14341-1-AP

antibody from Proteintech Group

Targeting: MAVS Cardif, IPS-1, KIAA1271, VISA

Provider product page for 14341-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [67]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]

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Product number: 14341-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14341-1-AP, RRID:AB_10548408
Product name: MAVS; VISA antibody
Antibody type: Polyclonal
Description: KD/KO validated MAVS; VISA antibody (Cat. #14341-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAVS protein structure - 14341-1-AP shown in red.

Submitted references FADD promotes type I interferon production to suppress porcine reproductive and respiratory syndrome virus infection.

Chang X, Wang M, Li Z, Wang L, Zhang G, Chang Y, Hu J
Frontiers in veterinary science 2024;11:1380144

Porcine reproductive and respiratory syndrome virus infection induces microRNA novel-216 production to facilitate viral-replication by targeting MAVS 3´UTR.

Luo X, Xie S, Xu X, Zhang Y, Huang Y, Tan D, Tan Y
Veterinary microbiology 2024 May;292:110061

Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.

Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624

Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.

Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)

TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I.

Sun Q, Han X, Meng L, Li H, Chen Y, Yin L, Wang C, Wang J, Li M, Gao X, Li W, Wei L, Ma C
Inflammation 2024 Aug;47(4):1328-1343

Fufang Luohanguo Qingfei granules reduces influenza virus susceptibility via MAVS-dependent type I interferon antiviral signaling.

Lu YH, Wang M, Lin JQ, Wang MY, Zhou LY, He SH, Yi YT, Wei X, Huang QJ, Su ZH, Yang J, Guo HW, He RR, Luo Z
Journal of ethnopharmacology 2024 Apr 24;324:117780

IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.

Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088

Plasminogen activator urokinase interacts with the fusion protein and antagonizes the growth of Peste des petits ruminants virus.

Wu J, Yang W, Li L, Wu J, He J, Ru Y, Ren J, Wang Y, Zheng H, Shang Y, Li D
Journal of virology 2024 Apr 16;98(4):e0014624

MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion.

Shi TT, Huang Y, Li Y, Dai XL, He YH, Ding JC, Ran T, Shi Y, Yuan Q, Li WJ, Liu W
Science advances 2023 Sep;9(35):eadg7053

Overexpression of the mitochondrial anti-viral signaling protein, MAVS, in cancers is associated with cell survival and inflammation.

Trishna S, Lavon A, Shteinfer-Kuzmine A, Dafa-Berger A, Shoshan-Barmatz V
Molecular therapy. Nucleic acids 2023 Sep 12;33:713-732

Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.

Zhao X, Stein KR, Chen V, Griffin ME, Lairson LL, Hang HC
Nature chemical biology 2023 Oct;19(10):1205-1214

Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.

Yu J, Shi H, Song K, Yang Y, Li X, Peng L, Fu B, Yi P
Viruses 2023 Oct 29;15(11)

Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells.

Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S
Virology journal 2023 Nov 29;20(1):280

TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination.

Chen YY, Ran XH, Ni RZ, Mu D
The Journal of biological chemistry 2023 May;299(5):104660

ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.

Yi J, Wang L, Du J, Wang M, Shen H, Liu Z, Qin Y, Liu J, Hu G, Xiao R, Ding J, Chen X, Wang H, Huang H, Ouyang G, Liu W
Developmental cell 2023 May 8;58(9):760-778.e6

Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway.

Gao M, Liu Z, Guo X, Zhang J, Cheng G, Hu X, Zhang W, Gu C
Archives of virology 2023 May 26;168(6):169

CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.

Yi J, Wang L, Hu GS, Zhang YY, Du J, Ding JC, Ji X, Shen HF, Huang HH, Ye F, Liu W
The EMBO journal 2023 May 15;42(10):e112408

IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.

Chen L, Li X, Deng Y, Bi Y, Yan Z, Yang Y, Zhang X, Li H, Xie J, Feng R
Viruses 2023 Mar 28;15(4)

Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.

