IP:14341-1-AP, 3ug; Detection:14341-1-AP 1:1000) with HEK-293 cells lysate 1700ug.
- Sample type
- cell line