Deng S, He W, Gong AY, Li M, Wang Y, Xia Z, Zhang XT, Huang Pacheco AS, Naqib A, Jenkins M, Swanson PC, Drescher KM, Strauss-Soukup JK, Belshan M, Chen XM
Nature communications 2023 Mar 16;14(1):1456

A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer.

Ding N, You AB, Yang H, Hu GS, Lai CP, Liu W, Ye F
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Jun 1;29(11):2095-2109

An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.

Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15

Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.

Zhou H, Yan Y, Gao J, Ma M, Liu Y, Shi X, Zhang Q, Xu X
Journal of virology 2023 Feb 28;97(2):e0175122

TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79

An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation.

Zhang B, Han H, Zhao X, Li AN, Wang Y, Yuan W, Yang Z, Li MD
EBioMedicine 2023 Aug;94:104694

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.

Carlson RJ, Leiken MD, Guna A, Hacohen N, Blainey PC
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 18;120(16):e2210623120

BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.

Huang JP, Li J, Xiao YP, Xu LG
Frontiers in immunology 2022;13:972184

DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS.

Xie J, Li X, Yang S, Yan Z, Chen L, Yang Y, Li D, Zhang X, Feng R
Frontiers in microbiology 2022;13:932842

Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells.

Ren Z, Jia G, He H, Ding T, Yu Y, Zuo Z, Hu Y, Zhong Z, Yu S, Deng H, Shen L, Cao S, Peng G, Wang Y, Cai D, Gou L, Ma X, Liu H, Zhou Z, Deng Y, Yang D, Deng J
Frontiers in microbiology 2022;13:846747

Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.

Zhang R, Lin H, You Q, Zhang Z, Bai L, Chen F, Zhu X, Zhang Z, Li Y
Journal of virology 2022 Oct 26;96(20):e0137522

MiR-29a inhibits MPP + - Induced cell death and inflammation in Parkinson's disease model in vitro by potential targeting of MAVS.

Yang YL, Lin TK, Huang YH
European journal of pharmacology 2022 Nov 5;934:175302

STING1 is essential for an RNA-virus triggered autophagy.

Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2022 Apr;18(4):816-828

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury.

Zhu Y, Huang G, Yang Y, Yong C, Yu X, Wang G, Yi L, Gao K, Tian F, Qian S, Zhou E, Zou Y
Journal of inflammation research 2021;14:6601-6618

HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.

Li X, Ma R, Wu B, Niu Y, Li H, Li D, Xie J, Idris A, Feng R
Frontiers in microbiology 2021;12:788870

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS.

Li W, Qiao J, You Q, Zong S, Peng Q, Liu Y, Hu S, Liu W, Li S, Shu X, Sun B
Frontiers in immunology 2021;12:750969

Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.

Yang B, Zhang G, Qin X, Huang Y, Ren X, Sun J, Ma S, Liu Y, Song D, Liu Y, Cui Y, Wang H, Wang J
Frontiers in immunology 2021;12:730483

Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3.

Ekanayaka P, Lee BH, Weerawardhana A, Chathuranga K, Park JH, Lee JS
Viruses 2021 Sep 6;13(9)

Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.

Zheng J, Xu Y, Khan A, Sun P, Sun Y, Fan K, Yin W, Wang S, Li H, Sun N
BMC veterinary research 2021 Sep 30;17(1):318

PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology.

Kim SH, Shin HJ, Yoon CM, Lee SW, Sharma L, Dela Cruz CS, Kang MJ
American journal of respiratory cell and molecular biology 2021 May;64(5):592-603

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.

Rebendenne A, Valadão ALC, Tauziet M, Maarifi G, Bonaventure B, McKellar J, Planès R, Nisole S, Arnaud-Arnould M, Moncorgé O, Goujon C
Journal of virology 2021 Mar 25;95(8)

Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.

Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, Ke Y, Wu T, Sun R, Qian J, Du Y
Cell reports 2021 Jun 22;35(12):109272

Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.

Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589

The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.

Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F
Cell reports 2021 Jan 19;34(3):108631

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.

Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H
Autophagy 2021 Feb;17(2):496-511

Induction of autophagy and suppression of type I IFN secretion by CSFV.

Xie B, Zhao M, Song D, Wu K, Yi L, Li W, Li X, Wang K, Chen J
Autophagy 2021 Apr;17(4):925-947

Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.

Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR
Theranostics 2020;10(20):9032-9049

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.

Luo Z, Liu LF, Jiang YN, Tang LP, Li W, Ouyang SH, Tu LF, Wu YP, Gong HB, Yan CY, Jiang S, Lu YH, Liu T, Jiang Z, Kurihara H, Yu Y, Yao XS, Li YF, He RR
Signal transduction and targeted therapy 2020 Sep 18;5(1):202

DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy.

Szymura SJ, Bernal GM, Wu L, Zhang Z, Crawley CD, Voce DJ, Campbell PA, Ranoa DE, Weichselbaum RR, Yamini B
BMC biology 2020 Mar 24;18(1):32

The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS.

Zhou D, Li Q, Jia F, Zhang L, Wan S, Li Y, Song Y, Chen H, Cao S, Ye J
Journal of immunology (Baltimore, Md. : 1950) 2020 Mar 1;204(5):1287-1298

TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.

Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y
The Journal of experimental medicine 2020 Jul 6;217(7)

A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.

Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711

Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation.

Wang Y, Wang P, Zhang Y, Xu J, Li Z, Li Z, Zhou Z, Liu L, Cao X
Immunity 2020 Dec 15;53(6):1168-1181.e7

Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro.

Luo Z, Liu LF, Wang XH, Li W, Jie C, Chen H, Wei FQ, Lu DH, Yan CY, Liu B, Kurihara H, Li YF, He RR
Frontiers in pharmacology 2019;10:78

The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.

Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5

Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.

Igase M, Shousu K, Fujiki N, Sakurai M, Bonkobara M, Hwang CC, Coffey M, Noguchi S, Nemoto Y, Mizuno T
Veterinary and comparative oncology 2019 Jun;17(2):184-193

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

Wang R, Zhu Y, Lin X, Ren C, Zhao J, Wang F, Gao X, Xiao R, Zhao L, Chen H, Jin M, Ma W, Zhou H
Autophagy 2019 Jul;15(7):1163-1181

NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.

Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.

Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y
Nature communications 2018 Mar 28;9(1):1243

TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.

Xing J, Zhang A, Minze LJ, Li XC, Zhang Z
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):183-192

MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells.

Hou P, Wang H, Zhao G, Hu G, Xia X, He H
BMC microbiology 2018 Dec 27;18(1):224

Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.

Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)

Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.

Jie C, Luo Z, Chen H, Wang M, Yan C, Mao ZF, Xiao GK, Kurihara H, Li YF, He RR
Oncotarget 2017 Dec 1;8(62):105615-105629

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation.

Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J
PLoS pathogens 2017 Apr;13(4):e1006321

MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).

Wan S, Ashraf U, Ye J, Duan X, Zohaib A, Wang W, Chen Z, Zhu B, Li Y, Chen H, Cao S
Oncotarget 2016 Nov 22;7(47):76667-76683

Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.

Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G
Journal of virology 2016 Nov 15;90(22):10259-10270

Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1.

Hwang KY, Choi YB
Journal of virology 2016 Jan 1;90(1):506-20

RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.

Gu M, Liu Z, Lai R, Liu S, Lin W, Ouyang C, Ye S, Huang H, Wang X
The EMBO journal 2016 Dec 1;35(23):2553-2565

Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-β expression.

Dong J, Xu S, Wang J, Luo R, Wang D, Xiao S, Fang L, Chen H, Jiang Y
The Journal of general virology 2015 Oct;96(10):3049-3058

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 14341-1-AP(MAVS; VISA antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using MAVS antibody 14341-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-MAVS; VISA (IP:14341-1-AP, 3ug; Detection:14341-1-AP 1:1000) with HEK-293 cells lysate 1700ug.
Sample type: cell line